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Colitis caused by Clostridium difficile infection is a growing cause of human morbidity and mortality, especially after antibiotic use in health care settings. The natural immunity of newborn infants and protective host immune mediators against C. difficile infection are not fully understood, with data suggesting that inflammation can be either protective or pathogenic. Here, we show an essential role for IL-17A produced by γδ T cells in host defense against C. difficile infection. Fecal extracts from children with C. difficile infection showed increased IL-17A and T cell receptor γ chain expression, and IL-17 production by intestinal γδ T cells was efficiently induced after infection in mice. C. difficile–induced tissue inflammation and mortality were markedly increased in mice deficient in IL-17A or γδ T cells. Neonatal mice, with naturally expanded RORγt+ γδ T cells poised for IL-17 production were resistant to C. difficile infection, whereas elimination of γδ T cells or IL-17A each efficiently overturned neonatal resistance against infection. These results reveal an expanded role for IL-17–producing γδ T cells in neonatal host defense against infection and provide a mechanistic explanation for the clinically observed resistance of infants to C. difficile colitis.

Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we report that vascular permeability–enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of neutrophil rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the bloodstream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed them to exhibit an activated phenotype and be capable of trafficking to the lungs where their presence was aligned with regions of vascular injury. Collectively, we demonstrate that increased microvascular leakage reverses the localization of directional cues across venular walls, thus causing neutrophils engaged in diapedesis to reenter the systemic circulation. This cascade of events offers a mechanism to explain how local tissue inflammation and vascular permeability can induce downstream pathological effects in remote organs, most notably in the lungs.

IBM announced today that Mediacorp, Singapore’s largest media company, has completed a digital transformation of its broadcast operations using IBM Hybrid Cloud solutions as part of the move to a new office building in Singapore’s one-north district. The Mediacorp broadcast operations team can now more quickly, seamlessly and efficiently deliver video and audio content to consumers across different platforms, including new mobile apps, interactive televisions and other connected devices.

NASCAR and The Weather Company, an IBM Busines, announced today a multi-year agreement that will optimize the weather-related decision process for NASCAR as it incorporates hyper-local weather data and forecasts into their races to improve race-day operations and fan engagement. As part of the agreement, The Weather Company, via The Weather Channel brand, becomes the Official Weather Partner of NASCAR.

IBM today introduced a new supercomputer powered by one of the world’s fastest microprocessors and cooled by an innovative water system.

At the Smarter Cities Forum in Shanghai today, IBM announced a collaboration with South China's largest hospital, Guang Dong Hospital of Traditional Chinese Medicine, to apply new analytics technology to help doctors uncover trends and new knowledge about disease treatment from thousands of anonymous Electronic Medical Records (EMR)The tool will also enable clinicians to perform empirical studies on the efficacy of certain traditional Chinese treatments.

98% de la Génération Z, avec un pouvoir d'achat estimé à 44 milliards de dollars, préfère faire ses achats en magasin

IBM (NYSE: IBM) today announced that Queensland Sugar Limited (QSL), a global leader in raw sugar marketing that manages over 90 percent of Australia’s raw sugar exports, has selected IBM advanced storage systems to support rapidly growing data demands.

Study Reveals Australian Office Workers Stressed by Irrelevant Email Overload

One-shot between Harry and Ginny a day before his Auror-training began. Canon, R&R

Six-year-old Teddy Lupin was feeling unnaturally nervous. One-shot Teddy's speech for his primary school about his parents, or people like his parents. R&R!

One-shot,*not what you might think* Now that Harry and Ginny are dating, Ron needs to get his brotherly duties out of way, but who is he going to talk to if not Harry? Read to find out... R&R!

What if, after Harry faces Voldemort in the Forest, he doesn't go to his mental construct of King's Cross Station? Rather he finds himself on the shore of the Black Lake in a host of Guardian Angels (one a little odd, another disturbingly familiar looking), and a tall, hooded black-robed figure. On a white horse. Named Binky...

Hello Everyone!

Chapter 02 of Starfighter has officially begun! I have really been looking forward to this moment and hope you enjoy the next installment of the story. With the first chapter of Starfighter in the capable hands of our printers, I am now free to work on pages again! Thank you so much for your patience and support; it is truly appreciated!

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Much love, - HamletMachine

The coronavirus outbreak has officially been labeled a pandemic by the World Health Organization, potentially grinding the global economy to a halt. Yet every step of the way, the Trump administration’s response has been to deny, blame, obfuscate, and generally cover up. 

Trump and his enablers are focused only on mitigating the economic consequences of the outbreak, especially before the election – mulling proposals like corporate tax cuts and bailouts for airlines and the hotel industry, but resisting the needs of average Americans and our broken healthcare system. 

The outbreak has also revealed the utter weakness of our social safety nets: workers may be forced to choose between a missed paycheck and risking their health because too many employers have no paid sick leave, schools are weighing whether or not to shut down because hundreds of thousands of poor children rely on them for hot meals, and our cruel for-profit healthcare system is preventing people from getting tested for the virus for fear of a hefty bill.

And, remember, 80 percent of Americans are living paycheck to paycheck. Coupled with Trump’s incompetence and narcissism, it’s a recipe for total disaster.

Meanwhile, the Democratic electorate is in the midst of a primary to unseat this sociopath. After Tuesday, Biden has kept his delegate lead with wins in Idaho, Michigan, Missouri, and Mississippi. And while the race isn’t over yet, it’s wise to start making contingency plans.

Biden’s biggest weakness is his failure to attract progressives and young voters. In a CNN exit poll for Michigan, Bernie won a whopping 82 percent of voters age 18-29. Without these voters, if Biden is the nominee, Democrats will not be able to get the votes needed to defeat Trump.

So what are Biden’s options for getting out the vote of this crucial portion of the Party? He must select a true progressive for Vice President, like Elizabeth Warren or even Bernie Sanders, who can push bold progressive ideas like a wealth tax, Medicare for All, tuition-free college, cancelling student debt, and a Green New Deal.

These progressive policies are also winners with the electorate – a majority of voters even in Mississippi and other southern states supported replacing the current healthcare system with a single-payer system, and polling continues to reflect this appetite for transformative change. Even if Bernie isn’t getting the support he counted on, his ideas are.

And don’t count Bernie out just yet. A debate is coming up this weekend that could boost his campaign enough to help him secure wins in later key states like Ohio and Pennsylvania.

But if he fails to get traction, he needs to do whatever he can to help reunite the party, and most importantly, keep working to shift the party in a progressive direction. Behind the scenes he needs to negotiate with Biden a pathway to gain progressive support.

Meanwhile, Biden needs to take up the issues of concern to young people, who are the future of the party and who Democrats can’t win without. This might seem like a pipe dream, but Biden has no choice. This is not 2016. The nation cannot afford another 4 years of Trump. If you’re angry – and rightfully so – use that anger to keep pushing the movement.

Místo zájezdu nové brýle a namísto pravidelné masáže konzultace s lékařem na dálku. Vládní opatření proti koronaviru změnila také čerpání zaměstnaneckých benefitů. Na rozdíl od výplat je však firmy nekrátí.

Kvůli koronavirové pandemii pracují z domova tisíce lidí. Home office má však určitý pracovně-právní rámec, což tuší málokdo. Jaká jsou práva a povinnosti zaměstnanců a co musí zaměstnavatel udělat, aby neporušil zákoník práce? Ve spolupráci s právníky Bořivojem Líbalem a Markem Poloni přinášíme praktický servis rad pro zaměstnance a zaměstnavatele.

Práci z domova u zaměstnanců soukromých firem nelze jednostranně nařídit, vzniká jen na základě dohody obou stran. U pedagogických pracovníků a zaměstnanců škol však platí trochu jiná pravidla. Ve spolupráci s právníky Bořivojem Líbalem a Markem Polonim přinášíme odpovědi na nejčastější dotazy pedagogů.

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The office formerly known as the U.S. Grand Lodge Ombudsman has been renamed to Ombuds. The purpose of this office remains as described on the U.S.G.L. Government Contacts page: The office of the U.S. Grand Lodge Ombuds serves as an official liaison between the general membership of O.T.O. within the United States and the various …

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I have often been surprised how dangerous it is to cross a street in Malta, especially if there is not a pedestrian crossing. It appears that motorists among themselves have a contest to see who can scare the pedestrians most.  It is not surprising that Malta is among the countries with the highest accident rates in traffic in Europe. If the roads were in a better condition the victims would, due to possible higher speed, probably be many more.
Another thing that amazes a foreigner from northern Europe, is the constant honking. If honking were an Olympic event Malta would undoubtedly win a medal of high value. Many people I have discussed this matter with have expressed a thought that may be Maltese driving licenses are issued by Disney World or come withe the cereal packages from Scotts.
Another thing that is surprising to a foreigner is the rule that cars, that have been involved in an accident, must not be moved before the police has arrived and documented the damages even how small these are. For instance I saw two cars touch each other at Tigné Seafront in Sliema. It was only a small dent on one car. Both cars stopped traffic so that no vehicles could pass the place of the accident. This happened in rush hour. A motorcycle police arrived after about 10 minutes and marked the cars position by spraying marks on the road. It took about ten seconds. The queue, which was formed, probably reached St. Julians. But, of course, many young Maltese men were excited; there was a good reason to honk!

In my last post I showed some simple ways you can use to help get your videos more views and subscribers. Now let's talk about getting some of that traffic over to your website or blog. Being that YouTube is the most used search engine in the world right now, and showing no signs of slowing down, this is something you want to tap into.

Traffic we all want it, so how do you get it? You’ve picked your topic, and you got your site up so how do you get visitors to your site. Getting website traffic can be frustrating at the very least, a major agonizing pain at the worst. Here are some tips on how to get website traffic.

When it comes to how to get website traffic, not all traffic types are equal and hold the same value. Many who are new to websites or blogs think that all traffic is one and the same. And while the number of visits might look good you have to actually look at the numbers to see the real story behind those numbers. This is one reason why using sites like Google Analytics or other traffic stat sites is important when it comes to unstanding what kind of traffic your getting. To understand if the traffic you’re getting is good or not you have to know what types of traffic are out there, they are 1. Social Traffic 2. Paid Traffic 3. Word Of Mouth 4. Search Traffic 5. Return Traffic

When it comes to ways you can increase traffic to your website there are dozens if not hundreds of ways to get more traffic. Depending on your website, the content or products you’re trying to get viewed, and the amount of time you can invest each day on your site, not all of those hundreds or ways are going to be as effective. You also want to avoid anything that could be considered “Black Hat SEO” as these types of tricks to increase your traffic may work in the short term, but get your website kicked out of search engine rankings.

When it comes to getting people to your site one of the ways you can do this is through social bookmaking sites. And while these all give your site excellent one way back links, there is one site that you should sign up to first to get more traffic, and that site is Stumbleupon. Why you should use Stumbleupon to get more traffic If you’re not familiar with Stumbleupon this is how it works for your site to get more traffic. Instead of using keywords like how you would for a search engine, visitors select categories that interest them such as videos, music, or computers to name a couple examples. Once they pick their categories and click on the stumble button their randomly taken to a site, article, or video that fits that category. They can then decided if the like or dislike that site by giving it thumbs up or down. The more thumbs up your site gets the more hits it will get because it will show up more frequently when people stumble that category. Visitors to your site can also write reviews and share it with other users or add a sites link to their list of favourite sites giving you even more exposure, back links, and that oh so coveted traffic..........

Google Keyword Tool and Google Traffic Estimator, both of which are free tools provided by Google to help you analyze and find keywords that you can use to help promote your website and drive targeted traffic to it. And while these tools are very similar (there pages look almost identical) there are some key differences between the two free tools.

In my opinion Stumbleupon is one of the best ways to get more traffic to your to your site, especially if it’s brand new and your looking to get noticed quickly. If you’re not familiar with Stumbleupon it’s a web based service that allows you to discover websites, blogs, and videos without having to use traditional methods such as Google. Instead you can choose what topics you want to look for, click stumble and your randomly shown sites that meet your search criteria, if you like it you can give it a “thumbs up”. What makes this so appealing to site owners is that the more thumbs up your site gets the more times it’ll appear when that topic is searched.

Traffic, if you have a website or a blog you want to get website traffic and as much of it as possible. It doesn’t matter if your site is to make money, to connect with others, for a business, or display your love for all things kittens, if you’re a site owner you want traffic. So how do you go about getting website traffic? Here is a list I put together of 100 different things you can do to get traffic to your website. These aren’t in any particular order of importance and not all of them will work for each site the same way. Some sites will have better results with some of these options then others..................

YouTube is one of the most important marketing tools out there when it comes to getting the message out about your business or your website. It’s currently the second most used search engine behind Google (which owns YouTube by the way) and is the biggest video sharing site in the world. Like it or hate it having videos on YouTube is a good way to promote what you have. But just having videos isn’t enough to get a tonne of traffic; you need to know how to optimize your YouTube channel and videos to get more traffic......................

Craigslist it’s not just a site to sell crappy used furniture, look for work, and view personals, it can also be a good place to advertise your website or promote your blog. Even though Craigslist has a lot of spam blockers and restrictions, a well written optimized ad can help give your site a boost of traffic. This is especially important for business sites looking to expand on generating local traffic.............

So you have a website, or a blog that you want to rank well in search results. One place that you can easily get back links from, build your sites online presence, and get found in search results is Yahoo Answers. If you’re stuck with other SEO building strategies or looking to diversify your back links this is a good place to start..............

Say goodbye to your uncomfortable wooden chair for good. READ MORE...

YES, OFFICER I've been drinking I had one beer

This publication presents information on support to carers and in particular respite care services provided or purchased by local authorities in Scotland over the financial years 2007 / 2008 to 2014 / 2015.

The power of the mind is becoming increasingly more apparent. That’s why you’re seeing all this focus on activities such as mindset development, meditation, and mindfulness. Our mindset forms the foundation and plays a big role in our overall success and happiness. That’s why it’s so important for us to find ways to improve our [...]Read More...

On May 4, 2011, the first organized "Star Wars" Day celebration happened in Toronto. See how it happened in our On This Day in Space video series!

"Thor: Love and Thunder" writer/director Taika Waititi has signed on to write and direct a "Star Wars" film.

In Northwest Portland, two former industrial structures have been given a new lease on life as Redfox Commons, a light-filled campus for creative, tech and retail workspaces. Local design practice LEVER Architecture led the adaptive reuse project that spans 60,000 square feet and is split between a west wing and a larger east wing across two floors. The architects reclaimed over 6,500 linear feet of timber and combined the salvaged material with new industrial-inspired elements — such as weathering steel cladding and ribbon windows — to pay homage to the building’s history. [...]

Our air fryer pork stuffing meatballs are the perfect holiday main course or appetizer. Juicy ground pork and stuffing seasonings come together to create these absolutely scrumptious air fryer meatballs! I’d like to thank The Ohio Pork Council for sponsoring this recipe. Air Fryer Pork Stuffing Meatballs Recipe Friends, do I have a holiday-blockbuster recipe […]

The post Air Fryer Pork Stuffing Meatballs appeared first on Dear Crissy.

Have you been finding it hard to generate traffic for your GDI business? Well this article will explain how you can use 3 free strategies to get free traffic for Global Domains International, review these strategies and take action.

What is the big thing about targeted Internet traffic? And why do so many people want to know how to drive traffic to their website? Here are 2 facts that will help you understand why you need targeted Internet traffic to your web site.

My plan is to give you 2 very easy techniques to get some real targeted web site traffic to your money site or Blog. One of the major issues that new marketers face is getting traffic.

When you are working out how to market your blog it is important to focus on what is most effective. Not only that, you need to go with what is also cost effective. I have some article marketing tips that will truly explode your blog traffic.

Are you asking yourself - how do I get more traffic to my web site? Well if you are, you are in luck, because I have 3 quick suggestions for you.

I am going to explain how to advertise your blog for free and drive massive traffic. There are so many ways to do this, however the average person will get overwhelmed and achieve nothing. I am going to make it nice and easy for you!