Evan M. Benjamin
Jan 1, 2002; 20:
Practical Pointers

Miklós Z. Rácz, Sébastien Bubeck.

Source: Statistics Surveys, Volume 11, 1--47.

Abstract:
Extracting information from large graphs has become an important statistical problem since network data is now common in various fields. In this minicourse we will investigate the most natural statistical questions for three canonical probabilistic models of networks: (i) community detection in the stochastic block model, (ii) finding the embedding of a random geometric graph, and (iii) finding the original vertex in a preferential attachment tree. Along the way we will cover many interesting topics in probability theory such as Pólya urns, large deviation theory, concentration of measure in high dimension, entropic central limit theorems, and more.

The womenswear line is new, and there’s already a variety of items to shop.

Basic facts The world contains an estimated 1 400 million cubic km of water. Only 0.003% of this vast amount, about 45 000 cubic km, are what is called “fresh water resources” - water that theoretically can be used for drinking, hygiene, agriculture and industry. But not all of this water is accessible. For example, seasonal flooding makes water extremely difficult [...]

"The more I look at biblical examples of ministry, the more I see a simple yet profoundly flexible grassroots approach to ministry that compels me to focus on things that really matter," shares Ben.

Students are understandably anxious about COVID-19. Teachers must address those fears in age-appropriate and educational ways, writes 4th grade teacher Ivy Higgins.

A guide to the fundamentals of heading featuring Sweden women's international Kosovare Asllani.

991 people in the US were asked about their mastery of three common tech tasks; the results aren't too encouraging.

"There's a science of learning, and ... there's not a single teacher who couldn't benefit, I think, from knowing these principles," said the executive director of Deans for Impact, a group of education school leaders.

DOVER – As the number of confirmed influenza cases in Delaware continues to rise, the Division of Public Health (DPH) is announcing two recent flu-related deaths, bringing the total number of deaths for the 2019-2020 season thus far to four. The most recent victim is a 29-year-old New Castle County man diagnosed with influenza B […]

India currently has solar modules manufacturing capacity of 7-8 gigawatts (GW). This includes the units of players like Adani Solar, Tata Solar, Waaree Energies and Vikram Solar.

DOVER, Del.– DNREC’s Division of Air Quality and industry partners will host Air Permitting Basics training workshops at 8 a.m., Wednesday, March 18, at DNREC’s Lukens Drive office, 391 Lukens Drive, New Castle, DE 19720, and again at 8 a.m., Thursday, March 26, in the DNREC Auditorium, 89 Kings Highway, Dover, DE 19901. Topics to be covered include an overview of DNREC’s Division of Air Quality and air permitting basics – with examples presented at the workshops for generators and boilers. Certificates for professional development hours will be available for those attending. Seating is limited and pre-registration is required. To register, and for more information, please visit https://dnrec.alpha.delaware.gov/air/permitting-basics/.

You may avoid double taxation on your income by claiming tax relief if India has signed the Double Taxation Avoidance Treaty (DTAA) with the country of your residence.

VPF is the voluntary contribution by employees towards their provident fund account over and above the 12% contribution towards EPF.

  In this article I will be demonstrating how to create a basic Node.js application using Intel Mashery's JamBase API with Intel Edison and XDK. You will find accompanying GitHub source in the provi...

There was an institutional response by the Centre and the situation was monitored at the highest political and executive level by the Prime Minister, the government said.

Alexander Kuznetsov v Camden London Borough Council [2019] EWHC 805 (Ch) In an application for relief from sanctions, the Claimant tenant, Kuznetsov, persuaded the High Court that it had a real prospect of establishing at trial that a letter between...

Although preserving food can seem time consuming and old-fashioned, freezing and pickling your produce is an easy way to save money and avoid food waste.

Disqualified lawmaker Lau Siu-lai was denied the opportunity to respond to allegations of not genuinely upholding Hong Kong’s mini-constitution before she was barred from trying to win back her seat in the Legislative Council, a judge has observed.Mr Justice Anderson Chow Ka-ming made the remark on Thursday while hearing an election petition from Lau, who has asked the High Court to determine whether pro-establishment lawmaker Chan Hoi-yan had been duly elected to the office of Kowloon West…

For many of Indonesia’s urban poor who work in the informal sector, social distancing is nearly impossible if they want to maintain their income. Two key policies can help.

Basic Statistics 2020 presents development indicators for 46 economies in Asia and the Pacific, including new data on economic, environmental, and social indicators used globally to track progress toward the Sustainable Development Goals.

Basic Statistics 2020 presents development indicators for 46 economies in Asia and the Pacific, including new data on economic, environmental, and social indicators used globally to track progress toward the Sustainable Development Goals.

Quarks are the subatomic particles thought to make up nearly everything we can see. Now it turns out they could be an illusion created by quantum trickery

Our measurements of the Hubble constant can't seem to come up with a consistent answer. What we learn next may alter our view of the cosmos, writes Chanda Prescod-Weinstein

Finland’s two-year test of universal basic income has concluded that it doesn't seem to disincentivise working, and improves recipients’ mental and financial well-being

Finland’s two-year test of universal basic income has concluded that it doesn't seem to disincentivise working, and improves recipients’ mental and financial well-being

Histone H2B monoubiquitylation (H2Bub1) has central functions in multiple DNA-templated processes, including gene transcription, DNA repair, and replication. H2Bub1 also is required for the trans-histone regulation of H3K4 and H3K79 methylation. Although previous studies have elucidated the basic mechanisms that establish and remove H2Bub1, we have only an incomplete understanding of how H2Bub1 is regulated. We report here that the histone H4 basic patch regulates H2Bub1. Yeast cells with arginine-to-alanine mutations in the H4 basic patch (H42RA) exhibited a significant loss of global H2Bub1. H42RA mutant yeast strains also displayed chemotoxin sensitivities similar to, but less severe than, strains containing a complete loss of H2Bub1. We found that the H4 basic patch regulates H2Bub1 levels independently of interactions with chromatin remodelers and separately from its regulation of H3K79 methylation. To measure H2B ubiquitylation and deubiquitination kinetics in vivo, we used a rapid and reversible optogenetic tool, the light-inducible nuclear exporter, to control the subcellular location of the H2Bub1 E3 ligase, Bre1. The ability of Bre1 to ubiquitylate H2B was unaffected in the H42RA mutant. In contrast, H2Bub1 deubiquitination by SAGA-associated Ubp8, but not by Ubp10, increased in the H42RA mutant. Consistent with a function for the H4 basic patch in regulating SAGA deubiquitinase activity, we also detected increased SAGA-mediated histone acetylation in H4 basic patch mutants. Our findings uncover that the H4 basic patch has a regulatory function in SAGA-mediated histone modifications.

Technology in bioanalysis, -omics, and computation have evolved over the past half century to allow for comprehensive assessments of the molecular to whole body pharmacology of diverse corticosteroids. Such studies have advanced pharmacokinetic and pharmacodynamic (PK/PD) concepts and models that often generalize across various classes of drugs. These models encompass the "pillars" of pharmacology, namely PK and target drug exposure, the mass-law interactions of drugs with receptors/targets, and the consequent turnover and homeostatic control of genes, biomarkers, physiologic responses, and disease symptoms. Pharmacokinetic methodology utilizes noncompartmental, compartmental, reversible, physiologic [full physiologically based pharmacokinetic (PBPK) and minimal PBPK], and target-mediated drug disposition models using a growing array of pharmacometric considerations and software. Basic PK/PD models have emerged (simple direct, biophase, slow receptor binding, indirect response, irreversible, turnover with inactivation, and transduction models) that place emphasis on parsimony, are mechanistic in nature, and serve as highly useful "top-down" methods of quantitating the actions of diverse drugs. These are often components of more complex quantitative systems pharmacology (QSP) models that explain the array of responses to various drugs, including corticosteroids. Progressively deeper mechanistic appreciation of PBPK, drug-target interactions, and systems physiology from the molecular (genomic, proteomic, metabolomic) to cellular to whole body levels provides the foundation for enhanced PK/PD to comprehensive QSP models. Our research based on cell, animal, clinical, and theoretical studies with corticosteroids have provided ideas and quantitative methods that have broadly advanced the fields of PK/PD and QSP modeling and illustrates the transition toward a global, systems understanding of actions of diverse drugs.

As COVID-19 continues to surge, cancer scientists engaged in basic research face unique challenges. At centers throughout the United States, investigators are confronting difficult decisions about which experiments to continue, while securing supplies and creating contingency plans for a complete shutdown.

Our measurements of the Hubble constant can't seem to come up with a consistent answer. What we learn next may alter our view of the cosmos, writes Chanda Prescod-Weinstein

Tottenham forward Son Heung-min finished his three-week military training in South Korea on Friday and was right near the top of the class.

Return to your basics at every chance you get and re-learn them many times over.

NHS hospitals are asking for basic items such as toothbrushes and sanitary products

The economic impact of Coronavirus will see millions of Brits unable to afford basics like toothpaste and soap. Chloe Street on why feeling clean should not be a privilege in the modern world

Whether you are dealing with a noise complaint or being asked for ID, having a grasp of your basic rights when dealing with the police can help.

Yokogawa Electric Corporation (TOKYO: 6841) announces that it has entered into a strategic alliance framework agreement to accelerate collaboration with Saudi Basic Industries Corporation (SABIC), ranked among the world's largest petrochemical manufacturers. The agreement includes selection of Yokogawa as a preferred supplier of control systems.