Joint venture had been pegged as a game-changer for Brazilian aircraft manufacturer

Brazil oil group says no further reductions after move to placate drivers backfires

Spring water case an example of kind of legal tangle that can await foreign investors

The winner of October’s election will have to address a budget dominated by special interests

Globo network dominates political debate despite rise of social media

Bollywood celebrated lockdown mother's day with throwback pictures

Our mothers are one of the most important people in our lives. They are the ones who bring us into this world and take the best care of us. Perhaps, therefore, a mother is considered to be next to God. Mother's

Every year the second Sunday in the month of May is observed as Mother's Day. This is the day dedicated to mothers and the amount of unconditional love they have for their children. The day is celebrated to acknowledge the bond

Angad also said that no matter how angry he gets with his wife, he says nothing can affect the love he has for her.

In the past few days, Russia also became the fifth worst-hit coronavirus outbreak nation, overtaking France and Germany.

Lewis Library - ML410.B8 S42 2018

Lewis Library - ML410.B8 B655 2018

The state-owned airline, which suspended regular passenger flights in March reported a 21% rise in profit for its financial year that ended on March 31

Sri Lanka has gradually begun relaxing curfew as the coronavirus outbreak is now “under control to a certain degree”, Prime Minister Mahinda Rajapaksa

To celebrate their anniversary, the actors went live on their social media channels.

Wood Ants Store Short- And Long-Term Memories on Different Sides of Their Brains  ScienceAlert

Guiluli is a Red Mighty, a mutation of humans born from the Corporate World War. After 54 years of existence, Pre-ev (non mutated) humans still don't much like the Red Mighties and as a result, the Red Mighties have created their own Nationland.

Despite all of the world's natural resources being either consumed or poisoned by the war, the Nationland has cleaned up its land, so they have pure water and soil free of contaminants in which to grow food. Yet another reason for those off the Nationland to dislike the Red Mighties.

I like the idea of the evolved/mutated species emerging from a human race destroyed by its own vices and desires. It seems that hominids may be ripe for another evolutionary step, after all we have been homo sapiens for a while now. Maybe this is the next step.

This is an interesting twist on a typical dystopian novel in that I feel there is way more hope of a future that isn't just trying to exist day to day but actually thrive as a civilization. The possibility of cleaning up what we have destroyed. Backbiters is a great read for those that enjoyed the Hunger Games, Divergent, Not a Drop to Drink.

The final total of books gifted to Ballou Library via the October Book Fair & Cyber Monday  holiday shopping (which continued all week), comes in just over 200 titles! Thank you so much for buying books and helping to spread the word for this DC high school!

The wish list remains open year-round and there are a ton of great books on it, all of them chosen and approved by Ballou students. These are books the teens want and we so enjoy doing everything we can to get these books to them.

In the coming days I will be moving things around a bit on the list, getting series books together so they are easier to find. (I really really REALLY wish that amazon had "search by title" and "search by author" functions. So frustrating!) And we will, of course, be continuing to assist Ballou to fill its shelves next year and hope that you will return to the list and also help us spread the word about the amazing work done by librarian Melissa Jackson.

Have a lovely holiday folks, and thanks again for all you do to support this high school library.

The circulation desk at Delft University of Technology. I'm Jealous.

Environmental NewsFOR IMMEDIATE RELEASE

WASHINGTON (April 22, 2019) – Today, U.S.

Environmental News FOR IMMEDIATE RELEASE

WASHINGTON (May 4, 2020) — This week, as part of the Environmental Protection Agency’s (EPA’s) month-long celebration of our nation’s progress in improving air quality over the last 50 years, we are celebrating the 14t

Das Jahr 2020 ist bislang ungewöhnlich trocken, die Waldbrandgefahr ist hoch. Eine Karte zeigt das Risiko bundesweit - und berücksichtigt dabei auch Faktoren wie Windrichtung und aufziehende Regenwolken.

Brandon Newman's stock rose considerably in the past six months. The 2019 guard from Valparaiso will play at Montverde (Florida) Academy as a senior.

Valparaiso Vikings were set up for a tournament run before defection of star guard, who has offers from IU and Purdue.

Messages to mothers and words of support were front and centre as Edmontonians cruised by MacTaggart Place retirement residence on Saturday afternoon.

Former New Zealand head coach and current England defence chief John Mitchell believes some good may come for rugby union from the coronavirus.

29 October 2014

In the most fragmented party system in the democratic world, the ongoing dominance of the same two parties in presidential elections is nothing short of remarkable.

gali_nette posted a photo:

β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to form β-cholesterylglucoside (β-GlcChol) in vitro. β-GlcChol is a member of sterylglycosides present in diverse species. How GBA1 and GBA2 mediate β-GlcChol metabolism in the brain is unknown. Here, we purified and characterized sterylglycosides from rodent and fish brains. Although glucose is thought to be the sole carbohydrate component of sterylglycosides in vertebrates, structural analysis of rat brain sterylglycosides revealed the presence of galactosylated cholesterol (β-GalChol), in addition to β-GlcChol. Analyses of brain tissues from GBA2-deficient mice and GBA1- and/or GBA2-deficient Japanese rice fish (Oryzias latipes) revealed that GBA1 and GBA2 are responsible for β-GlcChol degradation and formation, respectively, and that both GBA1 and GBA2 are responsible for β-GalChol formation. Liquid chromatography–tandem MS revealed that β-GlcChol and β-GalChol are present throughout development from embryo to adult in the mouse brain. We found that β-GalChol expression depends on galactosylceramide (GalCer), and developmental onset of β-GalChol biosynthesis appeared to be during myelination. We also found that β-GlcChol and β-GalChol are secreted from neurons and glial cells in association with exosomes. In vitro enzyme assays confirmed that GBA1 and GBA2 have transgalactosylation activity to transfer the galactose residue from GalCer to cholesterol to form β-GalChol. This is the first report of the existence of β-GalChol in vertebrates and how β-GlcChol and β-GalChol are formed in the brain.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

ROSEAU, Dominica (CMC): Well-travelled Barbadian umpire Gregory Brathwaite has been tipped to become the next Test umpire from the region. WEST INDIES Cricket Umpires Association secretary, Vivian Johnson, said the 50-year-old Brathwaite was...

A Manchester corporal is now on sick leave after receiving several blows to his face allegedly by a woman police inspector at work yesterday. It is reported that the incident happened in the guard room of the Mandeville Police Station.

“Badass” new method uses a magnetised protein to activate brain cells rapidly, reversibly, and non-invasively

Researchers in the United States have developed a new method for controlling the brain circuits associated with complex animal behaviours, using genetic engineering to create a magnetised protein that activates specific groups of nerve cells from a distance.

Understanding how the brain generates behaviour is one of the ultimate goals of neuroscience – and one of its most difficult questions. In recent years, researchers have developed a number of methods that enable them to remotely control specified groups of neurons and to probe the workings of neuronal circuits.

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State-of-the-art electron microscopy reveals the large-scale organization of the proteins that regulate neurotransmitter release

This spectacular image – which took the best part of a year to create – shows the fine structure of a nerve terminal at high resolution, revealing, for the very first time, an intricate network of fine filaments that controls the movements of synaptic vesicles.

The brain is soft and wet, with the consistency of a lump of jelly. Yet, it is the most complex and highly organized structure that we know of, containing hundreds of billions of neurons and glial cells, and something on the order of one quadrillion synaptic connections, all of which are arranged in a very specific manner.

Related: 3D model of a nerve terminal in atomic detail | Mo Costandi

Related: Blowing up the brain to reveal its finer details

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New research reveals the secret behind the remarkable intelligence of some bird species

Related: Blind cave fish evolved a shrunken brain to save energy

Calling someone “bird brain” used to be considered as an insult. Birds’ brains are very small compared to those of mammals, and what’s more, they lack the heavily wrinkled cerebral cortex, which is characteristic of the human brain, and widely believed to the seat of intelligence. It was, therefore, widely assumed that birds aren’t very clever creatures, but recently this has started to change.

Related: Ravens cooperate with friends not foes

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A new imaging technique may give researchers fresh insights into brain development, function, and disease

The human brain is often said to be the most complex object in the known universe, and there’s good reason to believe that it is. That lump of jelly inside your head contains at least 80 billion nerve cells, or neurons, and even more of the non-neuronal cells called glia. Between them, they form hundreds of trillions of precise synaptic connections; but they all have moveable parts, and these connections can change. Neurons can extend and retract their delicate fibres; some types of glial cells can crawl through the brain; and neurons and glia routinely work together to create new connections and eliminate old ones.

These processes begin before we are born, and occur until we die, making the brain a highly dynamic organ that undergoes continuous change throughout life. At any given moment, many millions of them are being modified in one way or another, to reshape the brain’s circuitry in response to our daily experiences. Researchers at Yale University have now developed an imaging technique that enables them to visualise the density of synapses in the living human brain, and offers a promising new way of studying how the organ develops and functions, and also how it deteriorates in various neurological and psychiatric conditions.

Related: Brain’s immune cells hyperactive in schizophrenia

Related: 3D model of a nerve terminal in atomic detail | Mo Costandi

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It’s not just your waistline that suffers as you put on weight. Researchers are beginning to find puzzling new links between obesity, memory loss and dementia

Lucy Cheke and her colleagues at the University of Cambridge recently invited a few participants into her lab for a kind of ‘treasure hunt’.

The participants navigated a virtual environment on a computer screen, dropping off various objects along their way. They then answered a series of questions to test their memory of the task, such as where they had hidden a particular object.

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New research shows that the rhythm of breathing directly impacts neural activity in a network of brain areas involved in smell, memory and emotions

The rhythm of breathing co-ordinates electrical activity across a network of brain regions associated with smell, memory, and emotions, and can enhance their functioning, according to a new study by researchers at Northwestern University. The findings, published in the Journal of Neuroscience, suggest that breathing does not merely supply oxygen to the brain and body, but may also organise the activity of populations of cells within multiple brain regions to help orchestrate complex behaviours.

Related: Your nose knows death is imminent | Mo Costandi

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New findings challenge our understanding of how the brain matures

Faces are important to us. From the moment we are are born, we prefer to look at faces than at other, inanimate objects, and, being social animals, we encounter faces every day of our lives. The face is the first thing we look to when identifying other people; faces also convey emotions, informing us of peoples’ mood, and from them we can usually determine a person’s sex and, sometimes, roughly how old they are. Eye movements can also reveal to us something about another person’s intentions.

Related: How your eyes betray your thoughts

Related: Live imaging of synapse density in the human brain

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New research provides evidence for the idea that sleep restores cellular homeostasis in the brain and helps us to forget irrelevant information

We spend one third of our lives sleeping, but we still do not know exactly why we sleep. Recent research shows that that the brain does its housekeeping while we sleep, and clears away its waste. According to another hypothesis, sleep plays the vital role of restoring the right balance of brain synapses to enhance learning, and two studies published in today’s issue of Science now provide the most direct evidence yet for this idea.

We do know that sleep is important for consolidating newly formed memories. During waking hours, we learn all kinds of new information, both consciously and unconsciously. To store it, the brain modifies large numbers of synaptic connections, making some of them stronger and larger, and it’s now thought that as we sleep other synapses are weakened or destroyed, so that the important new information is stored for later use, while irrelevant material, which could interfere with learning, is not.

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New research shows that we can train our brains to become memory champions

To many of us, having to memorize a long list of items feels like a chore. But for others, it is more like a sport. Every year, hundreds of these ‘memory athletes’ compete with one another in the World Memory Championships, memorising hundreds of words, numbers, or other pieces of information within minutes. The current world champion is Alex Mullen, who beat his competitors by memorizing a string of more than 550 digits in under 5 minutes.

You may think that such prodigious mental feats are linked to having an unusual brain, or to being extraordinarily clever. But they are not. New research published in the journal Neuron shows that you, too, can be a super memorizer with just six weeks of intensive mnemonic training, and also reveals the long-lasting changes to brain structure and function that occur as a result of such training.

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Researchers at MIT have developed a new method of electrically stimulating deep brain tissues without opening the skull

Since 1997, more than 100,000 Parkinson’s Disease patients have been treated with deep brain stimulation (DBS), a surgical technique that involves the implantation of ultra-thin wire electrodes. The implanted device, sometimes referred to as a ‘brain pacemaker’, delivers electrical pulses to a structure called the subthalamic nucleus, located near the centre of the brain, and effectively alleviates many of the physical symptoms of the disease, such as tremor, muscle rigidity, and slowed movements.

DBS is generally safe but, like any surgical procedure, comes with some risks. First and foremost, it is highly invasive, requiring small holes to be drilled in the patient’s skull, through which the electrodes are inserted. Potential complications of this include infection, stroke, and bleeding on the brain. The electrodes, which are implanted for long periods of time, sometimes move out of place; they can also cause swelling at the implantation site; and the wire connecting them to the battery, typically placed under the skin of the chest, can erode, all of which require additional surgical procedures.

Related: Blowing up the brain to reveal its finer details

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