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Determining the location of a load for a tower crane

A tower crane load location determiner is disclosed. One example includes a load location measurer to provide load location measurement information for a load coupled with a tower crane. In addition, a load position determiner utilizes the load location measurement information to determine a location of the load. A user accessible load location provider provides the determined location of the load.




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Methods, apparatus, and systems for providing an enhanced positive response for underground facility locate and marking operations based on an electronic manifest documenting physical locate marks on ground, pavement or other surface

A positive response notification to provide information regarding locate and/or marking operations for underground facilities may include time-stamp information to provide proof of a time at which the locate and/or marking operation was completed by a locate technician, and/or place-stamp information to provide proof of a presence of the locate technician at or near a work site. An electronic manifest image and/or a virtual white line image similarly may be included in a positive response notification. In one example, such images may be bundled together based on respective descriptor files (or descriptor metadata) that associates the corresponding images with a locate request ticket for the operation. In another example, a positive response notification may include environmental information regarding one or more environmental conditions present at or near the work site during the locate and/or marking operation.




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Electric steering wheel lock device

An electric steering wheel lock device includes a control circuit that starts and stops supplying power to a motor that actuates a lock mechanism to lock and unlock a movable member of a vehicle steering mechanism. The control circuit changes contact states of first and second relays to switch a supplying direction of the power. A drive restriction unit stops and starts supplying power to a drive circuit for the motor. The control circuit changes contact states of the first and second relays when the drive restriction unit stops supplying power to the drive circuit.




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Electric-hydraulic antilock braking system for a trailer

An electric-hydraulic antilock braking system (ABS) installed in a trailer is coupled with a tow vehicle to facilitate controlled braking of the trailer. A trailer in-cab controller (TIC) monitors vehicle networks for diagnostic information used in determining appropriate braking actions to be taken. A communication network can interconnect the TIC, a trailer actuator controller (TAC), and an ABS controller. The ABS controller receives current tow vehicle speeds and current trailer wheel speeds, and dynamically adjusts the brakes based on the differences in the speeds. A three-way solenoid valve or an equivalent valve structure thereto allows for the ABS system to be quickly activated and deactivated.




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Hydraulic block for a slip-controlled vehicle brake system

A flat, box-shaped hydraulic block for the mechanical fastening and hydraulic interconnection of solenoid valves, pump elements, etc. of a slip-controlled vehicle brake system connects connections of installation spaces for the pump elements to connectors for a brake master cylinder and connections of receptacles for pressure build-up valves which run past one another via flat chambers on longitudinal sides of the hydraulic block and short blind bores. As a result, the receptacles of the pressure build-up valves are connected to the connectors for the brake master cylinder. The chambers damp pressure pulses of the pump elements of a piston pump.




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Method and device for detecting blocking or sluggishness of a DC motor

The invention relates to a method for detecting blocking or sluggishness (M1, M3) of a DC motor (2). The method comprises the following steps: applying a voltage pulse (Uv,t=Os) to the DC motor (2); monitoring a motor current (IMotor) flowing through the DC motor (2); detecting a maximum value of the motor current (IMotor) following the application of the voltage pulse; checking whether a change in the motor current (IMotor) after reaching the maximum value exceeds a specific amount; signalling the blocking or the sluggishness (M1, M3) of the DC motor (2) if the change in the motor current (IMotor) after reaching the maximum value exceeds the specific amount.




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Method and system for locally controlling support of a flat object

A non-contact support platform system is provided for supporting a substantially flat object. The system includes a platform with a first plurality of pressure ports and a first plurality of vacuum ports for inducing a fluid cushion to support the object at a distance from the platform. The system further includes a second plurality of pressure ports located at a predetermined zone of the platform for increasing the distance of the object from the platform at the predetermined zone.




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Load lock chamber designs for high-throughput processing system

Methods and apparatus for transferring one or more substrates from a first pressure environment to a second pressure environment is provided. In one embodiment, a load lock chamber is provided. The load lock chamber comprises a first circular housing, and a second circular housing disposed within and movable relative to the first circular housing, one of the first circular housing or the second circular housing comprising a plurality of discrete regions, wherein at least a portion of the plurality of discrete regions are in selective fluid communication with one of at least two vacuum pumps based on the angular position of the second circular housing relative to the first circular housing.




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Method for locating a vehicle

A portable computing device can be used to locate a vehicle in a parking structure. In particular, the portable computing device can communicate with a parking system that manages the parking structure and/or with a vehicle in order to locate the vehicle. Communications between the portable computing device, parking system and vehicle can be based on one or more wireless connections, such as Bluetooth and/or Bluetooth LE connections.




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Method and system for locating a wireless access device in a wireless network

A wireless access device in a wireless network, whether a known or unknown entity, can be located using a geolocation system according to the present invention. A signal strength is determined by a wireless intrusion detection system (WIDS) node in a wireless network for each wireless access device that it detects. Based on the signal strength, an approximate distance from the node is determined, which, in one embodiment corresponds to a radius of a circle around the node. To account for error, an approximation band of the circle is calculated that will allow a user to determine the approximate location of the device within the wireless network.




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Location of cooperative tags with personal electronic device

The present disclosure relates to location and communication systems that can be utilized for locating people, pets and other objects with a software defined radio set. A personal electronic device (PED) such as a cellular telephone, personal data assistant (PDA) or other device that include a software defined radio set can be configured for operation as a locator device. The PED transmits a signal A transponder or micro-transponder (MT) that is tagged to an object is arranged to reply to a transmission received from the PED. The PED based locator is arranged to calculate a distance between the PED and the MT using the time-of-flight (TOF) between the transmission and the receipt of a reply. The absolute geographic position of the PED can be determined using satellite navigation information, while the position of the MT relative to the PED can be determined from the TOF information.




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Interlocking buttress material retention system

A surgical stapler is provided having a pair of jaws including a staple containing cartridge and an anvil. Buttress material is releasable affixed to the staple containing cartridge and the anvil. One of the jaws includes a pair of longitudinal projections at a first end of the jaw and configured to frictionally engage corresponding slots in a first end the buttress material. One of the jaws includes a post at a second end of the jaw. The buttress material includes a hole in a second end of the buttress material for receipt of the post.




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EEA tilt top anvil with ratchet/locking mechanism

A tilt anvil assembly is disclosed which includes a center rod and a head assembly pivotally mounted to the center rod. The head assembly includes a housing, a post and an anvil plate. The head assembly is pivotally secured to the center rod and pivotal in relation to the center rod in discrete steps between a non-tilted position and a fully tilted position via a plurality of partially tilted positions. The head assembly is configured to maintain a partially tilted position.




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Locking articulation mechanism

A surgical device including a handle assembly, an elongated body extending from the handle assembly, and an articulation mechanism connected to the handle assembly and configured to selectively articulate and lock an articulable tool assembly in one or more positions is provided. The articulation mechanism includes a main shaft member mounted for rotation and connected to an articulation linkage, a locking member configured to be received about the shaft portion of the main shaft member, the locking member defining a plurality of notches, an articulation handle fixedly secured to shaft portion of the main shaft member and configured for rotation relative to the locking member, and a lug member operatively mounted on the articulation handle and including a locking tab configured to be selectively received within a notch of the plurality of notches formed in the locking member.




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Metallocenes containing ligands of 2-substituted indenyl derivatives, process for their preparation, and their use as catalysts

The novel metallocenes of the formula I in which, preferably, M1 is Zr or Hf, R1 and R2 are alkyl or halogen, R3 and R4 are hydrogen, R5 and R6 are alkyl or haloalkyl, —(CR8R9)m—R7—(CR8R9)n— is a single- or multi-membered chain in which R7 may also be a (substituted) hetero atom, m+n is zero or 1, and R10 is hydrogen, form, together with aluminoxanes as cocatalysts, a very effective catalyst system for the preparation of polyolefins of high stereospecificity and high melting point.




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Bufferless nonblocking networks on chip

Network on Chips (NoC)s with a bufferless and nonblocking architecture are described. Core processors are communicatively coupled together on a substrate with a set of routing nodes based on nonblocking process. A network component routes data packets through the routing nodes and the core processors via communication links. A bufferless cross bar switch facilitates the communication of the data packets and/or path setup packets through the communication links among source processors and destination processors. The communication links include one or more channels, in which a channel comprises a data sub-channel, an acknowledgement sub-channel and a release sub-channel.




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Building blocks and building block fasteners

A building block (100) comprises a first mating portion and a second mating portion which are complementary. The first mating portion comprises a mating protrusion (140) which defines an axially extending through bore (144) and the second mating portion comprises an axially extending mating receptacle (180) which is complementary to the mating protrusion (140). The mating protrusion (140) and the mating receptacle (180) are in communication via the through bore (144), and a fastener anchoring device (146) adapted for engaging with an engagement means (920) of a fastener (900) is formed inside the through bore (144). The through bore (144) is adapted to permit axial insertion of the engagement means (920) of the fastener (900) into the mating protrusion (140). The fastener anchoring device (146) is adapted to obstruct axial passage of the engagement means (920) until the engagement means (920) overcomes the obstruction by negotiating rotationally with the fastener anchoring device (146) to thereby gain axial advancement and enter into engagement with the fastener anchoring device (146).




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Collapsible toy blocks

A collapsible and expandable children's toy building block is described. The toy blocks may be made in various sizes and shapes. The toy block includes an internal frame. A cover is positioned over the internal frame to form the toy block. The toy block converts from a collapsed position to an expanded position, and the toy block converts from the expanded position back to the collapsed position.




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Simplified modularized contact type of conductive building block

A simplified modularized contact type of conductive building block includes: a brick, at least one pair of conductive pieces, a circuit board and a base. The brick includes at least one pair of studs projected from a top thereof. The conductive piece has an insertion electrode and a connection electrode respectively disposed at two ends thereof and a contact electrode disposed between the insertion electrode and the connection electrode. The conductive pieces are inserted through the insertion through holes of the circuit board. The circuit board includes a positive electrode circuit and a negative electrode circuit respectively contacted with the at least one pair of the conductive pieces. The conductive pieces are further inserted through the through holes of the base. The circuit board and the base are fixed in the brick.




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Toy building block

A toy building block (1) for stacking is provided on top (4) with one or more studs (3) and in the bottom (7) with recesses (6). The studs (4) show a toothwheel-like cross-section with rounded teeth crests (12) and rounded grooves (10) between the teeth (12) as well. The recesses (6) are provided each with a number of vertically extending lands (14) matching in shape the grooves (10). The studs easily slide in and out of the recesses (6), yet a rotational arretation of low play is obtained. Preferably, the building blocks are produced by a blowing process and may be provided with screws (21) for a safe interconnection. External slots (46) may allow the combination with panels (47) bearing images, additional functional elements etc.




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Assembly kit for creating three-dimensional formations, especially toy structures from prefabricated modular building blocks

An improved set of toy building or construction blocks, each block having a substantially square cross-section and a generally rectilinear configuration. Incorporated into the structure of the individual toy blocks are transversely oriented slots, grooves and protrusions of predetermined size and location. The slots, grooves and protrusions of pre-determined size and location are of either male or female configuration disposed medially along one or more plane of each block. When the male protrusion of one block is introduced perpendicular to the female slot of one end of another block, a frictional engagement is created resulting in a right angle. When the male protrusion of one block is introduced to the female slot in a linear fashion the result is a line segment. Joining a plurality of said toy building or construction blocks using various perpendicular connections in conjunction with linear connections results in the stable formation of construction or geometric structures without the use of fasteners or other connecting elements.




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Interactive building block toy

An interlocking toy block set may include at least two blocks with at least one constraining groove formed in a surface of each of the at least two blocks. At least one connector may have at least two attachment members formed thereon. The attachment members may have a cross-sectional shape corresponding to a cross-sectional shape of the constraining grooves.




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Device for shaping a book casing spine to be oriented approximately evenly distributed toward a book block spine

A device is provided to shape a spine of a book casing positioned horizontally spread out flat and oriented to be distributed evenly over a spine of a book block. Two fold-shaping rails are arranged extending in a direction parallel to one another. A movable, shaping tool is arranged to face the inside of the book casing spine to shape a web on the book casing spine with the aid of the two fold-shaping rails. The shaping tool includes two spaced-apart support bars that extend parallel to the fold-shaping rails and are arranged to be adjustable so that together they adjust the web width of the book casing spine in a direction transverse to the direction of extension of the fold-shaping rails.




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Method and device for manufacturing adhesively bound printed products formed of a book block and a cover

Method and device for manufacturing adhesively bound printed products composed of a book block and a cover, in which the book block is conducted past processing stations of the adhesive binding device for processing and applying glue to its back. A cover is supplied to the back to which glue has been applied in a synchronously timed controlled manner. After merging of the cover with the book block, a measuring procedure for measuring a mutual actual position of cover relative to book block. Subsequently, this actual position is compared to a predetermined desired position, and, in the case of deviations, a correction value is determined and stored. Prior to the renewed occurrence of the pairing of drive member and clamp, an appropriate change of the mutual positions of clamp and drive member is carried out.




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Method and apparatus for producing stacks which form book blocks

In order to form stacks, of which each forms a book block, folded sheets are provided with an adhesive application or layer of adhesive before they are placed on one another. Said adhesive application is applied to the sheets adjacent to the folded edge of said sheets and extends in the direction of said folded edge which comes to lie in the spine of the book block. The adhesive can be applied as a continuous track or as a track which is interrupted multiple times, or else in a punctiform manner. The sheets are joined to one another in the stack by means of said adhesive application, with the result that they maintain their position within the stack during further transport of the stack.




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Device for joining book block and book cover

Device for joining book block and book cover includes conveyor device, embodied to lift a book block from a lower position into an upper position, and an adhesive application station applying adhesive to the outsides of the book block. Conveyor device and the adhesive application station are arranged so adhesive is applied to the outsides of the book block as it is conveyed by the conveyor device. A removal station is arranged below the adhesive application station and the conveyor device is structured to reverse a direction of movement and to lift and lower the book block and cover in a same vertical plane between the lower position and the upper position. Adhesive application station deactivates adhesive dispensing during the downward movement of the book block with cover.




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Machine for attachment of cover to book block and book binding apparatus having the same

A machine for attachment of a cover to a book block comprises a press plate elevating mechanism for elevating a press plate 8, a nip plate drive mechanism for sliding nip plates 9 and 10, and a controller 30 controlling the press plate elevating mechanism and the nip plate drive mechanism. The press plate 8 elevates from the lower standby position to an upper press position. The press plate 8 presses the cover 12 to the book block 4 at the upper press position. The cover 12 is attached to the book block 4 by pressing the cover 12 to the lower end surface of the book block 4. The press plate 8 is elevated from the intermediate position to the upper press position, staying at the intermediate position during a waiting time for adjustment. The press plate 8 elevates from the intermediate position to the upper press position.




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Method and device for pressing a book block

A method and a device for pressing a book block over the rounded back of a book block having a longitudinal axis extending in the center and along the back. The book block is clamped between two clamping jaws of a clamping device, in a region adjacent to the back of the book block, parallel to the longitudinal axis of the back. A pressing device presses a pressing member against the back, wherein the pressing member is placed approximately in the center of the back onto the book block back. At least a section of the pressing member is then moved across the back. Once the pressing member, which is oriented parallel to the longitudinal axis of the back, is placed onto the back it then moves along at least one continuously preselected movement path over the back.




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No flange damage wedge lock washers

No flange damage wedge lock washers are disclosed. The washers may comprise an upper washer and a lower washer. The lower washer may have a generally smooth bottom surface and at least one means for securement. The at least one means for securement may be arranged to keep together the lower washer and a flange without causing damage to the flange. A locking fastener assembly which comprises no flange damage wedge lock washers is also disclosed. The locking fastener assembly may include a lower washer having a generally smooth bottom surface and at least one means for securement. A method of manufacturing a locking fastener assembly which comprises no flange damage wedge lock washers is also disclosed. The locking fastener assembly of the method may include a lower washer having a generally smooth bottom surface and at least one means for securement.




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High temperature thread locking compound

An assembly includes a threaded hole, a threaded fastener, and a locking compound. The threaded fastener is positioned in the threaded hole with a portion of fastener threads mated with a corresponding portion of hole threads. The locking compound is between the mated fastener threads and hole threads. The locking compound includes an aluminum pigmented compound suspended in a water-based inorganic binder.




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Driving circuit and display device using multiple phase clock signals

In a driving circuit, one output circuit has a scanning signal line, a first transistor which controls electrical connection between the scanning signal line and a clock signal line which has a gate connected to a first node, the first node which is at an active potential in a first time period including a time period during which the active potential is output to the scanning signal line, a second transistor which electrically connects the first node and an inactive signal line which has a potential to open the transistor in a second time period other than the first time period, and the second transistor has a gate connected to a second node, wherein the second node has two kinds of timings to be charged for retaining the active potential.




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Method and system for synchronizing the phase of a plurality of divider circuits in a local-oscillator signal path

A method and system for synchronizing the output signal phase of a plurality of frequency divider circuits in a local-oscillator (LO) or clock signal path is disclosed. The LO path includes a plurality of frequency divider circuits and a LO buffer for receiving a LO signal coupled to the plurality of frequency divider circuits. The method and system comprise adding offset voltage and setting predetermined state to each of the frequency divider circuits; and enabling the frequency divider circuits. The method and system includes enabling the LO buffer to provide the LO signal to the frequency divider circuits after they have been enabled. When the LO signal drives each of the frequency divider circuits, each of the frequency divider circuits starts an operation. Finally the method and system comprise removing the offset voltage from each of the frequency divider circuits to allow them to effectively drive other circuits.




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Automatic lock for cargo container

An automatic lock affixed to a cargo container for interconnecting two stacked containers, and for automatically locking and unlocking without reliance upon the overcoming of a friction force to release the device.




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Universal digital block interconnection and channel routing

A programmable routing scheme provides improved connectivity both between Universal Digital Blocks (UDBs) and between the UDBs and other micro-controller elements, peripherals and external Inputs and Outputs (I/Os) in the same Integrated Circuit (IC). The routing scheme increases the number of functions, flexibility, and the overall routing efficiency for programmable architectures. The UDBs can be grouped in pairs and share associated horizontal routing channels. Bidirectional horizontal and vertical segmentation elements extend routing both horizontally and vertically between different UDB pairs and to the other peripherals and I/O.




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Bimodal clock generator

An apparatus relates generally to a clock generator is disclosed. The clock generator is coupled to receive an input clock signal and further coupled to provide an output clock signal. An address and control register is coupled to receive an address signal and the output clock signal. An access generator is coupled to receive the output clock signal. The clock generator includes: an input node coupled to receive the input clock signal; at least one pulse generator coupled to the input node to receive the input clock signal and further coupled to provide a clock control signal; and a control gate coupled to the input node to receive the input signal and further coupled to the at least one pulse generator to receive the clock control signal. The clock control signal is provided in a non-toggling state for a high-frequency mode and in a toggling state for a low-frequency mode.




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Latch circuit and clock control circuit

A latch circuit includes a latch unit and a clock propagation suppressing unit. The latch circuit holds and outputs input data of 0 or 1. The clock propagation suppressing unit compares the input data input to the latch unit with output data output from the latch unit. When it is detected that the input data matches the output data at 0, or that the input data matches the output data at 1, an externally input clock signal is prevented from propagating to the latch unit.




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Glitch free clock multiplexer

Apparatus for glitch-free switching between two clock sources on an integrated circuit. Clock gaters provide a clock from a single source that can be turned on and off without causing partial pulses to be created. Control circuitry going to the individual clock gaters provides the ability to shut all clocks off for a period of time equal to the longest clock period. By combining the clocks with an OR gate and gating all clocks off before switching from one clock to another, a glitch-free train of clock pulses can be created from individual clock inputs. Since clock glitches can cause erratic behavior in integrated circuits, this invention allows one to switch between different (unrelated) clocks without causing erratic behavior.




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Method and apparatus for clock transmission

Apparatus and methods are provided for an extraction circuit. In one configuration, an apparatus includes: an edge extraction circuit for receiving a first clock signal and outputting a second clock signal, wherein a duty cycle of the second clock is substantially smaller than a duty cycle of the first clock; a transistor for receiving the second clock signal and outputting a current signal; a transmission line for receiving the current signal on a first end and transmitting the current signal to a second end; a termination circuit for receiving the current signal at the second end and converting the current signal into a voltage signal; and an edge detection circuit for outputting a third clock by detecting an edge of the voltage signal. In one embodiment, the edge detection circuit comprises an inverter. In another embodiment, the edge detection circuit comprises a comparator.




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Method and apparatus for reducing power consumption in a digital circuit by controlling the clock

A method and apparatus that controls the clock of a digital circuit, and therefore power consumption, without substantially comprising performance is provided. The apparatus may include monitoring the utilization of a First in First Out (FIFO) buffer. For example in a systems and methods according to the invention, clock speed may be reduced when the FIFO is relatively empty and increased when the FIFO is relatively full. The clock speed may be controlled by a phase locked loop, a clock divider, a clock masking device or a combination of more than one of these methods. Power reduction may also be obtained by controlling the clocking of different stages of a pipelined device. One or more aspects of the inventions may be implemented in combination with other aspects of the invention to further reduce power use.




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Current reused stacked ring oscillator and injection locked divider, injection locked multiplier

A phase locked loop includes a voltage controlled oscillator and a frequency divider or frequency multiplier. The voltage controlled oscillator and the frequency divider/multiplier are coupled together in a stacked configuration. A drive current is supplied to the voltage controlled oscillator. The drive current passes from the voltage controlled oscillator to the frequency divider/multiplier, thereby driving the frequency divider/multiplier with the same drive current that was supplied to the voltage controlled oscillator.




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Digital system and method of estimating quasi-harmonic signal non-energy parameters using a digital Phase Locked Loop

The present invention proposes a digital system and method of measuring (estimating) non-energy parameters of the signal (phase, frequency and frequency rate) received in additive mixture with Gaussian noise. The first embodiment of the measuring system consists of a PLL system tracking variable signal frequency, a block of NCO full phase computation (OFPC), a block of signal phase primary estimation (SPPE) and a first type adaptive filter filtering the signal from the output of SPPE. The second embodiment of the invention has no block SPPE, and NCO full phase is fed to the input of a second type adaptive filter. The present invention can be used in receivers of various navigation systems, such as GPS, GLONASS and GALILEO, which provide precise measurements of signal phase at different rates of frequency change, as well as systems using digital PLLs for speed measurements.




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Crystal-less clock generator and operation method thereof

A crystal-less clock generator (CLCG) and an operation method thereof are provided. The CLCG includes a first oscillation circuit, a second oscillation circuit, and a control circuit. The first oscillation circuit is controlled by a control signal for generating an output clock signal of the CLCG. The second oscillation circuit generates a reference clock signal. The control circuit is coupled to the first oscillation circuit for receiving the output clock signal and coupled to the second oscillation circuit for receiving the reference clock signal. The control circuit is used to generate the control signal for the first oscillation circuit according to the relationship between the output clock signal and the reference clock signal.




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Digitally controlled injection locked oscillator

An injection locking oscillator (ILO) comprising a tank circuit having a digitally controlled capacitor bank, a cross-coupled differential transistor pair coupled to the tank circuit, at least one signal injection node, and at least one output node configured to provide an injection locked output signal; a digitally controlled injection-ratio circuit having an injection output coupled to the at least one signal injection node, configured to accept an input signal and to generate an adjustable injection signal applied to the at least one injection node; and, an ILO controller connected to the capacitor bank and the injection-ratio circuit configured to apply a control signal to the capacitor bank to adjust a resonant frequency of the tank circuit and to apply a control signal to the injection-ratio circuit to adjust a signal injection ratio.




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Digital phase locked loop having insensitive jitter characteristic for operating circumstances

Disclosed are a phase locked loop (PLL) of a digital scheme and a method thereof. More specifically, disclosed are a digital phase locked loop having a time-to-digital converter (TDC), a digital loop filter (DLF), and a digitally controlled oscillator (DCO), and that is designed to have a constant jitter characteristic at all times even though an operating condition of a circuit varies according to a process, voltage, temperature (PVT) change, and a method thereof.




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Method and device for removing at least one book block from and/or supplying at least one book block to a conveying section of a book production line

A method and device for the production of books, including: moving book blocks successively along a conveying section of a book production line; supplying a stack of book cases to the book production line; identifying a marking on each of the book blocks and the book cases; transmitting an identified marking on at least one book case to a machine control of the book production line; assigning a dataset stored in the machine control for a sequence of book cases to the supplied stack; determining a sequence in the machine control for book blocks positioned on the conveying section; comparing the dataset for the sequence of the book cases to the sequence of the book blocks; and removing and/or supplying at least one book block from or to the conveying section if the sequence of the book blocks deviates from the sequence of the book cases using the machine control.




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Monoclonal thyroid stimulating or blocking antibodies, peptide sequences corresponding to their variable regions, and their uses in diagnostic, preventive and therapeutic medicine

Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic immunization of mice, or fragments (F(ab')2, Fab or Fv) or humanized forms of such monoclonal antibodies or single chain forms (SCA; scFv) of such fragments, which antibodies, or their fragments, compete with bovine TSH for epitopes of the human TSHr, compete with autoantibodies from sera from Graves' patients as well as with autoantibodies from sera from patients harboring blocking autoantibodies for epitopes of the human TSHr, bind to conformational epitopes of the human TSHr located in the first 281 amino acids of the human TSHr, and usually also bind to TSFR receptors (TSHr) from different animals. Various uses of such antibodies, or of peptides corresponding to variable regions of such antibodies, are also described and claimed.




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Recombinant DNA constructs encoding ribonuclease cleavage blockers and methods for modulating expression of a target gene

This invention provides recombinant DNA constructs and methods for manipulating expression of a target gene that is regulated by a small RNA, by interfering with the binding of the small RNA to its target gene. More specifically, this invention discloses recombinant DNA constructs encoding cleavage blockers, 5-modified cleavage blockers, and translational inhibitors useful for modulating expression of a target gene and methods for their use. Further disclosed are miRNA targets useful for designing recombinant DNA constructs including miRNA-unresponsive transgenes, miRNA decoys, cleavage blockers, 5-modified cleavage blockers, and translational inhibitors, as well as methods for their use, and transgenic eukaryotic cells and organisms containing such constructs.




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Lock device of vehicle seat

A latch plate for a lock device is proposed which comprises a latch plate proper and a film that covers the latch plate proper. The latch plate proper includes upper and lower finger portions between which a striker catching recess is defined. An upper surface of the lower finger portion includes a depressed main portion located near the bottom of the striker catching recess, a raised leading end portion and a stepped portion provided between the depressed main portion and the raised leading end portion. The film covers the latch plate proper except the raised leading end portion. The film covers the depressed main portion of the upper surface in such a manner that an outer surface of the film is flush with the stepped portion. When the film is depressed by the striker, the stepped portion enhances a function is to stop a movement of the striker toward a mouth of the striker catching recess.




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Trimming circuit for clock source

A semiconductor trimming circuit includes parallel coupled PMOS devices coupled in parallel with parallel coupled NMOS devices and an additional pair of dummy NMOS devices. The dummy NMOS devices are coupled in parallel with the NMOS devices. A trimming circuit for an internal clock source may be formed with an array of such switches for selecting one or more trimming capacitors of the trimming circuit. Such an array has a low leakage current and permits good trimming linearity.




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Deposition of integrated protective material into zirconium cladding for nuclear reactors by high-velocity thermal application

A zirconium alloy nuclear reactor cylindrical cladding has an inner Zr substrate surface (10), an outer volume of protective material (22), and an integrated middle volume (20) of zirconium oxide, zirconium and protective material, where the protective material is applied by impaction at a velocity greater than 340 meters/second to provide the integrated middle volume (20) resulting in structural integrity for the cladding.