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Refineries, investors fear crude shortages over possible Venezuela sanctions

An unexpected rise in U.S. crude inventories offset fears of potential risk to Venezuelan crude supply because of possible U.S. sanctions.




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Poverty, poorer health make some in the Bronx more vulnerable to COVID-19

New York City has been the epicenter of the COVID-19 outbreak in the United States, with immigrant populations in areas such as the Bronx "disproportionately" affected, a commentary in JAMA Internal Medicine says.




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Blood Pressure Variability and Risk of Heart Failure in ACCORD and the VADT

OBJECTIVE

Although blood pressure variability is increasingly appreciated as a risk factor for cardiovascular disease, its relationship with heart failure (HF) is less clear. We examined the relationship between blood pressure variability and risk of HF in two cohorts of type 2 diabetes participating in trials of glucose and/or other risk factor management.

RESEARCH DESIGN AND METHODS

Data were drawn from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial and the Veterans Affairs Diabetes Trial (VADT). Coefficient of variation (CV) and average real variability (ARV) were calculated for systolic (SBP) and diastolic blood pressure (DBP) along with maximum and cumulative mean SBP and DBP during both trials.

RESULTS

In ACCORD, CV and ARV of SBP and DBP were associated with increased risk of HF, even after adjusting for other risk factors and mean blood pressure (e.g., CV-SBP: hazard ratio [HR] 1.15, P = 0.01; CV-DBP: HR 1.18, P = 0.003). In the VADT, DBP variability was associated with increased risk of HF (ARV-DBP: HR 1.16, P = 0.001; CV-DBP: HR 1.09, P = 0.04). Further, in ACCORD, those with progressively lower baseline blood pressure demonstrated a stepwise increase in risk of HF with higher CV-SBP, ARV-SBP, and CV-DBP. Effects of blood pressure variability were related to dips, not elevations, in blood pressure.

CONCLUSIONS

Blood pressure variability is associated with HF risk in individuals with type 2 diabetes, possibly a consequence of periods of ischemia during diastole. These results may have implications for optimizing blood pressure treatment strategies in those with type 2 diabetes.




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Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial

OBJECTIVE

To assess the efficacy and safety of a 1:1 fixed-ratio combination of insulin glargine and lixisenatide (iGlarLixi) versus lixisenatide (Lixi) in insulin-naive Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled on oral antidiabetic drugs (OADs).

RESEARCH DESIGN AND METHODS

In this phase 3, open-label, multicenter trial, 321 patients with HbA1c≥7.5 to ≤10.0% (58–86 mmol/mol) and fasting plasma glucose (FPG) ≤13.8 mmol/L (250 mg/dL) were randomized 1:1 to iGlarLixi or Lixi for 52 weeks. The primary end point was change in HbA1c at week 26.

RESULTS

Change in HbA1c from baseline to week 26 was significantly greater with iGlarLixi (–1.58% [–17.3 mmol/mol]) than with Lixi (–0.51% [–5.6 mmol/mol]), confirming the superiority of iGlarLixi (least squares [LS] mean difference –1.07% [–11.7 mmol/mol], P < 0.0001). At week 26, significantly greater proportions of patients treated with iGlarLixi reached HbA1c <7% (53 mmol/mol) (65.2% vs. 19.4%; P < 0.0001), and FPG reductions were greater with iGlarLixi than Lixi (LS mean difference –2.29 mmol/L [–41.23 mg/dL], P < 0.0001). Incidence of documented symptomatic hypoglycemia (≤3.9 mmol/L [70 mg/dL]) was higher with iGlarLixi (13.0% vs. 2.5%) through week 26, with no severe hypoglycemic events in either group. Incidence of gastrointestinal events through week 52 was lower with iGlarLixi (36.0% vs. 50.0%), and rates of treatment-emergent adverse events were similar.

CONCLUSIONS

This phase 3 study demonstrated superior glycemic control and fewer gastrointestinal adverse events with iGlarLixi than with Lixi, which may support it as a new treatment option for Japanese patients with T2DM that is inadequately controlled with OADs.




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Ohio State University agrees to $10M settlement with abuse victims

Ohio State University will pay more than $40 million to 162 former students who said a team doctor abused them over two decades, the school announced.




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Watch: Ariana Grande, Justin Bieber release at-home video for 'Stuck with U'

Ariana Grande and Justin Bieber released their music video for "Stuck With U."




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Watch: Kelly Clarkson on 'chaos' of filming 'The Voice' remotely

Kelly Clarkson discussed the challenges of filming "The Voice" at home amid the coronavirus pandemic.




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[ Politics ] Open Question : Why are other countries like New Zealand and Australia destroying the virus while America is killing people off to restart the economy?




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Stepping into the Vacuum: State and Cities Act on Immigration, But Do Restrictions Work?

Over the past decade, state and local policymakers have increasingly stepped into the void left by Washington over legislative reform of the immigration system and have enacted their own policies, particularly in regard to illegal immigration. This article explores this trend of increased activism and examines whether restrictive state immigration laws have had an effect on the size of immigrant populations at the state level.




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9/11, Iraq and the Desensitization of the Victimized

In the days after the attacks of Sept. 11, 2001, with the twin towers vanished from Manhattan's skyline, a poem by W.H. Auden could have been the song of a wounded nation. "September 1, 1939," written on the eve of World War II, seemed eerily prescient:




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Thoughtful Investments Are Needed to Effectively Engage Volunteers in Refugee Integration

WASHINGTON — Rapid arrivals of humanitarian migrants in Europe and North America have been matched by an equally unprecedented outpouring of public support. As offers to volunteer and donate pour in, many have asked whether this generosity can be harnessed to ease pressures on overburdened receiving communities and service providers. But using volunteers to meet the longer-term integration needs of resettled refugees and recognized asylum seekers is not an automatic salve: it requires thoughtful training and investment to be effective.




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Immigrant Workers Are Vital to the U.S. Coronavirus Pandemic Response, But Disproportionately Vulnerable

WASHINGTON — Six million immigrant workers are at the frontlines of keeping U.S. residents healthy, safe and fed during the COVID-19 pandemic, according to a Migration Policy Institute (MPI) analysis of U.S. Census Bureau data issued today. While the foreign born represented 17 percent of the 156 million civilians working in 2018, they account for larger shares in pandemic-response frontline occupations: 29 percent of all physicians in the United States, 38 percent of home health aides and 23 percent of retail-store pharmacists, for example.




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Effectively Serving Immigrant and Dual Language Learner Families through Home Visiting Programs

This MPI webinar marks the release of a policy brief that explores program and policy opportunities to improve home visiting services for immigrant and DLL families currently underparticipating in these programs due to a lack of culturally and linguistically responsive programming and other barriers




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The Colombian Response to the Venezuelan Migration Crisis: A Dialogue with Colombia’s Migration Czar

Felipe Muñoz, Advisor to the President of Colombia for the Colombian-Venezuelan Border, discusses how Colombia is coping with the influx of Venezuelan migrants, plans for future policy decisions surrounding this migration, and developments in regional and international cooperation.




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Latin American Responses to the Venezuelan and Nicaraguan Migration Crises

Leading policymakers and key stakeholders from Latin America, as well as representatives of major international institutions, offer their views on the challenges ahead as Latin American governments seek to chart strategies for responding to large-scale forced migration flows, such as those from Venezuela and Nicaragua.




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Welcome Wears Thin for Colombians in Ecuador as Venezuelans Become More Visible

Though Colombians displaced by a decades-long civil war found a welcome refuge in Ecuador, life has become more difficult for them in recent years, in part as a result of the influx of Venezuelans seeking safety. This article draws on surveys of migrants in Quito, comparing and contrasting the experiences of Colombians and Venezuelans, and assessing their perceptions of discrimination, victimization, trust in institutions, and hopes for the future.




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Effectively Serving Immigrant and Dual Language Learner Families through Home Visiting Programs

Marking a policy brief's release, this webinar explores the promise of home visiting services that support new parents alongside their infants and toddlers, plus strategies for improving how these programs work with immigrant and linguistically diverse families.




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The Colombian Response to the Venezuelan Migration Crisis: A Dialogue with Colombia’s Migration Czar

Felipe Muñoz, Advisor to the President of Colombia for the Colombian-Venezuelan Border, discusses how Colombia is coping with the influx of Venezuelan migrants, plans for future policy decisions surrounding this migration, and developments in regional and international cooperation.




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Latin American Responses to the Venezuelan and Nicaraguan Migration Crises

Leading policymakers and key stakeholders from Latin America, as well as representatives of major international institutions, offer their views on the challenges ahead as Latin American governments seek to chart strategies for responding to large-scale forced migration flows, such as those from Venezuela and Nicaragua. Spanish and English versions of the remarks are available.




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Leveraging the Potential of Home Visiting Programs to Serve Immigrant and Dual Language Learner Families

Home visiting programs for young families are growing in popularity across the United States, and have demonstrated their effectiveness in supporting maternal health and child well-being. At the same time, more infants and toddlers are growing up in immigrant families and households where a language other than English is spoken. Why then are these children under-represented in these programs? This brief explores common barriers, ways to address them, and why it is important to do so.





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The gender-fluid history of the Philippines | France Villarta

In much of the world, gender is viewed as binary: man or woman, each assigned characteristics and traits designated by biological sex. But that's not the case everywhere, says France Villarta. In a talk that's part cultural love letter, part history lesson, he details the legacy of gender fluidity and inclusivity in his native Philippines -- and emphasizes the universal beauty of all people, regardless of society's labels.




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How American and Chinese values shaped the coronavirus response | Huang Hung

To combat COVID-19, countries have enforced city-wide shutdowns, stay-at-home orders and mask mandates -- but the reaction (and adherence) to these rules has differed markedly in the East and West. In conversation with TED's head of curation Helen Walters, writer and publisher Huang Hung sheds light on how Chinese and American cultural values shaped their responses to the outbreak -- and provides perspective on why everyone needs to come together to end the pandemic. (Recorded April 16, 2020)





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Despite Fierce Teacher Opposition, West Virginia House Votes to Allow Charter Schools

The West Virginia House of Delegates passed its version of a sweeping education omnibus bill, which would allow the state's first charter schools.




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Tennessee voucher program challenge heads to court Wednesday




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Judge weighs Tennessee voucher program arguments




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Bobby Lee Verdugo, leader of 1968 LA school walkout, dies




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Some 2020 grads will take victory lap at Daytona speedway




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Tennessee voucher program challenge heads to court Wednesday




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Judge weighs Tennessee voucher program arguments




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Tennessee voucher program challenge heads to court Wednesday




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Judge weighs Tennessee voucher program arguments




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Bobby Lee Verdugo, leader of 1968 LA school walkout, dies




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Some 2020 grads will take victory lap at Daytona speedway




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New Science Standards to Face First State Vote Today, in Rhode Island

Rhode Island may become the first state to adopt the Next Generation Science Standards. The state board will vote later today.




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Criminal justice and the vulnerable / presented by Her Honour Judge Lees.




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Bless Family memories : in the Vales / by Gramother Christine.

A young artist inherits her Grammy's home in The Vales and begins to remember the stories her Grammy once shared with her. Where they real or has Grammy already lost her marbles a wee bit? When some friends come to visit she regales them with the stories and gives them a tub of her Grammy's favourite chees - the Bless Family Vegan Parmesan Cheese that she had procured from the famous Blessed Cheese cafe run by the Bless family.




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24 1/2 Almond Tree Grove i:n the Vales / by Grandmother Christine.

"24 1⁄2 Almond Tree Grove is the second story in the series In the Vales. A fun, light fantasy story about a young girl who inherits her Grammy's Cottage in the Vales, then starts to remember some of Grammy's favourite stories of her wee friends. The Almond Tree fairies are so helpful to us all, just read my wee story and see. "These stories allow you to enter into a parallel world set within our local community. They will take you on a journey to allow your imagination to tell the tales of the adventurous characters in a variety of unique situ's. The dialogue twists between now and then to provide a rich connection to the character's shenanigans, which motivates the reader to visualise beyond the text to create deeper meaning and connection to self, family and the community we live in."




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Secret wee caves : in the Vales / by Grandmother Christine.

Secret wee Caves the third story in the series "In the Vales" A fun, light fantasy story about a young girl who inherits her Grammy's Cottage in the Vales, then starts to remember some of Grammy's favourite stories of her wee friends. I hear Max the Purple Dragon is such a gentleman, find out more by reading my wee story. "These stories allow you to enter into a parallel world set within our local community. They will take you on a journey to allow your imagination to tell the tales of the adventurous characters in a variety of unique situ's. The dialogue twists between now and then to provide a rich connection to the character's shenanigans, which motivates the reader to visualise beyond the text to create deeper meaning and connection to self, family and the community we live in."




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Ghost train walk : in the Vales / by Grandmother Christine.

With two quick bursts of the Ghost train's whistle it indicates that the time is 12 midnight, but as quick as we rush out of the front door we have never been able to catch a glimpse of that train, till now! Grammy's tales are being shared through her granddaughter, but are they tales or real events and people, hmm? Read on to find out for yourself. He He. A fictional story set In the Vales as a Children's Bedtime Story. History and characters of this rolling countryside between sea and hills has been packaged up to be fun, informative and thought provoking.




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Source Murray Model - method for determining permitted take in the Victorian Murray, Kiewa and Ovens SDL resource units.




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Forum 2019 : 10C Pre CGT property - or is it? / [a[er presented by Julie van der Velde, VdV Legal.




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Secrets of the maze : in the Vales / created by Grandmother Christine.




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The Vernacont Wars: The Journey.




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Engaging men who use violence : invitational narrative approaches / Professor Sarah Wendt, Dr Kate Seymour, Fiona Buchanan, Chris Dolman, Dr Natalie Greenland.

"This study contributes to the limited evidence available on how invitational narrative approaches are used in the domestic and family violence field. It focused on invitational narrative ways of engaging and working with men who perpetrate domestic and family violence. Focusing on the processes and skills of practice embedded in invitational narrative ideas enabled the examination of different ways of engaging men that have the potential to lead to sustained change. Accordingly, the main aim of this study was to explore invitational narrative ways of working in order to build an understanding of the processes and skills that engage men and enable behavioural and attitudinal change." --Executive summary (page 6).




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The tale of many tails : [in the Vales] / created by Grandmother Christine.

A fun light story by Grammy of camping in the Vales with nighttime noises and shadows scaring all. She knew who was scurrying around the campsite. Would you like to know too? -- Publisher.




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In the closet of The Vatican : power, homosexuality, hypocrisy / Frédéric Martel ; translated by Shaun Whiteside.

Catholic Church -- Clergy -- Sexual behavior.




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The Virago story : assessing the impact of a feminist publishing phenomenon / Catherine Riley.

Virago Press -- History.




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Don Dunstan : the visionary politican who changed Australia / Angela Woollacott.

Dunstan, Don, 1926-1999 -- Career in Politics.