The main purpose of this paper is to study and characterize the existing of general asymptotic regional gradient observer which observe the current gradient state of the original system in connection with gradient strategic sensors. Thus, we give an approach based to Luenberger observer theory of linear distributed parameter systems which is enabled to determinate asymptotically regional gradient estimator of current gradient system state. More precisely, under which condition the notion of asymptotic regional gradient observability can be achieved. Furthermore, we show that the measurement structures allows the existence of general asymptotic regional gradient observer and we give a sufficient condition for such asymptotic regional gradient observer in general case. We also show that, there exists a dynamical system for the considered system is not general asymptotic gradient observer in the usual sense, but it may be general asymptotic regional gradient observer. Then, for this purpose we present various results related to different types of sensor structures, domains and boundary conditions in two dimensional distributed diffusion systems

Event-related desynchronization and synchronization (ERD/S) and movement-related cortical potential (MRCP) play an important role in brain-computer interfaces (BCI) for lower limb rehabilitation, particularly in standing and sitting. However, little is known about the differences in the cortical activation between standing and sitting, especially how the brain's intention modulates the pre-movement sensorimotor rhythm as they do for switching movements. In this study, we aim to investigate the decoding of continuous EEG rhythms during action observation (AO), motor imagery (MI), and motor execution (ME) for standing and sitting. We developed a behavioral task in which participants were instructed to perform both AO and MI/ME in regard to the actions of sit-to-stand and stand-to-sit. Our results demonstrated that the ERD was prominent during AO, whereas ERS was typical during MI at the alpha band across the sensorimotor area. A combination of the filter bank common spatial pattern (FBCSP) and support vector machine (SVM) for classification was used for both offline and pseudo-online analyses. The offline analysis indicated the classification of AO and MI providing the highest mean accuracy at 82.73$pm$2.38\% in stand-to-sit transition. By applying the pseudo-online analysis, we demonstrated the higher performance of decoding neural intentions from the MI paradigm in comparison to the ME paradigm. These observations led us to the promising aspect of using our developed tasks based on the integration of both AO and MI to build future exoskeleton-based rehabilitation systems.

Uncertain dynamic obstacles, such as pedestrians or vehicles, pose a major challenge for optimal robot navigation with safety guarantees. Previous work on motion planning has followed two main strategies to provide a safe bound on an obstacle's space: a polyhedron, such as a cuboid, or a nonlinear differentiable surface, such as an ellipsoid. The former approach relies on disjunctive programming, which has a relatively high computational cost that grows exponentially with the number of obstacles. The latter approach needs to be linearized locally to find a tractable evaluation of the chance constraints, which dramatically reduces the remaining free space and leads to over-conservative trajectories or even unfeasibility. In this work, we present a hybrid approach that eludes the pitfalls of both strategies while maintaining the original safety guarantees. The key idea consists in obtaining a safe differentiable approximation for the disjunctive chance constraints bounding the obstacles. The resulting nonlinear optimization problem is free of chance constraint linearization and disjunctive programming, and therefore, it can be efficiently solved to meet fast real-time requirements with multiple obstacles. We validate our approach through mathematical proof, simulation and real experiments with an aerial robot using nonlinear model predictive control to avoid pedestrians.

In this paper, some useful necessary and sufficient conditions for the unique solution of the generalized absolute value equation (GAVE) $Ax-B|x|=b$ with $A, Bin mathbb{R}^{n imes n}$ from the optimization field are first presented, which cover the fundamental theorem for the unique solution of the linear system $Ax=b$ with $Ain mathbb{R}^{n imes n}$. Not only that, some new sufficient conditions for the unique solution of the GAVE are obtained, which are weaker than the previous published works.

Traffic isn’t great, online sales are even worse, and let’s not talk about the lack of phone calls. Everyone, including you, is wondering the same thing — is your website a failure? Not yet, and not if you have anything to say about it. While a failing website can seem like a problem without a […]

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Does your website feature design straight out of the ’90s and functionality from the stone age? If so, it’s time for an upgrade — and WebFX can help. When it comes to website redesign checklists, we’re at the top of our game, and we know how to get things done. But where do you start […]

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In this article, we'll explore 10 quick and easy ways to improve your site's accessibility.

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Are you looking to generate more leads and revenue with your website? If so, it’s time to consider web design for lead generation to help you create a website that caters to your audience and encourages them to become leads for your business.  On this page, we’ll provide you with five lead generation website design […]

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Subscribe to our YouTube channel for the latest in digital marketing! we know you’ll love this additional resource! (how to host a website)   Transcript: What is website hosting?  This is to make a point, I promise.  When you go to a party, there’s always a host. The host is usually the one who sets […]

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Are you looking for a content management system (CMS) that will help you create the digital content you need? With so many options on the market, it’s challenging to know which one is the best CMS software for your business. On this page, we’ll take a look at the six best CMS’s for website development […]

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Subscribe to our YouTube channel for the latest in digital marketing! Transcript: Your website isn’t set in stone, so you shouldn’t treat it like it is.  Technology and the internet change quickly, and often. You should update your website regularly to keep up with the times. Having an up-to-date and optimized site creates a great […]

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If you’re looking to grow your business online, it’s time to start setting up different types of website conversions to help your company succeed. Whether you’re looking to earn more email subscribers or sell more products, you can set conversion goals that grow your business. On this page, we’ll discuss what a conversion goal is, […]

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What do Amazon, Hershey’s, and The Wall Street Journal have in common? They’ve all gotten named in lawsuits related to website accessibility and the Americans with Disabilities Act (ADA). They aren’t alone, either. In 2018, more than 2000 website accessibility lawsuits (a 177% increase from 2017) got filed, emphasizing the increased importance and focus on […]

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As a small or midsize business (SMB), your company website is often the first touchpoint for potential clients — and you want it to make a great first impression. The secret to hitting home with your audience is to have a sophisticated and lively website design that’s aesthetically pleasing and provides great user experience (UX). […]

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When you’re trying to grow your business online, you must monitor vital metrics to ensure your business is growing. One important metric is your website’s conversions. Conversions help you determine if you’re driving success with your digital marketing campaigns. So, what is website conversion? How can you improve your website conversion rate? Keep reading to […]

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Are you looking to build a new site for your business? If so, company website design templates can help you create the website you want. With so many templates available, how do you determine which one is best for your business? On this page, we’ll provide you with the top six company website design templates, […]

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Are you looking to start 2020 with a fresh web design for your business? If so, you must know what you need to do in 2020 to have a website that drives success for your business. With website statistics for 2020, you can see what to do and what to avoid, which will help you […]

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Did you know that over 70% of people will research a company on the web before deciding to buy or visit, yet 46% of small businesses in the U.S. don’t have a website? If you don’t have a site, people can’t research your company and determine if you’re a good fit for their needs. If […]

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Your website is your virtual business card and it often provides the first impression of your business to future customers — making it one of the most important aspects of your company. But if your website still has cobwebs from the 2000s, it’s time to put together a website redesign process. A website redesign process […]

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Need some inspiration to build a high converting website? Websites that convert persuade visitors to become customers. These websites drive more revenue, so if you want to increase your site’s revenue, use these examples of websites that convert as inspiration! We’ll go over what makes for the best converting websites and five examples of websites […]

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By Andrea Germanos Common Dreams On the heels of clean fuel milestones in Germany and Portugal , a new report finds that the renewable energy industry employed over 8.1 million people worldwide in 2015. According to the International Renewable Energy … Continue reading →

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The current application is directed to monitoring subsystems, and monitoring methods incorporated within the monitoring subsystems, that monitor operation of devices and systems in order to identify normal states and to quickly determine when a device or system transitions from a normal state to an abnormal state. The methods and monitoring components to which the current application is directed employ self-organizing maps and moving-average self-organizing maps to both characterize normal system behavior and to identify transitions to abnormal system behaviors.

Observation-based user profiling and profile matching are provided. The network behavior of users of a computer-implemented social network are observed and used for user profiling. By observing network behavior instead of necessarily relying on user self-reported data, accurate and objective user profiles can be formed; user profiling is accomplished based on the observed network behaviors with or without the knowledge of the user being profiled. The observed network behaviors can include the customization of a visual graphic, a media preference, a communication preference, or a selection of words from a word list. The user profiles can be with respect to a domain and two or more users can be matched based on their profiles with respect to the same domain. User ratings and profile updating based on the ratings are also provided.

The invention discloses quinoxaline derivatives or salts thereof having PDE9-inhibiting activity and being useful as treating agent of dysuria and the like, which are represented by the formula (I) in the formula, R1 and R2 each independently stands for hydrogen, halogen, alkyl, alkoxy, acyl, amino and the like,R3 stands for alkyl, aryl, saturated carbocyclic group, saturated heterocyclic group, acyl and the like,R4 stands for hydrogen, hydroxy, alkyl or amino,R5 and R8 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkoxy, cyano or nitro,R6 and R7 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, cyano, amino, carbocyclic group, heterocyclic group, COR9 or SO2R9,R9 stands for hydrogen, hydroxy, alkyl, amino, pyrrolidin-1-yl, piperidin-1-yl, pyperazin-1-yl or the like,X stands for S or O, andA1, A2 and A3 each independently stands for N or C.

The present invention provides 4,6-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same.

The invention relates to oxazolopyrimidine compounds of formula I, where A, R1 and R2 are defined as stated in the claims. The compounds of formula I are suitable, for example, for wound healing.

The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

This invention relates to novel 5-[(hydroxymethyl)aryl]-substituted pyrrolo[2,1-f][1,2,4]triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.

A composite sheet of the present invention comprises an oxetane-epoxy-based compound, represented by chemical formula 1, as a binder.

A primer solution for enhanced adhesion to a rigid substrate for aviation and aerospace applications includes an aminosilane-capped polyurethane prepolymer and a first solvent. The first solvent reacts with or modifies the surface of the rigid substrate, enabling the primer solution including the aminosilane-capped polyurethane prepolymer to become a part of the surface of the rigid substrate.

Titanocenes containing two 5-membered cyclodienyl groups, for example cyclopentadienyl, and one or two 6-membered carbocyclic or 5- or 6-membered heterocyclic aromatic rings which are substituted by a fluorine atom in at least one of the two ortho-positions to the titanium-carbon bond and contain, as a further substituent, unsubstituted or substituted 1-pyrryl, are suitable as photoinitiators for radiation-induced polymerization of ethylenically unsaturated compounds.

Beta-lactamase inhibiting compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition or carboxylate salt thereof; where n is zero, 1 or 2; X3 is H or Br, R1 is H, the residue of certain carboxy-protecting groups or the residue of an ester group readily hydrolyzable in vivo; one of R12 and R13 is H and the other is vinyl, certain aryl, alkylthio, alkylsulfonyl or certain heterocyclyl, aminomethyl, thiocarboxyamido or amidino groups; one of R2 and R3 is H and the other is as disclosed for the other of R12 and R13, or is Cl or CH2 OH, and R18 is H or certain acyl groups; intermediates useful in their production, methods for their preparation and use, and pharmaceutical compositions containing them.

The present invention relates to novel heterocycle-substituted diphosphonic acids, and the pharmaceutically-acceptable salts and esters thereof, in which the diphosphonate-substituted carbon atom moiety is attached to a carbon atom in a nitrogen-containing six membered ring heterocycle, preferably a piperidine ring. The heterocycle-substituted diphosphonic acid compounds have the general structure: ##STR1## wherein Z is a nitrogen-containing six membered ring heterocycle moiety selected from piperidinyl, diazinyl and triazinyl; m, n and m+n are from 0 to 10; Q is a covalent bond or a moiety selected from oxygen, sulfur or nitrogen; and R1, R2, R3 and R4 are substituent groups.The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.

Carbohydrate substituted dibenzo[d,g][1,3,2]dioxaphosphocin compounds of formula I ##STR1## where A is a carbohydrate residue are effective stabilizers for polymers processed at elevated temperatures and subject to thermal or oxidative degradation.

Carbohydrate substituted dibenzo[d,f][1,3,2]dioxaphosphepin compounds of formula I ##STR1## where A is a carbohydrate residue are effective stabilizers for polymers processed at elevated temperatures and subject to thermal or oxidative degradation.

A process for producing an alkali metal cyclopentadienylide is disclosed which comprises reacting in a solvent an alkali metal hydride with a disubstituted or trisubstituted 1,3-cyclopentadiene. Further, a process for producing a dihalobis(η-substituted-cyclopentadienyl)zirconium is disclosed which comprises reacting a zirconium halide with the above alkali metal cyclopentadienylide. The former process enables performing the reaction between the disubstituted or trisubstituted 1,3-cyclopentadiene and the alkali metal hydride at an easily controllable temperature of room temperature to about 150° C. and also enables obtaining the alkali metal cyclopentadienylide in high yield. The latter process enables obtaining the dihalobis(η-substituted-cyclopentadienyl)zirconium in high yield.

Polysubstituted cyclopentadiene compound wherein at least two different substituents are present from the group consisting of linear, branched and cyclic alkyls, aralkyls and alkenyls, and a process for the preparation of a cyclopentadiene compound substituted with at least two different groups chosen from the group consisting of linear, branched, cyclic and aromatic alkyls and alkenyls, characterized in that it comprises the reacting of a halide of a first substituting group in a mixture of the cyclopentadiene compound and an aqueous solution of a base, in which the quantity of the base relative to the cyclopentadiene compound is between 5 and 30 mol/mol, in the presence of a phase transfer catalyst, followed by the addition of a halide of a second or optionally a third substituting group to the reaction mixture.

The shape and number of surface defects are controlled so that the occurrence of failure is suppressed in an HDD device in which a magnetic head with a very small flying height, such as a DFH head, is mounted. A magnetic disk substrate is characterized in that when laser light with a wavelength of 405 nm and a laser power of 25 mW is irradiated with a spot size of 5 μm and scattered light from the substrate is detected, the number of defects detected to have a size of 0.1 μm to not more than 0.3 μm is less than 50 per 24 cm2 and, with respect to the defects, there is no defect in which, in a bearing curve obtained by a bearing curve plot method using an atomic force microscope, a portion from an apex of the defect to 45% thereof is located in an area of defect height higher than a virtual line connecting from the apex of the defect to 45% thereof.

A glass for a magnetic recording medium substrate permitting the realization of a magnetic recording medium substrate affording good chemical durability and having an extremely flat surface, a magnetic recording medium substrate comprised of this glass, a magnetic recording medium equipped with this substrate, and methods of manufacturing the same. The glass is an oxide glass not including As or F.

To provide a method for producing a magnetic disk, whereby a magnetic recording layer is formed at a high temperature. A method for producing a magnetic disk, which comprises a step of forming a magnetic recording layer on a glass substrate having a temperature of at least 550° C., wherein the glass substrate comprises, as represented by mol percentage, from 62 to 74% of SiO2, from 6 to 18% of Al2O3, from 2 to 15% of B2O3 and from 8 to 21%, in total, of at least one component selected from MgO, CaO, SrO and BaO, provided that the total content of the above seven components is at least 95%, and further contains less than 1%, in total, of at least one component selected from Li2O, Na2O and K2O, or contains none of these three components.

A photovoltaic cell, for example a thin-film photovoltaic cell, having a substrate glass made of aluminosilicate glass, has a glass composition which has SiO2 and Al2O3 as well as the alkali metal oxide Na2O and the alkaline earth oxides CaO, MgO, and BaO, and optionally further components. The glass composition includes 10 to 16 wt.-% Na2O, >0 to 1 to 10 wt.-% BaO, and the ratio of CaO:MgO is in the range of 0.5 to 1.7. The aluminosilicate glass used is crystallization stable because of the selected quotient of CaO/MgO and has a transformation temperature >580° C. and a processing temperature

To provide a glass ceramic body wherein the deterioration of the reflectance due to black coloration is suppressed, and the unevenness of the firing shrinkage is suppressed. A glass ceramic body comprising a glass matrix and alumina particles dispersed therein, wherein the glass matrix is not crystallized, a ceramic part composed of the dispersed alumina particles has an α-alumina crystal structure and a crystal structure other than the α-alumina crystal structure.

A substrate for p-Si TFT flat panel displays made of a glass having a high low-temperature-viscosity characteristic temperature and manufactured while avoiding erosion/wear of a melting tank during melting through direct electrical heating. The glass substrate comprises 52-78 mass % of SiO2, 3-25 mass % of Al2O3, 3-15 mass % of B2O3, 3-20 mass % of RO, wherein RO is total amount of MgO, CaO, SrO, and BaO, 0.01-0.8 mass % of R2O, wherein R2O is total amount of Li2O, Na2O, and K2O, and 0-0.3 mass % of Sb2O3, and substantially does not comprise As2O3, wherein the mass ratio CaO/RO is equal to or greater than 0.65, the mass ratio (SiO2+Al2O3)/B2O3 is in a range of 7-30, and the mass ratio (SiO2+Al2O3)/RO is equal to or greater than 5. A related method involves melting glass raw materials blended to provide the glass composition; a forming step of forming the molten glass into a flat-plate glass; and an annealing step of annealing the flat-plate glass.

A tempered glass substrate has a compression stress layer on a surface thereof, and has a glass composition comprising, in terms of mass %, 40 to 70% of SiO2, 12 to 21% of Al2O3, 0 to 3.5% of Li2O, 10 to 20% of Na2O, 0 to 15% of K2O, and 0 to 4.5% of TiO2, wherein the tempered glass substrate has a plate thickness of 1.5 mm or less, and an internal tensile stress in the tempered glass substrate is 15 to 150 MPa.

A process for the production of aromatics through the reforming of a hydrocarbon stream is presented. The process utilizes the differences in properties of components within the hydrocarbon stream to increase the energy efficiency. The differences in the reactions of different hydrocarbon components in the conversion to aromatics allows for different treatments of the different components to reduce the energy used in reforming process.

Bis-Phenol A (BPA) can now be replaced in industrial processes by BPA substitutes. The BPA substitutes can have structures that are derivatives of BPA. The BPA substitutes can be used in preparing epoxy composition, polycarbonate compositions, and polysulfonate compositions or for other uses in place of BPA.