Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Bacille Calmette-Guerin (BCG) vaccination may provide benefits beyond protecting against pediatric tuberculosis. Evidence suggests links between cell-mediated immunity from tuberculosis and bacterial/viral-related pneumonia but the impact of BCG on acute lower respiratory infection is not fully known.

BCG-vaccinated children had a lower risk of suspected acute lower respiratory infection. Protection was amplified when children were vaccinated against diphtheria-tetanus-pertussis (DTP). Number of DTP doses did not modify this effect, but order in which vaccines were received did. (Read the full article)

While Acer's Predator CG437K aims for the stars with its impressive feature set, this gaming monitor's achievements aren't as lofty as its goals. Some gamers may be willing to sacrifice picture quality for its size, but others should save their money and look at alternatives.

For Immediate Release  SAMUEL MCGARVEY TO REPRESENT DELAWARE IN 2018 POETRY OUT LOUD NATIONAL FINALS IN WASHINGTON Dover, Del. (February 28, 2018) – From a competitive field of 12 Delaware high school students, Samuel McGarvey, a sophomore from Tall Oaks Classical School, earned the title of 2018 Poetry Out Loud Delaware State Champion at the […]

Assuming that the shares are in the nature of ESOPs, they shall be taxed at two stages, once as perquisites in the hands of employees upon allotment and subsequently as capital gains upon sale of the shares.

Once tax liability is calculated, you may claim a deduction of TDS/ taxes paid on such rental income, to arrive at net tax demand due.

Conor McGregor will be a keen observer of this weekend's UFC 249 event according to his manager Audie Attar, who says that the Irishman wants to gauge the UFC's health and safety measures before entertaining a return to the cage.
Read Full Article at RT.com

While he says he has no interest in facing a top-ranked boxer, Floyd Mayweather is refusing to rule out a fight with the likes of Conor McGregor or Khabib Nurmagomedov, as long as the money is right.
Read Full Article at RT.com

The MCG in its statement shared the Australian DHHS's recommendation for those who were seated in section N42 of the ground during Sunday’s ICC Women’s T20 World Cup Final.

This Metasploit module exploits a backdoor in Webmin versions 1.890 through 1.920. Only the SourceForge downloads were backdoored, but they are listed as official downloads on the project's site. Unknown attacker(s) inserted Perl qx statements into the build server's source code on two separate occasions: once in April 2018, introducing the backdoor in the 1.890 release, and in July 2018, reintroducing the backdoor in releases 1.900 through 1.920. Only version 1.890 is exploitable in the default install. Later affected versions require the expired password changing feature to be enabled.

man-cgi versions prior to 1.16 suffer from a local file inclusion vulnerability.

An exploitable command injection vulnerability exists in the ACEManager iplogging.cgi functionality of Sierra Wireless AirLink ES450 FW 4.9.3. A specially crafted HTTP request can inject arbitrary commands, resulting in arbitrary command execution. An attacker can send an authenticated HTTP request to trigger this vulnerability.

An exploitable unverified password change vulnerability exists in the ACEManager upload.cgi functionality of Sierra Wireless AirLink ES450 FW 4.9.3. A specially crafted HTTP request can cause a unverified device configuration change, resulting in an unverified change of the user password on the device. An attacker can make an authenticated HTTP request to trigger this vulnerability.

An exploitable cross-site scripting vulnerability exists in the ACEManager ping_result.cgi functionality of Sierra Wireless AirLink ES450 FW 4.9.3. A specially crafted HTTP ping request can cause reflected javascript code execution, resulting in the execution of javascript code running on the victim's browser. An attacker can get a victim to click a link, or embedded URL, that redirects to the reflected cross-site scripting vulnerability to trigger this vulnerability.

An exploitable remote code execution vulnerability exists in the upload.cgi functionality of Sierra Wireless AirLink ES450 FW 4.9.3. A specially crafted HTTP request can upload a file, resulting in executable code being uploaded, and routable, to the webserver. An attacker can make an authenticated HTTP request to trigger this vulnerability.

An exploitable Information Disclosure vulnerability exists in the ACEManager EmbeddedAceGet_Task.cgi functionality of Sierra Wireless AirLink ES450 FW 4.9.3. A specially crafted HTTP request can cause an information disclosure, resulting in the exposure of confidential information, including, but not limited to, plaintext passwords and SNMP community strings. An attacker can make an authenticated HTTP request, or run the binary, to trigger this vulnerability.

An exploitable Permission Assignment vulnerability exists in the ACEManager EmbeddedAceSet_Task.cgi functionality of Sierra Wireless AirLink ES450 FW 4.9.3. A specially crafted HTTP request can cause a arbitrary setting writes, resulting in the unverified changes to any system setting. An attacker can make an authenticated HTTP request, or run the binary as any user, to trigger this vulnerability.

An exploitable information disclosure vulnerability exists in the ACEManager template_load.cgi functionality of Sierra Wireless AirLink ES450 FW 4.9.3. A specially crafted HTTP request can cause a information leak, resulting in the disclosure of internal paths and files. An attacker can make an authenticated HTTP request to trigger this vulnerability.

The Rifatron Intelligent Digital Security System DVR suffers from an unauthenticated and unauthorized live stream disclosure when animate.cgi script is called through Mobile Web Viewer module.

This Metasploit module exploits an unauthenticated remote command injection vulnerability found in Barco WePresent and related OEM'ed products. The vulnerability is triggered via an HTTP POST request to the file_transfer.cgi endpoint.

CGI Q3 F2019 Podcast EN

CGI Q4 & F2019 Podcast EN

CGI Q1 F2020 Podcast EN

CGI Q2 F2020 Podcast EN

South Africa vaccinates health workers in response to the pandemic.

A long-standing hypothesis suggests the BCG vaccine also serves to generally enhance the immune system, meaning it could protect against covid-19, and trials are under way to find out

The BCG tuberculosis vaccine boosts the production of immune cells and this may explain how it protects newborns from dying of sepsis

ABSTRACT

Although the pathogen recognition receptor pathways that activate cell-intrinsic antiviral responses are well delineated, less is known about how the host regulates this response to prevent sustained signaling and possible immune-mediated damage. Using a genome-wide CRISPR-Cas9 screening approach to identify host factors that modulate interferon-stimulated gene (ISG) expression, we identified the DNA binding protein Barrier-to-autointegration factor 1 (Banf1), a previously described inhibitor of retrovirus integration, as a modulator of basal cell-intrinsic immunity. Ablation of Banf1 by gene editing resulted in chromatin activation near host defense genes with associated increased expression of ISGs, including Oas2, Rsad2 (viperin), Ifit1, and ISG15. The phenotype in Banf1-deficient cells occurred through a cGAS-, STING-, and IRF3-dependent signaling axis, was associated with reduced infection of RNA and DNA viruses, and was reversed in Banf1 complemented cells. Confocal microscopy and biochemical studies revealed that a loss of Banf1 expression resulted in higher level of cytosolic double-stranded DNA at baseline. Our study identifies an undescribed role for Banf1 in regulating the levels of cytoplasmic DNA and cGAS-dependent ISG homeostasis and suggests possible therapeutic directions for promoting or inhibiting cell-intrinsic innate immune responses.

IMPORTANCE Although the interferon (IFN) signaling pathway is a key host mechanism to restrict infection of a diverse range of viral pathogens, its unrestrained activity either at baseline or in the context of an immune response can result in host cell damage and injury. Here, we used a genome-wide CRISPR-Cas9 screen and identified the DNA binding protein Barrier-to-autointegration factor 1 (Banf1) as a modulator of basal cell-intrinsic immunity. A loss of Banf1 expression resulted in higher level of cytosolic double-stranded DNA at baseline, which triggered IFN-stimulated gene expression via a cGAS-STING-IRF3 axis that did not require type I IFN or STAT1 signaling. Our experiments define a regulatory network in which Banf1 limits basal inflammation by preventing self DNA accumulation in the cytosol.