Tajikistan’s National Action Plan on implementing UN Security Council Resolution 1540, which was supported by the OSCE Office in Tajikistan as a way of enhancing the country’s chemical, biological, radiation and nuclear security, was presented to representatives of the international community in Dushanbe on 28 April 2016.

As well as bringing together representatives of international organizations dealing with non-proliferation issues, and embassies and diplomatic missions of the OSCE participating States and the UN members in Tajikistan, some 30 professionals in the area of chemical, biological, radiation and nuclear security in Tajikistan also attended the meeting. The discussion was held to mark the adoption of UN Security Council Resolution 1540 on 28 April 2004.

“As we have now already moved to the implementation phase of the Plan, I have no doubt that we all understand the importance of the need to provide resources that are indispensable for strengthening co-operation and collaboration in implementing the approved 1540 measures,” said Fabio Piana, Acting Head of the OSCE Office in Tajikistan. “Diplomatic missions of the OSCE participating States or UN Member States in Tajikistan are encouraged to take part in implementing Tajikistan’s National Action Plan, with the aim of ensuring the overall sustainability of our joint efforts.”

Ilkhom Mirsaidov, National co-ordinator on implementing the National Action Plan, thanked the OSCE for the assistance provided in developing the Plan – a process that took two years to accomplish. He also stressed the importance of multilateral co-operation and co-ordination of efforts during its implementation.

The National Action Plan, encompassing various implementation measures on nuclear, chemical, and biological security for 2016-2021, was adopted by Tajikistan’s Government on 9 February 2016.

The Office, in close co-operation with the OSCE Conflict Prevention Centre, United Nations Office for Disarmament Affairs, and the 1540 Committee Group of Experts, will continue to assist the Government in the Plan’s practical implementation.

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Convergence: Crypto and 3D Printing The convergence of cryptocurrency and 3D printing represents a natural evolution driven by the shared principles of decentralization, democratization, and innovation. Several key areas illustrate how these technologies are complementing each other: Digital Ownership with…

Methodological principles for determining international mobile roaming rates

Policy and methodological principles for determining co-location and access charges

QuantumPay (QTP) represents an ambitious technological initiative that blends blockchain technology and artificial intelligence (AI) to create a secure, efficient, and transparent digital transaction  StreetInsider.com

The US Defense Advanced Research Projects Agency (DARPA) is often held as a model for driving technology advances. For decades, it has contributed to military and economic dominance by bridging the gap between military and civilian applications. European policymakers frequently reference DARPA in discussions, as outlined in the 2024 Draghi Report, but an EU equivalent has yet to materialise. To create such an agency, the governance and management of European innovation programmes would need drastic changes. DARPA supports disruptive innovation Founded in 1958, DARPA operates under the US Department of Defense (DoD) with a straightforward mission: to fund high-risk technological…

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A Sheffield design and additive manufacturing business is using its system to help the pharmaceutical industry to save valuable time in its production process.

Drug manufacturer Heel has successfully implemented Werum PAS-X MES 3.3.0, Körber's NextGen MES for pharma, biotech, and cell & gene therapy, at its main plant in Baden-Baden, Germany.

Datalogic, provider of automatic data capture solutions, has launched its Memor 30 and 35 flagship mobile computers. The Memor 30/35 is designed to expedite operations with a superior scanning performance in all environments.

Datalogic, the global provider of automatic data capture and industrial automation solutions, has announced that the Memor 30/35 has been officially certified as a rugged device under the prestigious Android Enterprise Recommended (AER) program, meeting and surpassing key standards set by Android.

Location: Electronic Resource- 

Location: Electronic Resource- 

Location: Electronic Resource- 

Location: Engineering Library- R857.M3S853 2016

Location: Sciences Library Library- QE150.S44F75 2001

Location: Sciences Library Library- QE185.F68 2014

Location: Sciences Library Library- QE149.E37 no.14 1982

Location: Electronic Resource- 

Scientists advance Parkinson’s disease biomarker research one sniff at a time.

One of America’s enduring strengths has been its long embrace of technological innovation. From the widespread adoption of groundbreaking technologies such as the automobile and airplane, to the invention of common household appliances such as the dishwasher and microwave, America has never lost sight of technology’s critical role in driving economic development and societal progress.

Salami Rose Joe Louis plays Madame Lou's on Monday, November 11. by Dave Segal

Recording for Flying Lotus's Brainfeeder label, Salami Rose Joe Louis (Lindsay Olsen) has blazed a distinctive trail in that fertile sector of California's underground where electronic music and jazz converge. On early releases by this multi-instrumentalist and producer—such as 2019's Zdenka 2080—Olsen sings in a hushed, dulcet manner over sparse, melodious electronic music that wears its jazz inflections gracefully. Faint echoes of '90s and '00s introspective, minimalist IDM (intelligent dance music, if you don't know) acts such as Múm insinuate themselves, too. It's ultimately dream pop, but not in the cloying way manifested by the genre's try-hards.

With 2023's Akousmatikous and this year's collab with Flanafi, Sarah, SRJL's rhythms get jazzier and the instrumentation fuller, with help from Soccer96 and Miguel Atwood-Ferguson, among others. The songs are more kinetic while the vocals retain their breathy, Julee Cruise-like sweetness. The music's levitational feel and smooth propulsion belie lyrics about catastrophic ecological degradation and the dangers of propaganda/disinformation. Enchanting listeners through understatement and mutedly sparkling tones, Olsen offers the most pleasant dystopian sci-fi soundtracks extant. For this show at Madame Lou's tonight, she'll be joined by guitarist Flanafi, bassist Tone Whitfield, and drummer Luke Titus—most of whom played on the exceptional new Salami Live at 2131 North Kacey Street EP.

<a href="https://salamirosejoelouismusic.bandcamp.com/album/salami-live-at-2131-north-kacey-street">Salami Live at 2131 North Kacey Street by Salami Rose Joe Louis featuring Flanafi, Tone Whitfield, Nazir Ebo</a>

Salami Rose Joe Louis plays Madame Lou's Monday, Nov 11, 7:30 pm, $21, 21+.

In the first episode of a series learning Logic Pro X for Mac, Ming introduces how to create a new project and audio for a Logic Pro X project. He also shows us some useful shortcuts to make the process easier and more efficient. These shortcuts include:

Metronome: K
Recording: R
Pause or play: Space bar
Advance a bar: .
Go back one measure: ,
Solo or unsolo the current track: S
Mute or unmute the current track: M
Go back to the beginning of the project: Enter
Go to the end of the track: Option + Enter

Note: Logic Pro X is a professional grade digital audio workstation (DAW) and MIDI sequencer. It is suggested to have some familiarity with Digital Audio Workstations to get the most from this series.

In the second episode of his series learning Logic Pro X for Mac, Ming introduces two main sections. In the first part, Ming explains why the Interface and Microphone are important in professional recording and music editing, and how the Interface works. Ming uses logic to demonstrate how to slice and dice regions, efficiently move regions to neighboring regions, and export and merge projects into different audio formats. These shortcuts include:

Command + B: Bounce your project

Option + [ ] "Align the current region to the left or right of other regions.

Pause or play: Space bar.

See also: Learning Logic Pro X: Episode 1 - Creating a New Project

Note: Logic Pro X is a professional grade digital audio workstation (DAW) and MIDI sequencer. It is suggested to have some familiarity with Digital Audio Workstations to get the most from this series.

In the third instalment of his tutorial series on learning Logic Pro X for Mac, Ming demonstrates how to utilize the Automation feature in Logic Pro X to manipulate the volume and panning of your tracks. Used shortcuts include:

Switch Automation: A

See also:
Learning Logic Pro X: Exploring Interfaces, Choosing a Microphone, and Basic Editing Techniques
Learning Logic Pro X: Episode 1 - Creating a New Project

Note: Logic Pro X is a professional grade digital audio workstation (DAW) and MIDI sequencer. It is suggested to have some familiarity with Digital Audio Workstations to get the most from this series.

In the fourth instalment of his tutorial series on learning Logic Pro X for Mac, Ming demonstrates how to create, browse, and select virtual instruments in Logic Pro X. He then demonstrates how you can create a 5-bars long piece of music in a few minutes using a number of different virtual instruments. Used shortcuts include:

Turn on and off the midi note writing input on your computer: Command-K

Mentioned resource:

• sweetwater.com

See also:

Learning Logic Pro X: Automation
Learning Logic Pro X: Exploring Interfaces, Choosing a Microphone, and Basic Editing Techniques
Learning Logic Pro X: Episode 1 - Creating a New Project

Note: Logic Pro X is a professional grade digital audio workstation (DAW) and MIDI sequencer. It is suggested to have some familiarity with Digital Audio Workstations to get the most from this series.

In the fifth instalment of his tutorial series on learning Logic Pro X for Mac, Ming discusses how to insert a reverb plugin into a track, how to tweak the reverb using preset, and how to tweak the reverb parameters by personalizing them.

See also:

Learning Logic Pro X: Virtual Instruments
Learning Logic Pro X: Automation
Learning Logic Pro X: Exploring Interfaces, Choosing a Microphone, and Basic Editing Techniques
Learning Logic Pro X: Episode 1 - Creating a New Project

Note: Logic Pro X is a professional grade digital audio workstation (DAW) and MIDI sequencer. It is suggested to have some familiarity with Digital Audio Workstations to get the most from this series.

In the sixth instalment of his tutorial series on learning Logic Pro X for Mac, Ming discusses the importance of EQ and how to use Logic's own EQ plugins. Ming demonstrate how to select presets, and what the impact is from tweaking each parameter.

See also:

Learning Logic Pro X: Using Reverb
Learning Logic Pro X: Virtual Instruments
Learning Logic Pro X: Automation
Learning Logic Pro X: Exploring Interfaces, Choosing a Microphone, and Basic Editing Techniques
Learning Logic Pro X: Episode 1 - Creating a New Project

Note: Logic Pro X is a professional grade digital audio workstation (DAW) and MIDI sequencer. It is suggested to have some familiarity with Digital Audio Workstations to get the most from this series.

http://www.musicxray.com/xrays/2672425 Twanesia Ruffin - Soon Very Soon Master Logic

Logic’s new album, College Park, is his first record as an independent artist after parting ways with Def Jam. He tells Tom Power about the ups and downs of major labels, his turbulent early life and how he has prevailed in spite of setbacks.

Polar explorer and environmentalist, Robert Swan OBE, once said: “The greatest threat to our planet is the belief that someone else will save it.” “Bermuda remains on the precipice when it comes to protecting its natural resources, particularly its coral reef system, which provides us with provision, protection and pleasure. Therefore, it is vital that […]

[Updated with video] Scientists from Nekton undertaking the XL Catlin Deep Ocean Survey, have discovered a new “biological hotspot” on Argus Seamount, some 30 miles south west of Bermuda. Diving in cutting-edge manned submersibles adapted with the latest scientific and filming equipment, the scientists are the first to biologically document and sample the previously unexplored seamount. […]

Thirty-six boxes of 17th century archaeological material have returned to Bermuda after study at William and Mary, Williamsburg, Virginia. A spokesperson said, “The returned materials include archaeological finds and records relating to the First Forts Project, undertaken between 1993 and 2003 by the Department of Anthropology at the College of William & Mary and the […]

A Princeton-led team of astrophysicists has measured a surprising value for the “clumpiness” of the universe’s dark matter.

Jerusalemite of the week: India Abraham is a practitioner of medical tattooing who had already helped scores of people before Oct. 7, but her work has taken on even greater significance since then.

This article describes the current findings on phonics and phonological awareness instruction. It uses a question & answer format to explore 10 common questions that teachers ask about teaching phonics and phonemic awareness. Here are a few key questions addressed in the article: What are phonics and phonemic awareness? Should phonemic awareness be paired with print and taught together? Should phonological awareness be coordinated with phonics instruction? What is the best sequence for teaching phonics?

Anton Freund, Fedor Pakhomov and Giovanni Soldà
Proc. Amer. Math. Soc. 152 (), 4993-5005.
Abstract, references and article information

Recent studies have suggested that innate immune responses exhibit characteristics associated with memory linked to modulations in both vertebrates and invertebrates. However, the diverse evolutionary paths taken, particularly within the invertebrate taxa, should lead to similarly diverse innate immunity memory processes. Our understanding of innate immune memory in invertebrates primarily comes from studies of the fruit fly Drosophila melanogaster, the generality of which is unclear. Caenorhabditis elegans typically inhabits soil harboring a variety of fatal microbial pathogens; for this invertebrate, the innate immune system and aversive behavior are the major defensive strategies against microbial infection. However, their characteristics of immunological memory remains infantile. Here we discovered an immunological memory that promoted avoidance and suppressed innate immunity during reinfection with bacteria, which we revealed to be specific to the previously exposed pathogens. During this trade-off switch of avoidance and innate immunity, the chemosensory neurons AWB and ADF modulated production of serotonin and dopamine, which in turn decreased expression of the innate immunity-associated genes and led to enhanced avoidance via the downstream insulin-like pathway. Therefore, our current study profiles the immune memories during C. elegans reinfected by pathogenic bacteria and further reveals that the chemosensory neurons, the neurotransmitter(s), and their associated molecular signaling pathways are responsible for a trade-off switch between the two immunological memories.

Visual Abstract

Xiao-Ting Wen
Dec 17, 2020; 0:RA120.002119v1-mcp.RA120.002119
Research

Tirsa L. E. van Westering
Dec 1, 2020; 19:2047-2067
Research

This article has been withdrawn by the authors as part of this review overlapped with the contents of Pietrangelo A and Ridgway ND. 2018. Cellular and Molecular Life Sciences. 75; 3079-98.

Mendelian randomization (MR) of lipid traits in coronary artery disease (CAD) has provided evidence for causal associations of low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) in CAD, but many lipid trait genetic variants have pleiotropic effects on other cardiovascular risk factors that may bias MR associations. The goal of this study was to evaluate pleiotropic effects of lipid trait genetic variants and to account for these effects in MR of lipid traits in CAD. We performed multivariable MR using inverse variance-weighted (IVW) and MR-Egger methods in large (n ≥ 300,000) GWAS datasets. We found that 30% of lipid trait genetic variants have effects on metabolic syndrome traits, including body mass index (BMI), type 2 diabetes (T2D), and systolic blood pressure (SBP). Nonetheless, in multivariable MR analysis, LDL-C, high-density lipoprotein cholesterol (HDL-C), TG, BMI, T2D, and SBP are independently associated with CAD, and each of these associations is robust to adjustment for directional pleiotropy. MR at loci linked to direct effects on HDL-C and TG suggests locus- and mechanism-specific causal effects of these factors on CAD.

The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of sterols in 206 healthy volunteers and 8 individuals with genetic LCAT deficiency, including familial LCAT deficiency (FLD) and fish-eye disease (FED). In the healthy volunteers, the mean values of the ester-to-total molar ratios of the following sterols varied: 4β-hydroxycholesterol (4βHC), 0.38; 5,6α-epoxycholesterol (5,6αEC), 0.46; 5,6β-epoxycholesterol (5,6βEC), 0.51; cholesterol, 0.70; cholestane-3β,5α,6β-triol (CT), 0.70; 7-ketocholesterol (7KC), 0.75; 24S-hydroxycholesterol (24SHC), 0.80; 25-hydroxycholesterol (25HC), 0.81; 27-hydroxycholesterol (27HC), 0.86; and 7α-hydroxycholesterol (7αHC), 0.89. In the individuals with LCAT deficiency, the plasma levels of the FA-esterified forms of cholesterol, 5,6αEC, 5,6βEC, CT, 7αHC, 7KC, 24SHC, 25HC, and 27HC, were significantly lower than those in the healthy volunteers. The individuals with FLD had significantly lower FA-esterified forms of 7αHC, 24SHC, and 27HC than those with FED. It is of note that, even in the three FLD individuals with negligible plasma cholesteryl ester, substantial amounts of the FA-esterified forms of 4βHC, 5,6αEC, 7αHC, 7KC, and 27HC were present. We conclude that LCAT has a major role in the FA esterification of many plasma oxysterols but contributes little to the FA esterification of 4βHC. Substantial FA esterification of 4βHC, 5,6αEC, 7αHC, 7KC, and 27HC is independent of LCAT.

Accompanied with nutrition transition, non-HDL-C levels of individuals in Asian countries has increased rapidly, which has caused the global epicenter of nonoptimal cholesterol to shift from Western countries to Asian countries. Thus, it is critical to underline major genetic and dietary determinants. In the current study of 2,330 Chinese individuals, genetic risk scores (GRSs) were calculated for total cholesterol (TC; GRS_TC, 57 SNPs), LDL-C (GRS_LDL-C, 45 SNPs), and HDL-C (GRS_HDL-C, 65 SNPs) based on SNPs from the Global Lipid Genetics Consortium study. Cholesterol intake was estimated by a 74-item food-frequency questionnaire. Associations of dietary cholesterol intake with plasma TC and LDL-C strengthened across quartiles of the GRS_TC (effect sizes: –0.29, 0.34, 2.45, and 6.47; P_interaction = 0.002) and GRS_LDL-C (effect sizes: –1.35, 0.17, 5.45, and 6.07; P_interaction = 0.001), respectively. Similar interactions with non-HDL-C were observed between dietary cholesterol and GRS_TC (P_interaction = 0.001) and GRS_LDL-C (P_interaction = 0.004). The adverse effects of GRS_TC on TC (effect sizes across dietary cholesterol quartiles: 0.51, 0.82, 1.21, and 1.31; P_interaction = 0.023) and GRS_LDL-C on LDL-C (effect sizes across dietary cholesterol quartiles: 0.66, 0.52, 1.12, and 1.56; P_interaction = 0.020) were more profound in those having higher cholesterol intake compared with those with lower intake. Our findings suggest significant interactions between genetic susceptibility and dietary cholesterol intake on plasma cholesterol profiles in a Chinese population.

Familial LCAT deficiency (FLD) is a rare genetic disorder of HDL metabolism, caused by loss-of-function mutations in the LCAT gene and characterized by a variety of symptoms including corneal opacities and kidney failure. Renal disease represents the leading cause of morbidity and mortality in FLD cases. However, the prognosis is not known and the rate of deterioration of kidney function is variable and unpredictable from patient to patient. In this article, we present data from a follow-up of the large Italian cohort of FLD patients, who have been followed for an average of 12 years. We show that renal failure occurs at the median age of 46 years, with a median time to a second recurrence of 10 years. Additionally, we identify high plasma unesterified cholesterol level as a predicting factor for rapid deterioration of kidney function. In conclusion, this study highlights the severe consequences of FLD, underlines the need of correct early diagnosis and referral of patients to specialized centers, and highlights the urgency for effective treatments to prevent or slow renal disease in patients with LCAT deficiency.