John Cena!* Online resources only for free and end users due to the 'unprecedented period'

Video conferencing darling of the hour, Zoom, has tightened up support rules in order to "better serve" users.…

We previously established that global deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain. Because proinflammatory macrophages recruited to adipose tissue are central to the metabolic complications of obesity, we explored the role of ASXL2 in myeloid lineage cells. Unexpectedly, mice without Asxl2 only in myeloid cells (Asxl2ΔLysM) were completely resistant to diet-induced weight gain and metabolically normal despite increased food intake, comparable activity, and equivalent fecal fat. Asxl2ΔLysM mice resisted HFD-induced adipose tissue macrophage infiltration and inflammatory cytokine gene expression. Energy expenditure and brown adipose tissue metabolism in Asxl2ΔLysM mice were protected from the suppressive effects of HFD, a phenomenon associated with relatively increased catecholamines likely due to their suppressed degradation by macrophages. White adipose tissue of HFD-fed Asxl2ΔLysM mice also exhibited none of the pathological remodeling extant in their control counterparts. Suppression of macrophage Asxl2 expression, via nanoparticle-based siRNA delivery, prevented HFD-induced obesity. Thus, ASXL2 controlled the response of macrophages to dietary factors to regulate metabolic homeostasis, suggesting modulation of the cells’ inflammatory phenotype may impact obesity and its complications.

New experience reports published by Erowid on May 01 2020

New experience reports published by Erowid on May 02 2020

New experience reports published by Erowid on May 04 2020

New experience reports published by Erowid on May 05 2020

New experience reports published by Erowid on May 06 2020

New experience reports published by Erowid on May 08 2020

I am still holding on a call to the Internal Revenue Service, even though I called (800) 829-0115 two hours ago. This telephone number is the one often included in notices from the Internal Revenue Service for overdue business taxes. … Continue reading →

Pets at Home, the UK’s leading pet specialist retailer and IBM today announced the launch of Sales Assist, an IBM MobileFirst for iOS app for iPad which will be used across 440 stores nationwide to make it easier and simpler for customers to purchase the products they need.

IBM today announced that it will help deliver a tailored fan experience through the IBM Cloud at Atlanta’s new Mercedes-Benz Stadium, scheduled to open later this month.

Today IBM and Eurobank announced the first cloud-based digital platform for online international commercial trading. Using IBM's industry-leading Digital Experience software, with advanced cloud capabilities and social offerings, Eurobank is uniting exporters and importers from around the globe to enhance international trade operations and increase transactions.

IBM today announced the opening of IBM Studio Groningen, where IBM design, digital and industry experts will work with clients to help them engage with their customers using big data, mobile, cloud and social innovations.

Digital video consumption is viral and, according to a new study released today by IBM and International Broadcasting Convention (IBC), more than half of the 21,000 consumers surveyed are using mobiles every day to watch streaming videos, and that number is expected to grow 45 percent in the next three years.

IBM is bringing its expertise in sports venue infrastructure design and implementation to the practice field for newly formed Major League Soccer Club, Atlanta United, providing a year-round, state-of-the art technological experience for the players and staff.

The University of Canterbury (UC) is upgrading its centralised IT storage system with the IBM XIV and SONAS network attached storage arrays, to protect valuable research data and better meet user long term needs, while reducing operational costs.

Unitec today announced that the number of people employed in two Delivery Centres at its Mount Albert campus now exceeds 500, and continue to drive benefits for Unitec students and the Auckland economy.

CEMEX, S.A.B. de C.V. (BMV: CEMEXCPO), una de las compañías de materiales para la industria de la construcción líder en el mundo, e IBM (NYSE: IBM) anunciaron hoy que CEMEX llevará a cabo una importante transformación tecnológica diseñada para optimizar sus operaciones, mejorar notablemente la experiencia de sus clientes y aumentar la eficiencia del negocio.

Melbourne, Australia - 18 August 2014: IBM (NYSE: IBM) and the City of Melbourne today launched a new interactive online experience for this year’s Melbourne Spring Fashion Week (MSFW) to enhance the iconic event and help shoppers hunt down the best retail bargains. The launch of the experience signifies the beginning of a three-year partnership between the City of Melbourne and IBM as the Official Innovation and Technology Partner for MSFW.

IBM (NYSE: IBM) today announced it has partnered with academia, government and industry to launch the Smart Transport Research Centre (STRC) based at Queensland University of Technology (QUT), which is being opened today by the Minister for Transport, the honourable Annastacia Palasczuk. IBM will contribute its global consulting expertise and technology in developing smarter traffic solutions to help make Australia’s transportation infrastructure smarter, improve commuter experiences and reduce environmental impact.

IBM collaborates with academia and industry to educate and prepare IT professionals, telecommunications engineers, and electrical power engineers for the electricity networks of the future

IBM, (NYSE: IBM) today announced the findings of its 2016 Global Customer Experience Index (CEI) Study, which showed that Australia is above the global average when it comes to providing a good shopping experience for consumers, with a CEI rating of 43 percent compared with 40 percent globally. The results provided a snapshot of the Australian retail sector, revealing that some businesses are still struggling to provide a seamless cross-channel experience, personalisation and convenience for customers.

ESPN highlights the stories of athletes, coaches and other sports figures managing their mental health and well-being.

Experts, economen en politici: iedereen is nu al bezig met een tweede coronagolf. “Zolang er geen vaccin is, zal het nieuwe normaal blijven bestaan”  Het Nieuwsblad

Mother’s Day is coming up this weekend and, for a lot of us, it’s an event that won’t be like normal. The possibility of many Mother’s Day traditions, like a nice dinner at a restaurant, isn’t even possible in many areas, and social distancing closes the door on many ideas, whether it’s enforced in your area or not. So, what options are there for Mother’s Day that don’t involve just ordering a gift online somewhere and having it shipped to […]

The post 12 Inexpensive and Thoughtful Mother’s Day Gifts appeared first on The Simple Dollar.

Relativistic length contraction is theoretically predicted but not directly tested, which lead to incorrect interpretation of the theory illustrated by Bell’s spaceship paradox and Ehrenfest paradox. But these paradoxes can help us designing experiments to test length contraction. Ideal direct experimental proof should contain the following steps: 1. Measure the tested object’s length at rest,...

Length contraction is used to explain Michelson–Morley experiment. A Michelson interferometer is formed by 2 perpendicular arms. The journey of light along the vertical arm gives the time dilation law. The journey of light along the horizontal arm gives the length contraction law. The derivation scheme of the length contraction law is: 1. The time...

There are 2 types of length contraction, the physical meaning of each is explained below with the help of the example shown in Figure 1. The Earth and the star are stationary and the spaceship mobile. The 2 types of length contraction are: 1) Object contraction: In the frame of the Earth the length of...

Hannah Tweed from the ALLIANCE and Dianne Theakstone from Self-directed Support Scotland spoke to Iriss about the joint research they are undertaking on user experiences of self-directed support in Scotland.

This Scottish Government funded research intends to encourage and develop policy and best practice across the social care landscape.

Transcript of episode

Music Credit: Make your dream a reality by Scott Holmes.

Michael McEwan interviews Michael Byrne, the founder of LETS (Lived Experience Trauma Support) and author of Poems From A Mod: My Journey Through Trauma, Recovery And Survival. 

Michael was diagnosed with Complex Post Traumatic Stress Disorder based on many traumatic events in his life, including abuse as a child, the murder of his father and surviving the Clutha disaster. In April 2017 he had a devastating breakdown which was complete in late January 2018. Since then he has been in recovery.

Health warning: This episode describes scenes of traumatic events that listeners may find disturbing. 

Transcript of episode

Music Credit: Make your dream a reality by Scott Holmes.

Little is known about the effects of repeated imprisonment. Very few research studies have examined how those who are punished by the criminal justice system experience and interpret their sentences. Research that does exist, like my PhD, has largely focused on one single sentence. But people who have served many sentences (in other words, who have long punishment careers), are likely not to experience criminal punishments in isolation, but in the context of their wider lives and previous sentences. The aim of the Lives Sentenced project is to address this gap in the knowledge base by examining the life stories of 35 people with long punishment careers

ARCH, the National Respite Network and Resource Center in the United States of America identified that evidence-based research on respite care has, to large extent, been lacking. Across ages, needs and settings, respite is based upon the premise that providing caregivers periodic relief from daily, ongoing caregiving responsibilities will directly benefit them in terms of their physical health, immediate and long-term psychological health, and social-emotional relationships with family members. These benefits are assumed to result in secondary benefits for care receivers and even larger societal benefits in the form of cost benefits or improved employee productivity. Some research studies point to the merits of these assumptions. However, evidence-based research supporting this premise - or going beyond it to demonstrate how to best provide respite care that results in maximum benefits - has not been available. This report presents the findings of an expert panel composed of academics, researchers, service providers, advocates, policymakers and administrators representing a range of age groups, disabilities and professional disciplines. Over a period of 18 months the panel explored the current status of respite research, proposed strategies to overcome barriers to research, and developed a plan to encourage rigorous research in key areas.

Amazing! NYT found someone to clean up Trump’s “tests aren’t great because they tell you that you’re sick” argument. pic.twitter.com/1xvPpqsL9w

— Peter Kafka (@pkafka) May 9, 2020

Vem dar risada com a gente neste quadro “Experimentando Doces Gringos”! ???? Desta vez provamos doces de Dubai e Tailândia! Entre eles está um dos meus doces industrializados favoritos! Assista e veja se você também fica com água na boca!

O post Experimentando Doces: Dubai e Tailândia apareceu primeiro em Cozinha do Bom Gosto.

On the invitation of the Chengdu government, New York-based architecture firm ODA has created a visionary new masterplan for the southwestern Chinese city. Spanning 1 million square feet, the proposal would include four 13-story residential towers integrated into a 700,000-square-foot, mixed-use commercial park with modern buildings optimized for passive energy savings. Described by the firm as an “urban experiment in rearranging priorities for the public realm,” the masterplan emphasizes pedestrian-friendly design and indoor-outdoor living throughout.[...]

For those fortunate enough to have some outdoor space, gardening has become a top pandemic activity. It gets people outdoors doing something constructive while maintaining social distancing. You might even grow something to eat. But as all eco-conscious people know, gardening requires water. Sometimes a lot of water.[...]

While your home energy bill may have increased while you shelter in place, the planet’s overall energy use has taken a significant downturn. According to the International Energy Agency’s (IEA) first quarter report, global carbon emissions could be down by 8% this year, the biggest drop the agency has ever seen.[...]

Do you want some powerful article tips? How about some tips for quick article writing? Well, I have some great techniques to get better results.

1. Kommentar: Die Kritik an Rezo und dem Nannen-Preis zeigt ein Grundproblem des alten Journalismus (meedia.de, Tobias Singer) Als der Youtuber Rezo mit dem Nannen-Preis ausgezeichnet wurde, gab es nicht nur Glückwünsche, sondern auch Kritik. An manchen Stellen hieß es, die Wahl der Jury sei ein Fehler gewesen. Der Hauptvorwurf: Rezo sei kein Journalist und […]