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Because of its genetic complexity, the potato didn’t undergo a “green revolution” like other staple crops. It can take more than 15 years to breed a new kind of potato that farmers can grow, and genetic engineering just won’t work for tackling complex traits such as increased yield or heat resistance. Host Sarah Crespi talks with Staff Writer Erik Stokstad about how researchers are trying to simplify the potato genome to make it easier to manipulate through breeding. Researchers and companies are racing to perfect an injector pill—a pill that you swallow, which then uses a tiny needle to shoot medicine into the body. Such an approach could help improve compliance for injected medications like insulin. Host Meagan Cantwell and Staff Writer Robert F. Service discuss a new kind of pill—one that flips itself over once it hits the bottom of the stomach and injects a dose of medication into the stomach lining. This week’s episode was edited by Podigy. Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Michael Eric Nickel/Flickr; Music: Jeffrey Cook]

Dr Kathy Miller discusses beneficial changes that have resulted from the COVID-19 pandemic and implications for the future of medicine.
Medscape Oncology

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In this issue of JAMA Cardiology, Lim and colleagues report on cardiovascular functional reserve in people with end-stage renal disease before and after kidney transplant. They performed a 3-arm, prospective, concurrent cohort study to assess change in cardiovascular functional reserve after kidney transplant using state-of-the-art cardiopulmonary exercise testing (CPET). They also assessed left ventricular morphologic findings 1 year after transplant. They enrolled 81 participants with stage 5 chronic kidney disease (CKD) who underwent kidney transplant, 85 wait-listed participants with stage 5 CKD who had not undergone transplant, and 87 controls treated for hypertension only. The authors quantified cardiovascular functional reserve using CPET in parallel with transthoracic echocardiography. One year after transplant, a significant improvement in maximum oxygen consumption was found in the transplant group compared with the nontransplant group. Moreover, left ventricular function improved but not the body mass index.

Lower ozone levels led to higher grape and almond yields-and decarbonizing the state's economy could provide a further boost

Rotch Library - HT177.W3 S33 2019

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Interview with Gregg C. Fonarow, MD, author of Door-to-Needle Times for Tissue Plasminogen Activator Administration and Clinical Outcomes in Acute Ischemic Stroke Before and After a Quality Improvement Initiative

What to do when the wrong procedure is performed? In this first installment of JAMA Performance Improvement: Do No Harm we explore the options for dealing with this very difficult problem with Tami Minnier, RN, MSN, Paul Phrampus, MD, Linda Waddell, RN, MSN, and David Baker, MD, MPH, FACP. Air traffic audio courtesy of LiveATC.net, used with permission.

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Spend a weekend with the BMW 330i M Sport and it becomes apparent that plenty of fresh elements have been injected into the new 3 Series, says Pavan Lall.