DALLAS, 4 de abril del 2020 — El día de ayer, se publicó una investigación en Circulation, la revista insignia de la American Heart Association, cuyo objetivo es ayudar a generar aún más conciencia sobre las manifestaciones cardiovasculares del ...

WASHINGTON, D. C., 3 de abril del 2020— Hoy, más de 200 organizaciones de protección de pacientes, médicas y de salud pública enviaron una carta a altos funcionarios de la administración de Donald Trump, en la cual se apela a la Administración para que...

DALLAS, 8 de abril del 2020— El impacto mundial del COVID-19 continúa aumentando y, cada día, la comunidad científica aprende más sobre el efecto y la interacción de las enfermedades cardiovasculares con el COVID-19. Juntos, la American Heart Association...

Sala de prensa de la AHA sobre el COVID-19 Atención con el contenido actualizado a continuación. DALLAS, 9 de abril del 2020– Debido al aumento exponencial actual de la incidencia del COVID-19 en todo el mundo, el porcentaje de paros cardíacos con el...

Aspectos destacados de las declaraciones: Los factores sociales adversos, como el estado de los seguros, la inseguridad alimentaria, la falta de fondos para medicamentos y otros, pueden causar resultados clínicos negativos de la insuficiencia...

Puntos destacados de la investigación: Los adultos de mediana edad que caminaron una mayor cantidad de pasos al día mostraron un 43% menos de riesgo de padecer diabetes y un 31% menos de riesgo de hipertensión arterial, en comparación con personas de...

DALLAS, 3 de abril del 2020 – Debido al esfuerzo de médicos, científicos e investigadores de todo el mundo por comprender la pandemia del coronavirus (COVID-19), la American Heart Association está desarrollando un nuevo registro para agregar datos y...

DALLAS, 3 de abril del 2020 – Con la pandemia de COVID-19, más pacientes presentan disnea (dificultad para respirar) y necesitan ventiladores para ayudarlos a respirar. Debido a que los volúmenes de pacientes en hospitales y unidades de cuidados...

Botones para compartir de AddThis Compartir en Facebook Compartir en Twitter Compartir por correo electrónico Compartir para imprimir DALLAS y ARLINGTON, 23 de abril del 2020 — Debido a que la ciencia que emerge en torno al COVID-19...

We’ve used hex colors for years but 8-digit hexadecimal is still relatively new. While rgba is simple to understand, 8-digit hex is more difficult, as you need to provide a hex representation of a numeric value. The following is a hexadecimal chart of opacity! Opacity Value Hex Code 100 FF 99 FC 98 FA 97 […]

The post Hex Opacity Table appeared first on David Walsh Blog.

We study the dependence of the first eigenvalue of the Finsler $p$-Laplacian and the corresponding eigenfunctions upon perturbation of the domain and we generalize a few results known for the standard $p$-Laplacian. In particular, we prove a Frech'{e}t differentiability result for the eigenvalues, we compute the corresponding Hadamard formulas and we prove a continuity result for the eigenfunctions. Finally, we briefly discuss a well-known overdetermined problem and we show how to deduce the Rellich-Pohozaev identity for the Finsler $p$-Laplacian from the Hadamard formula.

We observe that the DeTurck Laplacian flow of G2-structures introduced by Bryant and Xu as a gauge fixing of the Laplacian flow can be regarded as a flow of G2-structures (not necessarily closed) which fits in the general framework introduced by Hamilton in [4].

Input transformation based defense strategies fall short in defending against strong adversarial attacks. Some successful defenses adopt approaches that either increase the randomness within the applied transformations, or make the defense computationally intensive, making it substantially more challenging for the attacker. However, it limits the applicability of such defenses as a pre-processing step, similar to computationally heavy approaches that use retraining and network modifications to achieve robustness to perturbations. In this work, we propose a defense strategy that applies random image corruptions to the input image alone, constructs a self-correlation based subspace followed by a projection operation to suppress the adversarial perturbation. Due to its simplicity, the proposed defense is computationally efficient as compared to the state-of-the-art, and yet can withstand huge perturbations. Further, we develop proximity relationships between the projection operator of a clean image and of its adversarially perturbed version, via bounds relating geodesic distance on the Grassmannian to matrix Frobenius norms. We empirically show that our strategy is complementary to other weak defenses like JPEG compression and can be seamlessly integrated with them to create a stronger defense. We present extensive experiments on the ImageNet dataset across four different models namely InceptionV3, ResNet50, VGG16 and MobileNet models with perturbation magnitude set to {epsilon} = 16. Unlike state-of-the-art approaches, even without any retraining, the proposed strategy achieves an absolute improvement of ~ 4.5% in defense accuracy on ImageNet.

The global health threat from COVID-19 has been controlled in a number of instances by large-scale testing and contact tracing efforts. We created this document to suggest three functionalities on how we might best harness computing technologies to supporting the goals of public health organizations in minimizing morbidity and mortality associated with the spread of COVID-19, while protecting the civil liberties of individuals. In particular, this work advocates for a third-party free approach to assisted mobile contact tracing, because such an approach mitigates the security and privacy risks of requiring a trusted third party. We also explicitly consider the inferential risks involved in any contract tracing system, where any alert to a user could itself give rise to de-anonymizing information.

More generally, we hope to participate in bringing together colleagues in industry, academia, and civil society to discuss and converge on ideas around a critical issue rising with attempts to mitigate the COVID-19 pandemic.

In response to the coronavirus disease (COVID-19) outbreak, there is an ever-increasing number of national governments that are rolling out contact-tracing Apps to aid the containment of the virus. The first hugely contentious issue facing the Apps is the deployment framework, i.e. centralised or decentralised. Based on this, the debate branches out to the corresponding technologies that underpin these architectures, i.e. GPS, QR codes, and Bluetooth. This work conducts a pioneering review of the above scenarios and contributes a geolocation mapping of the current deployment. The vulnerabilities and the directions of research are identified, with a special focus on the Bluetooth-based decentralised scheme.

In this paper we analyze a continuous version of the maximal covering location problem, in which the facilities are required to be interconnected by means of a graph structure in which two facilities are allowed to be linked if a given distance is not exceed. We provide a mathematical programming framework for the problem and different resolution strategies. First, we propose a Mixed Integer Non Linear Programming formulation, and derive properties of the problem that allow us to project the continuous variables out avoiding the nonlinear constraints, resulting in an equivalent pure integer programming formulation. Since the number of constraints in the integer programming formulation is large and the constraints are, in general, difficult to handle, we propose two branch-&-cut approaches that avoid the complete enumeration of the constraints resulting in more efficient procedures. We report the results of an extensive battery of computational experiments comparing the performance of the different approaches.

Selecting an appropriate model to forecast product demand is critical to the manufacturing industry. However, due to the data complexity, market uncertainty and users' demanding requirements for the model, it is challenging for demand analysts to select a proper model. Although existing model selection methods can reduce the manual burden to some extent, they often fail to present model performance details on individual products and reveal the potential risk of the selected model. This paper presents DFSeer, an interactive visualization system to conduct reliable model selection for demand forecasting based on the products with similar historical demand. It supports model comparison and selection with different levels of details. Besides, it shows the difference in model performance on similar products to reveal the risk of model selection and increase users' confidence in choosing a forecasting model. Two case studies and interviews with domain experts demonstrate the effectiveness and usability of DFSeer.

We study heterogeneous $k$-facility location games. In this model there are $k$ facilities where each facility serves a different purpose. Thus, the preferences of the agents over the facilities can vary arbitrarily. Our goal is to design strategy proof mechanisms that place the facilities in a way to maximize the minimum utility among the agents. For $k=1$, if the agents' locations are known, we prove that the mechanism that places the facility on an optimal location is strategy proof. For $k geq 2$, we prove that there is no optimal strategy proof mechanism, deterministic or randomized, even when $k=2$ there are only two agents with known locations, and the facilities have to be placed on a line segment. We derive inapproximability bounds for deterministic and randomized strategy proof mechanisms. Finally, we focus on the line segment and provide strategy proof mechanisms that achieve constant approximation. All of our mechanisms are simple and communication efficient. As a byproduct we show that some of our mechanisms can be used to achieve constant factor approximations for other objectives as the social welfare and the happiness.

There's one thing the Innovia Foundation can never say: That it hadn't been told.…

[IMAGE-1] I honestly don't know how people like Bryan Stevenson keep up the fight. Just Mercy is the true origin story of a literal social justice warrior, a Harvard-educated lawyer who, in the late 1980s, launched the Equal Justice Initiative in Montgomery, Alabama, to take on the neediest, most desperate cases.…

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The Inlander is a community newspaper covering news, politics, events, happy hour, everything that's happening today, things to do on the weekend, in Spokane, Coeur d'Alene, the greater Inland Northwest and beyond.

The present invention relates to a process for preparing a compound of formula wherein: R2 is cycloalkyl or alkyl, each of which may be optionally substituted; Y is —CONR3R4, —CN or CO2R5; R3, R4 and R5 are each independently H or alkyl; n is 1 to 6; wherein said process comprising the steps of: (i) treating a compound of formula (IV), where R1 is alkyl, with a compound of formula (V) and forming a compound of formula (IIIb); (ii) treating said compound of formula (IIIb) with a compound of formula (I1) to form a compound of formula (I).

The invention relates to Fatty Acid Fumarate Derivatives; compositions comprising an effective amount of a Fatty Acid Fumarate Derivative; and methods for treating or preventing cancer, a metabolic disorder or neurodegenerative disorder comprising the administration of an effective amount of a Fatty Acid Fumarate Derivative.

Provided are processes for the oxidative cleavage of a double bond in an unsaturated carboxylic acid. The process includes contacting the unsaturated carboxylic acid with a mild oxidizing agent and agitating the unsaturated carboxylic acid and the mild oxidizing agent for a time sufficient to cleave a double bond of the unsaturated carboxylic acid and produce a product comprising an aldehyde. The process is typically carried out in a mill, such as a ball, hammer, attrition, or jet mill.

A reagent composition for forming fatty acyl amido surfactants is provided which includes an alkali metal or alkaline earth metal salt of an amino compound; a polyol of molecular weight ranging from 76 to 300; and no more than 10% water.

The current invention describes processes for obtaining of concentrates of esters of eicosapentaenoic acid and docosahexaenoic acid for their use in massive and regular human consumption either as a pharmaceutical ingredient or as a food ingredient, which are characterized by having neutral and stable organoleptic properties, free of side effects, which are typical from marine oils derivatives, and with low content of Persistent Organic Pollutants (POP).

An object of the present invention is to provide a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof and to provide a pharmaceutical agent which contains said compound as an active ingredient and has a highly safe neurotrophic factor-like activity or an alleviating action for side effect induced by administration of anti-cancer agents. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof which is the compound of the present invention is specifically represented by the formula (1): (In the formula, Y is —O—, —NR— or —S—, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group) and has a quite high usefulness as a pharmaceutical agent such as a preventive or therapeutic agent for dementia, Alzheimer's disease, Parkinson's disease, depression, etc., a treating or repairing agent for spinal cord injury.

A process for producing C10-C26 monobranched fatty acids or alkyl esters thereof which includes isomerizing unsaturated C10-C26 fatty acids or alkyl esters thereof in the presence of a catalyst which comprises both a zeolite and a Lewis base. The zeolite can be reused after simple separation from the reaction products without having to regenerate. The process is particularly suitable for producing highly monobranched fatty acids or alkyl esters thereof.

Methods are provided for refining natural oil feedstocks and producing dibasic esters and/or dibasic acids. The methods comprise reacting a terminal olefin with an internal olefin in the presence of a metathesis catalyst to form a dibasic ester and/or dibasic acid. In certain embodiments, the olefin esters are formed by reacting the feedstock in the presence of a metathesis catalyst under conditions sufficient to form a metathesized product comprising olefins and esters, separating the olefins from the esters in the metathesized product, and transesterifying the esters in the presence of an alcohol to form a transesterified product having olefin esters.

This invention relates to an improved process for the preparation of green fatty acid methyl esters (FAME; commonly called as biodiesel) from different triglyceride oils using mixed metal oxides derived from layered double hydroxides (referred here as LDHs) as reusable solid heterogeneous base catalysts. This process uses very low alcohohoil molar ratio and catalyst and/or products are easily separable after the reaction through simple physical processes. The properties of thus obtained biodiesel meet the standard biodiesel values and can directly be used as transport fuel.

A method for lowering content of a sterol in a highly unsaturated fatty acid-concentrated oil in a method to concentrate a highly unsaturated fatty acid by using a lipase reaction, may include removing the free form of the sterol from a raw material oil that includes a highly unsaturated fatty acid-containing glyceride prior to performing the lipase reaction; and thereafter concentrating the highly unsaturated fatty acid in the glyceride by using a lipase that is less reactive for the highly unsaturated fatty acid.

The present invention provides: an uracil derivative represented by general formula (I) or a physiologically acceptable salt thereof (in the formula, R1 represents a hydrogen atom, a C1-10 alkyl group, a C2-6 alkene group or a 3- to 6-membered saturated or 4- to 6-membered unsaturated aliphatic ring group which may contain 1 to 2 hetero atoms independently selected from the group consisting of N, O and S; R2 represents a hydrogen atom, a halogen atom, a cyano group, —NRcRd, —N═CHN(CH3)2, or an C1-3 alkyl group; Ar1 and Ar2 independently represent a 5- to 6-membered aromatic ring group which may contain 1 to 3 hetero atoms independently selected from the group consisting of N, O and S; and L represents a 6-membered aromatic ring group which may contain 1 to 4 nitrogen atoms, a pyrazole group, a triazole group, or an imidazole group); and a therapeutic agent or prophylactic agent for various inflammatory diseases associated with elastase, comprises the compound or the like as an active ingredient.

The present invention relates to a novel acid addition salt of risperidone, wherein acid counterion is selected from the group consisting of pamoic acid, caproic acid, cypionic acid, decanoic acid, camphor sulfonic acid, enanthic acid, palmitic acid, fusidic acid, gluceptic acid, gluconic acid, lactobionic acid, lauric acid, levulinic acid and valeric acid, a process for the preparation and pharmaceutical composition comprising the same. Further, the invention relates to the use of said pharmaceutical composition comprising the acid addition salt of risperidone in the treatment of patient suffering from psychotic disorders.

Formaldehyde-free binder compositions are described that include an aldehyde or ketone, a nitrogen-containing salt of an inorganic acid, and an acidic compound. The acidic compound may be an organic acid, such as maleic acid or citric acid among others. The acidic compound is supplied in quantities that lower the pH of the binder composition to about 5 or less. The binder compositions may be used in methods of binding fiberglass and the resulting fiberglass products have an improved tensile strength due to the addition of the acidic compound.

Injection molded articles and process of forming the same are described herein. The processes generally include providing a polyolefin including one or more propylene heterophasic copolymers, the polyolefin having an ethylene content of at least 10 wt. % based on the total weight of the polyolefin; contacting the polyolefin with a polylactic acid and a reactive modifier to form a compatiblized polymeric blend, wherein the reactive modifier is produced by contacting a polypropylene, a multifunctional acrylate comonomer, and an initiator under conditions suitable for the formation of a glycidyl methacrylate grafted polypropylene (PP-g-GMA) having a grafting yield in a range from 1 wt. % to 15 wt. %; and injection molding the compatibilized polymeric blend into an article.

Beta-lactamase inhibiting compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition or carboxylate salt thereof; where n is zero, 1 or 2; X3 is H or Br, R1 is H, the residue of certain carboxy-protecting groups or the residue of an ester group readily hydrolyzable in vivo; one of R12 and R13 is H and the other is vinyl, certain aryl, alkylthio, alkylsulfonyl or certain heterocyclyl, aminomethyl, thiocarboxyamido or amidino groups; one of R2 and R3 is H and the other is as disclosed for the other of R12 and R13, or is Cl or CH2 OH, and R18 is H or certain acyl groups; intermediates useful in their production, methods for their preparation and use, and pharmaceutical compositions containing them.

A dielectric ceramic material comprises a primary component of barium titanate (BaTiO3) and at least one additive component. The additive component has a mole percentage from 1% to 50% and is selected from the group consisting of lithium tantalite (LiTaO3), barium cerate (BaCeO3), sodium metaniobate (NaNbO3) and the combinations thereof.

An adsorption process is disclosed for removal of acid gas contaminants from a liquid or gas which comprises providing an activated alumina adsorbent which is impregnated with a compound selected from the group consisting of one or more alkali metal compounds, one or more alkaline earth metal compounds, or a mixture of such compounds; contacting the liquid or gas containing acid gas contaminants with the activated alumina adsorbent to adsorb enough acid gas contaminant in the liquid or gas to lower the contaminant content of the liquid or gas, the alumina adsorbent being formed from agglomerated calcined alumina powder and provided with a mercury pore volume of pores greater than 500 angstroms at least 0.10 cc/g.

This invention relates to a method for increasing thermal stability of fuel, as well as in reducing nitrogen content and/or enhancing color quality of the fuel. According to the method, a fuel feedstock can be treated with a solid phosphoric acid catalyst under appropriate catalyst conditions, e.g., to increase the thermal stability of the fuel feedstock. Preferably, the fuel feedstock can be treated with the solid phosphoric acid catalyst at a ratio of catalyst mass within a contact zone to a mass flow rate of feedstock through the zone of at least about 18 minutes to increase the thermal stability of the fuel feedstock, along with reducing nitrogen content and/or enhancing color quality.

Disclosed is a method for removing weakly basic nitrogen compounds from a hydrocarbon feed stream by contacting the hydrocarbon feed stream with acidic clay to produce a hydrocarbon effluent stream having a lower weakly basic nitrogen compound content relative to the hydrocarbon feed stream. The hydrocarbon feed stream comprises an aromatic compound and a weakly basic nitrogen compound.

The invention provides a method for preventing discoloration of pyrithione-containing materials, in particular plastic materials or other material such as paints, coatings, adhesives or textiles which are exposed to an outdoor environment. The method is likewise suited for preventing discoloration of other pyrithione-containing materials such as personal care compositions like shampoos. A discoloration inhibitor that includes dehydroacetic acid or a salt thereof is added to the pyrithione-containing material. The discoloration is prevented without the addition of a cyclic organic phosphoric acid ester or an organic phosphite. Use of the discoloration inhibitor does not interfere with the antimicrobial effect of the pyrithione.

The invention relates to the treatment of carbonaceous radioactive waste, comprising the delivery of waste to one or more radioactive isotope separation stations isotopes, said isotopes being among at least carbon 14, chlorine 36, and tritium. Advantageously, the delivery to each of the stations occurs in wet form, with water being a common medium for conveying the waste to each of the separation stations.

Containers and methods for disposing unused pharmaceutical product are disclosed. Each container (100, 200, 300) may include a container body (104, 204, 304) with an internal chamber (116, 216, 316) for storing pharmaceutical product, along with a cover (124, 224, 324) for selectively limiting access to the chamber (116, 216, 316). An encapsulation component (128, 228, 328) may be selectively disposable within the chamber (116, 216, 316), and may be operable to encapsulate the pharmaceutical product within the container (100, 200, 300). For instance, the encapsulation component (128, 228, 328) may melt and/or flow into contact with the pharmaceutical product and thereafter solidify to encapsulate the pharmaceutical product. The encapsulation component (128, 228, 328) may melt and thereafter solidify between the cover (124, 224, 324) and shell (104, 204, 304) to limit removal of the cover (124, 224, 324) from the shell (104, 204, 304).

A method, apparatus, and system for switching from an existing target end device to a next target end device in a multi-expander storage topology by using Fast Context Switching. The method enhances Fast Context Switching by allowing Fast Context Switching to reuse or extend part of an existing connection path to an end device directly attached to a remote expander. The method can include reusing or extending at least a partial path of an established connection between an initiator and the existing target end device for a connection between the initiator and the next target end device, whereby the existing target end device and the next target end device are locally attached to different expanders.

A usage allocation of a hardware resource to each of a number of workloads over time is determined using a demand model. The usage allocation of the resource includes a current and past actual usage allocation of the resource, a future projected usage allocation of the resource, and current and past actual usage of the resource. A capacity allocation of the resource is determined using a capacity model. The capacity allocation of the resource includes a current and past capacity and a future projected capacity of the resource. Whether a gap exists between the usage allocation and the capacity allocation is determined using a mapping model. Where the gap exists between the usage allocation of the resource and the capacity allocation of the resource, a user is presented with options determined using the mapping model and selectable by the user to implement a remediation strategy to close the gap.

Methods and apparatus are provided for evaluating potential resource capacity in a system where there is elasticity and competition between a plurality of containers. A dynamic potential capacity is determined for at least one container in a plurality of containers competing for a total capacity of a larger container. A current utilization by each of the plurality of competing containers is obtained, and an equilibrium capacity is determined for each of the competing containers. The equilibrium capacity indicates a capacity that the corresponding container is entitled to. The dynamic potential capacity is determined based on the total capacity, a comparison of one or more of the current utilizations to one or more of the corresponding equilibrium capacities and a relative resource weight of each of the plurality of competing containers. The dynamic potential capacity is optionally recalculated when the set of plurality of containers is changed or after the assignment of each work element.

Disclosed herein are stabilized powder and aqueous formulations comprising a substantially water insoluble lipophilic bioactive compound and a micelle-forming surfactant. In one embodiment, the formulation further comprises a water soluble reducing agent, and/or a water insoluble reducing agent, and/or a metal chelator, and/or a metal bisulfite reducing agent, or combinations thereof, wherein the formulation remains substantially clear and stable when stored at or below room temperature for a period of at least 6 months or at least 12 months; and methods for preparing these formulations.

The disclosure relates to methods of making polymer particles, said methods including the steps of: making an aqueous gel reaction mixture; forming an emulsion having dispersed aqueous phase micelles of gel reaction mixture in a continuous phase; adding an initiator oil comprising at least one polymerization initiator to the continuous phase; and performing a polymerization reaction in the micelles. Further, the initiator oil is present in a volume % relative to a volume of the aqueous gel reaction mixture of between about 1 vol % to about 20 vol %. The disclosure also relates to methods of making nucleic acid polymer particles having the same method steps and wherein the aqueous gel reaction mixture includes a nucleic acid fragment, such as a primer.

A framework for implementing multitenant architecture is provided. The framework comprises a framework services module which is configured to provide framework services that facilitate abstraction of Software-as-a-Service (SaaS) services and crosscutting services for a Greenfield application and a non SaaS based web application. Further the abstraction results in a SaaS based multitenant web application. The framework further comprises a runtime module configured to automatically integrate and consume the framework services and APIs to facilitate monitoring and controlling of features associated with the SaaS based multitenant web application. The framework further comprises a metadata services module configured to provide a plurality of metadata services to facilitate abstraction of storage structure of metadata associated with the framework and act as APIs for managing the metadata. The framework further comprises a role based administration module that facilitates management of the metadata through a tenant administrator and a product administrator.