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“I can’t go back,” says Philippe Lançon, who wrote a memoir about his recovery from the massacre.

A Canadian grocery chain says its introducing a fleet of intelligent grocery carts that scan and weigh products as customers place them in the cart.

Famous supporters flocked to social media as Sen. Bernie Sanders ended his presidential campaign.

Strong Customer Authentication (SCA) came into effect on September the 14th 2019 as part of the latest General Data Protection Regulation. This new regulation affects many online merchants who sell to those within Europe and other businesses that operate within the region. This regulation was devised to limit the amount of online fraudulent activity and […]

The post Check if Your Stripe Checkout is SCA Compliant appeared first on Tips and Tricks HQ.

If you are just starting up your website, perhaps you are selling tangible items, or you have a hit single that you’ll be offering digital copies of, one of your pressing questions may be: “Which payment gateway should I use to accept payments from my customers?“. While there are pros and cons of using any […]

The post Benefits of Adding Multiple Payment Gateways to Your Website’s Checkout appeared first on Tips and Tricks HQ.

Around 2 300 Telkom employees have opted for voluntary severance packages since the start of a business restructuring process early this year, a spokesperson said on Tuesday.

A lack of high demand spectrum has been a long-running complaint by SA telecoms groups, who say that it is needed to reduce data prices and increase speed.

Here are the latest developments in the coronavirus crisis.

North lashed out at neighbour for holding military exercises, as Kim Jong Un sent message of praise to Xi Jinping.

So it is difficult to imagine who would want to stop the SARB if it would help reduce load shedding and contain further job losses.A similar argument arises in providing social houses to replace our dangerous rusty corrugated iron suburbs.

The Amateur Traveler talks to Rachel about Seoul, South Korea. Rachel is a college student from Hong Kong who studied in Seoul for the Summer. She talks about historic palaces, museums, customs and shopping in this city that she describes as a "kaleidoscope."

The Amateur Traveler talks to Raul from Atlanta about his recent trip to Krakow Poland. Learn about this former capital of Poland which is a treasure trove of history. Raul will take us to the cloth hall in the old town, Kazimierz and the Wawel Castle. We will also talk about his trips to the unusual Wieliczka salt mine with its rock salt carvings. A very poignant side trip to Auschwitz and Birkenau makes us confront the unspeakable evil done in those two places. Raul also traveled to Wadowice, the boyhood home of the man who would later be Pope John Paul II, and Black Madonna, the home of the Black Madonna. In between we talk about Polish food (lard for your bread sir?), museums, transportation and history.

The Amateur Traveler talks to Sarah from Whitehorse in the Yukon about that corner of Canada with long winters but dramatic scenery. She tells of of Winter festivals like the Yukon Sourdough Rendezvous as well as Summer festivals like Dawson City Music fest, Atlin Arts and Music Fest and the Kluane Mountain Bluegrass Festival. We talk about sporting events like the 24 Hours of Light and Kluane to Chilkat (Haines to Haines) bike races because Sarah says you have to like the outdoors to come to the Yukon. Sarah also gives us some itineraries for road warriors like the Top of the World Highway to Dawson (and the Dempster Highway for the bold among you) and the Golden Circle route into Alaska. We walk the Chilkoot Trail but without the requirement to bring 1,000 pounds of supplies like in the Yukon gold rush. It is the beauty of Kluane National Park that you will remember but strangely enough it was something else that Sarah was looking at when she decided to move to the Yukon.

The Amateur Traveler talks to Melody who has been living as an exchange student in Hong Kong. Melody tells us what to see in Hong Kong from the very western feeling Central neighborhood of Hong Kong island, the peak and the mid-level escalators to the more Chinese neighborhoods in Kowloon and the less populated New Territories. She also takes us out to some of the outlying islands like Lantau island with the Big Buddha & Po Lin Monastery, Cheung Chau Island with its famous bun festival, and the nearly uninhabited Po Toi island.

We talk about the 10,000 Buddha Monastery and eat dinner on plastic stools in the middle of the Temple street night market. We explore the fish, flower, bird and jade markets. Melody recommends the Star Ferry for a great view of Hong Kong island, especially at night.

For nightlife Melody recommends Wednesday and Thursday nights when ladies often get free drinks. Her favorite night spot is the Cavern and a famous one is the Fringe.

The Amateur Traveler talks to Fred who talks about a road trip to the Black Hills of South Dakota. Fred and his wife went to Mt Rushmore for sure, but also to other sites in the area that are less well known like Devil’s Tower, Deadwood, Wall Drug, Wind Cave National Park, Buffalo Gap National Grassland and Wind Cave National Park. There are a surprising number of sites to see in the Black Hills and Badlands of Southwest South Dakota.

The Amateur Traveler talks to Rease from 2 Nomads, 1 Narrative about South Korea. Rease and his girlfriend Nicki taught English for a year in Southern South Korea and also took time t travel around the country. We start in the city of Busan which also called Pusan and the only part of South Korea not to fall to the North in the Korean Conflict. Rease recommends we see Busan fish market and some of the old temples and then move on from Korea’s second largest city to the ancient capital of Gyeongju. Gyeongju is over 2000 years old and includes ancient temples and burial tombs and also has the largest of the Buddist temples in the country. Then Rease recommends we move along to some of the beaches, seaside towns and islands on the south coast which most western tourists don’t visit.

The Amateur Traveler talks to Shawn Farris about his trip to Serbia and Kosovo. Shawn either visited two countries (or one) in this contested area of the Balkans.

Hear about travel to North Korea as the Amateur Traveler talks to Matt from England about his recent trip to this closed and insular country. This may be one of the most unusual episodes of the Amateur Traveler as this may be one of the more unusual countries.

Hear about travel to the Island of Shikoku, Japan as the Amateur Traveler talks to Dan from Chicago about his recent trip back to the island. Dan also worked teaching English on Shikoku in the city of Imabari. Shikoku is the 4th largest of the islands in Japan and just across the from Hiroshima. Shikoku is mountainous, more traditional and more rural than the areas of Japan more tourists know.

Hear about travel to Indonesia as the Amateur Traveler talks to repeat guest Chris Willis about his trip to Indonesia. The main objective of Chris’s trip was to photograph Komodo dragons in the wild. Komodo dragons live on 2-3 islands which are not near any airport so getting there is half the experience.

Hear about travel to northern South Korea as the Amateur Traveler talks to Katie of aroundtheworldinktdays.com about the area of South Korea where she is living.

Hear about travel to North Dakota as the Amateur Traveler talks to resident Derrick Schiff about this often ignored state. 

Hear about hiking the Peaks of the Balkans trail in Albania, Kosovo, and Montenegro as the Amateur Traveler talks to Dan and Audrey from uncorneredmarket.com about this off the beaten track route in Europe.

Hear about travel to the Yukon Territory in Canada as the Amateur Traveler talks to Stephen Reynolds from Tourism Yukon about a recent trip that I did to his home.

Hear about travel to Central Europe (Prague, Krakow, Budapest) as the Amateur Traveler talks to 4 people who joined me on this year's Amateur Traveler trip: Darrell, Derrick, Loraine and Holly.

Hear about travel to Seoul, South Korea as the Amateur Traveler talks to Spencer Zentzch the CEO of Hacker Paradise about a city where he has live for 3 years over 6 different trips.

Hear about travel to Hong Kong as the Amateur Traveler talks to Marianne Rogerson from mumonthemove.com about the city where she lived for 4 years.

Hear about hiking the Kumano Koto trek in Japan as the Amateur Traveler talks to Sherry Ott about her experience on this trail that was used by medieval emperors on the Kii Peninsula. 

Hear about travel to the Yukon Territory in Canada as the Amateur Traveler talks to Stephen Reynolds from Tourism Yukon about a recent trip that I did to his home.

South Korea's capital closed down more than 2,100 bars and other nightspots Saturday because of a new cluster of coronavirus infections, and Germany scrambled to contain fresh outbreaks at slaughterhouses, underscoring the dangers authorities face as they try to reopen their economies.

Work(out) From Home is a weekly column where we review smart fitness machines and apps in the wake of the coronavirus outbreak. Thanks to technology, there are still plenty of ways to exercise if your gym is closed. Read more...

Rafael Nadal insists all players, including Novak Djokovic, will need to take a coronavirus vaccine should one become available.

A woman in her 90s living at the Bradford Valley Care Community is the latest coronavirus victim in the region.

The province is investing $1.5 million to support a housing project in Muskoka to help people with no place to call home.

The calendar may say May, but that didn't stop Mother Nature from blasting some wintry weather in Muskoka on Friday.

Chatham House is delighted to announce Koc Holding’s support for the Turkey Project, based in the Europe Programme.

Michal Bassani-Sternberg
Mar 1, 2015; 14:658-673
Research

The canonical pathway of eicosanoid production in most mammalian cells is initiated by phospholipase A2-mediated release of arachidonic acid, followed by its enzymatic oxidation resulting in a vast array of eicosanoid products. However, recent work has demonstrated that the major phospholipase in mitochondria, iPLA2γ (patatin-like phospholipase domain containing 8 (PNPLA8)), possesses sn-1 specificity, with polyunsaturated fatty acids at the sn-2 position generating polyunsaturated sn-2-acyl lysophospholipids. Through strategic chemical derivatization, chiral chromatographic separation, and multistage tandem MS, here we first demonstrate that human platelet-type 12-lipoxygenase (12-LOX) can directly catalyze the regioselective and stereospecific oxidation of 2-arachidonoyl-lysophosphatidylcholine (2-AA-LPC) and 2-arachidonoyl-lysophosphatidylethanolamine (2-AA-LPE). Next, we identified these two eicosanoid-lysophospholipids in murine myocardium and in isolated platelets. Moreover, we observed robust increases in 2-AA-LPC, 2-AA-LPE, and their downstream 12-LOX oxidation products, 12(S)-HETE-LPC and 12(S)-HETE-LPE, in calcium ionophore (A23187)-stimulated murine platelets. Mechanistically, genetic ablation of iPLA2γ markedly decreased the calcium-stimulated production of 2-AA-LPC, 2-AA-LPE, and 12-HETE-lysophospholipids in mouse platelets. Importantly, a potent and selective 12-LOX inhibitor, ML355, significantly inhibited the production of 12-HETE-LPC and 12-HETE-LPE in activated platelets. Furthermore, we found that aging is accompanied by significant changes in 12-HETE-LPC in murine serum that were also markedly attenuated by iPLA2γ genetic ablation. Collectively, these results identify previously unknown iPLA2γ-initiated signaling pathways mediated by direct 12-LOX oxidation of 2-AA-LPC and 2-AA-LPE. This oxidation generates previously unrecognized eicosanoid-lysophospholipids that may serve as biomarkers for age-related diseases and could potentially be used as targets in therapeutic interventions.

9 December 2013 , Volume 69, Number 11

Xolela Mangcu Biko: A Life (IB Taurus, £12.99)

Trans. Moscow Math. Soc. 80 (2020), 113-122.
Abstract, references and article information

Research Event

Event participants

Jennifer Lind, Associate Fellow, US and the Americas Programme and Asia-Pacific Programme, Chatham House
Chair: Tania Branigan, Leader Writer, The Guardian  

Research Event

Event participants

Antony Dapiran, Writer; Lawyer; Author of City on Fire: The Fight for Hong Kong
Chair: Jessie Lau, Journalist; Researcher; Artist; Board Member and Online Editor-in-Chief, NüVoices