Victor Oladipo made the move from Team Takeover to IU star. Hoosiers have their sights set on another guard from his AAU team.

Dozens of Indiana Democrats today endorsed Joe Biden for president, his campaign told IndyStar Thursday.

Indiana projects to return more 2019 production than almost any other team in the country.

Peyton Henderson had been suspended in the wake of an incident for which he still faces a court hearing.

The U.S. House of Representatives on Friday passed the latest aid package to help the U.S. economy stay afloat during the coronavirus outbreak.

As coronavirus shutters cookie booths in Indiana and around the country, Girl Scouts take sales online and embrace an entrepreneurial spirit.

The number of initial unemployment claims filed in Indiana last week has dropped compared to the number of new claims filed a week earlier.

An insurance payment due to Victor Oladipo's injury gives Pacers lowest payroll in NBA

Donnie Walsh has been plopped in the middle of America's most famous infectious disease doctor's basketball claim to fame.

Landmark restaurant has been in business since 1927.

Add spaghetti to chili and people call you crazy. Add spaghetti and Middle Eastern spices and you're a genius (at least in Cincinnati).

The sports bar and restaurant owned by former Colts football player and Super Bowl champion Gary Brackett is closing.

Despite a loss, Purdue sees positives from Big Ten tourney matchup with Maryland

A new location couldn't save the east-side restaurant.

Add spaghetti to chili and people call you crazy. Add spaghetti and Middle Eastern spices and you're a genius (at least in Cincinnati).

A member of Mike Pence's staff has tested positive for coronavirus, the White House confirms.

We're committed to telling as many stories of Indiana residents lost to the novel coronavirus as we can. Join us in remembering our Hoosier dead.

UFC middleweight Jacaré Souza tests positive for Covid-19 and will no longer compete at the controversial UFC 49 show.

Two youths have tested positive for the novel coronavirus in L.A. County's juvenile halls. The teens were only recently booked and were kept away from the general population, officials say.

Coronavirus infections explode at a Lompoc federal prison with 792 testing positive, making it the largest federal penitentiary outbreak in the nation.

Mark Herrmann spent six years with the Krannert School of Management before coming to work for the John Purdue Club

Indiana Gov. Eric Holcomb's responsibility and obligation is to the citizenry of Indiana, a letter to the editor says.

America relies on both legal and undocumented immigrant labor to ensure that food and other goods continue flowing across the country, Hackney writes.

Our government must do its part to protect working people from infectious diseases.

The primary way all citizens can support law enforcement is to follow the recommendations of state and local government leaders, Josh Minkler writes.

The fight to flatten the curve and slow the spread of the coronavirus is on all of us.

In one weekend Stoffel Vandoorne manages to qualify on pole position in two races and crash out of both of them.

Two Indians flown back from Gulf to Kerala test Covid-19 positive  Hindustan TimesView Full coverage on Google News

Eisner-winning cartoonist Brian Fies faces down another fire two years after losing his Northern California home. "I'm mostly numb," he says.

Ethiopian Prime Minister Abiy Ahmed has said that opposition politicians were trying to exploit uncertainty created by the coronavirus pandemic to seize power, risking instability.

Teams are averaging 113.4 points per game, the highest output since the early 1970s.

Monday night's game figures to have a big impact on the NFC playoff race.

The couple ran Oz, an Australian-themed eatery in Clarendon.

Any economic improvements aren’t helped by his actions.

Amazon.com said it's temporarily closing a small New York warehouse after one of its associates tested positive for the coronavirus. As Fred Katayama reports, it highlights the operational risk it faces as the disease spreads.

Major social advances have often emerged from the depths of disaster: the Black Death brought an end to serfdom, and Britain's welfare state emerged from the ruins of World War II.

A member of US Vice President Mike Pence's staff has tested positive for the novel coronavirus, briefly delaying his Friday flight to Iowa and prompting some fellow passengers on Air Force Two to disembark, according to a White House official.

Here is the latest news from around the world.

The US vice president's spokesperson became the second White House staffer this week to test positive for the coronavirus.

CNBC reports that an aide to Pence has tested positive for COVID-19. This follows yesterday's report that Trump's personal valet tested positive for the virus.

A spokeswoman for Pence did not immediately respond to CNBC’s request for comment.

Pence was scheduled to travel to Des Moines, Iowa, in the morning, but his departure from Andrews Air Force Base was delayed by nearly an hour as staff dealt with news of the diagnosis. Reporters traveling with Pence said several staffers disembarked from Air Force Two just before takeoff.

Photo of Pence: Know Your Meme Read the rest

Decision-making can be tough especially when the best choice isn’t glaringly obvious. We’re faced with this process every minute of the day. When do I wake up? What’s for lunch? Do I want to go out on a date with this person? What do I want to do with my life? Can I stay in […]

The post Stop Losing Sleep: 7 Steps for Stress-free Decision-making appeared first on Dumb Little Man.

Dan Greenberg, co-founder and CEO of native advertising solutions provider Sharethrough, discusses how buyers’ increased desire for contextual targeting and native advertising will benefit premium publishers in 2018.

T.J. Lovell had just 30 minutes to pack up his belongings from the tent city in Oppenheimer Park if he wanted access to a hotel room that he could share with his father.

The following article, NY Shame: Workers Who Tested Positive For COVID-19 Were Allowed To Remain On The Job At Nursing Homes, As Death Toll For Nursing Home Patients Exceeds 3,000, was first published on 100PercentFedUp.com.

The coronavirus crisis at New York’s nursing homes is even worse than previously thought. Monday night, the state Department of Health issued new data, adding more than 1,600 people who were presumed to have died of the virus in nursing homes, but did not have a confirmed diagnosis, to the official toll. As of May […]

Continue reading: NY Shame: Workers Who Tested Positive For COVID-19 Were Allowed To Remain On The Job At Nursing Homes, As Death Toll For Nursing Home Patients Exceeds 3,000 ...

The following article, President Trump’s Navy Valet Tests Positive for Coronavirus, was first published on 100PercentFedUp.com.

One of President Trump’s personal Navy valets has tested positive for coronavirus. The valet, a member of the US Navy who works at the White House, had symptoms of the coronavirus Wednesday morning. He was tested, and his test came back positive for the virus. President Trump was reportedly informed about the situation and fake […]

Continue reading: President Trump’s Navy Valet Tests Positive for Coronavirus ...

The following article, BREAKING: Vice President Mike Pence’s Press Sec Katie Miller, Wife of President Trump’s Sr. Advisor, Stephen Miller, Tests Positive For COVID-19, was first published on 100PercentFedUp.com.

Only moments ago, White House Press Secretary Kayleigh McEnany confirmed that a member of Vice President Mike Pence’s team tested positive for coronavirus. Watch: White House Press Secretary Kayleigh McEnany confirms a member of Vice President Mike Pence's team tested positive for coronavirus pic.twitter.com/3VaUXbwMq7 — Bloomberg QuickTake (@QuickTake) May 8, 2020 Reuters White House Correspondent […]

Continue reading: BREAKING: Vice President Mike Pence’s Press Sec Katie Miller, Wife of President Trump’s Sr. Advisor, Stephen Miller, Tests Positive For COVID-19 ...

Essex County OPP have released a composite drawing of a suspect reported to be impersonating a police officer in Lakeshore.

Previous studies have shown that sphingosine kinase interacting protein (SKIP) inhibits sphingosine kinase (SK) function in fibroblasts. SK phosphorylates sphingosine producing the potent signaling molecule sphingosine-1-phosphate (S1P). SKIP gene (SPHKAP) expression is silenced by hypermethylation of its promoter in acute myeloid leukemia (AML). However, why SKIP activity is silenced in primary AML cells is unclear. Here, we investigated the consequences of SKIP down-regulation in AML primary cells and the effects of SKIP re-expression in leukemic cell lines. Using targeted ultra-HPLC-tandem MS (UPLC-MS/MS), we measured sphingolipids (including S1P and ceramides) in AML and control cells. Primary AML cells had significantly lower SK activity and intracellular S1P concentrations than control cells, and SKIP-transfected leukemia cell lines exhibited increased SK activity. These findings show that SKIP re-expression enhances SK activity in leukemia cells. Furthermore, other bioactive sphingolipids such as ceramide were also down-regulated in primary AML cells. Of note, SKIP re-expression in leukemia cells increased ceramide levels 2-fold, inactivated the key signaling protein extracellular signal-regulated kinase, and increased apoptosis following serum deprivation or chemotherapy. These results indicate that SKIP down-regulation in AML reduces SK activity and ceramide levels, an effect that ultimately inhibits apoptosis in leukemia cells. The findings of our study contrast with previous results indicating that SKIP inhibits SK function in fibroblasts and therefore challenge the notion that SKIP always inhibits SK activity.

The protein-tyrosine phosphatase SHP2 is an allosteric enzyme critical for cellular events downstream of growth factor receptors. Mutations in the SHP2 gene have been linked to many different types of human diseases, including developmental disorders, leukemia, and solid tumors. Unlike most SHP2-activating mutations, the T507K substitution in SHP2 is unique in that it exhibits oncogenic Ras-like transforming activity. However, the biochemical basis of how the SHP2/T507K variant elicits transformation remains unclear. By combining kinetic and biophysical methods, X-ray crystallography, and molecular modeling, as well as using cell biology approaches, here we uncovered that the T507K substitution alters both SHP2 substrate specificity and its allosteric regulatory mechanism. We found that although SHP2/T507K exists in the closed, autoinhibited conformation similar to the WT enzyme, the interactions between its N-SH2 and protein-tyrosine phosphatase domains are weakened such that SHP2/T507K possesses a higher affinity for the scaffolding protein Grb2-associated binding protein 1 (Gab1). We also discovered that the T507K substitution alters the structure of the SHP2 active site, resulting in a change in SHP2 substrate preference for Sprouty1, a known negative regulator of Ras signaling and a potential tumor suppressor. Our results suggest that SHP2/T507K's shift in substrate specificity coupled with its preferential association of SHP2/T507K with Gab1 enable the mutant SHP2 to more efficiently dephosphorylate Sprouty1 at pTyr-53. This dephosphorylation hyperactivates Ras signaling, which is likely responsible for SHP2/T507K's Ras-like transforming activity.

12 February 2020