A method of operating a coordinate positioning apparatus comprising an articulated head having at least one rotational axis. The method comprises, in any suitable order, loading at least one interchangeable task module onto the articulated head; and loading at least one interchangeable task module counterweight on the articulated head. The at least one interchangeable task module counterweight at least partially counterbalances the weight of the at least one task module on the articulated head about the at least one axis.

A counterband tape for use in the heat setting tunnel of a carpet yarn heat setting machine. The tape is constructed from polyphenylene sulfide yarns. The counterband tape may be formed as a single layer woven fabric with a twill weave construction. The tape also may include a herringbone pattern.

A vanity assembly is provided. The vanity assembly can comprise a base, side walls, and a combination sink and countertop. The sink can have a drainage section located near a back side of the sink. The vanity assembly can further comprise a drawer configured to move relative to the sink, the drawer extending in front of the sink and utilizing a substantial portion of the space in front of the sink's drain section for storage. The drawer can have side wall sections and a bottom section configured to facilitate storage of common household items.

A socket for driving a threaded fastener into a material has teeth spaced around a fastener opening. The teeth cut out a counterbore hole that receives the head of the fastener as the fastener threads into the material.

An assembly for a counter mechanism for a drug delivery device is described comprising a drive member, wherein the drive member is adapted and arranged to be rotated in a first rotational direction and to be prevented from rotation in a second rotational direction which direction is opposite to the first rotational direction, an advancing member adapted and arranged to be axially moved and rotated with respect to the drive member, wherein the advancing member is adapted and arranged to mechanically cooperate with the drive member such that the drive member is rotated in the first rotational direction, and a display member which is configured to count a number of doses and to display the counted number of doses, wherein the assembly is adapted and arranged such that rotation of the drive member in the first rotational direction is converted into a counting movement of the display member. Furthermore, a drug delivery device comprising the assembly is described.

ACT for America, which the Southern Poverty Law Center has designated as an anti-muslim hate group, showed up on Saturday morning in cities nationwide, dubbing its protest a "March Against Sharia." Berkeley was spared, but the group appeared in nearby Santa Clara, and in Roseville, a suburb of Sacramento.…

Leander, through video conference, told the hosts about the rally at the Capitol where she stood, arms crossed, amid rally attendees.

Readers have placed online orders and bookstores are keeping a track of each order and are hoping to cater to every such customer once the situation gets better.

Former Timberline High School basketball star Sasha Weber has settled a lawsuit filed against the Roy chief of police. She says it was to move on with her life; the chief's attorneys say her claims were baseless and the settlement amounts to a "nuisance" payment.

Editorial page editor Kate Riley explains why The Seattle Times is running a front-page editorial urging Gov. Jay Inslee to veto a bill intended to deny public access to lawmakers’ records.

If your government failed to provide running water, electricity, roads, safety from gender violence, or other staples of everyday life, what would you do? In the Solomon Islands people are taking matters into their own hands, even schoolgirls. If their government can’t provide, they’ll try.

A group of farm workers claiming they were underpaid are hit with a rent bill in the lead-up to a Federal Court hearing.

'Brief Encounter' serves as a poignant little reminder of the volcano ready to erupt beneath the cover of a mediocre suburban life.

Weepies are a lot like liquorice jellybeans, rice pudding or Clive Palmer: You either love 'em or you hate 'em. There's no middle ground. Personally, I've always been a fan. There's nothing like a bit of good ol' cleansing hysteria to give a rinse to life's windscreen.

Countercultural movements, like Occupy Wall Street, are meant to be future-focussed — revolutionary even. So why do they often fade into commercialism? Are they simply a function of consumer capitalism? If so, what future do they have? And must they always be progressive?

Countercultural movements, like Occupy Wall Street, are meant to be future-focussed — revolutionary even. So why do they often fade into commercialism? Are they simply a function of consumer capitalism? If so, what future do they have? And must they always be progressive?

MORNING BRIEFING: Housing Minister optimistic debt will be wiped, city demands urgent action on climate emergency and councils increase rates.

Businesses in SA's Riverland are urged to be on the lookout for fake $100 notes after one was passed at a bakery and two other incidents were reported to police.

Arno joined a neo-Nazi skin head group to "repulse" society. He says governments are ignoring his warnings about far-right extremists like he once was.

WA and NSW cane toads are bigger, stronger and can travel further, but they lag behind Queensland toads in one significant feature testicle size.

Reports from people convinced they have seen Tasmanian tigers in the wild are released, with observers describing encounters with "cat-like creatures" they were "100 per cent certain" were thylacines.

The brothers shot and injured by police after wielding a knife and tomahawk during a confrontation in Victoria's north-east were of interest to counterterrorisminvestigators.

Friday on MSNBC's "The Beat," House Intelligence Committee chairman Rep. Adam Schiff (D-CA) said Attorney General Bill Barr's Justice Department doing President Donald Trump's "dirty work" by dropping the case against former National Security Advisor Michael Flynn was an attempt to "gaslight history."

The surviving members of Soundgarden have filed a counter-lawsuit

"They were looking for a problem."

In this paper (winner of the eCrime 2019 Best Paper award), we consider the types of things that can go wrong when you intend to make things better and more secure. Consider this scenario. You are browsing through Internet and see a news headline on one of the presidential candidates. You are unsure if the … Continue reading Identifying Unintended Harms of Cybersecurity Countermeasures →

One complaint people often make when they settle into a more frugal lifestyle is that their life begins to take on a feeling of “sameness,” in that each day feels more similar to the others than it did before they made frugal changes to their life. (This same shock is being felt by people under stay at home orders, too, for similar reasons.) I’ll give you a great example of this. Many people settle into a routine of eating out […]

The post Counteracting the “Sameness” of Frugal Living appeared first on The Simple Dollar.

Jedi Master Luke Skywalker, Lor San Tekka, and young Ben Solo encounter the Knights of Ren

We had space in our kitchen for more counters, but to get the real thing easily cost double or triple this PLATSA hack!  This was incredibly easy to assemble, and bonus we can move it around if we wish for a kitchen trolley (which is also double the cost of this hack). I do wonder […]

The post Easy kitchen countertop from an unexpected storage unit appeared first on IKEA Hackers.

Celebrate World Bee Day by participating in a global count of pollinators, including honeybees, with a free app available May 1.

Here is a list of notable officer-involved shootings by Indianapolis Metropolitan Police Department officers in recent years

Christi Gibson June 28, 2017 DES MOINES- With health insurance premiums on the rise and deductibles skyrocketing, not to mention the majority of insurance companies in Iowa abandoning the Affordable Care Act (Obamacare), Iowans are growing increasingly concerned about healthcare for themselves and their family members. The impending vote on […]

Here is a list of notable officer-involved shootings by Indianapolis Metropolitan Police Department officers in recent years

8 January 2020 , Volume 96, Number 1

4 March 2020 , Volume 96, Number 2

8 January 2020 , Volume 96, Number 1

9 August 2019

The use of AI in counterterrorism is not inherently wrong, and this paper suggests some necessary conditions for legitimate use of AI as part of a predictive approach to counterterrorism on the part of liberal democratic states.

Background: Patients with NHL who are treated with rituximab may develop resistant disease, often associated with changes in expression of CD20. The next generation β-particle emitting radioimmunoconjugate ¹⁷⁷Lu-lilotomab-satetraxetan (Betalutin®) was shown to up-regulate CD20 expression in different rituximab-sensitive NHL cell lines and to act synergistically with rituximab in a rituximab-sensitive NHL animal model. We hypothesized that ¹⁷⁷Lu-lilotomab-satetraxetan may be used to reverse rituximab-resistance in NHL. Methods: The rituximab-resistant Raji2R and the parental Raji cell lines were used. CD20 expression was measured by flow cytometry. ADCC was measured by a bioluminescence reporter assay. The efficacies of combined treatments with ¹⁷⁷Lu-lilotomab-satetraxetan (150MBq/kg or 350MBq/kg) and rituximab (4x10mg/kg) were compared with those of single agents or saline in a Raji2R-xenograft model. Cox-regression and the Bliss independence model were used to assess synergism. Results: Rituximab-binding in Raji2R cells was 36±5% of that in the rituximab-sensitive Raji cells. ¹⁷⁷Lu-lilotomab-satetraxetan treatment of Raji2R cells increased the binding to 53±3% of the parental cell line. Rituximab ADCC-induction in Raji2R cells was 20±2% of that induced in Raji cells, while treatment with ¹⁷⁷Lu-lilotomab-satetraxetan increased the ADCC-induction to 30±3% of the Raji cells, representing a 50% increase (p<0.05). The combination of rituximab with 350MBq/kg ¹⁷⁷Lu-lilotomab-satetraxetan synergistically suppressed Raji2R tumor growth in athymic Foxn1^nu mice. Conclusion: ¹⁷⁷Lu-lilotomab-satetraxetan has the potential to reverse rituximab-resistance; it increases binding and ADCC-activity in-vitro and can synergistically improve anti-tumor efficacy in-vivo.

Aging-dependent changes in tissue function are associated with the development of metabolic diseases. However, the molecular connections linking aging, obesity, and diabetes remain unclear. Lamin A, lamin C, and progerin, products of the Lmna gene, have antagonistic functions on energy metabolism and life span. Lamin C, albeit promoting obesity, increases life span, suggesting that this isoform is crucial for maintaining healthy conditions under metabolic stresses. Because β-cell loss during obesity or aging leads to diabetes, we investigated the contribution of lamin C to β-cell function in physiopathological conditions. We demonstrate that aged lamin C only–expressing mice (Lmna^LCS/LCS) become obese but remain glucose tolerant due to adaptive mechanisms including increased β-cell mass and insulin secretion. Triggering diabetes in young mice revealed that Lmna^LCS/LCS animals normalize their fasting glycemia by both increasing insulin secretion and regenerating β-cells. Genome-wide analyses combined to functional analyses revealed an increase of mitochondrial biogenesis and global translational rate in Lmna^LCS/LCS islets, two major processes involved in insulin secretion. Altogether, our results demonstrate for the first time that the sole expression of lamin C protects from glucose intolerance through a β-cell–adaptive transcriptional program during metabolic stresses, highlighting Lmna gene processing as a new therapeutic target for diabetes treatment.

Ted Kaptchuk, professor of medicine at Harvard Medical school - and leading placebo researcher, has just published an analysis on bmj.com describing the effect of open label placebo - placebos that patient's know are placebos, but still seem to have some clinical effect. Ted joins us to speculate about what's going on in the body, what this means...

Margaret Heffernan has thought a lot about whistleblowing, and why companies don't respond well to it. She wrote the "Book Wilful Blindness: Why We Ignore the Obvious at our Peril". In this podcast she talks about how culture, and groupthink, leads to a culture where whistleblowers are ignored, and why the NHS needs to change the way it treats...

Insulin-induced hypoglycemia leads to far-ranging negative consequences in patients with diabetes. Components of the counterregulatory response (CRR) system that help minimize and reverse hypoglycemia and coordination between those components are well studied but not yet fully characterized. Here, we tested the hypothesis that acyl-ghrelin, a hormone that defends against hypoglycemia in a preclinical starvation model, is permissive for the normal CRR to insulin-induced hypoglycemia. Ghrelin knockout (KO) mice and wild-type (WT) littermates underwent an insulin bolus-induced hypoglycemia test and a low-dose hyperinsulinemic-hypoglycemic clamp procedure. Clamps also were performed in ghrelin-KO mice and C57BL/6N mice administered the growth hormone secretagogue receptor agonist HM01 or vehicle. Results show that hypoglycemia, as induced by an insulin bolus, was more pronounced and prolonged in ghrelin-KO mice, supporting previous studies suggesting increased insulin sensitivity upon ghrelin deletion. Furthermore, during hyperinsulinemic-hypoglycemic clamps, ghrelin-KO mice required a 10-fold higher glucose infusion rate (GIR) and exhibited less robust corticosterone and growth hormone responses. Conversely, HM01 administration, which reduced the GIR required by ghrelin-KO mice during the clamps, increased plasma corticosterone and growth hormone. Thus, our data suggest that endogenously produced acyl-ghrelin not only influences insulin sensitivity but also is permissive for the normal CRR to insulin-induced hypoglycemia.

The American Dental Association has created a tip sheet with guidance from the National Institute for Occupational Safety and Health group at the Centers for Disease Control and Prevention to help health care professionals avoid buying or using counterfeit N95 respirators, which are often simply referred to as masks.

In the face of mounting public and political opposition to the war in Iraq, recent reports from the White House suggest that President Bush remains serenely confident.

It’s the middle of an election year and, according to the Pew Research Center, the country hasn’t been this polarized since the Civil War. In such a climate, it would seem to be an oxymoron for a company to push for both financial growth and tighter regulations. Gregg Renfrew, CEO & Founder of Beautycounter, wouldn’t […]