Construction of load-carrying geosynthetic-reinforced bridge abutments are surging worldwide. The design directly supports the load of bridge girders without the need of deep foundation. TRB is hosting a webinar on Tuesday, May 26, 2020 from 2:00 to 4:00 PM Eastern that will provide an overview, comparison, and discussion of methodologies used in the design of such bridge abutments. They have the potential of alleviating the “bump at the bridge,” expediting construction, and requiring comparatively smal...

Fostering Multimodal Connectivity Newsletter for April 2020 , released by the U.S. Federal Highway Administration

The Effects of Left-Turn Traffic-Calming Treatments on Conflicts and Speeds in Washington, D.C. , released by the Insurance Institute for Highway Safety

This episode originally aired on April 24, 2020. Ohio’s unemployment rate has reached 11.6% due to the COVID-19 pandemic, the 10th worst in the nation. Laid-off workers should be on the lookout for scams and schemes trying to swindle away unemployment benefits and federal stimulus checks.

This episode originally aired on April 24, 2020. Ohio’s unemployment rate has reached 11.6% due to the COVID-19 pandemic, the 10th worst in the nation. Laid-off workers should be on the lookout for scams and schemes trying to swindle away unemployment benefits and federal stimulus checks.

Within the academic aviation world, good textbooks can be hard to come by. Not only do few aviation textbook publishers exist, but the aviation industry is constantly changing. The TRB Airport Cooperative Research Program's latest Impacts on Practice brief, ACRP in the Classroom: Reimagining the Textbook at the University of North Dakota Department of Aviation , details how Dr. Kim Kenville uses ACRP Research Report 16, Second Edition: Guidebook for Managing Small Airports , in her classes. “This publica...

Sixty-eight percent of the states who responded to a survey indicated their agency has a documented process for as-built development. They said handwritten notes were the most commonly used method to capture as-built data (86%), followed by electronic notes (76%), and then photographs (33%). Some states use more than one option to capture as-built data. The TRB National Cooperative Highway Research Program's NCHRP Synthesis 548: Development and Use of As-Built Plans by State Departments of Transportation...

Although general aviation airports have historically been funded by federal, state, and local entities, the private sector is increasingly playing a larger role. This involvement has ranged on a continuum from service and management contracts to singular projects at airports that involve leasing mechanisms to long-term leases and the whole-scale private development of general aviation airports. In an era of declining resources and increasingly scrutinized public expenditures, private-sector involvement i...

Use of Surface Treatments to Extend Pavement Life: A Case Study on US 301, Sussex County, Virginia , released by the Virginia Department of Transportation

One of the most fascinating things about planet Earth is the way that life shapes the Earth and the Earth shapes life. We only have to look back to the Great Oxygenation Event (GOE) of 2.4 billion years ago to see how lifeforms have shaped the Earth. In that event, phytoplanktons called cyanobacteria pumped the …

Continue reading "New Data Show How Phytoplankton Pumps Carbon Out of the Atmosphere at an Enormous Scale"

The post New Data Show How Phytoplankton Pumps Carbon Out of the Atmosphere at an Enormous Scale appeared first on Universe Today.

Tiny meteorites that fell to Earth 2.7 billion years ago suggest that the atmosphere at that time was high in carbon dioxide, which agrees with current understanding of how our planet's atmospheric gases changed over time.

For obvious reasons, there has been a lot of attention paid to work going into developing vaccines that could prevent Covid-19 infection, and drugs that could treat it. In particular, there has been some excitement about new animal trial data for remdesivir, a drug developed by Gilead Sciences. Gilead's share price rose nearly 10% on the day the trial data were announced.
It will be some time yet before the safety and efficacy of remdesvir is established, if ever (it's worth noting that it was tried, unsuccessfully, as a treatment for Ebola). And since I started work on this post…

High-frequency audio could be used to stealthily track netizens

Technical folks looking to improve web privacy haven't been able to decide whether sound beyond the range of human hearing poses enough of a privacy risk to merit restriction.…

Apparently. But we’re so incredulous, we’re gonna test those claims on live internet TV…

Webcast “The journey to cloud” echoes through all organisations. It’s a Bildungsroman – a story of empowerment and betterment. A shiny, towering cityscape of gleaming edifices and elegant spires. It’s like an ascension into the actual clouds. Like dying and waking up in heaven.…

Immunosuppression continues to be a necessary component of transplantation, despite its association with a multitude of adverse effects. Numerous efforts have been made to circumvent the need for immunosuppression by using various techniques to achieve donor hyporesponsiveness. In this issue of the JCI, Morath et al. take this endeavor forward. Prior to transplantation, the researchers infused recipients with donor-modified immune cells and achieved immunologic hyporesponsiveness. This successful phase I trial also provides a possible avenue for achieving transplantation without the requisite immunosuppression.

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion.CONCLUSION These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of β3-AR agonists as a treatment for metabolic disease.TRIAL REGISTRATION Clinicaltrials.gov NCT03049462.FUNDING This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014).

Thinking of using TurboTax to file your tax returns? Think again. The Minnesota Department of Revenue advises against using Intuit software to file tax returns! It found unacceptable errors in Intuit tax software, including TurboTax, ProSeries, Lacerte, and Intuit online. Continue reading →

William Brighenti, who founded the Berlin Property Owners Association, argued that the town can’t afford a new police headquarters, and police should look to clear space in their current building. He thinks one way to accomplish this is to get rid of tactical gear. Continue reading →

The Berlin police department is looking to build a new facility, but some residents don't think spending $21 million should even be considered. Continue reading →

Are you as an employer having trouble paying online your unemployment compensationtaxes with the Connecticut Department of Labor? SNAFU. Continue reading →

Pulitzer Prize-winning reporter James Grimaldi of The Wall Street Journal, who has covered the Clinton Foundation for years, looks at the relationship between the Clinton Foundation and the State Department during Hillary Clinton’s time as secretary of state, and what it would be if she became president. Newly released State Department emails include exchanges between top members of the Clinton Foundation and Clinton’s top State Department advisers, including Huma Abedin and Cheryl Mills. The FBI reportedly wanted to investigate the Clinton Foundation earlier this year, but U.S. Attorney General Loretta Lynch pushed back. Continue reading →

At the Smarter Cities Forum in Shanghai today, IBM announced a collaboration with South China's largest hospital, Guang Dong Hospital of Traditional Chinese Medicine, to apply new analytics technology to help doctors uncover trends and new knowledge about disease treatment from thousands of anonymous Electronic Medical Records (EMR)The tool will also enable clinicians to perform empirical studies on the efficacy of certain traditional Chinese treatments.

Unitec today announced that the number of people employed in two Delivery Centres at its Mount Albert campus now exceeds 500, and continue to drive benefits for Unitec students and the Auckland economy.

IBM to Lead SAP S/4HANA Project for Department of Defence

IBM Australia (NYSE: IBM) today announced a four-year extension to its contract with Australian government agency, Department of Health & Ageing, for the provision of IT infrastructure services. The deal includes a variation to the final year of the existing agreement, and has a total value of $109m over five years.

I will meet you there this weekend!

I'll be at TABLE F2 with the lovely keshii! There's going to be a lot of amazing and beautiful people there!

I will have Starfighter: Chapter 01, t-shirts, hot shorts, AND ALSO, some sweet extras. This will be my first con with a table.. and it is all because of you guys! Thank you so, so much! I can only hope I can meet you guys so I can thank you in person; you have my humble love and affection.

I'll see you there, sweethearts! -HamletMachine

TCAF site!

If you're attending, stop by and say hello!

(I don't have a table number yet but I'll be sure to announce this as soon as I know! If not, I'm sure you can find where my table is in the directory!)

EDIT: OH MAN! I almost forgot— At last Yaoi-con, there was a sweet person who had lost her voice from a cold (ah, I'm not sure if I got your name) and had printed out some TCAF info so I could attend— SWEETHEART, IF YOU READ THIS, THANK YOU! I hope to see you there!) -Hamlet