An apparatus for forming at least one curved, rectangular bodied surgical needle which comprises frame means, flat press means associated with said frame means for imparting first flat surfaces to opposite sides of at least a portion of at least one needle blank, curving means associated with said frame means for imparting an arcuate profile to at least a portion of the at least one needle blank and side press means mounted on said frame portion for imparting second flat surfaces to opposite sides of the needle blank, wherein said second flat surfaces are imparted substantially perpendicular to said first flat surfaces. There is also disclosed a method of forming a curved rectangular bodied needle from a substantially round-elongated needle blank comprising the steps of flat pressing opposite sides of the needle blanks between a pair of flat press dies, drawing the needle blanks from at least one of said flat press dies onto a rotatable mandrel, curving the needle blanks between said rotatable mandrel and a reciprocable belt, rotating the needle blanks adjacent side press dies and depositing the needle blanks therebetween and side pressing opposite sides of the needle blanks between said side press dies, on sides of the needle blanks substantially perpendicular to the flat pressed sides. A surgical needle is also disclosed having a tapered distal portion, a rectangular central portion and a bored proximal portion formed according to the apparatus and method described above. The tapered distal portion of the needle has a generally circular cross-section, the rectangular central portion is generally square and the bored proximal portion also has a generally circular cross-section.

An apparatus for forming at least one curved, rectangular bodied surgical needle which comprises frame means, flat press means associated with said frame means for imparting first flat surfaces to opposite sides of at least a portion of at least one needle blank, curving means associated with said frame means for imparting an arcuate profile to at least a portion of the at least one needle blank and side press means mounted on said frame portion for imparting second flat surfaces to opposite sides of the needle blank, wherein said second flat surfaces are imparted substantially perpendicular to said first flat surfaces. There is also disclosed a method of forming a curved rectangular bodied needle from a substantially round-elongated needle blank comprising the steps of flat pressing opposite sides of the needle blanks between a pair of flat press dies, drawing the needle blanks from at least one of said flat press dies onto a rotatable mandrel, curving the needle blanks between said rotatable mandrel and a reciprocable belt, rotating the needle blanks adjacent side press dies and depositing the needle blanks therebetween and side pressing opposite sides of the needle blanks between said side press dies, on sides of the needle blanks substantially perpendicular to the flat pressed sides. A surgical needle is also disclosed having a tapered distal portion, a rectangular central portion and a bored proximal portion formed according to the apparatus and method described above. The tapered distal portion of the needle has a generally circular cross-section, the rectangular central portion is generally square and the bored proximal portion also has a generally circular cross-section.

There is disclosed an apparatus for forming curved and rectangular bodied needle blanks from a length of needle stock which includes a generally cylindrical inner mandrel having a plurality of longitudinal channels formed in an outer surface thereof, the mandrel being dimensioned and configured for insertion within the length of needle stock. The apparatus also includes a plurality of broaches insertable into the longitudinal channels such that an edge of each broach projects radially outwardly of the mandrel to form a plurality of inner grooves on an inner surface of the length of needle stock. There is also provided structure for forming outer grooves in an outer surface of the length of needle stock to form a substantially grooved length of needle stock, cutters for cutting the grooved length of needle stock to form rings of curved rectangular bodied needle blanks interconnected by web portions and structure for dividing the rings at the web portions to form a plurality of curved rectangular bodied needle blanks. There is also disclosed a method of forming needle blanks from a length of needle stock having a longitudinal cavity therethrough and defining a longitudinal axis by forming at least two inner grooves in an inner surface of the length of needle stock and substantially parallel to the longitudinal axis, forming a number of outer grooves, equal to the number of inner grooves, in an outer surface of the length of needle stock and in substantial radial alignment with the at least two inner grooves to form a grooved length of needle stock and sectioning the grooved length of needle stock to form individual needle blanks.

There is disclosed an apparatus for forming curved and rectangular bodied needle blanks from a length of needle stock which includes a generally cylindrical inner mandrel having a plurality of longitudinal channels formed in an outer surface thereof, the mandrel being dimensioned and configured for insertion within the length of needle stock. The apparatus also includes a plurality of broaches insertable into the longitudinal channels such that an edge of each broach projects radially outwardly of the mandrel to form a plurality of inner grooves on an inner surface of the length of needle stock. There is also provided structure for forming outer grooves in an outer surface of the length of the needle stock to form a substantially grooved length of needle stock, cutters for cutting the grooved length of needle stock to form rings of curved rectangular bodied needle blanks interconnected by web portions and structure for dividing the rings at the web portions to form a plurality of curved rectangular bodied needle blanks. There is also disclosed a method of forming needle blanks from a length of needle stock having a longitudinal cavity therethrough and defining a longitudinal axis by forming at least two inner grooves in an inner surface of the length of needle stock and substantially parallel to the longitudinal axis, forming a number of outer grooves, equal to the number of inner grooves, in an outer surface of the length of needle stock and in substantial radial alignment with the at least two inner grooves to form a grooved length of needle stock and sectioning the grooved length of needle stock to form individual needle blanks.

Channel-bodied surgical needles and surgical incision members are disclosed having a generally U-shaped cross-sectional body portion and a penetrating tip portion formed on at least one end thereof. Preferably, penetrating tip portions are formed at both ends of the channel-bodied portion. The surgical needle and/or surgical incision member may additionally includes apparatus engagement structure formed adjacent either end of the body portion and engagable with a suitable surgical suturing apparatus. The channel-bodied surgical needle and/or surgical incision member may additionally include securement structure for attachment of a length of suture material thereto. There is also disclosed apparatus for forming a channel-shaped body portion and the suture attachment structure. Additionally, methods for suturing tissue sections, particularly vascular tissue sections, with the channel-bodied surgical needle and the channel-bodied surgical incision members, are disclosed. Also, methods for forming the channel-bodied surgical needle and channel-bodied surgical incision member are disclosed.

A vibrating machine for producing a molded body by compacting a granular raw mixture includes an oscillatable vibrating table configured to receive a molding box. A clamping device is produced by at least two clamping closures, each including: a pivot bracket having a lower end being pivotally mounted on the vibrating table and an upper end including a cranking which is directed outward; a double-acting hydraulic pivot cylinder pivotally mounted on the vibrating table; a two-armed rocker arm pivotally connected to the pivot bracket and including an inner part that cooperates with the molding box and an outer part that cooperates with the hydraulic pivot cylinder; and a compression spring disposed between the cranking and the outer part of the rocker arm such that the rocker arm releases from a position closing the respective clamping closure upon a pressure in the hydraulic pivot cylinder being relieved.

The present disclosure provides antibodies, and antigen-binding fragments thereof that bind to EBOV glycoprotein. The present disclosure further provides hybridoma cell lines and methods for making and using the compositions provided herein.

The invention relates to a human Interleukin-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006; the binding to hIL-2 is characterized by a dissociation constant (KD)≦7.5 nmol/L; the binding to hIL-2 is characterized by an off-rate (Koff)≦1×10−4 s−1 and/or the antibody displays no measurable cross-reactivity to murine IL-2.

Cysteine engineered antibodies useful for the site-specific conjugation to a variety of agents are provided. Methods for the design, preparation, screening, selection and use of such antibodies are also provided.

Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (FR-α). The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor (“FR-α”), such as ovarian, breast, renal, colorectal, lung, endometrial, or brain cancer. The invention also relates to cells expressing the monoclonal antibodies, antibody derivatives, such as chimeric and humanized monoclonal antibodies, antibody fragments, and methods of detecting and treating cancer using the antibodies, derivatives, and fragments.

A device for transporting vehicle bodies, on which standardized holding components are provided. A guide device is provided for at least one continuous drive train which having a driving side and a slack side, and having a first return element and at least one second return element around which the at least one continuous drive train circulates. The at least one continuous drive train supports a plurality of coupling elements which are arranged and aligned in such a manner that they can work together with the standardized holding components provided on the vehicle body.

A multi-stage reactor system for preparing biodiesel is used to increase efficiency and yield and reduce impurities. A three-stage transesterification reaction for preparing biodiesel can include one high-shear cavitation reactor and two low-shear cavitation reactors, preferably in series, and optionally one or more separation vessels for removing waste and recycling triglyceride feedstock, catalyst and alcohol to the high-shear cavitation reactor.

The present invention provides assays for detecting and measuring the presence or level of anti-TNFα drug therapeutics and autoantibodies in a sample. The present invention is useful for optimizing therapy and monitoring patients receiving anti-TNFα drug therapeutics to detect the presence or level of autoantibodies (e.g., HACA and/or HAHA) against the drug.

In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

Starring in the skit for 'The Tonight Show Starring Jimmy Fallon', The Rolling Stones frontman gets onboard to support a non-profit providing for children in need during the coronavirus pandemic.

The 'Killing Eve' actress and the 'Spectre' actor have reportedly landed major roles in the upcoming big-screen adaptation of the classic stage show inspired by Roald Dahl's book.

HighLife Samples has launched the third volume in the Trance Midi Melodies series of sound packs, delivering a fresh batch of MIDI melodies and samples for Trance producers who want to get instant inspiration for their music productions. The pack includes 20 melodies and 20 bass loops in both MIDI and Wav formats (80 files […]

The post HighLife Samples releases Trance Midi Melodies Vol. 3 appeared first on rekkerd.org.

EarthTone has announced the release of its sample pack Anatolian Cura, a collection of professionally played and recorded traditional cura melodies. “Cura” is a stringed Turkish folk instrument and most commonly played in Anatolia. The smallest member of the baglama family with the highest pitched sound. It has only three strings, small body and short […]

The post EarthTone delivers traditional melodies of Cura & Cumbush appeared first on rekkerd.org.

You’ve heard the saying, “walk a mile in someone else’s shoes.” But does that literally mean you have to put yourself in someone’s position in order to understand where they are coming from? According to a study published in The Journal of Personality and Social Psychology, it just might. In this edition of Two Guys...

Dr. Art Markman and Dr. Bob Duke talk about some problems with research on embodied cognition and look at what it means and what it doesn’t.

Dierks Bentley and his band tapped into a long tradition of comedy and country music when they created a parody group to open for them on tour. Now, Hot Country Knights has a debut album.

Tourism operators on one of Tasmania's breathtaking islands are riding a wave of untapped beauty and are reeling in visitors with locally grown produce.

The deaths of a 70-year-old man and his son, aged 30, after their boat flipped on a dam west of Bundaberg on Friday evening has hit the community hard, a mayor says, as she urges families to "embrace each other" on Father's Day.

Almost two centuries on, families in Western Australia's south-west are still waiting for proper recognition of one of the state's bloodiest days but they hope change will come about soon.

Patients who end up on ventilators often face a long, slow and traumatic period of recuperation, which often includes relearning how to swallow, speak, breathe and walk.

The remains of a 77-year-old man and a 68-year-old woman are found on a property destroyed in the bushfires which ripped through northern NSW earlier this week.

The bodies of two climbing partners who fell to their deaths from a remote cliff face in South Australia's Flinders Ranges were discovered with the help of an aerial drone, one of the men's friends has revealed.

Jodie Lowe 2

The changing media landscape has meant former electrician Brodie Moss has an audience of more than 1 million, a comfortable full-time income, and the freedom to go fishing whenever he wants.

South Australia's recent "old mate" tourism campaign may have ended in tears both literally and figuratively but Tasmania is hoping to cash in on that controversy by releasing its own rival ad.

The search for two people missing off the coast of South Australia's Eyre Peninsula ends tragically as the bodies of a 35-year-old man and his five-year-old daughter are spotted in waters after they were swept from rocks at Cape Carnot.

Emergency crews recover the bodies of an Adelaide man and his five-year-old daughter who were hit by a freak wave on South Australia's Eyre Peninsula.

Australia's largest renewable biodiesel producer restarts operations at Barnawartha, in north-east Victoria, just three years after it was driven to closure.

The woman, 32, and man, 24, were reported missing in the Cairns area yesterday after they both failed to show up for work.

Researchers at Australia's first 'body farm' have observed that dead bodies move significantly when they decompose and believe it could be important in investigations.

"The Hot Zone" author Richard Preston gets candid about a failed 1990s movie adaptation that was once set to star A-listers Robert Redford and Jodie Foster before falling apart.

The couple tied the knot in December.