Množství politiků po celém světě v posledních dnech trápí zásadní otázka. Jak zabránit druhé vlně koronaviru bez škrcení ekonomiky? Možnou cestu ukázalo hlavní město Litvy. Majitelé menších podniků zde museli stejně jako na jiných místech v Evropě dočasně pozastavit svou živnost. Vedení Vilniusu ve snaze zabránit jejich krachu v rámci uvolňovaní restriktivních opatření rozhodlo o umožnění bezplatného využití veřejných prostor.

A team of scientists has observed, for the first time, the presence of warm water at a vital point underneath a glacier in Antarctica--an alarming discovery that points to the cause behind the gradual melting of this ice shelf while also raising concerns about sea-level rise around the globe.

Несмотря ни на что, жизнь продолжается, и наступает май - один из волшебных месяцев года. Во многих регионах и странах люди по-прежнему остаются дома, а это значит, что у всех дел есть шанс быть переделанными, и можно посвятить больше времени любимым сайтам.

In this paper (winner of the eCrime 2019 Best Paper award), we consider the types of things that can go wrong when you intend to make things better and more secure. Consider this scenario. You are browsing through Internet and see a news headline on one of the presidential candidates. You are unsure if the … Continue reading Identifying Unintended Harms of Cybersecurity Countermeasures →

NoSQL, no problem for Facebook-originating RocksDB

MongoDB and fellow database biz Rockset have integrated products in a bid to make it easier to work with the NoSQL database through standard relational database query language SQL.…

A review by SomeRandomHEFan (46). One of Humongous Entertainment's weaker attempts at conventional edutainment

Tattoo pistols are definitely the devices that are used to create and use tattoos. These pistols are also known as tattoo models. They have been utilized for several years to create stylish and delightful bits of system craft. Right now,… Continue Reading →

By 2060 Phoenix Arizona will have 132 days a year over 100F. Dallas will 55 and Pecos Texas 101 days. My view about problems: We should solve them. If the Earth really does heat up substantially then we should pull the CO2 back out of the atmosphere while also releasing cooling gases. If its practical we should also raise the albedo (surface reflectivity) of the planet. Right now cities should change their zoning laws and roads policies to make buildings, roads, and other surfaces more reflective. No more dark buildings. Use light colors of concrete, white shingles, and other surfaces that reflect more light. That would be beneficial even if the Earth was not heating up. Hot cities are unpleasant...

Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer therapeutics. The most advanced of these are small molecules that target the HIF-2 isoform through binding the PAS-B domain of HIF-2α. These molecules are undergoing clinical trials with promising results in renal and other cancers where HIF-2 is considered to be driving growth. Nevertheless, a central question remains as to whether such inhibitors affect physiological responses to hypoxia at relevant doses. Here, we show that pharmacological HIF-2α inhibition with PT2385, at doses similar to those reported to inhibit tumor growth, rapidly impaired ventilatory responses to hypoxia, abrogating both ventilatory acclimatization and carotid body cell proliferative responses to sustained hypoxia. Mice carrying a HIF-2α PAS-B S305M mutation that disrupts PT2385 binding, but not dimerization with HIF-1β, did not respond to PT2385, indicating that these effects are on-target. Furthermore, the finding of a hypomorphic ventilatory phenotype in untreated HIF-2α S305M mutant mice suggests a function for the HIF-2α PAS-B domain beyond heterodimerization with HIF-1β. Although PT2385 was well tolerated, the findings indicate the need for caution in patients who are dependent on hypoxic ventilatory drive.

IBM announced today that the U.S. Army’s Logistics Support Activity awarded IBM a contract to continue providing cloud services, software development and cognitive computing, constituting the technical infrastructure for one of the U.S. federal government’s biggest logistics systems.

Raised by his godfather, following the events of Halloween 1981, Harry spends his childhood, hidden from the Wizarding World, preparing to face his destiny. However, his world is turned upside down when he reunites with the beautiful redhead he rescued down in the Chamber.

On the cusp of the third wizarding war, the truth behind the events of Halloween 1981 and subsequent events finally come to light, when it is revealed that Harry Potter, forgotten and ignored by many, is the Boy Who Lived.

ESPN will be releasing two brand new 30 For 30 documentaries in Africa in May and early June, telling the stories of cyclist Lance Armstrong and martial artist Bruce Lee.