Archives, Room Use Only - UG573.R44 1880

Archives, Room Use Only - UG582.S4 S96 1914

Archives, Room Use Only - TK5627.J46 1862

Archives, Room Use Only - UG573.U78 1901

Archives, Room Use Only - TK5627.U55 1946

Archives, Room Use Only - UG607.U55 1905

Archives, Room Use Only - UG603.A76 1912

Archives, Room Use Only - TK5741.T74 1902

Archives, Room Use Only - TF615.B38 1913

Archives, Room Use Only - D570.346 406th.S33 1921

Archives, Room Use Only - UG580.S65 1916

Archives, Room Use Only - UG573.G53 1917

Archives, Room Use Only - UG575.G7 G74 1915

Archives, Room Use Only - V285.G7 S54 1937

Archives, Room Use Only - VK381.B76 1917

Archives, Room Use Only - UG573.U56 1916

Archives, Room Use Only - TK5262.B79 1876

Words to tattoo on your knuckles:

Over the past couple of years, my blog hasn’t felt my own, to a degree. It’s felt like I’ve been writ­ing for an audi­ence, post­ing stuff for oth­ers rather than myself. That’s arse-backwards. A blog should be about per­sonal expres­sion. The moment you start think­ing, and writ­ing, to please oth­ers then it’s a bind; it feels less like a per­sonal exer­cise and more of a job.

A beautiful, thoughtful redesign from Mark Boulton (and a responsive one at that). Go go, read read.

A wall is being constructed in front of a slum along the road connecting Sardar Vallabhbhai Patel International Airport to Indira Bridge.

The Congress requested the President to remind the central government of its 'raj dharma', Singh said.

Nearly 7,000 paramilitary forces have been deployed in the affected areas of the northeast district since Monday.

The Congress and other opposition parties have accused the police of bias and inaction in the Delhi violence.

Startup designs foldable japi

September 23, 2015

As an industry, we’ve worked to established many new practices and tools for nimble design teams, from A/B testing to measuring bounce rates and CTR performance. But a lot of these methods require engineers or some amount of technical know-how to execute, and they take place only after something has been launched.

The judicious application of “dumb data” can streamline your workflow and improve your designs

What many people don’t know is that there are some unexpected applications of data to consider earlier in the design process, which you, the designer, can do yourself. They’re not fancy, and you don’t need to know how to write SQL queries. The judicious application of just-enough “dumb data” can streamline your workflow and improve your designs in surprisingly useful ways.

Here are...read more
By Jocelyn Lin

September 28, 2015

Good design in any discipline usually carries a structure of order and harmony. Since the Renaissance, artists and architects have used a strong understanding of proportions to create aesthetically pleasing architecture. Many of these classical design principles have followed us into modern times and can be found today in effective web design.

Take an A4 piece of paper for example. If you take it and halve it, the resulting size is A5 with the same exact proportions. No other proportion has the same properties. 16th century architect, Andrea Palladio knew this well. It is believed that because, fundamentally, most architects—like Palladio—use a similar system of proportions to plan and design spaces, buildings can look very different while remaining similar at their cores.

Structure and Beauty

It’s in human nature to...read more
By Ling Lim

September 30, 2015

By their very nature, heuristics offer a hands-on approach to discovery, where knowledge is culled through trial and error. They are rules of thumb that give us a framework as we move through the research and design process.

In service design, this kind of framework is also valuable for assessing completed projects to find the weak links. A heuristic can apply to a single interaction as well as to the overall service eco-system. Heuristics can be applied to a single moment in time or to a user’s entire long-term relationship with a service.

This conceptual approach to design recognizes that experiences are coproduced, and that human interaction is a key component of many, if not all, services. As systems grow ever more sophisticated and interconnected, designers will continue to face new challenges. Service design heuristics can help us to frame and think about...read more
By Usability Matters

October 5, 2015

You may have recently seen an abundance of bug-eyed people puking rainbows on Snapchat. Thank Looksery for that. Launched last year as an entertainment app based on face recognition technology and special effects, Looksery was acquired by Snapchat last month.

Looksery technology propels Snapchat’s new special effects

Founded in 2013, Looksery launched in October 2014 after...read more
By Jordan Crone

October 6, 2015

Many important considerations impact software design. Business goals, user goals, user context, cultural considerations, platform paradigms, branding requirements, devices … the list goes on and on. While a primary focus for any software design effort should be the data or other content that’s being displayed, this keystone element is often given short shrift. This is unfortunate and shortsighted. Given the focus it your content will receive, it should be a primary consideration during the design process.

It is a common practice to represent data and content as “Lorem ipsum,” repeating data, or simply using “best case scenario” data. In reality, this isn’t what will be experienced in the final product. The data you have to work with can drastically affect the final design, and the design will influence the type, format, and presentation of data.

Infusing Real Content into Your Designs

Whether you’re using...read more
By Juan Sanchez

No-touch systems, infrastructure to work from home are some of the changes

If you are wondering when to apply which design methods, this mind map may help you.

O’REILLY DESIGN CONFERENCE - get the skills and insights you need to design the products of the future. Save 20% with code ALIST

A neutron crystallographic study of perdeuterated transthyretin reveals important aspects of the structure relating to its stability and its propensity to form fibrils, as well as evidence of a single water molecule that affects the symmetry of the two binding pockets.

Fracking: UK shale gas reserves 'significantly lower than previous estimates'  Energy Live News - Energy Made Easy

Fracking firm Cuadrilla signs secret deal with geological agency to 'destroy confidential documents'  iNews

The structural dimension of metal–organic frameworks (MOFs) is of great importance in defining their properties and thus applications. In particular, 2D layered MOFs are of considerable interest because of their useful applications, which are facilitated by unique structural features of 2D materials, such as a large number of open active sites and high surface areas. Herein, this work demonstrates a methodology for the selective synthesis of a 2D layered MOF in the presence of the competitive formation of a 3D MOF. The ratio of the reactants, metal ions and organic building blocks used during the reaction is found to be critical for the selective formation of a 2D MOF, and is associated with its chemical composition. In addition, the well defined and uniform micro-sized 2D MOF particles are successfully synthesized in the presence of an ultrasonic dispersion. Moreover, the laminated 2D MOF layers are directly synthesized via a modified bottom-up lamination method, a combination of chemical and physical stimuli, in the presence of surfactant and ultrasonication.

The present work reports on the charge and spin density modelling of YTiO3 in its ferromagnetic state (TC = 27 K). Accurate polarized neutron diffraction and high-resolution X-ray diffraction (XRD) experiments were carried out on a single crystal at the ORPHÉE reactor (LLB) and SPRING8 synchrotron source. The experimental data are modelled by the spin resolved pseudo-atomic multipolar model (Deutsch et al., 2012). The refinement strategy is discussed and the result of this electron density modelling is compared with that from XRD measured at 100 K and with density functional theory calculations. The results show that the spin and charge densities around the Ti atom have lobes directed away from the O atoms, confirming the filling of the t2g orbitals of the Ti atom. The dxy orbital is less populated than dxz and dyz, which is a sign of a partial lift of degeneracy of the t2g orbitals. This study confirms the orbital ordering at low temperature (20 K), which is already present in the paramagnetic state above the ferromagnetic transition (100 K).

The stressosome transduces environmental stress signals to SigB to upregulate SigB-dependent transcription, which is required for bacterial viability. The stressosome core is composed of RsbS and at least one of the RsbR paralogs. A previous cryo-electron microscopy (cryo-EM) structure of the RsbRA–RsbS complex determined under a D2 symmetry restraint showed that the stressosome core forms a pseudo-icosahedron consisting of 60 STAS domains of RsbRA and RsbS. However, it is still unclear how RsbS and one of the RsbR paralogs assemble into the stressosome. Here, an assembly model of the stressosome is presented based on the crystal structure of the RsbS icosahedron and cryo-EM structures of the RsbRA–RsbS complex determined under diverse symmetry restraints (nonsymmetric C1, dihedral D2 and icosahedral I envelopes). 60 monomers of the crystal structure of RsbS fitted well into the I-restrained cryo-EM structure determined at 4.1 Å resolution, even though the STAS domains in the I envelope were averaged. This indicates that RsbS and RsbRA share a highly conserved STAS fold. 22 protrusions observed in the C1 envelope, corresponding to dimers of the RsbRA N-domain, allowed the STAS domains of RsbRA and RsbS to be distinguished in the stressosome core. Based on these, the model of the stressosome core was reconstructed. The mutation of RsbRA residues at the binding interface in the model (R189A/Q191A) significantly reduced the interaction between RsbRA and RsbS. These results suggest that nonconserved residues in the conserved STAS folds between RsbS and RsbR paralogs determine stressosome assembly.

For Heusler-type Ni–Mn–Ga ferromagnetic shape-memory alloys, the configuration of the martensite variants is a decisive factor in achieving a large magnetic shape-memory effect through field-induced variant reorientation. Based upon the spatially resolved electron backscatter diffraction technique, the microstructural evolution associated with the martensitic transformation from austenite to seven-layered modulated (7M) martensite was investigated on a polycrystalline Ni53Mn22Ga25 alloy. It was clearly shown that grain interior nucleation led to the formation of diamond-shaped 7M martensite within the parent austenite matrix. This diamond microstructure underwent further growth through an isotropic expansion with the coordinated outward movement of four side habit planes, followed by an anisotropic elongation with the forward extension of a type-I twin pair. A two-step growth model is proposed to describe the specific morphology and crystallography of 7M martensite. In addition, the habit planes were revealed to possess a stepped structure, with the {1 0 1}A plane as the terrace and the {0 1 0}A plane as the step. The characteristic combination of martensite variants and the underlying mechanism of self-accommodation in the martensitic transformation have been analysed in terms of the minimum total transformation strain, where the deformation gradient matrix was constructed according to the experimentally determined orientation relationship between the two phases. The present results may deepen the understanding of special martensite microstructures during the martensitic transformation in ferromagnetic shape-memory alloys.

Rational structure-based drug design (SBDD) relies on the availability of a large number of co-crystal structures to map the ligand-binding pocket of the target protein and use this information for lead-compound optimization via an iterative process. While SBDD has proven successful for many drug-discovery projects, its application to G protein-coupled receptors (GPCRs) has been limited owing to extreme difficulties with their crystallization. Here, a method is presented for the rapid determination of multiple co-crystal structures for a target GPCR in complex with various ligands, taking advantage of the serial femtosecond crystallography approach, which obviates the need for large crystals and requires only submilligram quantities of purified protein. The method was applied to the human β2-adrenergic receptor, resulting in eight room-temperature co-crystal structures with six different ligands, including previously unreported structures with carvedilol and propranolol. The generality of the proposed method was tested with three other receptors. This approach has the potential to enable SBDD for GPCRs and other difficult-to-crystallize membrane proteins.

MICAL is an oxidoreductase that participates in cytoskeleton reorganization via actin disassembly in the presence of NADPH. Although three MICALs (MICAL1, MICAL2 and MICAL3) have been identified in mammals, only the structure of mouse MICAL1 has been reported. Here, the first crystal structure of human MICAL3, which contains the flavin-containing monooxygenase (FMO) and calponin-homology (CH) domains, is reported. MICAL3 has an FAD/NADP-binding Rossmann-fold domain for mono­oxygenase activity like MICAL1. The FMO and CH domains of both MICAL3 and MICAL1 are highly similar in structure, but superimposition of the two structures shows a different relative position of the CH domain in the asymmetric unit. Based on kinetic analyses, the catalytic efficiency of MICAL3 dramatically increased on adding F-actin only when the CH domain was available. However, this did not occur when two residues, Glu213 and Arg530, were mutated in the FMO and CH domains, respectively. Overall, MICAL3 is structurally highly similar to MICAL1, which suggests that they may adopt the same catalytic mechanism, but the difference in the relative position of the CH domain produces a difference in F-actin substrate specificity.