Teams face likely fixture congestion in a packed calendar as they attempt to make up for lost time when play can resume

Susan Munyoro says thyme would be the most ideal herb for a beginner. She is an agronomist who specialises on herbs production and international marketing. The crop thrives in hot areas and needs exposure to direct sunlight for six to eight hours, writes Shabibah Nakirigya

The US women clinched back-to-back World Cup wins with victory at last year's finals in France.

Interruptions to vaccination programmes caused by the COVID-19 pandemic could result in new waves of measles or polio outbreaks, health experts warn. A growing number of one-off immunisation campaigns and national routine vaccine introductions are being delayed amid social distancing and other measures to curb the spread of SARS-CoV-2, leaving millions unprotected. Uptake of routine […]

The post Polio, Measles Outbreaks ‘Inevitable’, Say Vaccine Experts appeared first on Inter Press Service.

The Premier League got a glimpse of what the future might hold after football finally returned with the start of the South Korean K-League on Friday. It was football, but just not as we know it as reigning champions Jeonbuk Motors beat Suwon Bluewings 1-0 in an empty World Cup...

The post S. Korea shows way forward for Premier League as football returns appeared first on Cyprus Mail.

1

Fresh coronavirus outbreaks at slaughterhouses in Germany and new cases reported Saturday in South Korea linked to a man who had visited multiple nightclubs highlighted the challenges authorities face as they seek to open up their economies.

The webinar will highlight the important role the MDBs are called to play in closing the SOGI data gap by supporting innovative forms of data generation and evidence-based policymaking in their countries.

A wholesale market in the central Chinese city of Wuhan played a role in the outbreak of the novel coronavirus last year, as the source or possibly as an “amplifying setting”, the World Health Organisation said on Friday, calling for more research.

Chinese authorities shut down the market in January as part of efforts to stop the spread of the virus and ordered a temporary ban on trade and consumption of wildlife.

“The market played a role in the event, that’s clear. But what role we don’t know; whether it was the source or amplifying setting or just a coincidence that some cases were detected in and around that market,” said Dr Peter Ben Embarek, a WHO expert on food safety and zoonotic viruses that cross the species barrier from animals to humans.

It was not clear whether live animals or infected vendors or shoppers may have brought the virus into the market, he told a Geneva news briefing.

US Secretary of State Mike Pompeo has said there is “a significant amount of evidence” the virus came from the Wuhan laboratory, although he has also said there wasn’t certainty.

Read: The Wuhan lab at the core of a virus controversy

No public evidence has linked the outbreak to the lab in Wuhan and scientists have said the coronavirus appears to have developed in nature. A German intelligence report cast doubts on Pompeo’s allegations, Der Spiegel reported.

Ben Embarek did not address the accusations. He noted that it took researchers a year to identify camels as the source of the Mers (Middle East Respiratory Syndrome) virus, a coronavirus that emerged in Saudi Arabia in 2012 and spread in the Middle East, adding: “It’s not too late.”

“What is important, what would be of great help, is to get hold of the virus before it adapted to humans, before the version we have now. Because then we would better understand how it adapted to humans, how it evolved,” he said.

“In terms of investigations, China has most probably, most likely, all the expertise needed to do these investigations. They have lot of very qualified researchers to that,” he said.

A common sight across Asia, wet markets traditionally sell fresh produce and live animals, such as fish, in the open air.

Many markets worldwide that sell live animals must be better regulated and hygiene conditions improved, and some should be closed down, Ben Embarek said. “But the vast majority can be fixed, can be better organised.”

It is often a question of controlling waste management, the movement of people and goods, and of separating live animals from animal products and from fresh goods, he said.

An estimated 29 million babies will be born in South Asia in the nine months after the Covid-19 outbreak was classified as a pandemic by the World Health Organisation (WHO), while five million births will be reported in Pakistan, according to a report released by the United Nations Children's Fund (Unicef).

The report — released on May 6 — has predicted that an estimated 116 million babies will be born across the world in the 40-week period between March 11 and December 16, with almost a quarter of them in South Asia.

India is expected to report 20 million births, the highest in the region, during this period, the report said, followed by Pakistan, Bangladesh (2.4 million) and Afghanistan (one million).

The report also warned that lockdown measures imposed to curb the spread of the coronavirus may cause disruptions in life-saving health services "putting millions of pregnant mothers and their babies at great risk".

"The continuing rapid spread of Covid-19 across South Asia means new mothers and newborns will be greeted by harsh realities, including global containment measures such as lockdowns and curfews, health centres overwhelmed with response efforts, supply and equipment shortages, and a lack of sufficient skilled birth attendants as health workers [...] are redeployed to treat Covid-19 patients.

"Unicef cautions that although evidence suggests that pregnant mothers are not more affected by Covid-19 than others, countries need to ensure they still have access to antenatal, delivery and post-natal services.

"Likewise, sick newborns need emergency services as they are at high risk of death. New families require care to ensure the health and well-being of mothers, support to start breastfeeding, and to get medicines, vaccines and nutrition to keep their babies healthy," the report said.

The UN body urged governments and healthcare providers to take a few steps to save lives in the coming months by:

• Helping women receive regular checkups during their pregnancy, skilled delivery care and post-delivery care
• Ensuring health workers are provided with the necessary personal protective equipment and priority testing and vaccination for Covid-19 when it becomes available
• Ensuring that all infection prevention and control measures are being followed at health facilities
• Allowing healthcare workers to reach pregnant women through home visits, encouraging women living in rural areas to visit maternal waiting homes, and using mobile health strategies for tele-consultations
• Training, protecting and equipping health workers with kits to attend to home births
• Allocating resources to lifesaving services and supplies for maternal and child health

The report also urged pregnant women to take precautionary measures by practicing social distancing, avoiding physical gatherings and using online health services.

Read: Mothers may pass coronavirus to unborn children, say Chinese doctors

It also advised them to continue breastfeeding their children even if they are infected as "the virus has not been found in samples of breast milk".

"Mothers with Covid-19 should wear a mask when feeding their baby, wash hands before and after touching the baby, and routinely clean and disinfect surfaces," it cautioned.

A document created by the nation's top disease investigators with step-by-step advice to local authorities on how and when to reopen restaurants and other public places during the still-raging outbreak has been shelved by the Trump administration.

SST Announces Qualification of Smartbit™ OTP NVM Technology for ON Semiconductor’s 110 nm CMOS Process

The number of deaths from the coronavirus in Mexico's best-known border city, Tijuana, has soared and the COVID-19 mortality rate is twice the national average, the health ministry says, after medical staff quickly fell ill as the outbreak rampaged through hospital wards.

U.S. deaths from the novel coronavirus topped 60,000 on Wednesday and the outbreak will soon be deadlier than any flu season since 1967, according to a Reuters tally.

The coronavirus has helped make Big Tech too big to fail. Before the pandemic, political pressure in D.C. and Brussels was mounting on Silicon Valley giants like Facebook. Gina Chon explains how their size has been an asset in a crisis, which will mute arguments to break them up.

Potbelly Corp said on Friday it is unable to file its quarterly report with the U.S. SEC by the May 8 deadline due to the COVID-19 crisis, adding to the restaurant chain's pandemic-led woes.

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Since December, when cases of a then-unknown respiratory disease were first reported in Wuhan, China, APHA has working to share information and ensure that public health has the resources it needs to address COVID-19.

Objective

De novo missense mutations in the RHOBTB2 gene have been described as causative for developmental and epileptic encephalopathy.

The Hippo pathway is an evolutionarily conserved signaling network that regulates organ size, cell fate, and tumorigenesis. In the context of organ size control, the pathway incorporates a large variety of cellular cues, such as cell polarity and adhesion, into an integrated transcriptional response. The central Hippo signaling effector is the transcriptional coactivator Yorkie, which controls gene expression in partnership with different transcription factors, most notably Scalloped. When it is not activated by Yorkie, Scalloped can act as a repressor of transcription, at least in part due to its interaction with the corepressor protein Tgi. The mechanism by which Tgi represses transcription is incompletely understood, and therefore we sought to identify proteins that potentially operate together with Tgi. Using an affinity purification and mass-spectrometry approach we identified Pits and CtBP as Tgi-interacting proteins, both of which have been linked to transcriptional repression. Both Pits and CtBP were required for Tgi to suppress the growth of the Drosophila melanogaster eye and CtBP loss suppressed the undergrowth of yorkie mutant eye tissue. Furthermore, as reported previously for Tgi, overexpression of Pits repressed transcription of Hippo pathway target genes. These findings suggest that Tgi might operate together with Pits and CtBP to repress transcription of genes that normally promote tissue growth. The human orthologs of Tgi, CtBP, and Pits (VGLL4, CTBP2, and IRF2BP2) have previously been shown to physically and functionally interact to control transcription, implying that the mechanism by which these proteins control transcriptional repression is conserved throughout evolution.

Kelsey L. Jones, Rahmatollah Rajabzadeh, Guncha Ishangulyyeva, Nadir Erbilgin, and Maya L. Evenden

Flight polyphenisms naturally occur as discrete or continuous traits in insects. Discrete flight polyphenisms include winged and wingless morphs, whereas continuous flight polyphenisms can take the form of short- or long-distance fliers. The mountain pine beetle (Dendroctonus ponderosae) exhibits polyphenic variation in flight distance but the consequences of this flight variation on life history strategies of beetles is unknown. This study assessed the effect of flight on two particular aspects of beetle biology: (1) an energetic trade-off between flight distance and host colonisation capacity; and (2) the relationship between flight distance and pheromone production. A 23-h flight treatment was applied to a subset of beetles using computer. After flight treatment, both flown and unflown (control) beetles were given the opportunity to colonise bolts of host trees, and beetles that entered hosts were aerated to collect pheromone. A trade-off occurred between initiation of host colonisation and percent body weight lost during flight, which indicates energy-use during flight affects host acceptance in female mountain pine beetles. Furthermore, production of the aggregation pheromone trans-verbenol by female beetles was influenced by both percent weight lost during flight and flight distance. Male production of exo-brevicomin was affected by beetle condition following flight but not by the energy used during flight. These novel results give new insight into the polyphenic flight behaviour of mountain pine beetles. Flight variation is adaptive by acting to maintain population levels through safe and risky host colonisation strategies. These findings suggest mechanisms that facilitate the extremities of the continuous flight polyphenism spectrum. These opposing mechanisms appear to maintain the high variation in flight exhibited by this species.

Klebsiella species are problematic pathogens in neonatal units and may cause outbreaks, for which the sources of transmission may be challenging to elucidate. We describe the use of whole-genome sequencing (WGS) to investigate environmental sources of transmission during an outbreak of extended-spectrum-β-lactamase (ESBL)-producing Klebsiella michiganensis colonizing neonates. Ceftriaxone-resistant Klebsiella spp. isolated from neonates (or their mothers) and the hospital environment were included. Short-read sequencing (Illumina) and long-read sequencing (MinION; Oxford Nanopore Technologies) were used to confirm species taxonomy, to identify antimicrobial resistance genes, and to determine phylogenetic relationships using single-nucleotide polymorphism profiling. A total of 21 organisms (10 patient-derived isolates and 11 environmental isolates) were sequenced. Standard laboratory methods identified the outbreak strain as an ESBL-producing Klebsiella oxytoca, but taxonomic assignment from WGS data suggested closer identity to Klebsiella michiganensis. Strains isolated from multiple detergent-dispensing bottles were either identical or closely related by single-nucleotide polymorphism comparison. Detergent bottles contaminated by K. michiganensis had been used for washing milk expression equipment. No new cases were identified once the detergent bottles were removed. Environmental reservoirs may be an important source in outbreaks of multidrug-resistant organisms. WGS, in conjunction with traditional epidemiological investigation, can be instrumental in revealing routes of transmission and guiding infection control responses.

The IR Biotyper is a new automated typing system based on Fourier-transform infrared (FT-IR) spectroscopy that gives results within 4 h. We aimed (i) to use the IR Biotyper to retrospectively analyze an outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) in a neonatal intensive care unit and to compare results to BOX-PCR and whole-genome sequencing (WGS) results as the gold standard and (ii) to assess how the cutoff values used to define clusters affect the discriminatory power of the IR Biotyper. The sample consisted of 18 isolates from 14 patients. Specimens were analyzed in the IR Biotyper using the default analysis settings, and spectra were analyzed using OPUS 7.5 software. The software contains a feature that automatically proposes a cutoff value to define clusters; the cutoff value defines up to which distance the spectra are considered to be in the same cluster. Based on FT-IR, the outbreak represented 1 dominant clone, 1 secondary clone, and several unrelated clones. FT-IR results, using the cutoff value generated by the accompanying software after 4 replicates, were concordant with WGS for all but 1 isolate. BOX-PCR was underdiscriminatory compared to the other two methods. Using the cutoff value generated after 12 replicates, the results of FT-IR and WGS were completely concordant. The IR Biotyper can achieve the same typeability and discriminatory power as genome-based methods. However, to attain this high performance requires either previous, strain-dependent knowledge about the optimal technical parameters to be used or validation by a second method.

The N-acetylglucosaminidase LytB of Streptococcus pneumoniae is involved in nasopharyngeal colonization and is responsible for cell separation at the end of cell division; thus, lytB mutants form long chains of cells. This paper reports the construction and properties of a defective pneumococcal mutant producing an inactive LytB protein (LytB_E585A). It is shown that an enzymatically active LytB is required for in vitro biofilm formation, as lytB mutants (either lytB or producing the inactive LytB_E585A) are incapable of forming substantial biofilms, despite that extracellular DNA is present in the biofilm matrix. Adding small amounts (0.5 to 2.0 μg/ml) of exogenous LytB or some LytB constructs restored the biofilm-forming capacity of lytB mutants to wild-type levels. The LytB_E585A mutant formed biofilm more rapidly than lytB mutants in the presence of LytB. This suggests that the mutant protein acted in a structural role, likely through the formation of complexes with extracellular DNA. The chain-dispersing capacity of LytB allowed the separation of daughter cells, presumably facilitating the formation of microcolonies and, finally, of biofilms. A role for the possible involvement of LytB in the synthesis of the extracellular polysaccharide component of the biofilm matrix is also discussed.

IMPORTANCE It has been previously accepted that biofilm formation in S. pneumoniae must be a multigenic trait because the mutation of a single gene has led to only to partial inhibition of biofilm production. In the present study, however, evidence that the N-acetylglucosaminidase LytB is crucial in biofilm formation is provided. Despite the presence of extracellular DNA, strains either deficient in LytB or producing a defective LytB enzyme formed only shallow biofilms.

At the end of 2019 and early 2020, an outbreak of pneumonia of unknown etiology emerged in the city of Wuhan in China. The cases were found to be caused by a novel beta coronavirus, which was subsequently named SARS-CoV-2 by the World Health Organization (WHO). The virus has since spread further in China and to other regions of the world, having infected more than 88 K people, and causing close to 3000 deaths as of March 1, 2020. More than 50 million people remain in quarantine at this time. Scientists and clinicians globally are working swiftly to combat COVID-19, the respiratory disease caused by the virus. Notably, diagnostic assays have been developed rapidly in many countries, and have played significant roles in diagnosis, monitoring, surveillance, and infection control. Starting February 29, 2020, the development and performance of molecular testing for SARS-CoV-2 in high complexity Clinical Laboratory Improvement Amendments (CLIA) laboratories prior to emergency use authorization was allowed by the US FDA. Although the epidemic is evolving rapidly, many valuable lessons have been learned and many questions remain to be answered. Here we invited multiple experts across the globe from clinical laboratories, public health laboratories, infection control, and diagnostic industry to share their views on the diagnosis, infection control, and public perception of SARS-CoV-2.

Purpose:

Preclinical data demonstrating androgen receptor (AR)–positive (AR⁺) triple-negative breast cancer (TNBC) cells are sensitive to AR antagonists, and PI3K inhibition catalyzed an investigator-initiated, multi-institutional phase Ib/II study TBCRC032. The trial investigated the safety and efficacy of the AR-antagonist enzalutamide alone or in combination with the PI3K inhibitor taselisib in patients with metastatic AR⁺ (≥10%) breast cancer.

We report the diagnostic challenges and the clinical course of a patient with an extraordinary presentation of B-lymphoblastic leukemia (B-ALL) with eosinophilia. We identified a novel ZBTB20-JAK2 gene fusion as a chimeric RNA transcript using the Archer platform. This gene fusion from the same patient was recently identified by Peterson et al. (2019) at the genomic level using a different sequencing technology platform. The configuration of this gene fusion predicts the production of a kinase-activating JAK2 fusion protein, which would normally lead to a diagnosis of Philadelphia chromosome–like B-ALL (Ph-like B-ALL). However, the unusual presentation of eosinophilia led us to demonstrate the presence of this gene fusion in nonlymphoid hematopoietic cells by fluorescence in situ hybridization (FISH) studies with morphologic correlation. Therefore, we believe this disease, in fact, represents blast crisis arising from an underlying myeloid neoplasm with JAK2 rearrangements. This case illustrates the difficulty in differentiating Ph-like B-ALL and myeloid/lymphoid neoplasm with eosinophilia and gene rearrangements (MLN-EGR) in blast crisis. As currently defined, the diagnosis of MLN-EGR relies on the hematologic presentations and the identification of marker gene fusions (including PCM1-JAK2, ETV6-JAK2, and BCR-JAK2). However, these same gene fusions, when limited to B-lymphoblasts, also define Ph-like B-ALL. Yet, our case does not conform to either condition. Therefore, the assessment for lineage restriction of gene rearrangements to reflect the pathophysiologic difference between B-ALL and MLN-EGR in blast crisis is likely a more robust diagnostic approach and allows the inclusion of MLN-EGR with novel gene fusions.

Windsor police are reminding the public to be cautious when meeting strangers to buy and sell items posted online following a robbery in Amherstburg last month. On April 30 at 9:45 p.m., the patrol officers with the Windsor Police Service Amherstburg Detachment attended the area of Sandwich Street North and Alma Street for a report […]

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Out of 200 employees tested at a German meat processing plant, 151 tested positive Thursday for coronavirus, triggering an "emergency mechanism" to delay the easing of social distancing restrictions.