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O holograma em vitrine da Holanda usado para tentar desvendar assassinato de prostituta

A morte por esfaqueamento de uma jovem húngara, assassinada logo após dar à luz, intriga a polícia há 15 anos.






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BREAKING! Supreme Court Decision Used For Immediate Nationwide Block of Border Crisis Rule! (Video)

In this video, Armed Scholar expounds on the recent decision by the US Supreme Court concerning our border and the flooding of illegal immigrants, including the Biden administration, through the Department of Homeland Security, concerning programs set up that promised citizenship to illegal aliens. The decision was handed down following the 2024 elections, striking down …




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US Senate To Revive Software Patents With PERA Bill Vote On Thursday

zoobab writes: The US Senate to set to revive Software Patents with the PERA Bill, with a vote on Thursday, November 14, 2024. A crucial Senate Committee is on the cusp of voting on two bills that would resurrect some of the most egregious software patents and embolden patent trolls. The Patent Eligibility Restoration Act (PERA), S. 2140, would dismantle vital safeguards that prohibit software patents on overly broad concepts. If passed, courts would be compelled to approve software patents on mundane activities like mobile food ordering or basic online financial transactions. This would unleash a torrent of vague and overbroad software patents, which would be wielded by patent trolls to extort small businesses and individuals. The EFF is inviting members of the public to contact their Senators.

Read more of this story at Slashdot.




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With Trump Returning To Power, Europe Chief Weighs Idea Of Buying More Natural Gas From US Instead Of Russia

By Ireland Owens President of the European Commission Ursula von der Leyen said Friday that she proposed to President-elect Donald Trump the idea that the U.S. could supply more natural gas to Europe to decrease the bloc’s reliance on Russia, according to Barron’s. The EU chief said the topic of tapping U.S. liquefied natural gas […]

The post With Trump Returning To Power, Europe Chief Weighs Idea Of Buying More Natural Gas From US Instead Of Russia appeared first on Liberty Unyielding.




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Biden’s Signature Climate ‘Boondoggle’ Might Be On Chopping Block After Trump Win

By David Blackmon In the wake of the election of President Donald Trump to serve a second term in office, along with presumptive Republican majorities in both houses of Congress, many are now asking about what the future will hold for the oddly named Inflation Reduction Act. Trump made it repeatedly clear on the campaign […]

The post Biden’s Signature Climate ‘Boondoggle’ Might Be On Chopping Block After Trump Win appeared first on Liberty Unyielding.




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GOP Senate Majority Leader-Hopefuls Scramble To Address Trump Demands Ahead Of Inauguration

By Julianna Frieman Republican senators competing for the majority leader position vowed Sunday to address President-elect Donald Trump’s demands ahead of his inauguration. Trump revealed Sunday that the Senate leader of his GOP majority must support recess appointments to assure his Cabinet positions be confirmed expeditiously and unobstructed. The three senators contending for the leadership […]

The post GOP Senate Majority Leader-Hopefuls Scramble To Address Trump Demands Ahead Of Inauguration appeared first on Liberty Unyielding.



  • Law and Government

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The importance of GOP senators

(Nov. 4. Note: This ran the day before the election. The final result is 53 GOP senators, including McCormick.)  No matter who wins the presidency, a significant Republican majority in […]

The post The importance of GOP senators appeared first on Quin Hillyer.




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Nature presenter Chris Packham settles case over axing of green policy

The TV presenter says the previous Tory administration was "reckless" to scale back climate policy.




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Politicians not ambitious enough to save nature, say scientists

Representatives of 196 countries have been meeting in Cali, Colombia, as part of the COP biodiversity summit.




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'I'm in a very fortunate position' - Newey on Aston Martin move

Adrian Newey tells BBC Sport's Joe Wilson "it is easy to become stale", but his "passion has always been for trying to find ways to make the car go faster" after joining Aston Martin.




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F1 Q&A: Will Ferrari snatch constructors' crown from McLaren?

BBC F1 correspondent Andrew Benson answers your questions as we approach the final three races of the 2024 season.




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Ruben Gallego defeats Trump ally Kari Lake in Arizona Senate race

He is on course to become the battleground state's first Latino US senator, according to a CBS News.




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Trump Officially Nominates Amy Coney Barrett To Fill Supreme Court Vacancy

President Trump officially announced that he has selected Judge Amy Coney Barrett as his nominee to fill the vacancy of late Justice Ruth Bader Ginsburg to the Supreme Court, setting up a bitter Senate confirmation battle with just five weeks left until Election Day. “I stand before you today to fulfill one of my highest […]

The post Trump Officially Nominates Amy Coney Barrett To Fill Supreme Court Vacancy appeared first on Hispolitica.




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Pelosi says Trump’s Taxes Are a ‘National Security’ Issue

House Speaker Nancy Pelosi (D-CA) in an interview with MSNBC called the New York Times report on President Trump taxes a question of “national security issues,” citing owed money to foreign interests. In an interview with MSNBC host Andrea Mitchell, Pelosi sounded the alarm that foreign governments might have “leverage” on the president due to […]

The post Pelosi says Trump’s Taxes Are a ‘National Security’ Issue appeared first on Hispolitica.




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Trump On Coronavirus: ‘Don’t Let It Dominate You, Don’t Be Afraid Of It’

President Trump returned to the White House Monday evening after spending three-day being treated for COVID-19 at Walter Reed National Military Center, released an upbeat video message telling Americans not to be afraid of the virus. “One thing that’s for certain — Don’t let it dominate you,” Trump said in a one-minute long video filmed […]

The post Trump On Coronavirus: ‘Don’t Let It Dominate You, Don’t Be Afraid Of It’ appeared first on Hispolitica.




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Abuse survivors call for further Church of England resignations

The Archbishop of Canterbury has announced he will step down over a damning report into abuse.




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Lionesses face Portugal in Nations League opener

England face Portugal in their opening game of the 2025 Nations League after Uefa announce the match schedule for the competition.




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How Nations League affects World Cup qualifying

BBC Sport looks at what England, Scotland, Wales and Northern Ireland have to play for in the Nations League - and how it ties into the World Cup.




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Lunatic Democrat Murders His Wife and Kids Over His Hate for Donald Trump

This is how mentally deranged liberals are… a Democrat in Minnesota was so filled with rage that Donald Trump won the election last week that he murdered his own wife and kids and then committed suicide to prevent them all from having to live during the next Trump presidency. Notice how you never heard any […]

The post Lunatic Democrat Murders His Wife and Kids Over His Hate for Donald Trump appeared first on The Lid.




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Trump to Work on National Concealed Carry Reciprocity

According to reports, one of the issues that Donald Trump hopes to address in his second belated term is to institute concealed carry permits reciprocity in every state, allowing a person with a permit in one state to legally carry his firearm in every other state. On Sunday, Donald Trump Jr. posted a video of […]

The post Trump to Work on National Concealed Carry Reciprocity appeared first on The Lid.




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News24 | Archbishop of Canterbury Justin Welby announces resignation over abuse scandal

The leader of the world's Anglican communion, Archbishop of Canterbury Justin Welby, announced Tuesday he was resigning following a damning report that concluded the Church of England covered up a serial abuse case.




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News24 | 'Gravest international crimes': Israel cruelty in Gaza has 'no limits', UN aid chief warns

The United Nations's humanitarian aid chief told a meeting of the Security Council (UNSC) that "acts reminiscent of the gravest international crimes" are being committed in Gaza.




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News24 | INTERVIEW | 'Rock star without an instrument': Booker-winner Shehan Karunatilaka talks Seven Moons

"I realised I could sustain the writing life, whether anyone reads it or not. It’s what separates writers from civilians. It’s probably a mental disorder."




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In Harmony with Nature

My father, the birder, is often excited to share his sightings with me — especially so this summer when he got back from a long-planned trip to South Africa. 153 species! I love how he finds joy and peace by connecting with the world through observing birds, interacting with fellow birders, and telling tales of his birding adventures. In so many wonderful ways, Dad’s daily routines and way of life are linked to nature and the birds he loves.




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Accept Donations via PayPal from Your WordPress Site Easily

Do you run a charitable website? Or do you offer content free to the public? Perhaps it is time that you add a donation button to start monetizing your website. In this tutorial, we will walk you through the process of adding a PayPal donation button to your WordPress website, and even those without developer […]

The post Accept Donations via PayPal from Your WordPress Site Easily appeared first on Tips and Tricks HQ.





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‘Utterly Unacceptable’: After Helping Trump Win, Elon Musk Makes Crucial Endorsement For Senate Majority Leader

The following article, ‘Utterly Unacceptable’: After Helping Trump Win, Elon Musk Makes Crucial Endorsement For Senate Majority Leader, was first published on Conservative Firing Line.

Despite a landslide victory for Donald Trump and his “Make America Great Again” agenda last week, a ferocious battle has suddenly broken out in the U.S. Senate over who will be the chamber’s new leader, with some saying outgoing Majority Leader Mitch McConnell is trying to thwart the plans of the president-elect. “What the hell …

Continue reading ‘Utterly Unacceptable’: After Helping Trump Win, Elon Musk Makes Crucial Endorsement For Senate Majority Leader ...




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Lunatic Democrat Murders Wife and Kids, Commits Suicide Over His Hate for Donald Trump

The following article, Lunatic Democrat Murders Wife and Kids, Commits Suicide Over His Hate for Donald Trump, was first published on Conservative Firing Line.

This is how mentally deranged liberals are… a Democrat in Minnesota was so filled with rage that Donald Trump won the election last week that he murdered his own wife and kids and then committed suicide to prevent them all from having to live during the next Trump presidency. Notice how you never heard any …

Continue reading Lunatic Democrat Murders Wife and Kids, Commits Suicide Over His Hate for Donald Trump ...




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Cavtat, Croatia Guide: A Quiet Alternative to Dubrovnik

Cavtat, Croatia, might be the biggest surprise of your trip! This peaceful seaside town in the far south of Croatia is so close to Dubrovnik, and yet a world away. If you want to visit Dubrovnik but would rather stay somewhere with a quiet, more relaxing atmosphere — oh, and cheaper, too! — Cavtat (pronounced […]

The post Cavtat, Croatia Guide: A Quiet Alternative to Dubrovnik appeared first on Adventurous Kate.




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Testimony before the North Dakota Senate Industry, Business and Labor Committee

Chairman Klein and members of the Senate Industry, Business and Labor Committee- My name is David Heinemeier Hansson, and I’m the CTO and co-founder of Basecamp, a small internet company from Chicago that sells project-management software and email services. I first testified on the topic of big tech monopolies at the House Antitrust Subcommittee’s field… keep reading




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Trump to Pick Senator Marco Rubio for Crucial Cabinet Position: Report

President-elect Donald Trump is expected to nominate Florida Sen. Marco Rubio as his secretary of state, reports late Monday indicate. According to The Wall Street Journal, while the nomination isn’t […]

The post Trump to Pick Senator Marco Rubio for Crucial Cabinet Position: Report appeared first on The Western Journal.




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Only One Thing Can Cool the Nation's Political Rhetoric

Candidates and pundits were not overstating things when they characterized the 2024 election as the most important in decades or perhaps even in the nation’s entire history. Every election is […]

The post Only One Thing Can Cool the Nation's Political Rhetoric appeared first on The Western Journal.




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Dem Lawmaker Says the Quiet Part Out Loud as She Suddenly Changes Her Tune on the Senate Filibuster

Americans will only achieve healthy public discourse when we agree on basic principles and start telling the truth. As it stands, however, too many elected officials engage in hypocrisy by […]

The post Dem Lawmaker Says the Quiet Part Out Loud as She Suddenly Changes Her Tune on the Senate Filibuster appeared first on The Western Journal.




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NFL Analyst Michael Strahan Speaks Out After Becoming Embroiled in National Anthem Controversy

One of the greatest pass rushers in NFL history appears to be taking a pass himself when it comes to directly addressing a raging controversy. Pro Football Hall of Famer […]

The post NFL Analyst Michael Strahan Speaks Out After Becoming Embroiled in National Anthem Controversy appeared first on The Western Journal.




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Fired FEMA Worker Reveals Discrimination Against Trump Supporters Was Even Worse Than First Reported

Just because you’re paranoid, it doesn’t mean you’re wrong. And for any supporters of President-elect Donald Trump who feel that they’ve been unfairly targeted by the government, but were summarily […]

The post Fired FEMA Worker Reveals Discrimination Against Trump Supporters Was Even Worse Than First Reported appeared first on The Western Journal.




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Sport | SA's new marathon king Onalenna Khonkhobe tipped to shine on international stage

The rare feat of winning both the Two Oceans and Soweto marathons has marked Onalenna Khonkhobe’s breakthrough season, establishing him as one of South Africa’s rising road-running stars.




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Commentary: Secret Service Agents Placed on Leave After Trump Assassination Attempt

Commentary by Susan Crabtree originally published by RealClearPolitics and RealClearWire Three weeks ago, Acting Secret Service Director Ronald Rowe angrily pushed back on senators’ calls to immediately fire or discipline key agents directly responsible for the security failures that led to the assassination attempt against former President Trump at last month’s campaign rally in Butler, …




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Commentary: Second Assassination Attempt Forces New Reckoning for Trump, Secret Service

Commentary by Susan Crabtree and Philip Wegmann originally published by The second assassination attempt against former President Donald Trump while he was golfing at one of his Florida courses on Sunday is forcing the United States Secret Service to further tighten security around the Republican presidential nominee and to reevaluate just how much Trump should …




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A novel method produces native light-harvesting complex II aggregates from the photosynthetic membrane revealing their role in nonphotochemical quenching [Bioenergetics]

Nonphotochemical quenching (NPQ) is a mechanism of regulating light harvesting that protects the photosynthetic apparatus from photodamage by dissipating excess absorbed excitation energy as heat. In higher plants, the major light-harvesting antenna complex (LHCII) of photosystem (PS) II is directly involved in NPQ. The aggregation of LHCII is proposed to be involved in quenching. However, the lack of success in isolating native LHCII aggregates has limited the direct interrogation of this process. The isolation of LHCII in its native state from thylakoid membranes has been problematic because of the use of detergent, which tends to dissociate loosely bound proteins, and the abundance of pigment–protein complexes (e.g. PSI and PSII) embedded in the photosynthetic membrane, which hinders the preparation of aggregated LHCII. Here, we used a novel purification method employing detergent and amphipols to entrap LHCII in its natural states. To enrich the photosynthetic membrane with the major LHCII, we used Arabidopsis thaliana plants lacking the PSII minor antenna complexes (NoM), treated with lincomycin to inhibit the synthesis of PSI and PSII core proteins. Using sucrose density gradients, we succeeded in isolating the trimeric and aggregated forms of LHCII antenna. Violaxanthin- and zeaxanthin-enriched complexes were investigated in dark-adapted, NPQ, and dark recovery states. Zeaxanthin-enriched antenna complexes showed the greatest amount of aggregated LHCII. Notably, the amount of aggregated LHCII decreased upon relaxation of NPQ. Employing this novel preparative method, we obtained a direct evidence for the role of in vivo LHCII aggregation in NPQ.




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A guide to the Chinese Communist Party's National Congress

A guide to the Chinese Communist Party's National Congress The World Today rescobales.drupal 21 September 2022

In the first of a three-part series examining the global importance of the CCP’s 20th National Congress, Yu Jie explains how it makes its big decisions.

Why does the CCP National Congress matter?

The world’s most populous country and its smallest state have little in common with one exception: how they select their leader. Like the Vatican, the Chinese Communist Party (CCP) shrouds its leadership selection process in secrecy.

Every five years, a week-long conclave – the Party Congress – is held and at its end a new cohort of leaders is presented that will steer the world’s second largest economy for the next five years.

October’s Congress will reveal the depth and breadth of Xi Jinping’s power

The congress is the most important date in China’s political calendar. It not only selects China’s leadership team but acts as a signpost indicating the direction the country will be heading in the near future, with implications for decades to come. It also reveals the breadth and depth of power held by Xi Jinping, the party’s general-secretary.

The 20th CCP National Congress, opening on October 16 and expected to last a week, is taking place during unsettling times. While Xi Jinping is expected to embark on his third term as general-secretary of the party after the removal of a two-term limit in February 2018, it is hardly a crowning glory. Xi’s China is battling an economic maelstrom at home while juggling fraught foreign relations abroad.

What does the National Congress do?

Quite simply, the CCP National Congress is the gathering that defines China’s political leadership and sets the tone for its relationship with the rest of the world.

It serves to fulfil three primary functions:

First, it sets the party’s principal agenda across all policy sectors, from macroeconomics to the price of food. During the week, it draws up a consensus-based evaluation of the party’s work over the past five years, which includes a detailed examination of the party’s current situation.

Second, it introduces any revisions to the party constitution deemed necessary, for instance on changes to the criteria for leadership recruitment or amendments to the party’s ‘guiding ideology’.

Third, it selects the leadership team that will steer China for the next five years, a function that attracts the most international attention but is not the sole purpose of the congress.

How is the party leadership team chosen?

The congress comprises 2,300 delegates representing all levels of the party hierarchy across 34 provinces and regions – from the governors of towns and cities, to Olympic champions, astronauts, and even the odd stand-up comedian to mark the ‘inclusiveness’ of the party.

The votes that decide the next cohort of party leaders come from three committees only: the Central Commission for Discipline Inspection, with 205 members and 171 alternate members (alternate members are simply substitutes to replace a member if they die, retire or are dismissed); the Central Committee, with 204 members; and the Politburo, with 25 members, only one of whom is a woman.

Unlike multiparty elections in liberal democracies, neither the full 25 members of the Politburo nor the seven members of its Standing Committee are nominated by or directly voted for by constituents.

A procedure known as ‘democratic recommendation’ is essentially a straw poll that includes all congress participants. They are then given a ballot listing the names of around 200 Politburo candidates in stroke order – the Chinese equivalent to alphabetical order. This short-listing process is completed in the run-up to the congress. Some pundits asserted that this process was put on hold after 2017, yet this has not been formally confirmed within the party constitution.

A few senior delegates may express their preferences to their colleagues anonymously during this process. All the shortlisted candidates must meet the criteria for Politburo membership, which means serving at either a ministerial rank or above or in the People’s Liberation Army at military region level or above and being younger than 62.

Based on the result of this straw poll, and more importantly on the preferences of current Politburo members, the incumbent Politburo and its Standing Committee will approve the nominees, conclude the Seventh Plenum of the 19th Party Congress and call for the 20th Congress. The delegates at the Party Congress then ceremonially cast their votes for the Politburo at the Party Congress although the result is pre-agreed, a procedure somewhat similar to the US Electoral College.

What are the rules for choosing Politburo members?

The Politburo Standing Committee (PSC) consists of between five and nine members, with seven selected at the 19th Congress. It is the supreme decision-making body of the Communist Party as well as the People’s Republic of China.

If the 20th Congress follows convention, there are three de-facto rules to be followed:

First, Politburo and Standing Committee members must retire at 68. This age limit is known as ‘Eight down, Seven up’.

Second, new appointments to the PSC are drawn exclusively from regular Politburo members. The only exceptions to this rule have been Xi Jinping and Li Keqiang, who were appointed at the 17th Party Congress in 2007.

Standing Committee members must retire at 68, but it is highly unlikely that 69-year-old Xi Jinping will stand down

This exception follows the third convention, under which PSC appointees are among the youngest senior party leaders eligible. Potentially three vacancies could arise in 2022, as Xi himself is 69 but it is highly unlikely that he would step down. That would be a radical departure from past precedents.

The extent to which past procedure is applied could act as a signal as to whether Xi Jinping is consolidating his power, while the size of the standing committee will be scrutinized to assess how much power Xi wields.

If the procedure for leadership appointments at the 20th Congress deviates from these conventions, it could indicate two things. First, the CCP faces a new set of challenges and requires the introduction of new rules to shape the top leadership. Or, second, Xi has gained substantial personal power that allows him to bypass the collective leadership system endorsed by Deng Xiaoping and choose appointees to suit his own taste. There has thus far been little evidence from the official media to reflect on any changes.

Changes in party institutional constraints, however, raise the danger of undermining governance at home and China’s relations abroad.

Read the two further articles in this series: the second discusses the key domestic policy themes that Xi Jinping is expected to outline at this year’s congress; the third analyses the foreign policy issues likely to be discussed at the congress.   

 




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20th CCP National Congress: Five issues to watch

20th CCP National Congress: Five issues to watch Expert comment LJefferson 13 October 2022

Interpreters of the Chinese Communist Party’s tea leaves will be paying close attention to the issues that will shape China’s trajectory for the next five years.

Xi Jinping’s expected anointment for an unprecedented third term as general secretary of the Chinese Communist Party (CCP) is likely to generate global headlines when the party’s five-yearly National Congress begins on 16 October.

But with that outcome so widely forecast, interpreters of the CCP’s tea leaves will be paying closer attention to a range of more contested – and sometimes byzantine – issues that will shape China’s trajectory for the next five years, and reverberate around the world.

These are five key issues to watch out for during Xi’s political report, a dry but authoritative account of the CCP’s policy priorities for the next five years, and the subsequent deliberations over personnel appointments.

1. From market economy to ‘common prosperity’

As the world grapples with the economic impact of Russia’s invasion of Ukraine, the Chinese economy is entering particularly choppy waters. China is forecast to grow at a slower rate than the rest of Asia for the first time in more than 30 years, according to the World Bank, as the impact of Xi’s COVID zero policies compounds a growing list of structural and cyclical challenges.

Xi is under pressure to offer some new prescriptions for the world’s second biggest economy, and he is likely to signal further shifts away from the market economics that propelled Chinese growth for decades toward his vision of ‘common prosperity’.

China is forecast to grow at a slower rate than the rest of Asia for the first time in more than 30 years.

His ambition is to redefine progress, not in terms of producing double-digit growth, but in tackling long-standing challenges such as demographic decline, social inequality and high property prices – thereby meeting ‘people’s ever-growing needs for a better life’.

China’s leader may have arrived at the right diagnosis, but he has so far failed to find measures that deliver common prosperity. He will use the Party Congress to redesign some policy measures, likely putting a stronger focus on the development of rural areas to promote economic dynamism and generate employment opportunities.

2. COVID zero to endure?

While most of the world has opened up and learned to live with COVID-19, China is still pursuing a COVID zero policy that requires frequent lockdowns, stringent movement controls and closed borders. This approach has intensified economic pressures, exacerbated high youth unemployment, and is testing the patience of China’s upwardly mobile middle classes.

Those not employed by the state have been particularly hard hit and it is difficult to see how China’s economy can start to crank up again until Beijing reduces internal restrictions and reconnects with the world.

COVID zero has intensified economic pressures, exacerbated high youth unemployment, and is testing the patience of China’s upwardly mobile middle classes.

Xi has championed the COVID zero policy, which Beijing continues to insist is vital to protect vulnerable people and support economic and social stability. So, observers will be playing close attention to his political report for any signs of a possible softening or indications of alternative future pathways for managing the pandemic. But a wholesale shift does not appear to be on the cards.

3. Xi Jinping’s team

Sinologists’ enthusiasm for predicting leadership changes in the CCP is not matched by their ability to do so. The party’s roots as a secret organization ensure that it keeps a tight lid on information about top leaders.

Observers will be closely following appointments to the seven-member Politburo Standing Committee, the apex of power for the CCP and China’s supreme decision-making body. These choices will shape China’s future policy trajectory and give some signals about the extent of Xi’s concentration of power and his future plans.

The party’s roots as a secret organization ensure that it keeps a tight lid on information about top leaders.

Names to watch for possible promotion include Xi allies such as He Lifeng, currently head of the National Development Reform Commission, a key economic planning entity, and Zhang Qingwei, currently the party secretary of Hunan, an important and populous province.

As Vice Premier Sun Chunlan, the only woman on the Politburo, reaches the retirement age, there is also likely to be a slot open for her replacement, with Shan Yiqin, the party secretary of Guizhou, one potential option.

Tracking the fate of key Xi allies will also indicate how far he has managed to overturn the collective leadership system he inherited in 2012 and how comprehensively the CCP endorses this more centralized approach to governing China.

4. Taiwan

After the escalating tensions of the last few months, analysts will be looking for any possible change in tone when Xi speaks about Taiwan, a self-governing island that China claims as a renegade province. During the past five years, Xi has approached the outside world with a mix of high-octane rhetoric with pragmatism and patience.




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Labour Party Conference – International affairs networking brunch

Labour Party Conference – International affairs networking brunch 24 September 2024 — 11:00AM TO 12:00PM Anonymous (not verified) Labour – Grace 1 Suite, Hilton Hotel, Liverpool

Hosted by Sir Simon Fraser, Chairman of Chatham House.

This event is taking place at the Hilton Hotel, Grace 1 Suite, Liverpool.

You are warmly invited to join us for an exclusive networking brunch at the 2024 Labour Party Conference.

Sir Simon Fraser, Chairman of Chatham House, and Olivia O’Sullivan, Director of Chatham House’s UK in the World Programme, will deliver opening remarks, followed by an interactive networking session where you will have the chance to engage with a wide range of stakeholders. Join us to connect with key senior parliamentary, corporate and media attendees at the Labour Party Conference.

This event will be taking place outside of the secure zone.




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Naturally occurring hotspot cancer mutations in G{alpha}13 promote oncogenic signaling [Molecular Bases of Disease]

Heterotrimeric G-proteins are signaling switches broadly divided into four families based on the sequence and functional similarity of their Gα subunits: Gs, Gi/o, Gq/11, and G12/13. Artificial mutations that activate Gα subunits of each of these families have long been known to induce oncogenic transformation in experimental systems. With the advent of next-generation sequencing, activating hotspot mutations in Gs, Gi/o, or Gq/11 proteins have also been identified in patient tumor samples. In contrast, patient tumor-associated G12/13 mutations characterized to date lead to inactivation rather than activation. By using bioinformatic pathway analysis and signaling assays, here we identified cancer-associated hotspot mutations in Arg-200 of Gα13 (encoded by GNA13) as potent activators of oncogenic signaling. First, we found that components of a G12/13-dependent signaling cascade that culminates in activation of the Hippo pathway effectors YAP and TAZ is frequently altered in bladder cancer. Up-regulation of this signaling cascade correlates with increased YAP/TAZ activation transcriptional signatures in this cancer type. Among the G12/13 pathway alterations were mutations in Arg-200 of Gα13, which we validated to promote YAP/TAZ-dependent (TEAD) and MRTF-A/B-dependent (SRE.L) transcriptional activity. We further showed that this mechanism relies on the same RhoGEF-RhoGTPase cascade components that are up-regulated in bladder cancers. Moreover, Gα13 Arg-200 mutants induced oncogenic transformation in vitro as determined by focus formation assays. In summary, our findings on Gα13 mutants establish that naturally occurring hotspot mutations in Gα subunits of any of the four families of heterotrimeric G-proteins are putative cancer drivers.




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International Arbitration: Exploring India’s Potential

International Arbitration: Exploring India’s Potential 15 November 2019 — 9:30AM TO 5:30PM Anonymous (not verified) 17 October 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE

As India’s economic clout grows, so does its aspiration to become a favoured arbitration destination in a globalized world dominated by foreign investments flows and cross border transactions. India’s bid to enhance its status as an arbitration destination depends largely on the suitability of its legal environment in meeting the demands of an increasingly sophisticated approach to disputed resolution. This conference will assess these, and other related, issues.

To register your interest in attending this event, please contact Nisha Ramdas by phone +91 9650977833 or by e-mail nisha@globaldialoguereview.com.




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International relations: The ‘how not to’ guide

International relations: The ‘how not to’ guide Expert comment NCapeling 11 October 2022

A centenary special issue of International Affairs explores past foreign policy failures to help policymakers avoid future catastrophes.

Policy decisions in international relations frequently have a long-lasting effect on the world order, shaping the lives of millions. Often acting under pressure and severe time constraints, decision-makers must rely on their own experience and the best expertise available. And so, despite many striving for a more peaceful and prosperous world, policy failures are all too common.

The second of International Affairs’ centenary special issues – devised and guest-edited by Amrita Narlikar and Daniel W. Drezner – is a ‘how not to guide’ for international relations. Focusing on historic failures, 14 experts examine what went wrong, and how policy practitioners and researchers can get it right together.

Between theory and outcome fall two ‘shadows’: one of decision-makers not taking advantage of sound academic policy advice – in some cases ignoring it because they think they already know best – and a second of bias in academic analyses and researchers simply erring, or erring on the side of their own self-importance. Between these two, there lies a joint path toward better policies.

The special issue provides policymakers with cautionary lessons, transforming well-known cases into a guide of what not to do in international politics. Building on that, the collection also suggests ways forward, including borrowing the medical Hippocratic Oath of ‘do no harm’, which in international relations serves as a cautionary warning against action merely for action’s sake, and then going decidedly beyond this minimum requirement.

A series of comics also accompanies the articles, produced in collaboration with Sequential Potential comics.

In their introduction, Drezner and Narlikar draw out four overarching factors which increase the likelihood of foreign policy failure – these are a focus on short-term successes, underestimating the power of narratives, hubris, and technocratic bubbles. If academics and policymakers can work together with these careful considerations, perhaps mistakes can avoid being repeated.

Richard Toye examines three pivotal moments in the UK’s history – the Munich crisis of 1938, the Suez crisis and war of 1956, and the Iraq war of 2003. He finds that in these cases the failures were over-determined, a consequence of Britain’s relative decline rather than its cause.

Daniel W. Drezner reviews two high profile failures of sanction use – United Nations (UN) sanctions on Iraq during the two Gulf wars, and the US re-imposition of sanctions on Iran in 2018. In both cases the main goals were not achieved and the costs were great. Drezner highlights ten ‘do’s and don’ts’ for sanctions as a result.

Amrita Narlikar shows how the World Trade Organization (WTO) has become an almost perfect example of how not to negotiate, even when taking into account recent limited successes. She identifies three broad categories of bargaining failures and explores the impact of narratives on the course of events, giving a clear list of do’s and don’ts for international negotiation.

Harold James also looks at three historic moments, the financial crises in 1931, 1997, and 2008. While responses to the crises initially looked successful, ironically in each case the drive to avoid past mistakes opened the door for the next crisis.

Cecilia Emma Sottilotta considers recent disasters in the European Union (EU) – the eurozone crisis and COVID-19 pandemic – and recommends for policymakers to find a middle ground between supranationalism and intergovernmentalism in crisis situations.

The growth of Chinese influence is a key issue in international relations today. Various articles in the special issue explain how not to deal with a rising China, coming from different angles. Exploring the US-China relationship, Janice Gross Stein is critical of the narrative around US decline and Chinese growth. The world should look beyond GDP as an indicator of a country’s growth and pay attention to strategic choices made by leaders in both states.

Joseph S. Nye Jr also provides a US perspective, arguing that while some historic analogies are misleading, the US should contemplate the cautionary narrative of sleepwalking into World War One when thinking about its relationship with China.

Amitabh Mattoo gives a south Asian view, asserting there is a need to understand Chinese policies in the region. Through examining China’s relations with India, Pakistan, and Sri Lanka he concludes that because China is adopting aggressive policies in the region, states must start cooperating with like-minded allies.

Yuen Foong Khong answers two questions in his paper tackling which ‘how not to’s’ are relevant when learning from history, and whether policymakers are aware of them. His research points to four things to avoid, which he then applies to how the Cold War analogy is used to understand contemporary US-China relations.

On the theme of foreign interference, Igor Istomin looks at the Soviet support for Mao Zedong’s Communist Party in the 1920s to 1940s. He argues strongly against interfering with major powers, as short-term gains cannot last.

From Iraq and Afghanistan to Somalia and the Balkans, there have been many failed interventions by the West since the end of the Cold War. Stephanie Carvin asserts the overreliance on automated weaponry has allowed supposedly ‘easy wars’ to turn into ‘forever wars’ – and this is not likely to stop.




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Reflections at 100: Women in international affairs

Reflections at 100: Women in international affairs Audio MVieira 19 December 2022

How have women contributed to international relations?

The last episode of Reflections at 100, marking the centenary of International Affairs, looks at women’s contributions to international thought.

Isabel and Krisztina speak to Dr Katharina Rietzler about women’s contributions to the journal and international relations, especially in the UK. Then, Krisztina speaks to Professor Barbara Savage about Black women’s contributions to international relations in the US. To wrap up this episode, Leah de Haan sheds light on Chatham House’s Equality, Diversity and Inclusion (EDI) initiative and Jo Hills shares their thoughts about putting together the archive collections.   

Reflections at 100 is a mini-series accompanying the journal’s centenary Archive Collections. The collections bring together articles from our archive which speak to the past, present and future of current affairs issues. In each podcast episode, we speak to contributors from a specific collection and explore what the research tells us about policy-making today. 

Explore the Archive Collection freely until the end of December 2022, including Katharina’s introduction: 100 years of women in International Affairs.

International Affairs was started at Chatham House in 1922 to communicate research to members who could not attend in person. Over the last 100 years it has transformed into a journal that publishes academically rigorous and policy relevant research. It is published for Chatham House by Oxford University Press. Read the latest issue here. 




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The near death and uncertain future of the US National Security Council

The near death and uncertain future of the US National Security Council 27 January 2023 — 9:00AM TO 10:00AM Anonymous (not verified) 9 January 2023 Chatham House

What role should the US National Security Council play in an era of great power competition?

Please plan to arrive at Chatham House from 08:45 GMT as the event will begin promptly at 09:00 GMT

Over the last three years, the US National Security Council (NSC) has gone from being neglected to necessary again, in Washington.

After former US President Donald Trump ignored and then tried to dismantle the NSC, current US President Joe Biden has restored the body but chosen not to reform it.

Born in the days before the Cold War and empowered during the War on Terror, what role should the NSC play in an era of great power competition?

Plus, how must it, and the rest of Washington, evolve to meet the challenges and opportunities that remain in the 21st century?




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National security and transatlantic unity top Biden’s agenda

National security and transatlantic unity top Biden’s agenda Expert comment NCapeling 1 February 2023

The timing of the State of the Union address is significant as Joe Biden tries to maintain focus on Ukraine and China while navigating partisanship at home.

Although primarily a domestic affair, the president’s remarks in the annual State of the Union (SOTU) telegraph the US’s foreign policy priorities to the rest of the world. They reveal the prism through which the US understands its national security and its role in the world.

The 2023 address comes as the first anniversary of the Ukraine invasion rapidly approaches, and the US is also trying to build international support for tough economic measures towards China. Domestically, Republican control of the House of Representatives will exert new pressure on US foreign policy choices. Electoral pressures are also around the corner and Joe Biden should announce soon whether he plans to run for president in 2024.

Alliances and partnerships are a driving force for Biden. As pressure to end the war in Ukraine intensifies, maintaining transatlantic unity on Ukraine will be a key priority for the president. And as US electoral politics rise to the fore, ensuring the visibility of Europe’s role as a security provider in its own backyard will be essential.

For a US president who sees China and the Indo-Pacific as America’s most significant long-term geopolitical challenge – and the only peer competitor to the US – transatlantic unity on China will also come under pressure.

Ukraine, China, and controlling domestic division

Republican leaders who now chair key committees in the House of Representatives continue to signal support for Ukraine, and polling shows a majority of US public opinion (54 per cent) favours sending either weapons or air defence systems.

But recent polls also reveal a growing gap between Democrat and Republican supporters with a slight majority of Republicans (52 per cent) now opposing further support for Ukraine.

Biden’s ability to demonstrate that America and its European partners remain unified in their policy towards Ukraine and Russia will help him ward off partisanship at home. Congressional approval of $45 billion for Ukraine in its end of year spending budget will help the president remain above the fray of partisan politics for now. But if there is an absence of clear signs Ukraine is succeeding in its war aims, the challenge of maintaining domestic support could become more difficult.

Bipartisanship is strong on China, Republicans are more singular and hawkish in their approach to China than the US president, and the public support tough measures

A greater US focus on China, India, and on the Indo-Pacific in 2023 is also likely. Bipartisanship is strong on China, Republicans are more singular and hawkish in their approach to China than the US president, and the public support tough measures. At a time of war in Europe, the president will place great emphasis on the need to maintain transatlantic unity and to work with a broader coalition of partners in the Indo-Pacific.

The groundwork for focus on China has already been laid. Throughout 2022, the Biden administration worked steadily, but quietly, to set out its China policy. Just before Russia’s invasion of Ukraine in February 2022, the US released its new US-Indo Pacific Strategy stressing regional partnerships – especially the Quad and ASEAN – and it’s determination to shape essential norms for the region.

It stated boldly – albeit in a document which was largely unnoticed – that the objective is not to change China but to ‘shape the strategic environment in which it operates’, a policy which signifies a clear departure from the more ideological approach pursued by the US during Donald Trump’s final year in office. And in May, the US announced its economic strategy for the region, the Indo-Pacific Economic Framework.

Now the terrain for competition with China and alignment with US partners and allies is heavily focused on technology and the daylight between national security and economic strategy in US China policy is rapidly disappearing. Biden’s policy focus of ‘invest (at home), align (with allies and partners), and compete (with China)’ has overshadowed earlier talk of cooperation between the US and China.

Those listening carefully to the State of the Union and who have followed US policy will also note the unchallenged hegemony of neoliberalism is rapidly vanishing

But as China opens its doors and Europe looks to bolster its economies, the US will have to work far harder to maintain transatlantic unity. Japan and the Netherlands embracing the US adoption of export controls on semiconductor chips is a positive sign, but the US’s economic strategy towards China may present harder choices to come for Europe. If China leans into its diplomacy, the pressure on transatlantic unity will also grow.

The new US Congress will only sharpen the president’s tough stance on China. Some Republican leaders still deny climate change and have demonstrated little interest in cooperating with China on debt relief for developing countries. The prospects for addressing critical global challenges appear dim without China’s collaboration, and the UK and Europe should work with the US president and Congress to correct this.

President Biden has clearly recognized that diplomacy will be critical in the months ahead. At a time of growing tensions, the potential for misperceptions or misunderstandings to create conflict will also increase, and so a US – and also European – commitment to broadening and deepening diplomacy with China is urgent but it also needs to be patient and sustained.

A new American industrial policy?

Those listening carefully to the State of the Union and who have followed US policy will also note the unchallenged hegemony of neoliberalism is rapidly vanishing. The American state appeared to be disturbingly absent in the early months of the US pandemic response – but now it is back and, in a surprising turn of events, is being cast as a solution not a problem.