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Diverting the Mannich reaction to access 2,2-disubstituted indolin-3-ones by merging 1,2-aryl migration and copper-catalyzed aerobic oxidation

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00481G, Research Article
Jia-Chen Xiang, Yu-Die Wang, Peng Yuan, Hui-Min Zhu, Tong Lei, An-Xin Wu, Zhixin Liao
Three typical substrates for the Mannich reaction, p-anisidine, aldehyde, and a nucleophile, did not afford the predictable linear Mannich base under an aerobic copper oxidation condition, but rendering a 2,2-disubstituted indolin-3-one product.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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New treatment option for young women with hormone-sensitive breast cancer

A drug used for treating breast cancer, known as exemestane, is more effective than a common breast cancer prevention drug, tamoxifen, in preventing breast cancer recurrence in young women who also receive post-surgical treatment to suppress ovarian function. The combined results of the Tamoxifen and Exemestane Trial and Suppression of Ovarian Function Trial were presented at the 2014 ASCO Annual Meeting in Chicago.




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One-fourth of people living with diabetes in India, Lancet study estimates

Of the 82.8 crore, India's share formed over a quarter (21.2 crore). Another 14.8 crore were in China, while 4.2 crore, 3.6 crore and 2.2 crore lived in the US, Pakistan and Brazil, respectively, the researchers found




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Coast Guard Chief S Paramesh calls on India's High Commissioner to Sri Lanka, discusses maritime security




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Canada: Peel Police requests temple body to postpone event amid 'threats'




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South Korea to double marine protection zone, address climate change




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An electrically conducting 3D coronene-based metal–organic framework

J. Mater. Chem. A, 2024, Advance Article
DOI: 10.1039/D3TA07120K, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marina I. Schönherr, Patricia I. Scheurle, Laura Frey, Marta Martínez-Abadía, Markus Döblinger, Andre Mähringer, Dominik Fehn, Lena Gerhards, Irina Santourian, Alfred Schirmacher, Tatjana Quast, Gunther Wittstock, Thomas Bein, Karsten Meyer, Aurelio Mateo-Alonso, Dana D. Medina
A novel electrically conducting cubic mesoporous metal–organic framework (MOF), consisting of hexahydroxy-cata-hexabenzocoronene (c-HBC) and FeIII ions is presented.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Machine Learning Enabled Exploration of Multicomponent Metal Oxides for Catalyzing Oxygen Reduction in Alkaline Media

J. Mater. Chem. A, 2024, Accepted Manuscript
DOI: 10.1039/D4TA01884B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Xue Jia, Hao Li
Low-cost metal oxides have emerged as promising candidates used as electrocatalysts for oxygen reduction reaction (ORR) due to their remarkable stability under oxidizing conditions, particularly in alkaline media. Recent studies...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Highly selective and high-performance sulfonated poly(ether ether ketone)-based hybrid membrane enabled by complexed UiO-66-NH2 and sulfonated graphitic carbon nitride for vanadium flow battery

J. Mater. Chem. A, 2024, Accepted Manuscript
DOI: 10.1039/D4TA00988F, Paper
Caiyuan Zhao, Haixia Wang, Lang Li, Liping Liu, Xinrui Cui, Haifeng Shi
A series of sulfonated poly(ether ether ketone) (SPEEK) hybrid membranes (SPEEK/NF) with a constant 1 wt% complexed nanofillers (NF) comprising of UiO-66-NH2 and sulfonated graphitic carbon nitride (s-g-C3N4) are prepared...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Jack Stoll finds a new home one day after being released by the Eagles

The Eagles former tight end was quickly picked up off waivers this week, now heading to play for the Dolphins.




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'Any relief on bank guarantee will be provided across the sector': Scindia on Vodafone Idea request for waiver of bank guarantees for spectrum




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A multifunctional “three-in-one” fluorescent theranostic system for hepatic ischemia–reperfusion injury

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC04962D, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jihong Liu, Dongni Yin, Wen Zhang, Xin Wang, Tony D. James, Ping Li, Bo Tang
A single-component multifunctional fluorescent theranostic system (MB-Gly) for use during hepatic ischemia-reperfusion injury (HIRI) has been developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rajnath Singh stresses on adaptive defence to cope with Age of Grey Zone, hybrid warfare




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China's largest air show takes off with fighter jets, attack drones

China has poured resources into modernising and expanding its aviation capabilities as it faces off against the United States and others around regional flashpoints like Taiwan.




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Indonesia and Australia hold joint military drills after signing a new defense agreement

The Indonesian and Australian militaries are holding joint combat drills off Indonesia’s main island of Java with about 2,000 troops training in air, maritime, amphibious and land operations




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Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors

RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Vodafone Idea narrows Q2 loss to ₹7,176 crore




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Andhra Pradesh government deploys drones to detect ganja palnatations

State collaborates with NCB and Google to map and track cannabis plantations using satellite imagery technology




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Doctor stabbed at Kalaignar Centenary Super Speciality Hospital in Chennai; one arrested

The oncologist who was attacked has been identified as Balaji Jagannath. He has been admitted in the ICU, and his condition is said to be critical




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MUDA ‘scam’: Raichur MP Kumar Naik, CM’s PA questioned by ED




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The first money lesson a child should learn is the habit of saving, says Nirmala Sitharaman

The government is focussing on four “I”s infrastructure, investment, innovation and inclusivity to realise the goal set for 2047




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Complete laying of roads and repair works in Zone II, GVMC Commissioner directs officials in Visakhapatnam




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Tax evasion rampant as only 23% of transactions being traced, says Chief Commissioner of IT




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Indonesia's volcanic eruption grounds international flights on tourist island of Bali

Indonesia's Mount Lewotobi Laki Laki volcano on the remote island of Flores in East Nusa Tenggara province spewed towering columns of hot ash high into the air since its initial huge eruption on November 4 killed nine people and injured dozens of others




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Vodafone Idea Q2 net loss narrows 17% to ₹7,175.9 crore

Subscriber base declines by 14 million users in the quarter




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<I>Citadel: Honey Bunny</I>: Samantha's Here To Slay!

Citadel: Honey Bunny is a decent watch with an average story, sharp stunts and brilliant music, observes Divya Nair.




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'Citadel Makers Could Have Done More...'

'On the big screen, we focus on hope for your dreams whereas OTT is the bitter reality.'




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Honey Bunny: Samantha's Here To Slay!

Citadel: Honey Bunny is a decent watch with an average story, sharp stunts and brilliant music, observes Divya Nair.




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India's smartphone mkt grows 6%, Vivo tops

Smartphone supplies in India grew by 6 per cent to 4.6 crore in the July-September quarter with Vivo leading the chart and iQoo clocking the highest growth rate among top 10 brands, a report by market research firm IDC said on Wednesday. The market was dominated by Chinese players, with leading brands cornering around 72 per cent market share during the quarter. "The Indian smartphone market grew for the fifth consecutive quarter.




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Tell Everyone Your Startup Idea

This artice is a guest post from Joel Gascoigne. Joel is is the founder of Buffer, a smarter way to share great articles with friends and followers. He Tweets at @joelgascoigne and writes regularly on his blog about startups, life, learning and happiness. I was speaking at an event last week about the lessons I’ve learned along my startup journey, mostlyRead More →

The post Tell Everyone Your Startup Idea first appeared on Rob Walling - Serial Entrepreneur.




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SketchNotes of My Talk: “How to Make More Money from Your Business”

In October I spoke at Dan & Ian’s DCBKK event in Bangkok, Thailand about how to make more money from your business. Through the mad illustration skills of one Maggie Appleton, here are SketchNotes summarizing my entire talk in a single image (click the image for a hi-res version).

The post SketchNotes of My Talk: “How to Make More Money from Your Business” first appeared on Rob Walling - Serial Entrepreneur.




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New Dumbphone Has Smart Branding

The makers of a Barbie-branded fliphone say it could help overcome smartphone addiction in young people. If nothing else, it could be a test case of form vs function. The handset is as overwhelmingly pink as you might expect, but is closer to a late 90s handset than a modern smartphone. It's made from HMD, which is the company that makes Nokia branded handsets. The device has virtually no modern features and doesn't allow app installation. It supports voice calls and basic texting but has no web browser or touchscreen. It has a single game, a Barbie-themed version of Snake. A Plethora Of Pink ... (view more)




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Do Phone 'Drying' Videos Really Work?

YouTube videos that claim to fix a waterlogged phone really can work according to a semi-scientific test. But results are not guaranteed and it's not a reason to take excessive risks. Numerous videos (and some dedicated phone apps) all claim to fix a soggy phone in the same way. The theory is that the main risk is liquid getting into the phone through the speaker, which inherently can't be airtight - rather, quite the opposite. The videos "work" simply by playing a specific oscillating tone at a deep frequency that causes the speaker to push air at just the right force to dislodge the water. ... (view more)




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Windows File Explorer Can Remotely Access Android Phone

Windows users will soon be able to access files on their Android phone or tablet without a USB cable. The feature is already available in test editions of Windows 11. The feature, first reported back in June, has now arrived for members of the Windows Insider Program, which gives early access to in-development and test features. They will also need to install the "Cross device experience host" tool from the Microsoft store. Windows does already offer some wireless connectivity with Android phones such as using it as a webcam or getting on-screen notifications from the phone replicated on the ... (view more)




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Someone Threatening to Post Video, Pics? Here's What to Do

Infopackets Reader Franco I. writes: " Dear Dennis, Please help - someone is threatening to share a video of me (in the buff) on Facebook! A few days ago, I met a girl on Omegle (a chat website). We had lots of shared interests and seemed to hit it off pretty good. After some back and forth, things escalated to the point where she started sharing pictures of herself scantily dressed. She asked for my phone number, then wanted to do a video call using Google Chat . As soon as I answered, she was already unclothed with toys in hand. She claimed her microphone was broken, so I never got to ... (view more)




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Making Room for Everyone This Christmas

How should our parish communities live out the fullness of our Orthodox Faith by including and making a space for those who need a space in our worship that acknowledges their worth and our need to be a spiritual home for everyone? Fr. Barnabas talks with Summer Kinard, an author, a singer, and the mother of five autistic children. Then be sure to listen for a very special announcement from Fr. Barnabas in the second half of the show.




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"We Need Everyone": New Award Recognizes the Importance of Scientific Community

In the lab of Minna Roh-Johnson, PhD, great science and great mentorship are inextricable. Now, up to $250,000 in federal funding from the National Cancer Institute has made that philosophy concrete by advancing cancer research and building scientific community.




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One in a Million H/E Giclee on Hand-Textured Canvas

One in a Million H/E Giclee on Hand-Textured Canvas by Trevor Mezak is a(n) Limited Edition. The Edition is Limited to Limited Edition of 50 pcs




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bar none LIMITED EDITION CANVAS

bar none LIMITED EDITION CANVAS by Will Bullas is a(n) Limited Edition. The Edition is Limited to Limited Edition of 75 pcs




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Jammin Limited Edition Stone Lithograph

Jammin Limited Edition Stone Lithograph by William Tolliver is a(n) Limited Edition. The Edition is Limited to Limited Edition pcs




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NEVER ALONE LIMITED EDITION PRINT

NEVER ALONE LIMITED EDITION PRINT by Scott Kennedy is a(n) Limited Edition. The Edition is Limited to Limited to 2250 pcs




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Lawyer, wife arrested for alleged fraud, money-laundering

Police arrested high-profile lawyer Sittra Biabungkerd and his wife on a highway east of Bangkok on Thursday morning and charged them with fraud and money laundering in connection with a billionaire’s allegation that she lost 71 million baht to him.




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Ukrainian robbed of B8m in digital money in Phuket

PHUKET: A Ukrainian man who visited a friend's room on this southern tourist island claims he was forced to transfer cryptocurrency worth more than 8 million baht to a group of armed men.




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Neoproterozoic-Cambrian stratigraphy of the Mackenzie Mountains, northwestern Canada, part II: archival stratigraphic data for the Backbone Ranges Formation and related units, Mackenzie Mountains, Northwest Territories, Canada (NTS 95-L and 105-P)

MacNaughton, R B. Geological Survey of Canada, Open File 8668, 2020, 26 pages, https://doi.org/10.4095/327238
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_327238.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_327238.jpg" title="Geological Survey of Canada, Open File 8668, 2020, 26 pages, https://doi.org/10.4095/327238" height="150" border="1" /></a>




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The Eskimo Lakes Fault Zone renamed Husky Lakes Fault Zone, Tuktoyaktuk Peninsula, Northwest Territories

Hadlari, T; Millar, R A; Lane, L S. Geological Survey of Canada, Open File 8740, 2020, 4 pages, https://doi.org/10.4095/326948
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326948.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326948.jpg" title="Geological Survey of Canada, Open File 8740, 2020, 4 pages, https://doi.org/10.4095/326948" height="150" border="1" /></a>




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Clast-lithology data from till samples collected from the southern Core Zone, Quebec and Newfoundland and Labrador(NTS 23-I and 23-P): samples collected in 2014, 2015, and 2016

Rice, J M; Paulen, R C; Ross, M; McClenaghan, M B. Geological Survey of Canada, Open File 8721, 2020, 14 pages, https://doi.org/10.4095/326083
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326083.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326083.jpg" title="Geological Survey of Canada, Open File 8721, 2020, 14 pages, https://doi.org/10.4095/326083" height="150" border="1" /></a>




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Natural attenuation of spilled crude oil by cold-adapted soil bacterial communities at a decommissioned High Arctic oil well site

Ferguson, D K; Li, C; Jiang, C; Chakraborty, A; Grasby, S E; Hubert, C R J. Science of the Total Environment vol. 722, 137258, 2020 p. 1-12, https://doi.org/10.1016/j.scitotenv.2020.137258
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20190541.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20190541.jpg" title="Science of the Total Environment vol. 722, 137258, 2020 p. 1-12, https://doi.org/10.1016/j.scitotenv.2020.137258" height="150" border="1" /></a>




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U-Pb zircon ages of plutonic rocks in the eastern Slave Craton and adjacent Thelon tectonic zone, Nunavut, determined by laser-ablation inductively coupled multi-collector mass spectrometry

Berman, R G; Camacho, A. Geological Survey of Canada, Open File 8703, 2020, 20 pages, https://doi.org/10.4095/321633
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/of8703.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/of8703.jpg" title="Geological Survey of Canada, Open File 8703, 2020, 20 pages, https://doi.org/10.4095/321633" height="150" border="1" /></a>




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Field data for till samples collected in 2014, 2015, and 2016 in the southern Core Zone, Quebec and Labrador (NTS 23-P and 23-I)

Rice, J M; McClenaghan, M B; Paulen, R C; Pyne, M D; Ross, M; Campbell, H E. Geological Survey of Canada, Open File 8655, 2020, 11 pages, https://doi.org/10.4095/321471
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/of8655.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/of8655.jpg" title="Geological Survey of Canada, Open File 8655, 2020, 11 pages, https://doi.org/10.4095/321471" height="150" border="1" /></a>




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40Ar/39Ar hornblende and biotite cooling ages for metaplutonic rocks of the central Thelon Tectonic Zone, Nunavut

Camacho, A; Berman, R G; Sanborn-Barrie, M. Geological Survey of Canada, Open File 8625, 2020, 77 pages, https://doi.org/10.4095/315135
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/of8625.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/of8625.jpg" title="Geological Survey of Canada, Open File 8625, 2020, 77 pages, https://doi.org/10.4095/315135" height="150" border="1" /></a>