The present disclosure provides systems for mitigating brake vibration. In various embodiments, a brake force distribution arrangement may comprise: a member in operable communication with an actuator having at least two contact surfaces such that as one of the at least two contact surfaces moves in a direction of actuation of the actuator the other moves in a direction opposite to the direction of actuation of the actuator.

The invention is a hydrogen generator including a housing, a reaction area, a fluid reservoir, a pellet comprising a first reactant within the reaction area, a fluid comprising a second reactant within the fluid reservoir, a fluid flow path between the fluid reservoir and the reaction area, and a hydrogen outlet. The fluid flow path comprises a follower assembly biased toward the pellet, the follower assembly includes an articulated joint and a follower, and the second reactant can react with the first reactant in the reaction area to produce hydrogen gas and byproducts.

Systems and apparatuses are provided in which outlets are coupled to a power distribution unit (PDU) or PDU module in various configurations. The outlets may be coupled to a recessed surface within a PDU housing. The outlets and recessed surface may be formed as part of a single mold. The outlets may be coupled to a printed circuit board that is at least partially disposed within the PDU housing. The outlets may extend away from the recessed surface or printed circuit board towards or beyond a front face of the PDU housing.

An abrasive element comprises a body of crystalline abrasive material. The body has an array of cutting elements formed of crystalline abrasive material which projects from a surface of the body. The shape, size and form of the projections is controlled in the production process. The body may be a natural or synthetic crystal. The body may be a film formed by deposition. The body may be diamond or cubic boron nitride. The body may be monocrystalline or polycrystalline. The projections may be aligned along a crystallographic plane or planes.

An adjustable refrigerant distribution device and a heat exchanger having same. The heat exchanger comprises: first and second collecting pipes; a heat exchanger core body; and a refrigerant distribution device, the refrigerant distribution device comprises a first distribution pipe, a first inlet pipe and a first drive assembly. The pipe wall of the first distribution pipe is provided with a first distribution hole. The first distribution pipe is inserted into at least one of the first and the second collecting pipes. The first inlet pipe is located outside at least one collecting pipe and is in communication with the first distribution pipe, and the first drive assembly drives the first distribution pipe to move relative to at least one collecting pipe. The distribution pipe of the refrigerant distribution device and the heat exchanger can translate along the axial direction, thereby adjusting refrigerant distribution so as to satisfy different distribution requirements.

A household distribution box comprises a distribution box case; two service lines introduced from a transformer into the distribution box case of a consumer; three main lines installed in the distribution box case and provided with two lines and a second service line; two sub-lines installed in the distribution box case and formed by branching the second service line among the main lines into two lines; a first circuit breaker installed in the distribution box case; a second circuit breaker installed in the distribution box case; and a controller connected to the first circuit breaker.

Embodiments of showerheads having a detachable gas distribution plate are provided herein. In some embodiments, a showerhead for use in a substrate processing chamber includes a body having a first side and an opposing second side; a gas distribution plate disposed proximate the second side of the body; and a clamp disposed about a peripheral edge of the gas distribution plate to removably couple the gas distribution plate to the body, wherein the body is electrically coupled to the gas distribution plate through the clamp.

A device and method for heat distribution in a hybrid motor vehicle are provided. The device includes an engine cooling circuit; and a refrigerant circuit for a combined operation in a refrigeration heat pump mode and a reheating mode, includes an evaporator, a compressor, a heat exchanger to supply heat from the refrigerant to air being conditioned for a passenger compartment; and a heat exchanger to transfer heat between a refrigerant of the refrigerant circuit and coolant of the engine cooling circuit, wherein the heat exchanger operates as an evaporator for the heat transfer, and as a condenser for the heat transfer from the condensing refrigerant to the coolant.

News you don't want to miss for April 20:

1. Fifty-one employees at Safeway's distribution warehouse in Tracy have been infected with covid-19, including one death, the San Francisco Chronicle reports.…

Ohio is among the top states for several agricultural crops and for food production and processing. But while farming is considered an essential business under the various shutdown orders, it's a tough time for those who run the state's 76,000 farms. Statehouse correspondent Jo Ingles has more.

New food parcel service feeds vulnerable in Castle Vale and Stockland Green.

Libsyn is the #1 commercial podcast hosting provider and is bringing new updates!

Shares of SG Blocks, Inc. (SGBX), a fabricator of container-based structures, are surging almost 34 percent or $1.47 in Tuesday's morning trade at $5.80. The stock has traded in a range of $1.16 to $35.00 in the past 52 weeks.

(United States Ninth Circuit) - Affirming the district court's summary judgment in favor of Fox, holding that their use of the name 'Empire' was protected by the First Amendment and therefore was outside of the reach of the Lanham Act and their use of the word as a show title did not infringe on a record label's trademark rights.

(United States Federal Circuit) - Affirming in part and reversing in part the inter partes review decision of the US Patent and Trademark Office Patent Trial and Appeal Bard holding claims for methods of distributing nitric oxide gas cylinders for pharmaceutical applications used in treating respiratory failure as unpatentable as obvious because, while the Board didn't err as to most of the rulings, it did as to one.

Chinese Music Streaming Service To Release Billboard "Best Of Asia" Album Series

Pittsburgh-based MTS Records Has Signed An Exclusive Physical And Digital Distribution Deal With The Music And Video Distributor Based In Pottstown, PA.

DC made a good choice in moving away from Diamond.

The post The Coronavirus Journal: Alternative Distribution Will Help Us Survive appeared first on The Beat.

Recent experiences with combustible gas releases in residential buildings have led to a proposal for NFPA Standards Development for locating combustible gas detectors and consensus on installation location requirements. NFPA is considering a proposed

Despite widespread interest, there is little systematic evidence on the relationship between income, wealth, and charitable giving. We use the Panel Study of Income Dynamics to provide descriptive statistics on this relationship. We find that, irrespective of specifica­tion, donative behavior increases with greater resources.

We explored two measures of inequality that described the full income distribution in cities. One measure is an income gini based on family incomes in 1929 for 33 cities and in 1933 for up to 48 cities in 1933 were spread throughout the country. We also estimated gini coefficients that made use of contract rents for renters and implicit rents for home owners for up to 955 cities throughout the country. We were able to expand to all counties when looking at a top-end inequality measure, the number of taxpayers per family. All three measures varied substantially across the country. We show the correlations between the various measures and also estimate the relationship between the measures and various relief programs developed by governments at all levels during the period.

Repeat Software, a UK software developers has awarded distribution to QBS Distribution ("QBSD"), a European software distributor based in Wembley, London.

California public schools are likely to be closed for the remainder of the school year, Gov. Gavin Newsom said Tuesday to anxious parents and educators.

With school closed for the coronavirus, LAUSD, the nation's second-largest district, has given out about 10 million meals since March 18.

Job Description - Manager - Distribution Engineering ExecuPOWER is a full-service engineering consulting firm specializing in power delivery consulting services to the utility sector. We are looking for a licensed professional engineer to start and lead the distribution division at our firm in Kin

2020-03-27 -

The DOJ ordered an Orange County company to stop distributing hand-sanitizer products until it got FDA approval or removed certain claims from its labeling.

strataconf: As infrastructure gets simpler, interesting big data apps can emerge on BDAS, @Cloudera & other Hadoop distributions http://t.co/jaATalPL4P

Noah Taylor
Trans. Amer. Math. Soc. 373 (2020), 3541-3559.
Abstract, references and article information

Mahbub Alam and Anish Ghosh
Trans. Amer. Math. Soc. 373 (2020), 3357-3374.
Abstract, references and article information

M. V. Pratsiovytyi and S. P. Ratushniak
Theor. Probability and Math. Statist. 99 (2020), 211-228.
Abstract, references and article information

S. S. Lohvinenko and K. V. Ralchenko
Theor. Probability and Math. Statist. 99 (2020), 149-168.
Abstract, references and article information

D. V. Gusak and E. V. Karnaukh
Theor. Probability and Math. Statist. 99 (2020), 77-89.
Abstract, references and article information

Background: Targeting cancer-associated fibroblasts (CAFs) has become an attractive goal for diagnostic imaging and therapy as they can constitute as much as 90% of tumor mass. The serine protease fibroblast activation protein (FAP) is overexpressed selectively in CAFs, drawing interest in FAP as a stromal target. The quinoline-based FAP-inhibitor PET tracer, ⁶⁸Ga-FAPI-04, has been previously shown to yield high tumor-to-background ratios (TBR) in patients with various cancers. Recent developments towards an improved compound for therapeutic application have identified FAPI-46 as a promising agent due to a longer tumor retention time in comparison with FAPI-04. Here we present a PET biodistribution and radiation dosimetry study of ⁶⁸Ga-FAPI-46 in cancer patients. Methods: Six patients with different cancers underwent serial ⁶⁸Ga-FAPI-46 PET/CT scans at three time points following radiotracer injection: 10 minutes, 1 hour, and 3 hours. The source organs consisted of the kidneys, bladder, liver, heart, spleen, bone marrow, uterus, and body remainder. OLINDA/EXM v.1.1 software was used to fit and integrate the kinetic organ activity data to yield total body and organ time-integrated activity coefficients/residence times and finally organ absorbed doses. Standardized uptake values (SUV) and TBR were generated from the contoured tumor and source organ volumes. Spherical volumes in muscle and blood pool were also obtained for TBR (Tumor SUV_max / Organ SUVmean). Results: At all timepoints, the highest organ SUV_max was observed in the liver. Tumor and organ mean SUVs decreased whereas TBRs in all organs but the uterus increased with time. The highest TBRs at 3 hours were observed with the bone marrow (31.1), muscle (22.8), heart (19.1), and spleen (19.0). Organs with the highest effective doses were the bladder wall (2.41E-03 mSv/MBq), followed by ovaries (1.15E-03 mSv/MBq) and red marrow (8.49E-04mSv/MBq). The average effective total body dose was 7.80E-03 mSv/MBq. Thus for administration of 200 MBq ⁶⁸Ga-FAPI-46 the effective total body dose is 1.56 mSv ± 0.26 mSv, in addition to approximately 3.7 mSv from one low-dose CT scan done for attenuation correction. Conclusion: ⁶⁸Ga-FAPI-46 PET/CT has a favorable dosimetry profile with an estimated whole body dose of 5.3 mSv for an administration of 200 MBq (5.4 mCi) of ⁶⁸Ga-FAPI-46 (1.56± 0.26 mSv from the PET tracer and 3.7 mSv from one low-dose CT scan). The biodistribution study showed high TBRs increasing over time, suggesting high diagnostic performance and favorable tracer kinetics for potential therapeutic applications.

Targeting tumor-expressed receptors using selective molecules for diagnostic, therapeutic or both diagnostic and therapeutic (theragnostic) purposes is a promising approach in oncological applications. Such approaches have increased significantly over the past decade. Peptides such as gastrin-releasing peptide receptors (GRPR) targeting radiopharmaceuticals are small molecules with fast blood clearance and urinary excretion. They demonstrate good tissue diffusion, low immunogenicity, and highly selective binding to their target cell-surface receptors. They are also easily produced. GRPR, part of the bombesin (BBN) family, are overexpressed in many tumors, including breast and prostate cancer, and therefore represent an attractive target for future development.

We reviewed ¹¹¹In-DOTA-anti-CD45 antibody (BC8) imaging and bone marrow biopsy measurements to ascertain biodistribution and biokinetics of the radiolabeled antibody and to investigate differences based on type of hematologic malignancy. Methods: Serial whole-body scintigraphic images (4 time-points) were obtained after infusion of the ¹¹¹In-DOTA-BC8 (176-406 MBq) in 52 adult patients with hematologic malignancies (lymphoma, multiple myeloma, acute myeloid leukemia and myelodysplastic syndrome). Counts were obtained for the regions of interest for spleen, liver, kidneys, testicles (in males), and two marrow sites (acetabulum and sacrum) and correction for attenuation and background was made. Bone marrow biopsies were obtained 14-24 hours post-infusion and percent of administered activity was determined. Radiation absorbed doses were calculated. Results: Initial uptake in liver averaged 32% ± 8.4% (S.D.) of administered activity (52 patients), which cleared monoexponentially with biological half-time of 293 ± 157 hours (33 patients) or did not clear (19 patients). Initial uptake in spleen averaged 22% ± 12% and cleared with a biological half-time 271 ± 185 hours (36 patients) or longer (6 patients). Initial uptake in kidney averaged 2.4% ± 2.0% and cleared with a biological half-time of 243 ± 144 hours (27 patients) or longer (9 patients). Initial uptake in red marrow averaged 23% ± 11% and cleared with half-times of 215 ± 107 hours (43 patients) or longer (5 patients). Whole-body retention half-times averaged 198 ± 75 hours. Splenic uptake was higher in the AML/MDS group when compared to the lymphoma group (p ≤ 0.05) and to the multiple myeloma group (p ≤ 0.10). Liver represented the dose-limiting organ. For liver uptake, no significant differences were observed between the three malignancy groups. Average calculated radiation absorbed doses per unit administered activity for a therapy infusions of ⁹⁰Y-DOTA-BC8 were for red marrow: 470 ± 260 cGy/MBq, liver 1100 ± 330 cGy/MBq, spleen 4120 ± 1950 cGy/MBq, total body 7520 ± 20 cGy/MBq, osteogenic cells 290 ± 200 cGy/MBq, and kidneys 240 ± 200 cGy/MBqR. Conclusion: ¹¹¹In-DOTA-BC8 had long retention time in liver, spleen, kidneys, and red marrow, and the highest absorbed doses were calculated for spleen and liver. Few differences were observed by malignancy type. The exception was greater splenic uptake among leukemia/MDS group when compared to lymphoma and multiple myeloma groups.

BiTE® (Bispecific T-cell engager) molecules are designed to engage and activate cytotoxic T-cells to kill tumor cells. Little is known about their biodistribution in immunocompetent settings. To explore their pharmacokinetics and the role of the immune cells, BiTE molecules were radiolabeled with positron emission tomography (PET) isotope zirconium-89 (89Zr) and studied in immunocompetent and immunodeficient mouse models. PET images and ex-vivo biodistribution in immunocompetent mice with 89Zr-muS110, targeting mouse CD3 (Kd = 2.9 nM) and mouse EpCAM (Kd = 21 nM), and 89Zr-hyS110, targeting only mouse CD3 (Kd = 2.9 nM), showed uptake in tumor, spleen and other lymphoid organs, while the human-specific control BiTE 89Zr-AMG 110 showed similar tumor uptake but lacked spleen uptake. 89Zr-muS110 spleen uptake was lower in immunodeficient than in immunocompetent mice. After repeated administration of non-radiolabeled muS110 to immunocompetent mice 89Zr-muS110 uptake in spleen, and other lymphoid tissues, decreased and was comparable to uptake in immunodeficient mice, indicating saturation of CD3 binding sites. Autoradiography and immunohistochemistry demonstrated colocalization of 89Zr-muS110 and 89Zr-hyS110 with CD3-positive T-cells in the tumor and spleen but not with EpCAM expression. Also, uptake in the duodenum correlated with a high incidence of T-cells. This study shows that in immunocompetent mice the BiTE 89Zr-muS110 distribution is predominantly based on its high affinity CD3 binding arm. Significance: 89Zr-muS110 biodistribution is mainly dependent on the T-cell targeting arm with limited contribution of its second arm, targeting EpCAM. These findings highlight the need for extensive biodistribution studies of novel bispecific constructs as results might have implications for their respective drug development and clinical translation.

Vincent Mignard
Apr 29, 2020; 0:jlr.RA120000628v1-jlr.RA120000628
Research Articles

The levels and composition of sphingolipids and related metabolites are altered in aging and common disorders such as diabetes and cancers, as well as in neurodegenerative, cardiovascular, and respiratory diseases. Changes in sphingolipids have been implicated as being an essential step in mitochondria-driven cell death. However, little is known about the precise sphingolipid composition and modulation in mitochondria or related organelles. Here, we used LC–MS/MS to analyze the presence of key components of the ceramide metabolic pathway in vivo and in vitro in purified endoplasmic reticulum (ER), mitochondria-associated membranes (MAM), and mitochondria. Specifically, we analyzed the sphingolipids in the three pathways that generate ceramide: sphinganine in the de novo ceramide pathway, sphingomyelin in the breakdown pathway, and sphingosine in the salvage pathway. We observed sphingolipid profiles in mouse liver, mouse brain, and a human glioma cell line (U251). We analyzed the quantitative and qualitative changes of these sphingolipids during staurosporine (STS)-induced apoptosis in U251 cells. Ceramide, especially C16-ceramide, levels increased during early apoptosis possibly through a conversion from mitochondrial sphinganine and sphingomyelin, but sphingosine and lactosyl- and glucosyl-ceramide levels were unaffected. We also found that ceramide generation is enhanced in mitochondria when sphingomyelin levels are decreased in the MAM. This decrease was associated with an increase in acid sphingomyelinase (ASM) activity in MAM. We conclude that meaningful sphingolipid modifications occur in MAM, the mitochondria, and ER during the early phases of apoptosis.

When you attempt to save a report distribution in SAS Visual Analytics Designer, you might see the error shown in the following display:  imgalt="" src="{fusion_65868_1_distributionerror.png}" />

Immunotherapy is becoming the mainstay for treatment of a variety of malignancies, but only a subset of patients responds to treatment. Tumor-infiltrating CD8-positive (CD8+) T lymphocytes play a central role in antitumor immune responses. Noninvasive imaging of CD8+ T cells may provide new insights into the mechanisms of immunotherapy and potentially predict treatment response. We are studying the safety and utility of ⁸⁹Zr-IAB22M2C, a radiolabeled minibody against CD8+ T cells, for targeted imaging of CD8+ T cells in patients with cancer. Methods: The initial dose escalation phase of this first-in-humans prospective study included 6 patients (melanoma, 1; lung, 4; hepatocellular carcinoma, 1). Patients received approximately 111 MBq (3 mCi) of ⁸⁹Zr-IAB22M2C (at minibody mass doses of 0.2, 0.5, 1.0, 1.5, 5, or 10 mg) as a single dose, followed by PET/CT scans at approximately 1–2, 6–8, 24, 48, and 96–144 h after injection. Biodistribution in normal organs, lymph nodes, and lesions was evaluated. In addition, serum samples were obtained at approximately 5, 30, and 60 min and later at the times of imaging. Patients were monitored for safety during infusion and up to the last imaging time point. Results: ⁸⁹Zr-IAB22M2C infusion was well tolerated, with no immediate or delayed side effects observed after injection. Serum clearance was typically biexponential and dependent on the mass of minibody administered. Areas under the serum time–activity curve, normalized to administered activity, ranged from 1.3 h/L for 0.2 mg to 8.9 h/L for 10 mg. Biodistribution was dependent on the minibody mass administered. The highest uptake was always in spleen, followed by bone marrow. Liver uptake was more pronounced with higher minibody masses. Kidney uptake was typically low. Prominent uptake was seen in multiple normal lymph nodes as early as 2 h after injection, peaking by 24–48 h after injection. Uptake in tumor lesions was seen on imaging as early as 2 h after injection, with most ⁸⁹Zr-IAB22M2C–positive lesions detectable by 24 h. Lesions were visualized early in patients receiving treatment, with SUV ranging from 5.85 to 22.8 in 6 target lesions. Conclusion: ⁸⁹Zr-IAB22M2C imaging is safe and has favorable kinetics for early imaging. Biodistribution suggests successful targeting of CD8+ T-cell–rich tissues. The observed targeting of tumor lesions suggests this may be informative for CD8+ T-cell accumulation within tumors. Further evaluation is under way.

Per Björntorp
Dec 1, 1991; 14:1132-1143
Diet and Diabetes

Aboriginal Australians -- Land tenure.

Edinburgh : Young J. Pentland, 1889.

Annalisa Fabretti, Samantha Leorato.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1611--1647.

Abstract:
We propose a method to generate random distributions with known quantile distribution, or, more generally, with known distribution for some form of generalized quantile. The method takes inspiration from the random Sequential Barycenter Array distributions (SBA) proposed by Hill and Monticino (1998) which generates a Random Probability Measure (RPM) with known expected value. We define the Sequential Quantile Array (SQA) and show how to generate a random SQA from which we can derive RPMs. The distribution of the generated SQA-RPM can have full support and the RPMs can be both discrete, continuous and differentiable. We face also the problem of the efficient implementation of the procedure that ensures that the approximation of the SQA-RPM by a finite number of steps stays close to the SQA-RPM obtained theoretically by the procedure. Finally, we compare SQA-RPMs with similar approaches as Polya Tree.

Karl Ewald, Ulrike Schneider.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 944--969.

Abstract:
We derive expressions for the finite-sample distribution of the Lasso estimator in the context of a linear regression model in low as well as in high dimensions by exploiting the structure of the optimization problem defining the estimator. In low dimensions, we assume full rank of the regressor matrix and present expressions for the cumulative distribution function as well as the densities of the absolutely continuous parts of the estimator. Our results are presented for the case of normally distributed errors, but do not hinge on this assumption and can easily be generalized. Additionally, we establish an explicit formula for the correspondence between the Lasso and the least-squares estimator. We derive analogous results for the distribution in less explicit form in high dimensions where we make no assumptions on the regressor matrix at all. In this setting, we also investigate the model selection properties of the Lasso and show that possibly only a subset of models might be selected by the estimator, completely independently of the observed response vector. Finally, we present a condition for uniqueness of the estimator that is necessary as well as sufficient.

Raj Kamal Maurya, Yogesh Mani Tripathi.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 2, 345--369.

Abstract:
We consider estimation of the multicomponent stress-strength reliability under progressive Type II censoring under the assumption that stress and strength variables follow Burr XII distributions with a common shape parameter. Maximum likelihood estimates of the reliability are obtained along with asymptotic intervals when common shape parameter may be known or unknown. Bayes estimates are also derived under the squared error loss function using different approximation methods. Further, we obtain exact Bayes and uniformly minimum variance unbiased estimates of the reliability for the case common shape parameter is known. The highest posterior density intervals are also obtained. We perform Monte Carlo simulations to compare the performance of proposed estimates and present a discussion based on this study. Finally, two real data sets are analyzed for illustration purposes.

Fredy Castellares, Artur J. Lemonte, Marcos A. C. Santos.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 90--111.

Abstract:
We introduce a two-parameter discrete distribution that may have a zero vertex and can be useful for modeling overdispersion. The discrete Nielsen distribution generalizes the Fisher logarithmic (i.e., logarithmic series) and Stirling type I distributions in the sense that both can be considered displacements of the Nielsen distribution. We provide a comprehensive account of the structural properties of the new discrete distribution. We also show that the Nielsen distribution is infinitely divisible. We discuss maximum likelihood estimation of the model parameters and provide a simple method to find them numerically. The usefulness of the proposed distribution is illustrated by means of three real data sets to prove its versatility in practical applications.