The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent studies examining the neural bases of stress responses have generally attributed increments in these systems to be monolithic, regardless of whether an active or passive coping strategy is employed. Using the shock probe defensive burying test (SPDB) to measure stress-coping features naturalistically in male and female rats, we identify a neural pathway whereby activity changes may promote distinctive response patterns of hemodynamic and HPA indices typifying active and passive coping phenotypes. Optogenetic excitation of the rostral medial prefrontal cortex (mPFC) input to the ventrolateral periaqueductal gray (vlPAG) decreased passive behavior (immobility), attenuated the glucocorticoid hormone response, but did not prevent arterial pressure and heart rate increases associated with rats’ active behavioral (defensive burying) engagement during the SPDB. In contrast, inhibition of the same pathway increased behavioral immobility and attenuated hemodynamic output but did not affect glucocorticoid increases. Further analyses confirmed that hemodynamic increments occurred preferentially during active behaviors and decrements during immobility epochs, whereas pathway manipulations, regardless of the directionality of effect, weakened these correlational relationships. Finally, neuroanatomical evidence indicated that the influence of the rostral mPFC->vlPAG pathway on coping response patterns is mediated predominantly through GABAergic neurons within vlPAG. These data highlight the importance of this prefrontal->midbrain connection in organizing stress-coping responses and in coordinating bodily systems with behavioral output for adaptation to aversive experiences.

God brings a young boy back to life and his parents recognise Jesus as Lord.

A Turkish believer remains strong in his faith through persecution.

OM worker Janice uses art to create conversations about the gospel on the streets of England.

Two lifelong friends from the US bring a message of hope, friendship and a future to marginalised locals during OM Zambia’s first-ever wheelchair camp.

An English nurse embraces the challenge of a lifetime on Lake Tanganyika.

Meet one woman who serves God as the only community health worker for over 2,000 people in six remote villages of Zambia.

OM Team Leader Theo picks up litter during a Transform outreach and thinks about how God deals with the sinful rubbish in our lives.

Artists participating in the Incarnate training and discipleship programme of OM Arts in Italy are inspired by conversations with locals.

Transform in Europe inspired a dance ministry in Australia - dance, discussions and discipleship.

Lawrence and Susan Tong encourage the OM Switzerland team during their annual retreat.

A family in need receives free firewood and, for the first time, understands that God is bigger than their needs.

India vs South Africa: Tilak Varma played an unbeaten 107-run knock from 56 balls at a strike rate of 191.07

Your digital assets are the building blocks for brand voice. Use them wisely

MANILA, Philippines — A 27-year-old individual was arrested for threatening a victim at gunpoint, assaulting officers during his arrest and possessing a hand grenade, the Quezon City Police District (QCPD) announced on Wednesday. According to the QCPD’s report, the victim was walking along Villareal Street in Barangay Gulod in Novaliches at 3 a.m. on Monday, Nov. 11, when the suspect appeared and threatened him with a handgun. The victim escaped and ran to the Novaliches Police Station. Officers at the station proceeded to arrest the suspect, but he resisted by kicking the cops until he was subdued. The Novaliches Police […]...

Keep on reading: QC cops nab suspect for grave threat, assault; seize hand grenade

Biden and Trump have sharply criticized each other for years, and their respective teams hold vastly different positions on policies from climate change to Russia to trade.

KKL-JNF allocates NIS 4m. to upgrade, create memorial at Re'im Recreation Site in Be'eri Forest, where 384 people were murdered at Nova music festival on October 7.

Dutch parliamentarians clashed on Wednesday in a heated debate to discuss the attacks on Israeli fans after a football match last week, with some lawmakers pointing fingers and others urging unity.

The Netherlands is still dealing with the political fallout from last week’s violence in Amsterdam, when fans of Tel Aviv Maccabi were assaulted by men on scooters in several parts of the capital.

Five Macabi fans were briefly hospitalised after being beaten up following a match with the local Ajax team last Thursday, in what Dutch Prime Minister Dick Schoof termed an incident of “unadulterated anti-Semitism”.

After the match, groups of men on scooters engaged in “hit-and-run” attacks on Maccabi fans in areas of the city.

Police said the attackers were mobilised by calls on social media to target Jewish people.

Far-right MP Geert Wilders, leader of the biggest party in the coalition government, said the perpetrators of the violence against Maccabi Tel Aviv fans were “all Muslims” and “for the most part Moroccans”.

The anti-Islam Wilders called for the attackers to be prosecuted “for terrorism.”

“For the first time since the Second World War there was a hunt on Jews,” Wilders said, adding “I am sick of being criticised when I tell the truth.”

But the firebrand MP drew the ire of opposition parties, who accused him of “adding fuel to fire”.

‘Dividing the country’

While unanimously condemning the violence, left-wing parties have called for dialogue with the Muslim community instead of “dividing the country”.

“I share the condemnation of the violence in Amsterdam and yes, there was indeed anti-Semitic violence,” left-wing opposition leader Frans Timmermans said.

“You are simply stoking the fires while this country has a need for politicians to unite people and find solutions,” Timmermans told Wilders.

Amsterdam mayor Femke Halsema on Tuesday called the attacks a “poisonous cocktail” of anti-Semitism and hooliganism.

Events ahead of the match heightened tensions, including anti-Arab chants by Maccabi fans, who also set fire to a Palestinian flag on the city’s central square and vandalising a taxi.

After the match, which passed off peacefully, reports emerged of social media calls to attack Jews, Amsterdam police said.

The violence took place against the backdrop of an increasingly polarised Europe, with heightened tensions following a rise in antisemitic, anti-Israeli and Islamophobic attacks since the start of the Gaza conflict.

The Dutch PM indicated that the government would present concrete steps to tackle antisemitism on Friday.

Eight people remained in custody over the violence.

1. Oncologist stabbed at Chennai govt hospital ‘by 26-year-old whose mother is undergoing cancer treatment’  The Indian Express
2. Video: Chennai man calmly walks away after stabbing doctor, wipes knife  India Today
3. Indian Medical Association condemns brutal attack on doctor in Chennai  The New Indian Express
4. Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock  The Hindu
5. 'No law and order': BJP, AIADMK attack ruling DMK after government doctor stabbed in Chennai  The Times of India

The fluffy chick’s chunky form is slimming down as he starts to fledge

Alison Hammond's fall not even halfway into the Great British Bake Off's week eight caused chaos in the tent.

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The series has transcended expectations in a huge way

West was a star of the stage and the screen and died in his sleep, his children have announced

Good morning, Bay Area. Prepare for more rain Wednesday as a cold front pushes across California's north coast. And if you are flying, expect more confusion over the name of the airport that resides in Oakland. A federal judge granted an injunction to stop Oakland's airport from calling itself the San Francisco Bay Oakland International Airport, a move that rankled San Francisco International airport, who sued claiming the name change would cause confusion. Mark Calvey has more. In stock news, Instacart…

California's Attorney General Kamala Harris on Wednesday scripted history as she won the U.S. Senate seat from the state, becoming the first Indian-American to reach the feat.

A former college lecturer who helped create over 15,000 jobs across the north-east by training youths to become entrepreneurs has won an award from the Schwab Foundation for Social Entrepreneurship.

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