Robert SASAKI has added a photo to the pool:

This is a challenging time for everyone. But nothing is as challenging as being trapped in another country...literally. I was planning to fly home for a week at the end of March. I was so convinced I would be there that I extended by a week so I could run

The virus simmered quietly in Cuba for about a year before infecting thousands.

The Clippers' 120-105 rout of Houston was many things: a sixth consecutive win, a defensive showcase for three quarters and a muscular step toward the postseason.

Slick-fielding infielder Roberto Baldoquin cost the Angels $14 million to sign out of Cuba in 2015, but he was released recently because his bat didn't develop.

Sutter and Yuba counties allowed businesses to reopen on Monday amid the coronavirus crisis after a similar decision was made in Modoc County in California's northeastern corner.

Hosni Mubarak for decades kept a cold peace with Israel and crushed political dissent at home until a 2011 protest movement drove him from power.

The general manager of the Troubadour, which famously launched Elton John's career, says 'to survive, we're going to need all the help we can get.'

Arsenal have been told the kind of funds they must commit to sign Odsonne Edouard from Celtic in the summer transfer window.

DUBAI hotels are slashing prices by up to 60 percent as part of its wider plans to boost tourism to the country.

DUBAI hotels are slashing prices by up to 60 percent as part of its wider plans to boost tourism to the country.

IU alum and Dallas Mavericks owner Mark Cuban pitches an idea to Kentucky basketball coach John Calipari as if he was a 'Shark Tank' contestant.

Dallas Mavericks owner and IU alum is taken aback to learn the NBA is stopping play in the wake of a player's coronavirus test

Two days ago Mario Hidalgo, CEO of the Spanish airline “Hola Airlines“ , announced that Hola Airlines (Baleares Link Express SL) has been obliged by the US government to stop its operations in Cuba . The US Government threatened Hola Airlines via Boeing to end the service of maintenance of the Boeing aircraft belonging to the [...]

11 photos: Businesses and restaurants open to customers in rural California counties.

Mavs owner Mark Cuban isn't comfortable opening team facility for practice because they can't test all players and staff for coronavirus.

A chronology of key events

A chrtonology of key events

Key facts, figures and dates

An overview of Aruba including key facts, political leaders and the media

Tart rhubarb and creamy custard—sweetened with just a hint of orange zest and nestled inside a flaky crust—are a match made in rustic pie heaven. This no-fuss single crust pie takes only a few minutes to prepare.

Continue reading "Rhubarb Custard Pie" »

The Seychelles (and Dubai)

The Amateur Traveler talks to Sam about his recent trip to Cuba with his brother. Sam visited Havana and Trinadad. He reveled in the local music, the warmth of the people, the beautiful and enigmatic scenery and tolerated the food. Sam who is one eighth Cuban also met family that he had not known about until recently. Sam’s highlights include walking with tourists and locals alike along the malecon on the shore of Havana. As a photographer he came back with over a thousand pictures of the people, the colonial architecture and the classic cars of Cuba. A small sample of Sam’s work can be seen in the iTunes enhanced version of the show.

Hear about cruising to Cuba as the Amateur Traveler talks again to Dave Grenewetzki about his trip on a ship based People to People trip to Cuba.

Dr Paola Subacchi, director of Chatham House’s International Economics Department, has been awarded the prestigious Order of the Star of Italy.

The linear ubiquitin assembly complex (LUBAC) is an essential component of the innate and adaptive immune system. Modification of cellular substrates with linear polyubiquitin chains is a key regulatory step in signal transduction that impacts cell death and inflammatory signaling downstream of various innate immunity receptors. Loss-of-function mutations in the LUBAC components HOIP and HOIL-1 yield a systemic autoinflammatory disease in humans, whereas their genetic ablation is embryonically lethal in mice. Deficiency of the LUBAC adaptor protein Sharpin results in a multi-organ inflammatory disease in mice characterized by chronic proliferative dermatitis (cpdm), which is propagated by TNFR1-induced and RIPK1-mediated keratinocyte cell death. We have previously shown that caspase-1 and -11 promoted the dermatitis pathology of cpdm mice and mediated cell death in the skin. Here, we describe a reciprocal regulation of caspase-1 and LUBAC activities in keratinocytes. We show that LUBAC interacted with caspase-1 via HOIP and modified its CARD domain with linear polyubiquitin and that depletion of HOIP or Sharpin resulted in heightened caspase-1 activation and cell death in response to inflammasome activation, unlike what is observed in macrophages. Reciprocally, caspase-1, as well as caspase-8, regulated LUBAC activity by proteolytically processing HOIP at Asp-348 and Asp-387 during the execution of cell death. HOIP processing impeded substrate ubiquitination in the NF-κB pathway and resulted in enhanced apoptosis. These results highlight a regulatory mechanism underlying efficient apoptosis in keratinocytes and provide further evidence of a cross-talk between inflammatory and cell death pathways.

Invitation Only Research Event

Event participants

Rodrigo Malmierca, Minister for Foreign Trade and Investment, Cuba
Chair: Dr Christopher Sabatini, Senior Research Fellow for Latin America, Chatham House; Lecturer, Columbia University, School of International and Public Affairs

Jean-Francois Chassagneux and Camilo A. Garcia Trillos
Math. Comp. 89 (2020), 1895-1932.
Abstract, references and article information

Phạm Tiến Sơn
Proc. Amer. Math. Soc. 148 (2020), 2739-2741.
Abstract, references and article information

The linear ubiquitin assembly complex (LUBAC) is an essential component of the innate and adaptive immune system. Modification of cellular substrates with linear polyubiquitin chains is a key regulatory step in signal transduction that impacts cell death and inflammatory signaling downstream of various innate immunity receptors. Loss-of-function mutations in the LUBAC components HOIP and HOIL-1 yield a systemic autoinflammatory disease in humans, whereas their genetic ablation is embryonically lethal in mice. Deficiency of the LUBAC adaptor protein Sharpin results in a multi-organ inflammatory disease in mice characterized by chronic proliferative dermatitis (cpdm), which is propagated by TNFR1-induced and RIPK1-mediated keratinocyte cell death. We have previously shown that caspase-1 and -11 promoted the dermatitis pathology of cpdm mice and mediated cell death in the skin. Here, we describe a reciprocal regulation of caspase-1 and LUBAC activities in keratinocytes. We show that LUBAC interacted with caspase-1 via HOIP and modified its CARD domain with linear polyubiquitin and that depletion of HOIP or Sharpin resulted in heightened caspase-1 activation and cell death in response to inflammasome activation, unlike what is observed in macrophages. Reciprocally, caspase-1, as well as caspase-8, regulated LUBAC activity by proteolytically processing HOIP at Asp-348 and Asp-387 during the execution of cell death. HOIP processing impeded substrate ubiquitination in the NF-κB pathway and resulted in enhanced apoptosis. These results highlight a regulatory mechanism underlying efficient apoptosis in keratinocytes and provide further evidence of a cross-talk between inflammatory and cell death pathways.

This week host Matt Egan kicks things off by chatting to staff writer Lewis Painter about the (genuinely) impressive Huawei P9 phone release. Then, acting editor at Macworld.co.uk David Price jumps in to discuss Whatsapp encryption (12:30) and the Panama Papers. Finally, Christina Mercer, online editor at Techworld.com, introduces you to the wonderful world of Li-Fi (24:30).  

See acast.com/privacy for privacy and opt-out information.

“The United States has launched a stunning attack on Cuba’s medical-aid missions, with the Trump administration pressing countries to reject them during the coronavirus pandemic,” Steve Sweeny reported in the Morning Star, March 26, 2020. Given...

Bangladeshis in 2017 suddenly emerged as one of the top migrant groups entering Europe illegally. While Europe is a new destination, Bangladeshi labor migration has been an important part of the country's development since the 1970s, with growing numbers heading abroad, largely to the Gulf Cooperation Council countries. This article explores and contextualizes the new phenomenon of Bangladeshi migration to Europe.

The Cuban Revolution unleashed a massive exodus from the island. Cuba is now among the top origin countries of immigrants in the United States—where for decades they have received preferential treatment—with smaller numbers across Europe and Latin America. This article explores the evolution of Cuban migration, particularly within the context of the Cold War and shifting U.S. policies toward the country.

Katherine M Flegal
Jul 1, 1991; 14:628-638
Supplement 3: Diabetes in Hispanic Americans

Wiesbaden : Bergmann, 1905.

Leipzig : F.C.W. Vogel, 1908.

London (46 Pall Mall) : Pub.d by R. Bowyer & M. Parkes, 1st Jan.y 1830.

Amstelodami : Typis A. Wolfgang, 1674.

The NBA gave its approval for teams to reopen their practice facilities on a limited basis on Friday, but only three teams have confirmed they will. And Dallas Mavericks owner Mark Cuban is in no hurry for his team to join the list.

The post FIRST Global Challenge Dubai Inspires STEM Students and the World appeared first on SOLIDWORKS Education Blog.

Endotracheal intubation of newborn infants is a common procedure. Competency in this skill is mandatory for many pediatric training programs. The safety and benefits of using a stylet for intubating newborn infants are unknown.

Pediatric trainees are commonly unsuccessful at performing endotracheal intubation. Adverse events of using a stylet are uncommon. The use of a stylet does not increase success rates. (Read the full article)

Provider training level is associated with lower rates of successful tracheal intubation in selected neonatal settings. However, little is known about the association of training level with tracheal intubation success and adverse events in the PICU.

Our results demonstrate the association of training level on the first attempt and overall success rate as well as the incidence of adverse tracheal intubation–associated events in a large-scale, prospective assessment across 15 academic PICUs. (Read the full article)