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Increased normal zone propagation velocity in superconducting segments

There is described herein a superconducting segment and method of making same comprising one or several layers with very high electrical resistivity, acting as a current flow diverter when the current transfers from the superconductor to the stabilizer. The purpose of this current flow diverter is: i) to increase the contact resistance between the superconductor and the stabilizer, by reducing the contact area, and ii) to force the current to flow along a specific path, so as to increase momentarily the current density in a specific portion of the stabilizer. The consequence of i) and ii) is that heat generated at the extremities of the normal zone is increased and spread over a longer length along the superconducting segment, which increases the NZPV and thus, the uniformity of the quench.




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Script compliance and quality assurance based on speech recognition and duration of interaction

Apparatus and methods are provided for using automatic speech recognition to analyze a voice interaction and verify compliance of an agent reading a script to a client during the voice interaction. In one aspect of the invention, a communications system includes a user interface, a communications network, and a call center having an automatic speech recognition component. In other aspects of the invention, a script compliance method includes the steps of conducting a voice interaction between an agent and a client and evaluating the voice interaction with an automatic speech recognition component adapted to analyze the voice interaction and determine whether the agent has adequately followed the script. In yet still further aspects of the invention, the duration of a given interaction can be analyzed, either apart from or in combination with the script compliance analysis above, to seek to identify instances of agent non-compliance, of fraud, or of quality-analysis issues.




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Analysis filterbank, synthesis filterbank, encoder, de-coder, mixer and conferencing system

An embodiment of an analysis filterbank for filtering a plurality of time domain input frames, wherein an input frame comprises a number of ordered input samples, comprises a windower configured to generate a plurality of windowed frames, wherein a windowed frame comprises a plurality of windowed samples, wherein the windower is configured to process the plurality of input frames in an overlapping manner using a sample advance value, wherein the sample advance value is less than the number of ordered input samples of an input frame divided by two, and a time/frequency converter configured to provide an output frame comprising a number of output values, wherein an output frame is a spectral representation of a windowed frame.




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Decoding apparatus, decoding method, encoding apparatus, encoding method, and editing apparatus

A decoding apparatus (10) is disclosed which includes: a storing means (11) for storing encoded audio signals including multi-channel audio signals; a transforming means (40) for transforming the encoded audio signals to generate transform block-based audio signals in a time domain; a window processing means (41) for multiplying the transform block-based audio signals by a product of a mixture ratio of the audio signals and a first window function, the product being a second window function; a synthesizing means (43) for overlapping the multiplied transform block-based audio signals to synthesize audio signals of respective channels; and a mixing means (14) for mixing audio signals of the respective channels between the channels to generate a downmixed audio signal. Furthermore, an encoding apparatus is also disclosed which downmixes the multi-channel audio signals, encodes the downmixed audio signals, and generates the encoded, downmixed audio signals.




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Manner of pronunciation-influenced search results

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating search results. In one aspect, a method includes obtaining a transcription of a voice query, and data that identifies an accent of the voice query, submitting the transcription and the data that identifies the accent of the voice query to a search engine to generate one or more accent-influenced results of the voice query, and providing the accent-influenced results to a client device for display.




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Adaptive grouping of parameters for enhanced coding efficiency

The present invention is based on the finding that parameters including: a first set of parameters of a representation of a first portion of an original signal and a second set of parameters of a representation of a second portion of the original signal can be efficiently encoded when the parameters are arranged in a first sequence of tuples and a second sequence of tuples. The first sequence of tuples includes tuples of parameters having two parameters from a single portion of the original signal and the second sequence of tuples includes tuples of parameters having one parameter from the first portion and one parameter from the second portion of the original signal. A bit estimator estimates the number of necessary bits to encode the first and the second sequence of tuples. Only the sequence of tuples, which results in the lower number of bits, is encoded.




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Encoder, decoder and methods for encoding and decoding data segments representing a time-domain data stream

An apparatus for decoding data segments representing a time-domain data stream, a data segment being encoded in the time domain or in the frequency domain, a data segment being encoded in the frequency domain having successive blocks of data representing successive and overlapping blocks of time-domain data samples. The apparatus includes a time-domain decoder for decoding a data segment being encoded in the time domain and a processor for processing the data segment being encoded in the frequency domain and output data of the time-domain decoder to obtain overlapping time-domain data blocks. The apparatus further includes an overlap/add-combiner for combining the overlapping time-domain data blocks to obtain a decoded data segment of the time-domain data stream.




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Audio encoder, audio decoder, methods for encoding and decoding an audio signal, and a computer program

An encoder for providing an audio stream on the basis of a transform-domain representation of an input audio signal includes a quantization error calculator configured to determine a multi-band quantization error over a plurality of frequency bands of the input audio signal for which separate band gain information is available. The encoder also includes an audio stream provider for providing the audio stream such that the audio stream includes information describing an audio content of the frequency bands and information describing the multi-band quantization error. A decoder for providing a decoded representation of an audio signal on the basis of an encoded audio stream representing spectral components of frequency bands of the audio signal includes a noise filler for introducing noise into spectral components of a plurality of frequency bands to which separate frequency band gain information is associated on the basis of a common multi-band noise intensity value.




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Thought recollection and speech assistance device

Some embodiments of the inventive subject matter include a method for detecting speech loss and supplying appropriate recollection data to the user. Such embodiments include detecting a speech stream from a user, converting the speech stream to text, storing the text, detecting an interruption to the speech stream, wherein the interruption to the speech stream indicates speech loss by the user, searching a catalog using the text as a search parameter to find relevant catalog data and, presenting the relevant catalog data to remind the user about the speech stream.




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System and methods for matching an utterance to a template hierarchy

A system and methods for matching at least one word of an utterance against a set of template hierarchies to select the best matching template or set of templates corresponding to the utterance. Certain embodiments of the system and methods determines at least one exact, inexact, and partial match between the at least one word of the utterance and at least one term within the template hierarchy to select and populate a template or set of templates corresponding to the utterance. The populated template or set of templates may then be used to generate a narrative template or a report template.




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Multi-resolution switched audio encoding/decoding scheme

An audio encoder for encoding an audio signal has a first coding branch, the first coding branch comprising a first converter for converting a signal from a time domain into a frequency domain. Furthermore, the audio encoder has a second coding branch comprising a second time/frequency converter. Additionally, a signal analyzer for analyzing the audio signal is provided. The signal analyzer, on the hand, determines whether an audio portion is effective in the encoder output signal as a first encoded signal from the first encoding branch or as a second encoded signal from a second encoding branch. On the other hand, the signal analyzer determines a time/frequency resolution to be applied by the converters when generating the encoded signals. An output interface includes, in addition to the first encoded signal and the second encoded signal, a resolution information identifying the resolution used by the first time/frequency converter and used by the second time/frequency converter.




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Apparatus and method for encoding and decoding an audio signal using an aligned look-ahead portion

An apparatus for encoding an audio signal having a stream of audio samples has: a windower for applying a prediction coding analysis window to the stream of audio samples to obtain windowed data for a prediction analysis and for applying a transform coding analysis window to the stream of audio samples to obtain windowed data for a transform analysis, wherein the transform coding analysis window is associated with audio samples within a current frame of audio samples and with audio samples of a predefined portion of a future frame of audio samples being a transform-coding look-ahead portion, wherein the prediction coding analysis window is associated with at least the portion of the audio samples of the current frame and with audio samples of a predefined portion of the future frame being a prediction coding look-ahead portion, wherein the transform coding look-ahead portion and the prediction coding look-ahead portion are identically to each other or are different from each other by less than 20%; and an encoding processor for generating prediction coded data or for generating transform coded data.




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Time warp contour calculator, audio signal encoder, encoded audio signal representation, methods and computer program

A time warp contour calculator for use in an audio signal decoder receives an encoded warp ratio information, derives a sequence of warp ratio values from the encoded warp ratio information, and obtains warp contour node values starting from a time warp contour start value. Ratios between the time warp contour node values and the time warp contour starting value are determined by the warp ratio values. The time warp contour calculator computes a time warp contour node value of a given time warp contour node, on the basis of a product-formation having a ratio between the time warp contour node values of the intermediate time warp contour node and the time warp contour starting value and a ratio between the time warp contour node values of the given time warp contour node and of the intermediate time warp contour node as factors.




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Error concealment method and apparatus for audio signal and decoding method and apparatus for audio signal using the same

An error concealment method and apparatus for an audio signal and a decoding method and apparatus for an audio signal using the error concealment method and apparatus. The error concealment method includes selecting one of an error concealment in a frequency domain and an error concealment in a time domain as an error concealment scheme for a current frame based on a predetermined criteria when an error occurs in the current frame, selecting one of a repetition scheme and an interpolation scheme in the frequency domain as the error concealment scheme for the current frame based on a predetermined criteria when the error concealment in the frequency domain is selected, and concealing the error of the current frame using the selected scheme.




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Method for configuring displets for an interactive platform for analyzing a computer network performance

A method for configuring an interactive platform for monitoring the performance and the quality of a computer network, the monitoring data being suitable to be displayed on a dynamic page of type webpage in a form of graphic components called “displets”; including providing, on the interactive platform a configuration interface in which are defined, for at least one given user, filtering criteria for displaying displets, the criteria being defined in the form of parameters for configuring the rights of the at least one user.




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Multi-lane time-synched visualizations of machine data events

A visualization can include a set of swim lanes, each swim lane representing information about an event type. An event type can be specified, e.g., as those events having certain keywords and/or having specified value(s) for specified field(s). The swim lane can plot when (within a time range) events of the associated event type occurred. Specifically, each such event can be assigned to a bucket having a bucket time matching the event time. A swim lane can extend along a timeline axis in the visualization, and the buckets can be positioned at a point along the axis that represents the bucket time. Thus, the visualization may indicate whether events were clustered at a point in time. Because the visualization can include a plurality of swim lanes, the visualization can further indicate how timing of events of a first type compare to timing of events of a second type.




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User interface with enlarged icon display of key function

To improve the consumer experience with portable electronic devices, a user interface combines the use of capacitive sensors with tactile sensors in an input device. When a user places a finger, stylus, or other input instrument near a given key button, a capacitive sensor causes the display to display temporarily an indication of the function of that key in an enlarged format. The user may then press the associated key button to activate the desired function. In one exemplary embodiment, the capacitive sensor fixes the functionality to the function indicated in the display. In this embodiment, a tactile input applied to any key, whether the correct key, multiple keys, or a single incorrect key, results in activating the function indicated in the display as a result of the capacitive input.




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Device, method, and graphical user interface for managing concurrently open software applications

A method includes displaying a first application view. A first input is detected, and an application view selection mode is entered for selecting one of concurrently open applications for display in a corresponding application view. An initial group of open application icons in a first predefined area and at least a portion of the first application view adjacent to the first predefined area are concurrently displayed. The initial group of open application icons corresponds to at least some of the concurrently open applications. A gesture is detected on a respective open application icon in the first predefined area, and a respective application view for a corresponding application is displayed without concurrently displaying an application view for any other application in the concurrently open applications. The open application icons in the first predefined area cease to be displayed, and the application view selection mode is exited.




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System and method for functional elements

Systems and methods whereby, for example, one or more functional elements can be established and/or employed. Such functional elements might serve a number of purposes. For instance, such functional elements might be employable in interoperating with devices, software, and/or the like, in working with entities, and/or the like. Such functional elements may, for example, be arrangeable in an associative and/or hierarchical manner.




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Isocyanate and isothiocyanate compounds for cancer treatment

The present invention relates to novel isocyanate and isothiocyanate compounds, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans and animals. The novel isocyanate and isothiocyanate compounds are distinguished, as compared with the known isocyanate and isothiocyanate compounds, by improved therapeutical breadth, i.e. fewer side effects while having high anti-tumor activity.




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Aliphatic polycarbonate quench method

The present disclosure is directed to, in part, an aliphatic polycarbonate polymerization reaction initiated by combining an epoxide with carbon dioxide in the presence of a catalytic transition metal-ligand complex to form a reaction mixture, and further quenching that polymerization reaction by contacting the reaction mixture with an acid containing a non-nucleophilic anion produces a crude polymer solution with improved stability and processability.




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System and method for using state replication between application instances to provide a collaborative desktop environment

Described herein are systems and methods for enabling a collaborative remote desktop environment. The system includes a computing device and a first application instance that has an application state associated therewith. The first application instance includes, or is associated with, a current state component and application data/data files. The system further includes an application launcher that is used to instantiate a second application instance operating either on the same or on a different computing device. The second application instance similarly has an application state associated therewith and is associated with the application launcher. Upon receiving a request from the second user to interact with the first application instance, the application state and the application data/data files are communicated to the application launcher, and the application launcher instantiates the second application instance so that its state is substantially identical to that of the first application instance.




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Policy control for encapsulated data flows

Systems and methodologies are described that facilitate communicating encapsulation information for a related mobility protocol type utilized in communicating over a data flow with reduced specific implementation on the policy server to support different mobility protocol types. In this regard, encapsulation information can be transmitted to the policy server from a network gateway such that the policy server can forward the encapsulation information to a serving gateway along with policy rules related to a data flow type. The serving gateway can utilize the encapsulation information to detect and interpret the encapsulated data flow according to the policy rules. In this regard, the serving gateway can provide support (e.g., quality of service support) for the flow. The encapsulation information can relate to a mobility protocol type, an encapsulation header, an indication that encapsulation is required, parameters regarding locating an encapsulation header in a message, and/or the like.




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System and method for supporting video processing load balancing for user account management in a computing environment

A system and method can support user account management in a computing environment. The computing environment can include a video encoding pool to support load balancing and a managing server, such as a privileged account manager server. The video encoding pool includes a set of nodes that are able to perform one or more video processing tasks for another node. Furthermore, the managing server can receive a request from a managed node in the computing environment for delegating a video processing task, and can select one or more nodes from the video encoding pool to load babalance and to perform the video processing task.




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Watch case including a sintered caseband

The watch case of this invention includes a caseband (2) made from sintered material and a back cover (10) secured to the caseband by means of at least two pins (12). Each pin passes through a first hole (14) provided in a first projection (16) formed in the caseband and two second holes (13, 15) provided respectively in two second projections (17, 18) formed in the back cover, said second projections being arranged respectively on either side of said first projection. Each pin being axially retained in its holes by the elastic effect provided by the seal when the caseband lies on the back cover.




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Arrangement for automatically switching a videorecorder on and off in the absence of a code signal but in presence of a FBAS signal

The disclosed device enables the recording of television broadcasts which are preprogrammed in a memory. The presence of data lines of the television signal in combination with the presence of a color television signal is checked. When the data lines stop, the video recorder is switched on in real time by a clock time signal.




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Device and method for providing accurate time and/or frequency

A device and method provide for an accurate output from a unit, such as an oscillator and/or clock providing an output indicative of frequency and/or time. The device includes a processing section having a microprocessor that develops a model characterizing the performance of the device, including establishing predicted accuracy variations, and the model is then used to correct the unit output. An external reference is used to provide a reference input for updating the model, including updating of predicted variations of the unit, by comparison of the reference input with the unit output. The ability of the model to accurately predict the performance of the unit improves as additional updates are carried out, and this allows the interval between the updates to be lengthened and/or the overall accuracy of the device to be improved. The accuracy of the output is thus adaptively optimized in the presence of systematic and random variations.




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Radio paging selective receiver with display for notifying presence of unread message based on time of receipt

A radio paging selective receiver determines that a received message is unread based on the time difference between the message reception time and the current time being larger that some predetermined value of time, and the paging selective receiver provides an indication of the unread message by displaying the reception time of the unread message in a second fashion which is visibly different from a first fashion normally used to display the current time.




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Electronic postage meter system having plural clock system providing enhanced security

A system includes a system time counter associated with a micro controller and a secure clock module having a real time clock and an elapsed time counter. The system synchronizes operation between the secure clock module and the system time counter. The synchronized time entered into the system time counter is utilized in the operation of the system. The real time clock time can be caused to be entered into the elapsed time counter at certain point in the operation of the system. The relationship of the time provide enhanced systems security.




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Equatorial sundial apparatus utilizing one or more concave cylindrical focusing mirrors

An equatorial sundial apparatus with an adjustable base assembly utilizing one or more concave cylindrical focusing mirrors. One of the benefits that is derived from this apparatus is the use of one or more concave cylindrical mirrors to project a focused beam of light onto a calibrated surface from which the time can be read. This sundial has the additional benefit of not suffering from blurring of the time indicator in a shadow or non-focused beam of light typical of other sundials. This sundial's focused light forms a sharply demarcated indicator from which time can be read to the minute. A further benefit of this apparatus is the ability to incorporate multiple concave cylindrical focusing mirrors to reduce the size of the visual field or screen where the time is read and to incorporate various shapes and designs for ornamental purposes without significant compromise of the sundials accuracy for telling time. An additional benefit of this apparatus is the ability to quickly, accurately and easily adjust the apparatus to the proper tilt upon setup according to the latitude where it will be located by means of an adjustable base assembly.




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Method and device for synchronizing integrated circuits

A method and device for synchronizing the time between at least two integrated circuits (201, 202), which receive the same pulse signal. In the integrated circuits (201, 202) a counter (204, 206) is used to count the number of pulses in the received pulse signal to synchronize the common time between said integrated circuits.




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Lighter and method for eliminating smoking that includes interactive self-learning software

Smoking cessation lighter is configured for lighting cigarettes for a smoker, and learning software is provided for monitoring smoking behavior of a smoker during a first data collection period and guiding a smoker's smoking cessation by directing the smoker when the smoker is to smoke a cigarette based on data collected during the first data collection period. The learning software monitors user behavior and collects data during use of the lighter by the smoker after the initial data collection period in order to analyze and further guide the smoker based on the smoker's cheating behavior, the smoker's behavior of lighting a cigarette for a friend, and the smoker's behavior of skipping use of the lighter at a time when the smoker has been directed to light a cigarette by the lighter.




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Cache policies for uncacheable memory requests

Systems, processors, and methods for keeping uncacheable data coherent. A processor includes a multi-level cache hierarchy, and uncacheable load memory operations can be cached at any level of the cache hierarchy. If an uncacheable load misses in the L2 cache, then allocation of the uncacheable load will be restricted to a subset of the ways of the L2 cache. If an uncacheable store memory operation hits in the L1 cache, then the hit cache line can be updated with the data from the memory operation. If the uncacheable store misses in the L1 cache, then the uncacheable store is sent to a core interface unit. Multiple contiguous store misses are merged into larger blocks of data in the core interface unit before being sent to the L2 cache.




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Single instance buffer cache method and system

Provided is a method and system for reducing duplicate buffers in buffer cache associated with a storage device. Reducing buffer duplication in a buffer cache includes accessing a file reference pointer associated with a file in a deduplicated filesystem when attempting to load a requested data block from the file into the buffer cache. To determine if the requested data block is already in the buffer cache, aspects of the invention compare a fingerprint that identifies the requested data block against one or more fingerprints identifying a corresponding one or more sharable data blocks in the buffer cache. A match between the fingerprint of the requested data block and the fingerprint from a sharable data block in the buffer cache indicates that the requested data block is already loaded in buffer cache. The sharable data block in buffer cache is used instead thereby reducing buffer duplication in the buffer cache.




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Data bus efficiency via cache line usurpation

Embodiments of the current invention permit a user to allocate cache memory to main memory more efficiently. The processor or a user allocates the cache memory and associates the cache memory to the main memory location, but suppresses or bypassing reading the main memory data into the cache memory. Some embodiments of the present invention permit the user to specify how many cache lines are allocated at a given time. Further, embodiments of the present invention may initialize the cache memory to a specified pattern. The cache memory may be zeroed or set to some desired pattern, such as all ones. Alternatively, a user may determine the initialization pattern through the processor.




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Distributed cache coherency protocol

Systems, methods, and other embodiments associated with a distributed cache coherency protocol are described. According to one embodiment, a method includes receiving a request from a requester for access to one or more memory blocks in a block storage device that is shared by at least two physical computing machines and determining if a caching right to any of the one or more memory blocks has been granted to a different requester. If the caching right has not been granted to the different requester, access is granted to the one or more memory blocks to the requester.




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Prefetch optimizer measuring execution time of instruction sequence cycling through each selectable hardware prefetch depth and cycling through disabling each software prefetch instruction of an instruction sequence of interest

A prefetch optimizer tool for an information handling system (IHS) may improve effective memory access time by controlling both hardware prefetch operations and software prefetch operations. The prefetch optimizer tool selectively disables prefetch instructions in an instruction sequence of interest within an application. The tool measures execution times of the instruction sequence of interest when different prefetch instructions are disabled. The tool may hold hardware prefetch depth constant while cycling through disabling different prefetch instructions and taking corresponding execution time measurements. Alternatively, for each disabled prefetch instruction in the instruction sequence of interest, the tool may cycle through different hardware prefetch depths and take corresponding execution time measurements at each hardware prefetch depth. The tool selects a combination of hardware prefetch depth and prefetch instruction disablement that may improve the execution time in comparison with a baseline execution time.




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Using extended asynchronous data mover indirect data address words

An abstraction for storage class memory is provided that hides the details of the implementation of storage class memory from a program, and provides a standard channel programming interface for performing certain actions, such as controlling movement of data between main storage and storage class memory or managing storage class memory.




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Using extended asynchronous data mover indirect data address words

An abstraction for storage class memory is provided that hides the details of the implementation of storage class memory from a program, and provides a standard channel programming interface for performing certain actions, such as controlling movement of data between main storage and storage class memory or managing storage class memory.




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Methanol carbonylation process with rhodium catalyst and a metallic co-catalyst selected from transition metals, zinc, beryllium, indium, tin, strontium and barium

A carbonylation process for making acetic acid using a metallic co-catalyst composition, effective as a rhodium stabilizer and/or rate promoter, at molar ratios of metal/rhodium of about 0.5 to 40. The process includes reacting methanol with carbon monoxide in the presence of a rhodium-based catalytic metal complex with about 1 to 20 weight percent methyl iodide, less than about 8 weight % water and about 0.5 to about 30 weight percent methyl acetate. The crude acetic acid is flashed and further purified.




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Method for increasing methionine productivity using a mixture of methyl mercaptan and dimethyl sulfide

The present invention relates to a method for increasing L-methionine productivity and organic acid productivity. More particularly, the present invention relates to a method which involves adding a mixture containing methyl mercaptan and dimethyl sulfide at a appropriate ratio to O-acetyl homoserine or O-succinyl homoserine and to an enzyme having an activity of converting methionine precursor into L-methionine, so as to perform an enzyme reaction, to thereby improve the conversion rate of L-methionine and organic acid from the L-methionine precursor, and thus increasing L-methionine yield as compared to conventional method.




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Composition for maintaining function of platelets

A composition for maintaining a function of platelets, the composition comprising, as an active ingredient, a compound represented by the following general formula (I) or a salt thereof, or a solvate thereof: wherein X represents a phenylene group;Y represents any one of a hydrogen atom and —(CH2)mR1;wherein m represents an integer of any one of 0 to 4; andR1 is any one of —NR5COR2, —NR5SO2R2, and —NR3R4;wherein R2 represents any one of a C1 to C6 alkyl group, an aryl group, a C1 to C6 alkoxy group, and the like;R3 and R4 represent a C1 to C6 alkyl group or the like; andR5 represents any one of a hydrogen atom, a C1 to C6 alkyl group, and the like; and Z represents any one of a hydrogen atom and a C1 to C6 alkyl group.




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Methods for production of high concentration of arginine bicarbonate solution at high pressure

Methods of producing arginine bicarbonate solutions in very high concentrations including reacting an arginine slurry containing a first portion of arginine with a source of carbon dioxide gas at elevated pressure and temperature, adding subsequent portions of arginine to the resulting solution and further reacting with compressed carbon dioxide until a final solution containing in excess of 50% by weight are provided which include preparing an arginine solution by subjecting an arginine water slurry to elevated pressure and temperature and reacting the arginine solution with a source of carbon dioxide gas to form a solution comprising arginine and bicarbonate anion and recovering arginine bicarbonate from the solution.




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Hydrocarboxylation of aqueous formaldehyde using a dehydrating recycle stream to decrease water concentration

Disclosed is a process for the production and purification of glycolic acid or glycolic acid derivatives by the carbonylation of aqueous formaldehyde. The water in the hydrocarboxylation zone is reduced via reaction with the ester bonds in a recycle stream comprising glycolic acid oligomers and/or methyl glycolate oligomers.




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Nucleic acids targeting TCTP for use in the treatment of chemo- or hormone-resistant cancers

The present invention concerns a TCTP antagonist, in particular a nucleic acid targeting an m RNA encoding Translationally-Controlled Tumor Protein (TCTP), wherein said nucleic acid is capable of reducing the amount of TCTP in cells, for use in the treatment or prevention of hormone-independent cancer or chemo-resistant cancer, such as an androgen-independent prostate cancer.




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Functional ligands to target molecules

The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules. The present invention further relates to methods for generating, for example, functional biomolecules, particularly to functional nucleic acids, that bind with functional activity to another biomolecule, such as a receptor molecule. More than one or multiple targets as used herein may generally include different types of targets, and/or may also include a multitude of a singular type of targets at different conditions, such as, for example, temperature, pH, chemical environment, and/or any other appropriate conditions.




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Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments

Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.




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Compositions and methods for silencing SMAD4

The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA (e.g., dsRNA such as siRNA) that target SMAD4 gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for treating anemia of inflammation in humans).




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Compositions and methods for treating cancer

Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.




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Functionalization and purification of molecules by reversible group exchange

Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.