ine

China conducts 1st Covid vaccine test on monkeys

China conducts 1st Covid vaccine test on monkeys




ine

Inactivated PiCoVacc vaccine found safe, efficacious in animal study

The vaccine was able to induce specific neutralising antibodies in all three animal models tested




ine

[ASAP] Direct Identification of a-Bisabolol Enantiomers in an Essential Oil Using a Combined Ion Mobility–Mass Spectrometry/Quantum Chemistry Approach

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00982




ine

[ASAP] Dysidealactams and Dysidealactones: Sesquiterpene Glycinyl-Lactams, Imides, and Lactones from a <italic toggle="yes">Dysidea</italic> sp. Marine Sponge Collected in Southern Australia

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00041




ine

[ASAP] Irijimasides A–E, Macrolide Glycosides from an <italic toggle="yes">Okeania</italic> sp. Marine Cyanobacterium

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00042




ine

[ASAP] Genomics–Metabolomics Profiling Disclosed Marine <italic toggle="yes">Vibrio spartinae</italic> 3.6 as a Producer of a New Branched Side Chain Prodigiosin

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01159




ine

[ASAP] Naphthacemycins from a <italic toggle="yes">Streptomyces</italic> sp. as Protein-Tyrosine Phosphatase Inhibitors

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00417




ine

[ASAP] Synthesis of the 1,2,4-Thiadiazole Alkaloid Polyaurine B

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00166




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[ASAP] Irpexine, an Isoindolinone Alkaloid Produced by Coculture of Endophytic Fungi, <italic toggle="yes">Irpex lacteus</italic> and <italic toggle="yes">Phaeosphaeria oryzae</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00047




ine

[ASAP] Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00561




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[ASAP] Correction to Corrected Structure of Natural Hyacinthacine C<sub>1</sub> via Total Synthesis

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00389




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[ASAP] Antitubercular Ilamycins from Marine-Derived <italic toggle="yes">Streptomyces atratus</italic> SCSIO ZH16 ?<italic toggle="yes">ilaR</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00151




ine

[ASAP] Antineoplastic Agents. 607. Emetine Auristatins

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00031




ine

[ASAP] Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00194




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[ASAP] Isolation of Taste-Active Triterpenoids from <italic toggle="yes">Quercus robur</italic>: Sensory Assessment and Identification in Wines and Spirit

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00106




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[ASAP] Phaeosphaones: Tyrosinase Inhibitory Thiodiketopiperazines from an Endophytic <italic toggle="yes">Phaeosphaeria fuckelii</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00046




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[ASAP] Review of Biology and Ecology of Pharmaceutical Marine Sponges<source>Biology and Ecology of Pharmaceutical Marine Sponges</source>. Edited by Ramasamy Santhanam, Santhanam Ramesh, and Anbu Jeba Sunilson. <publisher-name>CRC Press

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00352




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[ASAP] Iheyamides A–C, Antitrypanosomal Linear Peptides Isolated from a Marine <italic toggle="yes">Dapis</italic> sp. Cyanobacterium

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00250




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[ASAP] Cucurbitane-Type Triterpenoids from the Vines of <italic toggle="yes">Momordica charantia</italic> and Their Anti-inflammatory Activities

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00592




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[ASAP] Bromo-spiroisoxazoline Alkaloids, Including an Isoserine Peptide, from the Caribbean Marine Sponge <italic toggle="yes">Aplysina lacunosa</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01286




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[ASAP] Effect of Temperature on <sup>1</sup>H NMR Spectra, Antitrypanosomal Activity, Conformational Analysis, and Molecular Docking of Curine Derivatives from <italic toggle="yes">Berberis brevissima</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00397




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Jest 26, JS one liners, and comparing Ember to React

#487 — May 8, 2020

Unsubscribe  :  Read on the Web

JavaScript Weekly

Jest 26 Released: The Popular Testing Framework — Jest is a popular testing framework that works with pretty much everything. This release focuses on getting the dependency count and install size down (this causes some breaking changes, unsurprisingly), adds a new fake timer implementation, drops Node 8 support, and initial, experimental ESM support to play with.

Christoph Nakazawa

1LOC: A Collection of One-Line JS Snippets — A neat little collection of vanilla JavaScript one-liners divided into various categories (arrays, date/time, checking objects, DOM work, etc.) You can submit your own for inclusion too.

Nguyen Huu Phuoc

Hardcore Functional Programming in JavaScript — Brian Lonsdorf teaches you functional programming concepts in JavaScript such as pure functions, currying, composition, functors, monads and more.

Frontend Masters sponsor

Debug Anything: The Basics — A six part series (all ready to read now) on debugging your JavaScript and TypeScript code with the debugger built into Visual Studio Code.

Charles Szilagyi

Comparing Ember Octane and React — This is about as detailed a comparison as you could hope for and a demonstration of just how much Ember contributes to the JavaScript ecosystem. Octane really kicks things up a notch for Ember, too.

Chris Garrett

Deno 1.0 is Due Next Week: Here's What You Need to Know — In 2018 Node's creator Ryan Dahl told us 10 Things I Regret About Node.js and revealed a prototype of Deno, a new V8-based runtime, and here's what you need to know about it. Short of time? This two-minute video sums up the biggest wins quickly.

David Else

Our newest newsletter..

Carrying on from the Deno item above, yes, we've started Deno Weekly, a new newsletter dedicated to the newest runtime in the JavaScript/TypeScript world. Issue 2 goes out just after 1.0 is released next week.

Even if you don't stick with Deno long term, feel free to subscribe then unsubscribe at any time — we won't take offence ????

Subscribe to Deno Weekly here or enjoy issue 1 here.

???? Jobs

JavaScript Developer at X-Team (Remote) — Join X-Team and work on projects for companies like Riot Games, FOX, Coinbase, and more. Work from anywhere.

X-Team

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

???? Tutorials

How To Build a Vue Survey App Using Firebase — A step-by-step guide to building a functional survey app using Vue.js and Firebase for both authentication and as a database.

David Atanda

A Brief Look at ES2020's Promise.any — When you need to know when at least 1 promise got resolved among an iterable of Promise objects, Promise.any() is the solution.

Marios Fakiolas

ES2020: Everything You Need to Know — An ES2020 roundup!

Martin McKeaveney

Building a Crossword Puzzle Generator — As a NY Times crossword addict, I love a good crossword, but if you’d rather figure out how to make your computer solve them, be my guest ???? This post guides you on how to approach the problem.

Mitchum

Git Best Practices for SOC 2 Compliance Quick Wins — Get quick wins for your SOC 2 compliance audit, and raise developer productivity at the same time.

Datree.io sponsor

Getting Started with Sapper and SvelteSapper is a Svelte-powered framework.

Chris Boakes

A ES2015+ Cheatsheet — A one-page guide to ES2015+ features based around brief example snippets.

Devhints.io

How to Fix ESLint Errors Upon Save in VS Code — A quick-fire tip.

David Walsh

How to Build a Blog with Next 9.3, Netlify, and Markdown — Learn how to build a Next.js-powered Markdown blog and deploy it to the Netlify platform.

Cassidy Williams

A Canvas Engine Comparison: PixiJS vs Two.js vs Paper.js — A benchmark of three popular 2D rendering engines/drawing APIs. Note: This will tax your system.

SlayLines

???? BTW, if you like videos, we need to shout out Florin Pop's YouTube channel as he's just passed 20k subscribers by posting neat JavaScript videos and live streams nearly every day for the past six months! ???? Lots of great stuff on there for JavaScript developers of all skill levels.

???? Code & Tools

Selecto.js: Make Elements Selectable Within an Area — Let’s say you have a number of elements that represent choices, data, whatever, and you want users to be able to select a subset of them by clicking/pointing and dragging. That’s what this does. Live examples here.

Daybrush (Younkue Choi)

Visual Studio Code April 2020 Released — Probably the most widely used editor in the JavaScript space now and April brings some neat new features like being able to work on GitHub issues within the editor.

Microsoft

Stream Chat API & JavaScript SDK for Custom Chat Apps — Build real-time chat in less time. Rapidly ship in-app messaging with our highly reliable chat infrastructure.

Stream sponsor

Majestic 1.7: A Zero Config GUI for Jest — A tool to help make your JavaScript testing life a little easier. Run npx majestic in the folder of any project that uses Jest to give it a quick try.

Raathi Kugarajan

Pico: Take Browser Screenshots Client-Side with JavaScript — Different from capturing a webpage using Puppeteer or a similar tool in that the screenshot taking happens entirely client side.

Gripeless

React Flow: A Library for Rendering Interactive Graphs — If you have a need to lay out graphs in a visual way and be able to smoothly pan and zoom around such graphs, this is an interesting new library. Live demo here.

Moritz Klack

MongoDB Is Easy. Now Make It Powerful. Free Download for 30 Days.

Studio 3T sponsor

NeutralinoJS: Build Cross-Platform Apps Using JS, HTML and CSS — Sounds just like Electron, right? Not quite. NeutralinoJS use less memory and are smaller as they don’t ship a full browser inside. 1.4.0 just dropped.

Neutralinojs

Slugify 1.0: Simply Turns Strings into URL/Filename-Friendly 'Slugs' — e.g. ‘I ♥ Dogs’ becomes ‘i-love-dogs’

Sindre Sorhus

RxJS Primitives: A Set of Libraries That Provide Operators for RxJS

Tane Piper

⚡️ Quick releases:




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No timeline to remove income tax exemptions, says Nirmala Sitharaman

"We have not made up our minds as yet (on the removal of all exemptions)... We are trying step by step, move forward and no particular timeline given," she said




ine

Re"evolutionary" Regenerative Medicine

Interview with Helen M. Blau, PhD, author of Re"evolutionary" Regenerative Medicine




ine

Use of Radioactive Iodine for Thyroid Cancer

Interview with Megan R. Haymart, MD, author of Use of Radioactive Iodine for Thyroid Cancer




ine

Quality of Life, Burnout, Educational Debt, and Medical Knowledge Among Internal Medicine Residents

Interview with Colin P. West, MD, PhD, author of Quality of Life, Burnout, Educational Debt, and Medical Knowledge Among Internal Medicine Residents




ine

Risk of Intussusception Following Administration of a Pentavalent Rotavirus Vaccine in US Infants

Interview with Irene M. Shui, ScD, author of Risk of Intussusception Following Administration of a Pentavalent Rotavirus Vaccine in US Infants




ine

Questioning the Use of Epinephrine to Treat Cardiac Arrest

Interview with Clifton W. Callaway, MD, PhD, author of Questioning the Use of Epinephrine to Treat Cardiac Arrest




ine

Neonatal Abstinence Syndrome and Associated Health Care Expenditures: United States, 2000-2009

Interview with Stephen W. Patrick, MD, MPH, MS, author of Neonatal Abstinence Syndrome and Associated Health Care Expenditures: United States, 2000-2009




ine

Risk of Adverse Fetal Outcomes Following Administration of a Pandemic Influenza A(H1N1) Vaccine During Pregnancy

Interview with Björn Pasternak, MD, PhD, author of Risk of Adverse Fetal Outcomes Following Administration of a Pandemic Influenza A(H1N1) Vaccine During Pregnancy




ine

Structural Brain Changes in Migraine

Interview with Lenore J. Launer, PhD, author of Structural Brain Changes in Migraine




ine

Association of Online Patient Access to Clinicians and Medical Records With Use of Clinical Services

Interview with Ted E. Palen, MD, PhD, MSPH, author of Association of Online Patient Access to Clinicians and Medical Records With Use of Clinical Services




ine

Association of Childhood Pertussis With Receipt of 5 Doses of Pertussis Vaccine by Time Since Last Vaccine Dose, California, 2010

Interview with Lara K. Misegades, PhD, MS, author of Association of Childhood Pertussis With Receipt of 5 Doses of Pertussis Vaccine by Time Since Last Vaccine Dose, California, 2010




ine

General Medicine vs Subspecialty Career Plans Among Internal Medicine Residents

Interview with Colin P. West, MD, PhD, author of General Medicine vs Subspecialty Career Plans Among Internal Medicine Residents




ine

Prevalence of and Risk Factors for Autopsy-Determined Atherosclerosis Among US Service Members, 2001-2011

Interview with Bryant J. Webber, MD, author of Prevalence of and Risk Factors for Autopsy-Determined Atherosclerosis Among US Service Members, 2001-2011




ine

Reengineering US Health Care

Interview with Ezekiel J. Emanuel, MD, PhD, author of Reengineering US Health Care




ine

Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy: A Randomized Clinical Trial

Interview with Ellen M. Lavoie Smith, PhD, author of Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy: A Randomized Clinical Trial




ine

Immunogenicity of 2 Doses of Human Papillomavirus Vaccine in Younger Adolescents Versus 3 Doses in Young Women: A Randomized Clinical Trial

Interview with Simon R. M. Dobson, MD, author of Immunogenicity of 2 Doses of Human Papillomavirus Vaccine in Younger Adolescents Versus 3 Doses in Young Women: A Randomized Clinical Trial




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Repeat Bone Mineral Density Screening and Prediction of Hip and Major Osteoporotic Fracture

Interview with Sarah D. Berry, MD, author of Repeat Bone Mineral Density Screening and Prediction of Hip and Major Osteoporotic Fracture




ine

2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)

Interview with Paul A. James, MD, author of 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)




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Cognitive Behavioral Therapy Plus Amitriptyline for Chronic Migraine in Children and Adolescents

Interview with Scott W. Powers, PhD, author of Cognitive Behavioral Therapy Plus Amitriptyline for Chronic Migraine in Children and Adolescents




ine

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial

Interview with Maurice W. Dysken, MD, author of Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial




ine

Association of Varying Number of Doses of Quadrivalent Human Papillomavirus Vaccine With Incidence of Condyloma

Interview with Lisen Arnheim-Dahlström, PhD, author of Association of Varying Number of Doses of Quadrivalent Human Papillomavirus Vaccine With Incidence of Condyloma




ine

Proportion of US Adults Potentially Affected by the 2014 Hypertension Guideline

Interview with Ann Marie Navar-Boggan, MD, PhD, author of Proportion of US Adults Potentially Affected by the 2014 Hypertension Guideline




ine

Sustained Care Intervention and Postdischarge Smoking Cessation Among Hospitalized Adults

Interview with Nancy A. Rigotti, MD, author of Sustained Care Intervention and Postdischarge Smoking Cessation Among Hospitalized Adults




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Preschool Full or Half Days and School Readiness

Interview with Arthur J. Reynolds, PhD, author of Association of a Full-Day vs Part-Day Preschool Intervention With School Readiness, Attendance, and Parent Involvement




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Varenicline for Smoking Cessation Through Smoking Reduction

Interview with Jon O. Ebbert, MD, MSc, author of Effect of Varenicline on Smoking Cessation Through Smoking Reduction




ine

Genetic Variant and Vincristine Peripheral Neuropathy in ALL

Interview with William E. Evans, PharmD, author of Association of an Inherited Genetic Variant With Vincristine-Related Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia




ine

Ebola Vaccine After Needlestick

Interview with Mark J. Mulligan, MD, author of Emergency Postexposure Vaccination With Vesicular Stomatitis Virus-Vectored Ebola Vaccine After Needlestick




ine

Autism Occurrence by MMR Vaccine Status Among US Children

Interview with Anjali Jain, MD, author of Autism Occurrence by MMR Vaccine Status Among US Children With Older Siblings With and Without Autism