Scientists map ancient underwater landslides in the region chosen for Jakarta's replacement.

It wasn’t the typical retirement ceremony at the headquarters of the London Police Service on Dundas Street Friday.

The Middlesex-London Health Unit is reporting that a man in his 40s has died from COVID-19.

Grim new evidence that temporary closures and pandemic-related layoffs are hammering the local job market.

Routh's return as Superman was as healing as it was unexpected: "It was almost more special than the first time."

Zimbabwe market stall owner Aaron Makaya saw a business opportunity when President Emmerson Mnangagwa made face masks mandatory in public places to prevent the spread of coronavirus.

Police made a number of arrests and issued fines as they broke up a small anti-lockdown protest in central London.

HOUSE OF THE WEEK | Former mayor Tom Rust knew what he wanted to build and where he wanted to build it.

The new parents showed up at the first official MLB game in Europe on Saturday.

The presidential election is closer than you think, but thus far the celebrities are staying pretty far away.

The Digital Development Group foresees dynamic growth in its industry. “On Nov. 21st we launched our first channel. We are excited to announce 5 more channels coming before year-end. On the heels of those developments we believe it is important to continue to define our mission.”

DigiDev is targeting the revolutionary “OTT” technology arena. “OTT” or Over The Top devices piggyback on existing network services in consumers’ homes or offices; pull content from the Internet and deliver it to their TV or Internet enabled device. DigiDev uses OTT technology to deliver programming to billions of desktops, mobile and smart/Internet enabled TV devices around the world.

“The market for digital distribution to 'smart' (Internet enabled) devices (smart-TV, tablet, smart-phones) continues to grow at an astonishing rate,” states Martin W. Greenwald, Chairman and CEO of DigiDev. “AppleTV, GoogleTV, and Roku sales this Holiday season are running considerably ahead of last year’s tally.”

Need to open a Numbers file but you’re on a Windows PC? No problem, you can use iCloud to access, edit, and open Numbers files, even if you don’t have an iPhone, iPad, or Mac with an official Numbers app handy. Today, we live in an era where people own multiple devices that are powered ... Read More

MacOS Catalina introduced a handy way to tile windows for multitasking, improving upon the split screen multitasking features that were available in previous MacOS releases. These new simple tiling window multitasking options are available from any window, and now you can easily choose to tile a window to the left or right side of the ... Read More

strataconf: RT @synergicpartner: We are pleased to announce that we will sponsor next #strataconf in London!!! @strataconf @synergicpartner #BigData ht…

London, England

The Amateur Traveler talks to Sam Oppenheim who makes a rare 4th appearance on the show to talk about Bali in Indonesia. Sam started his exploration of Bali in Ubud which is the cultural capital of the area. He met two of the people mentioned in the popular book Eat, Pray, Love: Wayan and Ketut Liyer. In Ubud he attended some of the traditional Balinese dances (Legong, Barong and Kecak). Sam explored the Hindu temples and the resort area of Kuta Beach with its famous nightlife, dove a ship wreck and explored the island by motorcycle. Sam’s does regret was not getting down to Nusa Dua on the southern tip with its wonderful sunsets or out to Komodo.

The Amateur Traveler talks to Lash from LashWorldTour.com about the Island of Java in the nation of Indonesia. She cycled through the countryside and visited the major cities of this populous island in Indonesia.

The Amateur Traveler talks to to Gary Arndt about the 4 micro-states in Europe: Andorra, Liechtenstein, Monaco, San Marino.  "They all have very unique histories and the one thing that they are all very small"

The Amateur Traveler talks to Amber, an American Tour Guide in London, about her adopted city. Amber is an American expat from London who now takes people on walking tours of London.

Hear about travel to London as the Amateur Traveler talks to Amber from americantourguideinlondon.com. In this second part of a two part episode on London

Hear about travel to Indonesia as the Amateur Traveler talks to repeat guest Chris Willis about his trip to Indonesia. The main objective of Chris’s trip was to photograph Komodo dragons in the wild. Komodo dragons live on 2-3 islands which are not near any airport so getting there is half the experience.

Hear about travel to Orlando, Florida as the Amateur Traveler talks to Jason Cochran who is the editor of Frommers.com and the editor to the Frommer's Guide to Orlando Florida about vacationing in America's favorite destination spot. We talk about Walt Disney World, the increasingly popular Universal Studios, with a mention of some of the other things to do in Orlando.

Hear about hiking Japan's Nakasendo Trail as the Amateur Traveler talks to Dave Grenewetzki about his experiences on this trip into the Japanese countryside between Kyoto and Tokyo.

Hear about travel to Lombok in Indonesia as the Amateur Traveler talks to Jason Andrew Jenkins from AnEpicEducation.com about his family's recent 5 week trip to this island paradise.

Hear about travel to the island of Sumatra in Indonesia as the Amateur Traveler talks to Luke Mackin from wildsumatra.com about this far-flung destination he now calls home.

Hear about visiting Universal Orlando Resort as the Amateur Traveler talks to Eric Stoen from travelbabbo.com about he and his kids favorite theme parks.

Hear about travel to Lombok in Indonesia as the Amateur Traveler talks to Jason Andrew Jenkins from AnEpicEducation.com about his family's recent 5 week trip to this island paradise.

If you love to travel and have a few million spare dollars, you can buy a condo on any of several luxury cruise ships and live there year-round, taking your home with you as you sail around the world.

A man is in custody following a six-hour standoff in eastern Prince Edward Island that started when police responded to a domestic dispute that quickly escalated when officers learned the suspect could be armed.

Salomon Rondon says he was on his way to joining Manchester United in January only for Dalian Professional to block the move.

Spotify will gain more than 10 million US listeners in 2020   February 25, 2020 (New York, NY) – Pandora is no longer the most popular music streaming service in the […]

Research Event

Event participants

David Roberts, Assistant Professor and School of Security Studies Lead for Regional Security and Development, King's College London
Kristian Coates Ulrichsen, Associate Fellow, Middle East and North Africa Programme, Chatham House
Chair: Sanam Vakil, Deputy Director and Senior Research Fellow, Middle East and North Africa Programme, Chatham House

Chatham House is pleased to announce the speaker line-up for its second annual London Conference, at Lancaster House on 1-2 June 2015. 

The ribosome biogenesis factor Las1 is an essential endoribonuclease that is well-conserved across eukaryotes and a newly established member of the higher eukaryotes and prokaryotes nucleotide-binding (HEPN) domain-containing nuclease family. HEPN nucleases participate in diverse RNA cleavage pathways and share a short HEPN nuclease motif (RφXXXH) important for RNA cleavage. Most HEPN nucleases participate in stress-activated RNA cleavage pathways; Las1 plays a fundamental role in processing pre-rRNA. Underscoring the significance of Las1 function in the cell, mutations in the human LAS1L (LAS1-like) gene have been associated with neurological dysfunction. Two juxtaposed HEPN nuclease motifs create Las1's composite nuclease active site, but the roles of the individual HEPN motif residues are poorly defined. Here using a combination of in vivo experiments in Saccharomyces cerevisiae and in vitro assays, we show that both HEPN nuclease motifs are required for Las1 nuclease activity and fidelity. Through in-depth sequence analysis and systematic mutagenesis, we determined the consensus HEPN motif in the Las1 subfamily and uncovered its canonical and specialized elements. Using reconstituted Las1 HEPN-HEPN' chimeras, we defined the molecular requirements for RNA cleavage. Intriguingly, both copies of the Las1 HEPN motif were important for nuclease function, revealing that both HEPN motifs participate in coordinating the RNA within the Las1 active site. We also established that conformational flexibility of the two HEPN domains is important for proper nuclease function. The results of our work reveal critical information about how dual HEPN domains come together to drive Las1-mediated RNA cleavage.

8 January 2020 , Volume 96, Number 1

8 January 2020 , Volume 96, Number 1

8 January 2020 , Volume 96, Number 1

8 January 2020 , Volume 96, Number 1

8 January 2020 , Volume 96, Number 1

8 January 2020 , Volume 96, Number 1

8 January 2020 , Volume 96, Number 1

8 January 2020 , Volume 96, Number 1

8 January 2020 , Volume 96, Number 1

8 January 2020 , Volume 96, Number 1

6 November 2019 , Volume 96, Number 1

The first issue of International Affairs in 2020 explores the geopolitics of the 'Indo-Pacific' region.

Research Event

Event participants

David Roberts, Assistant Professor and School of Security Studies Lead for Regional Security and Development, King's College London
Kristian Coates Ulrichsen, Associate Fellow, Middle East and North Africa Programme, Chatham House
Chair: Sanam Vakil, Deputy Director and Senior Research Fellow, Middle East and North Africa Programme, Chatham House

Nica M. Borradaile
Dec 1, 2006; 47:2726-2737
Research Articles

Thursday 19 and Friday 20 November 2020, St. Pancras Renaissance Hotel

One hundred years since its founding in 1920, Chatham House continues to foster mutual understanding between nations through rigorous debate, trusted dialogue, independent analysis and influential ideas. 

Since its launch in 2014, the London Conference, the institute’s annual flagship event, has established itself as a principal international forum where global connectivity can be explored and better understood drawing an internationally diverse and multigenerational gathering of participants and offering positive solutions to global challenges.

This year, drawing on the theme of Imagining Alternatives: Solutions for the World Beyond 2020, the London Conference 2020 will form the central pillar in the institute’s programme to mark its centenary throughout 2020. 

This year’s agenda focuses on the changing nature of geopolitics and the global economy through the lens of our core research themes – sustainable and equitable growth, preventing conflict and improving the rules-based order. Each theme seeks opportunities for positive policy change, with emphasis on the impact of technological change, and a keen focus on empowering the next generation.