Archives, Room Use Only - TK9946.H68 1914

Archives, Room Use Only - QC611.H46 1831

Archives, Room Use Only - VK381.B76 1917

Nearly 7,000 paramilitary forces have been deployed in the affected areas of the northeast district since Monday.

When humanity's away, the animals will play.With much of the world driven indoors to quarantine during the coronavirus pandemic lockdown, some species not often seen -- or, at least, rarely in such large numbers, and certainly not against such empty backdrops -- are exploring cities across the globe. We must sadly report that though there have been many circulating on social media, many of these optimistic posts have turned out to be fake -- there were no dolphins in Venice's celebrated canals, or drunken elephants ambling through China's Yunnan province.However, there are some other instances where animals have, in fact, come out to explore city streets.

I thought it would be fun to document the smallest possible valid HTML documents for each version, so here goes :)

Researchers develop an MS shotgun proteomic method to tackle small numbers of cancer cells in blood.

Researchers find that morphologically normal cells near a tumor have undergone molecular changes similar to the tumor cells.

The flight was received at a specially prepared bay at the Tiruchi International Airport.

Shriya Saran urges fans to help small businesses during the COVID-19 crisis

Lockdown effect: Retailers eye renegotiating contracts at malls

They are set to arrive at Kochi port today

Total fatalities stand at 3,739, while infections number 137,115. According to figures posted on Twitter by Health Minister Fahrettin Koca, 89,480 patients have recovered.

Most of the 698 Indians, of whom 440 are from Kerala, were stranded in the island country after they lost their jobs

We may be required to socially distance here in the physical world, but Alexandria Ocasio-Cortez is still making house calls-in Animal Crossing.

Passengers showing Covid-19 symptoms are being disembarked first, followed by others in small groups, district-wise, says a Cochin Port Trust official

This is the Indian Navy’s first massive evacuation exercise during the Covid-19 lockdown

This is the Indian Navy's first massive evacuation exercise from foreign soil during the COVID-19 lockdown.

Small-animal physiology studies are typically complicated, but the level of complexity is greatly increased when performing live-animal X-ray imaging studies at synchrotron and compact light sources. This group has extensive experience in these types of studies at the SPring-8 and Australian synchrotrons, as well as the Munich Compact Light Source. These experimental settings produce unique challenges. Experiments are always performed in an isolated radiation enclosure not specifically designed for live-animal imaging. This requires equipment adapted to physiological monitoring and test-substance delivery, as well as shuttering to reduce the radiation dose. Experiment designs must also take into account the fixed location, size and orientation of the X-ray beam. This article describes the techniques developed to overcome the challenges involved in respiratory X-ray imaging of live animals at synchrotrons, now enabling increasingly sophisticated imaging protocols.

A new diamond-anvil cell apparatus for in situ synchrotron X-ray diffraction measurements of liquids and glasses, at pressures from ambient to 5 GPa and temperatures from ambient to 1300 K, is reported. This portable setup enables in situ monitoring of the melting of complex compounds and the determination of the structure and properties of melts under moderately high pressure and high temperature conditions relevant to industrial processes and magmatic processes in the Earth's crust and shallow mantle. The device was constructed according to a modified Bassett-type hydro­thermal diamond-anvil cell design with a large angular opening (θ = 95°). This paper reports the successful application of this device to record in situ synchrotron X-ray diffraction of liquid Ga and synthetic PbSiO3 glass to 1100 K and 3 GPa.

Possibilities in auxiliary technique combinations with small- and wide-angle X ray scattering are described, as well as more complicated sample environments used in X-ray and neutron scattering.

A review of recent and ongoing development and results within the field of biological solution small-angle X-ray scattering (BioSAXS), with a focus on the increasing complexity of biological samples, data collection and data evaluation strategies.

Small earthquake recorded in Stirling on Christmas Day  Daily Record

UK Geothermal: boiling beneath the surface?  Power Technology

Green light for Cheshire geothermal energy research  BBC News

'Sonic boom' as small earthquake shakes Cornwall  ITV News

Protein–protein and protein–ligand interactions often involve conformational changes or structural rearrangements that can be quantified by solution small-angle X-ray scattering (SAXS). These scattering intensity measurements reveal structural details of the bound complex, the number of species involved and, additionally, the strength of interactions if carried out as a titration. Although a core part of structural biology workflows, SAXS-based titrations are not commonly used in drug discovery contexts. This is because prior knowledge of expected sample requirements, throughput and prediction accuracy is needed to develop reliable ligand screens. This study presents the use of the histidine-binding protein (26 kDa) and other periplasmic binding proteins to benchmark ligand screen performance. Sample concentrations and exposure times were varied across multiple screening trials at four beamlines to investigate the accuracy and precision of affinity prediction. The volatility ratio between titrated scattering curves and a common apo reference is found to most reliably capture the extent of structural and population changes. This obviates the need to explicitly model scattering intensities of bound complexes, which can be strongly ligand-dependent. Where the dissociation constant is within 102 of the protein concentration and the total exposure times exceed 20 s, the titration protocol presented at 0.5 mg ml−1 yields affinities comparable to isothermal titration calorimetry measurements. Estimated throughput ranges between 20 and 100 ligand titrations per day at current synchrotron beamlines, with the limiting step imposed by sample handling and cleaning procedures.

The crystal structure of the c-type cytochrome NirC from Pseudomonas aeruginosa has been determined and reveals the simultaneous presence of monomers and 3D domain-swapped dimers in the same asymmetric unit.

The title mol­ecule, C11H8F3NO3, adopts a cis configuration across the –C=C– double bond in the side chain and the dihedral angle between the phenyl ring and side chain is 47.35 (1)°. The –COOH group adopts a syn conformation (O=C—O—H = 0°), unlike the anti conformation observed in related maleamic acids. In the crystal, inversion dimers linked by pairs of O—H⋯O hydrogen bonds are connected via N—H⋯O hydrogen bonds and C—H⋯O inter­actions into (100) sheets, which are cross-linked by another C—H⋯O inter­action to result in a three-dimensional network. The Hirshfeld surface fingerprint plots show that the highest contribution to surface contacts arises from O⋯H/H⋯O contacts (26.5%) followed by H⋯F/F⋯H (23.4%) and H⋯H (17.3%).

The asymmetric unit of the title compound, [Fe(NCS)2(C12H9NO)4], consists of an FeII ion that is located on a centre of inversion, as well as two 4-benzoyl­pyridine ligands and one thio­cyanate anion in general positions. The FeII ions are coordinated by two N-terminal-bonded thio­cyanate anions and four 4-benzoyl­pyridine ligands into discrete complexes with a slightly distorted octa­hedral geometry. These complexes are further linked by weak C—H⋯O hydrogen bonds into chains running along the c-axis direction. Upon heating, this complex loses half of the 4-benzoyl­pyridine ligands and transforms into a compound with the composition Fe(NCS)2(4-benzoyl­pyridine)2, that might be isotypic to the corresponding MnII compound and for which the structure is unknown.

In the crystal structure of the title com­pound, [Ni(NCS)2(CH3CN)2(C12H9NO)2] or Ni(NCS)2(4-benzoyl­pyridine)2(aceto­nitrile)2, the NiII ions are octa­hedrally coordinated by the N atoms of two thio­cyanate anions, two 4-benzoyl­pyridine ligands and two aceto­nitrile mol­ecules into discrete com­plexes that are located on centres of inversion. In the crystal, the discrete com­plexes are linked by centrosymmetric pairs of weak C—H⋯S hydrogen bonds into chains. Thermogravimetric measurements prove that, upon heating, the title com­plex loses the two aceto­nitrile ligands and transforms into a new crystalline modification of the chain com­pound [Ni(NCS)2(4-benzoyl­pyridine)2], which is different from that of the corresponding CoII, NiII and CdII coordination polymers reported in the literature. IR spectroscopic investigations indicate the presence of bridging thio­cyanate anions but the powder pattern cannot be indexed and, therefore, this structure is unknown.

After crystallization during ionothermal syntheses in phospho­nium-containing ionic liquids, the structure of (NH4)3Al2(PO4)3 [tri­ammonium dialuminum tris­(phosphate)] was refined on the basis of powder X-ray diffraction data from a synchrotron source. (NH4)3Al2(PO4)3 is a member of the structural family with formula A3Al2(PO4)3, where A is a group 1 element, and of which the NH4, K, and Rb forms were previously known. The NH4 form is isostructural with the K form, and was previously solved from single-crystal X-ray data when the material (SIZ-2) crystallized from a choline-containing eutectic mixture [Cooper et al. (2004). Nature, 430, 1012–1017]. Our independent refinement incorporates NH4 groups and shows that these NH4 groups are hydrogen bonded to framework O atoms present in rings containing 12 T sites in a channel along the c-axis direction. We describe structural details of (NH4)3Al2(PO4)3 and discuss differences with respect to isostructural forms.