The present invention relates to in vitro methods of assessing the susceptibility or responsiveness of a subject to the treatment with an epidermal growth factor receptor (EGFR) inhibitor/antagonist, wherein the subject has been diagnosed or suspected of suffering from inflammation-associated. These methods comprise determining the level of expression of EGFR in myeloid cells in a sample from the subject, wherein an expression of EGFR in the myeloid cells is indicative of the subject being susceptible to the treatment with an EGFR inhibitor/antagonist. The invention also relates to EGFR inhibitors/antagonists for use in the treatment or amelioration of inflammation-associated cancer. The invention furthermore provides in vitro methods of prognosing the survival time, progression-free survival time or disease course of a subject that has been diagnosed or suspected of suffering from from inflammation-associated cancer. In addition thereto, the invention relates to in vitro diagnostic methods of assessing the proneness of a subject to develop inflammation-associated cancer in which the expression of EGFR is determined in myeloid cells from the subject.

The diagnosis of male infertility is based predominantly on the results of standard semen analysis for concentration, total motility, progressive motility, volume, pH, viscosity and/or morphology. When sperm enter the female reproductive tract, they must undergo a series of physiological changes, known as capacitation, in order to fertilize an egg. This process involves plasma membrane changes that occur in response to stimuli within the female tract. These changes include removal of sterols and redistribution of the ganglioside GM1. Semen analysis identifies only half the cases of male infertility due to standard semen analysis providing little information on sperm functional competence. Previous data demonstrated that localization of the ganglioside, GM1, identifies sub-populations of sperm capable of undergoing the functional maturation process known as capacitation and tracks strongly with fertility.

The present disclosure provides robust, high-throughput, and clinically applicable methods for simultaneously separating and quantifying the biologically active forms of Vitamin B1 (TPP) and Vitamin B6 (PLP) from human whole blood.

A population of bright and stable nanocrystals is provided. The nanocrystals include a semiconductor core and a thick semiconductor shell and can exhibit high extinction coefficients, high quantum yields, and limited or no detectable blinking.

East Bay resident Miles Woodruff, CEO of the pioneering vegan-seafood brand Sophie's Kitchen, has just donated 3,000 cases of plant-based Toona to the Food Bank of Contra Costa and Solano County as well as several other Bay Area food shelters.

Amidst the Covid-19 outbreak, the company's brand-new Lemon Grass Toona flavor has not yet arrived in grocery stores — but 100 percent of it is now being provided to people in need.…

Celebrated chef-restaurateur Kyle Itani, who helms both Itani Ramen and Hopscotch Restaurant & Bar in Uptown Oakland, has just launched a brand-new project: a takeout sushi spot.

Operating out of Itani Ramen and serving its fare via pickup and delivery, Nikkei Sushi will be open Wednesday through Sunday, 2 p.m. - 8 p.m. during its soft opening with hours extending in the future.…

Celebrated chef-restaurateur Kyle Itani, who helms Itani Ramen and Hopscotch Restaurant & Bar in Uptown Oakland, has just launched a brand-new project: a takeout sushi spot.

Stories you shouldn’t miss:

1. Alameda County Public Health Director Muntu Davis contends that gentrification should be examined in terms of health impacts because of the displacement and stress it causes for low-income residents, the Bay Area News Group$ reports.…

If you happen to run into any medical residents anytime soon, they may look a little fatigued and broke, especially if they happen to be residents or pediatricians of UCSF Benioff Children’s Hospital of Oakland. Today, the CIR/SEIU Healthcare union that represents resident physicians and pediatricians said it plans to rally in front of the hospital on Friday at 12:15 p.m. along with nurses and community leaders to demand better wagers and working conditions.…

The city's 911 system can leave callers waiting for more than 120 seconds before an operator ever answers. Seconds of delay in an emergency can lead to death. As a result, 911 calls are supposed to be answered quickly.…

A ground fault circuit interrupter (GFCI) breaker testing system can include an enclosure having at least one wall that forms a cavity. The system can also include at least one GFCI breaker disposed within the cavity. The system can further include a sensing circuit assembly having at least one switch, where the at least one switch is electrically coupled to the at least one GFCI breaker. The system can also include a user interface assembly disposed, at least in part, outside the cavity, where the user interface assembly is coupled to the sensing circuit assembly, where the user interface assembly instructs the at least one switch to test the at least one GFCI breaker.

The present invention provides a chip and an electronic device. The chip comprises at least one pin, and the chip comprises at least one ESD (Electrostatic Discharge) protection circuit inside, and the ESD protection circuit is employed to reduce or eliminate a damage of electrostatic to other elements or circuit inside the chip, and the ESD protection circuit is located corresponding to a pin, and the ESD protection circuit is electrically coupled to the pin. The electronic device comprises the aforesaid chip.

A switching regulator control circuit is used in a switching regulator that converts an input voltage into an output voltage by the switching of a switching device, and generates a switching signal for controlling the ON/OFF operation of the switching device. The switching regulator control circuit has a fault detector and a fault protector. The fault detector detects, based on the duty ratio of the switching signal or a variable correlated to it and included in a control signal used to generate the switching signal, a fault state where the duty ratio falls outside the normal modulation range. The fault protector stops the switching of the switching device when the fault detector detects a fault state.

A circuit board upon which to mount an integrated circuit chip may include a first interconnect zone on the surface of the circuit board having first contacts with a first pitch, and a second interconnect zone, surrounding the first zone, having second contacts or traces with a second pitch that is smaller than the first pitch. The first contacts may have a design rule (DR) for direct chip attachment (DCA) to an integrated circuit chip. The first contacts may be formed by bonding a sacrificial substrate having the first contacts to a surface of the board; or by laser scribing trenches where the conductor will be plated to create the first contacts. Such a board allows DCA of smaller footprint processor chips for devices, such as tablet computers, cell phones, smart phones, and value phone devices.

I SHOULD like to pay tribute to Alan Wiltshire the Echo and Romsey Advertiser reporter whose death was sadly announced last week

The UK-based mixer-maker and audiophile favorite MasterSounds has a small piece of joy to brighten up DJs’ days. They’ve released the third generation of their Radius 2 and Radius 4 mixers, and have adjusted their price points to cater to artists with a lower spending budget (especially now). These mixers are homegrown, too—MasterSounds mixers are […]

The post A third generation of Radius 2 + 4 rotary mixers: New tech upgrades, lower price appeared first on DJ TechTools.

Now how can I be more of a “guy” for my boyfriend? My boyfriend and I were having relationship issues until we tried something new: pegging. He wanted to try it, but he was afraid and sometimes said the idea disgusted him.…

A reading list specifically appropriate to these trying times. Okay, you're stuck in the house, but is it really that awful? OK, probably.…

A vehicular brake device that implements ESC/TRC control suppresses hydraulic pressure variations produced during open/close control of a brake actuator holding valve or depressurizing valve. While a brake operating member is not operated and a wheel cylinder pressure supplying control is executed to supply target wheel cylinder pressure to respective wheel cylinders, the target servo pressure is set to a first predetermined target servo pressure smaller than a maximum output pressure of the servo pressure generating device. When wheel cylinder pressure supplying control starts, the target servo pressure is set as the target wheel cylinder maximum value when a firstly occurred rising inclination of the target wheel cylinder maximum value is equal to or more than a minimum increment of an output of the servo pressure generating device per unit time and at the same time when the target wheel cylinder pressure is below the first determined target servo pressure.

The invention relates to a storage tank (1) in a motor vehicle for receiving an aqueous urea solution for the SCR of nitrogen oxide in the exhaust gas. The storage tank (1) comprises a tank body which forms a storage volume (2) for the urea solution. The storage tank (1) furthermore comprises a filling pipe for filling the storage volume (2) and means for venting the storage volume (2) during the refuelling, wherein the filling pipe (3) has a filling head (9) at a remote end, and the filling head (9) forms an orifice stub (10). The orifice stub (10) defines an orifice (11) for receiving a fuel pump nozzle. Said orifice stub furthermore has an external thread for receiving a complementary union thread of a refuelling cylinder for refuelling by the gas displacement method. The orifice stub forms at least one secondary air opening when the refuelling cylinder is attached, and therefore, when a refuelling cylinder is attached, a sealing seat is bridged by the refuelling cylinder and refuelling by the gas displacement method is possible even if counterflow venting through the filling tube (3) does not take place.

The vehicle exhaust device has an exhaust passage from an exhaust port of an engine body to an exhaust muffler provided behind the engine body, and the exhaust passage is formed by a plurality of exhaust passage forming units. The exhaust device includes an exhaust gas sensor attached to one of the exhaust passage forming units, such as a collecting pipe, halfway on the exhaust passage. At least a portion of the exhaust gas sensor is covered from a front side thereof with one of the exhaust passage forming units, such as an individual exhaust pipe, upstream of an attached position of the exhaust gas sensor.

The heat shield assembly includes an inner-most layer that is directly engagable with an exhaust component and is of a non-ceramic material with a first heat capacity and a first thermal conductivity. The heat shield assembly additionally includes an insulating layer that surrounds the inner-most layer and is of a material that has a second heat capacity which is lower than the first heat capacity and has a second thermal conductivity which is lower than the first thermal conductivity. The direct engagement of the inner-most layer with the exhaust component allows heat to be easily transferred between the exhaust component and the inner-most layer.

A system includes a gas turbine system having a turbine combustor, a turbine driven by combustion products from the turbine combustor, and an exhaust gas compressor driven by the turbine. The exhaust gas compressor is configured to compress and supply an exhaust gas to the turbine combustor. The gas turbine system also has an exhaust gas recirculation (EGR) system. The EGR system is configured to recirculate the exhaust gas along an exhaust recirculation path from the turbine to the exhaust gas compressor. The system further includes a main oxidant compression system having one or more oxidant compressors. The one or more oxidant compressors are separate from the exhaust gas compressor, and the one or more oxidant compressors are configured to supply all compressed oxidant utilized by the turbine combustor in generating the combustion products.

In a rotary machine, a method of assembling a rotary machine, and a method of performing maintenance of a rotary machine, a combustor casing as an outer casing configured from upper and lower casings forming a half split shape, an intermediate shaft cover as an inner casing configured from upper and lower casings forming a half split shape and supporting a combustor in the combustor casing, and a pressing support mechanism that presses and supports a portion to be fit of the combustor casing and a fitting portion of the intermediate shaft cover in an axial direction of a rotor are provided, and thus, detachment of the casing is made easy and maintainability of an inside thereof is improved in the method of performing maintenance of a rotary machine.

A vehicle includes a turbocharger, an exhaust-side variable valve, a vacuum servo device, an exhaust-side negative pressure hose, an exhaust-side check valve, a negative pressure supply valve, and circuitry. The exhaust-side negative pressure hose connects the vacuum servo device and a negative pressure extracting portion disposed in the exhaust passage. The exhaust-side check valve is disposed in the exhaust-side negative pressure hose to permit a gas flow only from the vacuum servo device to the exhaust passage. The negative pressure supply valve is provided in the exhaust-side negative pressure hose to open and close the exhaust-side negative pressure hose. The circuitry configured to control the exhaust-side variable valve to delay the valve timing with respect to an exhaust top dead center so as to generate negative pressure in the exhaust passage and to open the negative pressure supply valve while the negative pressure is generated in the exhaust passage.

A hydraulic system for a work machine includes a first control valve including a first direction switch to switch a direction in which the operation fluid is to flow through a first hydraulic actuator and a pressure compensator to maintain a differential pressure to a constant pressure, the differential pressure being a difference between a pressure of the operation fluid to be inputted to the pressure compensator and a pressure of the operation fluid to be outputted from the pressure compensator. And, the hydraulic system includes a second control valve including a second direction switch to switch a direction in which the operation fluid is to flow through a second hydraulic actuator and a flow rate prioritizer to prioritize a flow rate of the operation fluid to be outputted to the second hydraulic actuator.

Methods, apparatuses and systems are disclosed for chemically etching parts by generating an enclosed chemical etching chamber in contact with a part surface and directing a flow of chemical etchant solution in contact with a part region to be etched.

A surface machining method for a single crystal SiC substrate, including: a step of mounting a grinding plate which includes a soft pad and a hard pad sequentially attached onto a base metal having a flat surface, a step of generating an oxidation product by using the grinding plate, and a step of grinding the surface while removing the oxidation product, wherein abrasive grains made of at least one metallic oxide that is softer than single crystal SiC and has a bandgap are fixed to the surface of the hard pad.

A machine (1) and a method for thermobonding using an emission of electromagnetic waves (13), for example microwaves, to activate one or a plurality of adhesive layers located between a support and one or a plurality of layers of flexible covering, through a bed of particles (4) fluidized by a humidified gas. A multi-layer upholstery item including at least one non-permeable layer and produced in a single operation is also described.

The present invention relates to a process for detaching a component from an electronic assembly. In particular, the present invention relates to a process for detaching a component bonded with a liquid optically clear adhesive (LOCA) in a display module by using electromagnetic radiation (EMR).

A plasma system includes a source electrode, an RF source power generation unit, an RF source power output unit, and a source power output managing unit. The source power output managing unit determines an amplitude and a duty cycle of a pulse RF source power based on information on an amplitude of a continuous wave RF source power.

A dry etching apparatus includes a process chamber, a stage, a gas supply device and a plasma generating device. The stage is in the process chamber and is configured to support a wafer, wherein the wafer has a center region and a periphery region surrounding the center region. The gas supply device is configured to supply a first flow of an etching gas to the center region and supply a second flow of the etching gas to the periphery region. The plasma generating device is configured to generate plasma from the etching gas.

Apparatus for and method of rapidly chilling a beverage in which a vessel having high thermal mass relative to the amount of beverage to be introduced into the vessel is cooled through contact with a cooling module to a temperature low enough that a volume of beverage introduced into the vessel is rapidly cooled.

An ice making machine having a refrigeration system designed for hydrocarbon (HC) refrigerants, and particularly propane (R-290), that includes dual independent refrigeration systems and a unique evaporator assembly comprising of a single freeze plate attached to two cooling circuits. The serpentines are designed in an advantageous pattern that promotes efficiency by ensuring the even bridging of ice during freezing and minimizing unwanted melting during harvest by providing an even distribution of the heat load. The charge limitations imposed with flammable refrigerants would otherwise prevent large capacity ice maker from being properly charged with a single circuit. The ice making machine includes a single water circuit and control system to ensure the proper and efficient production of ice. Material cost is conserved as compared to a traditional dual system icemaker.

An ice machine may include a compressor, a first heat exchanger, an expansion device, an evaporator, an ice tray, and a water pump. The first heat exchanger may receive compressed working fluid from the compressor. The expansion device may receive working fluid from the first heat exchanger. The evaporator may receive working fluid from the expansion device. The ice tray may be in a heat transfer relationship with the evaporator. The ice tray may include a plurality of ice molds. The water pump may be in fluid communication with the ice molds and may be configured to pump water from a water source to the ice molds.

Apparatus for and method of rapidly chilling a beverage in which a vessel having high thermal mass relative to the amount of beverage to be introduced into the vessel is cooled through contact with a cooling module to a temperature low enough that a volume of beverage introduced into the vessel is rapidly cooled.

A device and method for heat distribution in a hybrid motor vehicle are provided. The device includes an engine cooling circuit; and a refrigerant circuit for a combined operation in a refrigeration heat pump mode and a reheating mode, includes an evaporator, a compressor, a heat exchanger to supply heat from the refrigerant to air being conditioned for a passenger compartment; and a heat exchanger to transfer heat between a refrigerant of the refrigerant circuit and coolant of the engine cooling circuit, wherein the heat exchanger operates as an evaporator for the heat transfer, and as a condenser for the heat transfer from the condensing refrigerant to the coolant.

The present invention relates to a method, device and computer program for terminating a defrosting cycle within a refrigerated transport container. The container may include: a transport volume, a cooling unit comprising an evaporator arranged in a cooling space, a return air grid arranged to separate said cooling space from said transport volume, means for sensing temperature indicative of the return air temperature of air returning to said cooling space from said transport volume or the temperature of the return air grid, means for actively heating said evaporator during defrosting cycles, and a processor configured for controlling the duration of said defrosting cycles. The method includes: establishing an indicator(s) indicative of frost and/or ice build-up on said return air grid, and terminating a defrosting cycle when an indicator(s) of frost and/or ice build-up on said return air grid indicates that said return air grid is free of frost and/or ice.

A system for adaptive cooling and energy harvesting comprising at least one thermoelectric device capable of acting as a thermoelectric cooler and as a thermoelectric generator, a hierarchical multiple-level control system, and electronics controlled by the control system and connected to the thermoelectric device. The electronics selectively configure the thermoelectric device in at least in a thermoelectric cooler operating mode and in a thermoelectric generation operating mode. The thermoelectric device can incorporate quantum-process and quantum-well materials for higher heat transfer and thermoelectric generation efficiencies. The invention provides for thermoelectric devices to additionally operate in temperature sensing mode. The hierarchical control system can comprise a plurality of control system, each of which can operate in isolation and can be interconnected with additional subsystems associated with other hierarchical levels. The hierarchical control system can comprise linear (additive) control, bilinear (additive and multiplicative) control, nonlinear control, and hysteresis.

Copenhagen at the Minerva Theatre is an exhilarating look back at a mysterious meeting during WW2 that may have altered the outcome of the war.

There’s a lot to like in This Is My Family which is directed by Daniel Evans with a light comic touch.

Despite a surge in support for independence in the last few weeks, the Better Together campaign came through with a majority sufficient to put to bed the question of independence for Scotland, at least for now.

The end to the fluoride saga in the Southampton city region will put a big hole in the correspondence bag for this paper’s daily letters page.

THE perfect venue for those looking for the ultimate fairytale.

News you don't want to miss for April 8:

1. Schools in Alameda County, and five other Bay Area counties, will not re-open this academic year, the San Francisco Chronicle reports.…

News you don't want to miss for April 9:

1. Six residents at a nursing home in Hayward have died from covid-19, the East Bay Times reports.…

News you don't want to miss for Easter Weekend:

Oakland will temporarily close 74 miles of city streets to automobile traffic in an effort to give ample space for pedestrians, bike riders, and runners during the covid-19 shelter in place, The Guardian reports.…

News you don't want to miss for April 13:

1. "If the country’s most popular coronavirus model proves accurate, California will reach the peak of its outbreak this Wednesday," the San Francisco Chronicle reports, when it will reach a predicted 66 deaths.…

News you don't want to miss for April 29:

1. Alameda County and five other Bay Area counties issued a revised shelter in place order on Wednesday that will allow for some outdoor activities to resume, such as, construction work, landscaping, gardening, golf and tennis, SFGate reports.…

News you don't want to miss for May 6:

1. Former Oakland Chief of Police Anne Kirkpatrick filed a lawsuit alleging the Oakland Police Commission, which fired her earlier this year, did so as retaliation for Kirkpatrick blowing the whistle on their own wrongdoing, including seeking personal favors, the San Francisco Chronicle reports.…