One of the reasons I enjoy the MAcc program so much is because it allows me the flexibility to take elective classes that spark my professional interests. As a student who one day aspires to be the CFO of a company, I wanted to take extra HRM (human resource management) classes to understand more about … Continue reading "Intro to Organizational Business Coaching"

Boy Scouts of America (BSA) filed for Chapter 11 bankruptcy to achieve two key objectives ...

Tune in online this month to find out how to protect your business from data extortionists

Webcast It's been "the year of ransomware" for about the past three years. And while you may be tired of hearing about the trend and just getting used to the reality, you may also like to remember: instances of attacks are climbing – quickly – and we’re now reaching a level where more than half of ransomware schemes result in a business paying out.…

we know how politics works in the United States. Whoever—whatever political party gets into government is going to merge with the bureaucracy pretty damn fast. It will be in a position where it has some levers in its hand. And so, as a result, corporate lobbyists will move in to help control those levers. So it doesn’t make much difference in the end. What does make a difference is political accountability, a general deterrence set to stop political organizations behaving in a corrupt manner. Continue reading →

IBM today announced the findings of a major new study of over 1,900 Chief Financial Officers (CFOs) and senior finance executives from 81 countries and 35 industries worldwide, which reveals that more than 60 percent of CFOs plan major changes to respond to the new economic climate.

The United States Cybersecurity and Infrastructure Security Agency (CISA) yesterday issued a fresh advisory alerting organizations to change all their Active Directory credentials as a defense against cyberattacks trying to leverage a known remote code execution (RCE) vulnerability in Pulse Secure VPN servers—even if they have already patched it. The warning comes three months after another

The Ottawa Senators reports four more COVID-19 cases. The Senators played at Honda Center on March 10 and at Staples Center on March 11.

Halting funding of the WHO is another in a long line of decisions made by the Trump administration abdicating U.S. leadership on science.

The people behind GivingTuesday launched the #GivingTuesdayNow campaign to ask people to be kind and generous during the novel coronavirus outbreak.

Gov. Eric Holcomb has begun reaching out to the business community to learn how to begin reopening the economy as safely as possible.

Mobilized teams trained to help during  crisis & trauma By Heather Sherrill Editor-in-Chief Over winter...

A chronology of key events

Key facts, figures and dates

A guide to the 34-member regional grouping

For many, moving from everyone’s-working-from-the-office to everyone’s-working-at-home isn’t so much a transition as it is a scramble. A very how the fuck? moment. That’s natural. And people need time to figure it out. So if you’re in a leadership position, bake in time. You can’t expect people to hit the ground running when everything’s different.… keep reading

(American Geriatrics Society) For only the second time in its near 80-year history, the American Geriatrics Society (AGS) will award one of its highest honors typically reserved for individuals to West Health, a family of nonprofit organizations dedicated to lowering healthcare costs to enable older adults to successfully age in place.

Eelke P. Béguin
Apr 24, 2020; 0:RA120.001964v1-mcp.RA120.001964
Research

Research Event

Event participants

Louise Mushikiwabo, Secretary General, Organisation Internationale de la Francophonie (OIF)
Chair: Bob Dewar CMG, Associate Fellow, Africa Programme, Chatham House

The vessel wall is continuously exposed to hemodynamic forces generated by blood flow. Endothelial mechanosensors perceive and translate mechanical signals via cellular signaling pathways into biological processes that control endothelial development, phenotype and function. To assess the hemodynamic effects on the endothelium on a system-wide level, we applied a quantitative mass spectrometry approach combined with cell surface chemical footprinting. SILAC-labeled endothelial cells were subjected to flow-induced shear stress for 0, 24 or 48 hours, followed by chemical labeling of surface proteins using a non-membrane permeable biotin label, and analysis of the whole proteome and the cell surface proteome by LC-MS/MS analysis. These studies revealed that of the >5000 quantified proteins 104 were altered, which were highly enriched for extracellular matrix proteins and proteins involved in cell-matrix adhesion. Cell surface proteomics indicated that LAMA4 was proteolytically processed upon flow-exposure, which corresponded to the decreased LAMA4 mass observed on immunoblot. Immunofluorescence microscopy studies highlighted that the endothelial basement membrane was drastically remodeled upon flow exposure. We observed a network-like pattern of LAMA4 and LAMA5, which corresponded to the localization of laminin-adhesion molecules ITGA6 and ITGB4. Furthermore, the adaptation to flow-exposure did not affect the inflammatory response to tumor necrosis factor α, indicating that inflammation and flow trigger fundamentally distinct endothelial signaling pathways with limited reciprocity and synergy. Taken together, this study uncovers the blood flow-induced remodeling of the basement membrane and stresses the importance of the subendothelial basement membrane in vascular homeostasis.