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Xiaomi Mi 10 5G With 108-Megapixel Camera Launched in India

Mi 10 5G has been officially launched in India. The new Mi smartphone by Xiaomi is powered by a Qualcomm Snapdragon 865 SoC and is available with up to 256GB of onboard storage.




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Design your own app: A beginners guide to Pixate

  Pixate is what you’d call an app prototyping tool and they are a dime a dozen. For the uninitiated, prototyping is how you generate mockups or prototypes of applications without the need to know...




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Apple AirPods Can’t Compete With Enhanced Google Pixel Buds

Google's Pixel Buds are playing a very different game to the competition. ......




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Dupixent (dupilumab)

Title: Dupixent (dupilumab)
Category: Medications
Created: 2/26/2020 12:00:00 AM
Last Editorial Review: 2/26/2020 12:00:00 AM




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ARHGEF7 ({beta}-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function

Background

Previous studies showed that Cdc42, a member of the prototypical Rho family of small GTPases and a regulator of the actin cytoskeleton, is critical for the normal development and health of podocytes. However, upstream regulatory mechanisms for Cdc42 activity in podocytes are largely unknown.

Methods

We used a proximity-based ligation assay, BioID, to identify guanine nucleotide exchange factors that activate Cdc42 in immortalized human podocytes. We generated podocyte-specific ARHGEF7 (commonly known as β-PIX) knockout mice by crossing β-PIX floxed mice with Podocin-Cre mice. Using shRNA, we established cultured mouse podocytes with β-PIX knockdown and their controls.

Results

We identified β-PIX as a predominant guanine nucleotide exchange factor that interacts with Cdc42 in human podocytes. Podocyte-specific β-PIX knockout mice developed progressive proteinuria and kidney failure with global or segmental glomerulosclerosis in adulthood. Glomerular podocyte density gradually decreased in podocyte-specific β-PIX knockout mice, indicating podocyte loss. Compared with controls, glomeruli from podocyte-specific β-PIX knockout mice and cultured mouse podocytes with β-PIX knockdown exhibited significant reduction in Cdc42 activity. Loss of β-PIX promoted podocyte apoptosis, which was mediated by the reduced activity of the prosurvival transcriptional regulator Yes-associated protein.

Conclusions

These findings indicate that β-PIX is required for the maintenance of podocyte architecture and glomerular function via Cdc42 and its downstream Yes-associated protein activities. This appears to be the first evidence that a Rho–guanine nucleotide exchange factor plays a critical role in podocytes.




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Enhanced Efflux Pump Expression in Candida Mutants Results in Decreased Manogepix Susceptibility [Mechanisms of Resistance]

Manogepix is a broad-spectrum antifungal agent that inhibits glycosylphosphatidylinositol (GPI) anchor biosynthesis. Using whole-genome sequencing, we characterized two efflux-mediated mechanisms in the fungal pathogens Candida albicans and Candida parapsilosis that resulted in decreased manogepix susceptibility. In C. albicans, a gain-of-function mutation in the transcription factor gene ZCF29 activated expression of ATP-binding cassette transporter genes CDR11 and SNQ2. In C. parapsilosis, a mitochondrial deletion activated expression of the major facilitator superfamily transporter gene MDR1.




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Google Pixel 4a: Everything We Know So Far

Last year the release of Google's Pixel 3a heralded a shift in the mid-range phone market. Coming in at $649 and packing some flagship specs, it changed what people should expect from a a phone at that price. Other brands followed suit, including Apple with its recently released iPhone SE. Suffice to say, the arrival of Googles new budget device, the Pixel 4a, is cause for some excitedment. Here's what we know about it so far. More »
    




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RPGCast – Episode 276: “Manic Pixie Dream Girl”

The Vita gets all the games. Elder Scrolls Online wants all the money. Xbox One wants all the games. PlayStation 4 has all the indies....




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Google’s Slick Pixel Buds Finally Give Android Users the AirPods They Deserve

Comfort, however, can be an issue




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Pixel 4a: Google's next cheaper smartphone could be arriving in May

The Pixel 3a was a big hit, can the 4a follow that lead?




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Apixaban may be more effective and safer than rivaroxaban, research suggests

Adults with non-valvular atrial fibrillation prescribed apixaban have a lower rate of ischaemic stroke and systemic blood clots compared with those prescribed rivaroxaban, according to a retrospective cohort study in Annals of Internal Medicine.

To read the whole article click on the headline




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Could Sanofi and Regeneron's Dupixent also treat age-related macular degeneration?

Sanofi and Regeneron’s Dupixent has become a popular treatment for atopic dermatitis and asthma. Now, a research team in Japan has discovered that IL-4 and its receptor—which Dupixent inhibits—could be promising targets for treating the eye disease age-related macular degeneration.




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Apixaban therapy is effective and safe for cancer-associated VTE




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How To Use Disney Pixar Movies To Teach Kids About Friendship - Hide and Seek

Watch Arlo and Spot’s friendship grow in this heartwarming clip. THE GOOD DINOSAUR Available on Digital HD, Blu-ray and Disney Movies Anywhere today!






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Pixar director, story artist Rob Gibbs passes away

Veteran director, story artist and writer of many Pixar films -- Rob Gibbs passed away at the age of 55. A company spokesperson confirmed the news, the cause of death was not immediately known, cited The Hollywood Reporter. The artist, who has spent more than 20 years with the company, has contributed immensely to the animation industry. Gibbs' contribution to many well-known and successful Pixar films, included 'Toy Story 2', 'Finding Nemo', 'Monsters, Inc., and more.

His credits also included the short film 'Tokyo Mater' in 2008, and the series 'Mater's Tall Tales' and 'Tales From Radiator Springs' from the 2012 Cars franchise - 'Brave'. The California resident also contributed to 'Monsters University', and also the upcoming 'Monsters at Work' series for Disney+ and 'Incredibles 2.'He is survived by his daughter Mary, who was the voice of Boo in several 'Monsters, Inc.' projects.

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Iran TEDPIX Stock Market Index

The TEDPIX increased 593824 or 154.60% since the beginning of 2020, according to trading on a contract for difference (CFD) that tracks this benchmark index from Iran. Historically, the Iran TEDPIX Stock Market Index reached an all time high of 980571 in May of 2020. The TEDPIX is a major stock market index which tracks the performance of the major companies listed on the Tehran Stock Exchange.




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Google said to be preparing its own chips for use in Pixel phones and Chromebooks

Google is reportedly on the verge of stepping up their hardware game in a way that follows the example set by Apple, with custom-designed silicon powering future smartphones. Axios reports that Google is readying its own in-house processors for use in future Pixel devices, including both phones and eventually Chromebooks, too. Google’s efforts around its […]




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NTAs 2020: Pixie Lott oozes elegance in a backless lemon dress

The singer, 29, looked incredible in a pale lemon form-fitting gown as she posed up a storm in front of the paparazzi before heading into the ceremony.




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Tallulah Willis copies Demi Moore's pixie haircut from Ghost film

The 25-year-old debuted her new haircut onto Instagram over the week. It all started Sunday, when Tallulah posted a mirror selfie showcasing her significantly shorter new locks.




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Pixie Lott posts nude swimsuit photo in New Year's post

The singer, 28, promised a 'magical' 12 months are ahead as she spent New Year's Day soaking up the sunshine at Sri Panwa Private Villas in Phuket, Thailand, on Wednesday.




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Pixie Lott soaks up the sun in Thailand while balancing a coconut on her head

'Your wings already exist all you have to do is fly. Can u see the butterfly?' the beauty asked her 641k Instagram followers alongside a picture of her balancing a coconut on her head at the resort.




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Glastonbury 2019: Pixie Geldof showcases her toned torso in a tiny black crop top

The socialite, 28, looked festival ready, as she flaunted her toned torso, in a pair of leopard print trousers and a tiny black crop top.




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Wimbledon 2019: Pixie Lott wows in VERY daring white jumpsuit

Pixie Lott and Oliver Cheshire joined a host of stars for day 11 of Wimbledon on Friday.




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Pixie Lott performs on The Voice final in tiny shorts

The pop star, 26, bounced around The Voice stage, gyrating to the floor in a racy ensemble of glittering waistcoat, tiny shorts and over-the-knee boots as she performed new single Baby on the ITV show.




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Pixie Lott looks chic in thigh-skimming white mini dress for filming in London

The blonde showed off her summer tan in a pretty white mini dress as she was followed by a camera crew while walking through the crowded streets. 




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Pixie Lott puts on an affectionate display with fiance Oliver Cheshire

The-29-year-old looked loved up with fiance Oliver Cheshire, 31, when the pair partied the night away at the Vogue x Tiffany afterparty at Annabel's on Sunday




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V Festival 2013: Pixie Lott and Laura Whitmore lead the way in the fashion stakes opting for tiny shorts at V Festival

They are both known for their slim figures and their love of fashion.




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Pride Of Britain Awards: Pixie Lott, Kimberley Walsh and Ashley Roberts look glamorous

It’s an opportunity to praise those who give that extra bit back to society and help make the world a better place.




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Ellie Goulding leads the glamour while Pixie Lott wears leather at Q Awards

Ellie Goulding scored sartorial points at the Q Awards on Monday, arriving in a sheer, layered polka-dot dress to Grosvenor House Hotel.




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Jada Pinkett Smith trades out her golden curls as she debuts a chic new buzzed blonde pixie cut

Jada Pinkett Smith changed up her always stylish hair with a new blonde pixie cut. The 48-year-old actress showed off the striking look in a short video posted to Instagram.




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Motorola's new $1,000 Edge Plus phone comes with a headphone jack, 5G connectivity, and a 108-megapixel camera — you can get it on May 14




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ROB WAUGH: The Pixelbook Go is deliciously slim and worth the money

Google's Pixelbook Go is a Chromebook (basically running a browser, but with a few additional apps). I realised that it can actually do pretty much anything from word processing to website editing




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60 Minutes reporter Allison Langdon reveals Roxy Jacenko's daughter Pixie is 'struggling

Pixie Curtis, five, is 'really struggling' with her father Oliver Curtis' absence since he was jailed for insider trading in June, claims 60 Minutes reporter Allison Langdon




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Roxy Jacenko let Pixie speak to Oliver Curtis in jail

The mother-of-two said her Instagram star daughter 'cried for the whole day' after talking to the disgraced investment banker - who was jailed for two years in June.




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Roxy Jacenko's daughter Pixie Curtis sings song in the back of the car on Instagram

Roxy Jacenko's daughter Pixie Curtis appeared in a video singing a song in the back of the family car on Sunday night when she, her mother and brother Hunter went out for Chinese food.




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Roxy Jacenko's daughter Pixie Curtis impresses fans with her dance moves

Pixie Curtis has showcased her love for music as the Instagram star was seen dancing and singing on a day out with the family, in a video uploaded by her mum Roxy Jacenko on Sunday




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Pixie Lott and Oliver Cheshire on BAFTAs 2020 red carpet

The Voice Kids judge, 29, made a bold fashion statement in a white satin ruffled midi dress with a high-neck and backless detailing.




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Oscars 2020: Olivia Colman debuts BLONDE pixie haircut

She's currently basking in a fresh round of critical and fan acclaim for her portrayal of Queen Elizabeth II in the latest series of Netflix's The Crown.




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ROB WAUGH: The Pixelbook Go is deliciously slim and worth the money

Google's Pixelbook Go is a Chromebook (basically running a browser, but with a few additional apps). I realised that it can actually do pretty much anything from word processing to website editing




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Leaked billboard mock-ups reveal Google's budget-focused Pixel 4a will retail at $399

The Pixel 4A will debut at $399 which is on par with the tech giant's previous budget offering, the Pixel 3A according to leaked renders of billboard ads for the Google-made device posted by Evan Blass.




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Google may be developing own processor for powering its line of Pixel phones and Chromebook laptops

Google's development of a processor for Pixel phones and Chromebooks could materialize a chip as soon as early next year and could help the tech giant support on-board artificial intelligence.




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Indian Consumers Don't Care About Megapixels As Much As Brands Do

The report added that 79 per cent of the consumers in the sub-Rs 30,000 price band believe that image quality is not dependent on the number of megapixels.




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Android 11 Developer Preview 3: How To Download On Google Pixel Devices

The third and possibly the final installment of the Android 11 Developer Preview has been released for Google Pixel smartphones. The new developer preview comes with build number RPP3.200230.017 and brings several new features in addition to the April 2020 security




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Best DSLR Cameras Wth High Megapixels Count To Buy In India

A smartphone camera can never match a photograph taken by a professional DSLR, as they have big lenses that can capture more light and the larger aperture will also help you capture the subject in a detailed manner. Though most of




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Green Day, BTS, The Pixies, Stormzy: World Tour Concerts Cancelled Due To Coronavirus

Coronavirus (COVID-19) has now spread over at least 53 countries and has infected more than 82,000 people with a death toll of more than 2,800 people. Since health scares have been increasing all over the world, it has also affected the




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Pixel launch: Is Google Assistant's AI an assault on privacy?

Sure, artificial intelligence can make life simpler by suggesting you places to eat, tell you weather, or even crack a joke. The more you use it, the more it learns about your habits and preferences. The protocols pertaining to artificial intelligence, or the lack of it, make our data less secure and more vulnerable.




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Inside pixinsight / Warren A. Keller

Online Resource




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PIX: TV actress Krystle D'Souza's Turkey vacay

Let's take a tour of Turkey through Krystle's eyes.