sci

Death researcher on pandemics and our fascination with dying

Pandemics of the past can teach us about the current one, says John Troyer, who studies how we use technology to alter the experience of death




sci

Providence review: Chilling sci-fi where an AI becomes god by accident

Is our love affair with AI really about building a new kind of deity to meet human needs no amount of rationality can fill? Max Barry's disturbing novel Providence lays out the case, says Sally Adee




sci

The science of boredom can tell us how to keep ourselves amused

Boredom can be unpleasant, but we can learn from some of the world's dullest people how to keep ourselves amused, says boredom researcher James Danckert




sci

Vivarium review: An indie sci-fi that packs a creepy punch

In Vivarium, a young couple in need of a starter home meet an estate agent who is very definitely not what he seems, and nor is the estate he shows them, finds Simon Ings




sci

Tom Gauld's fantastic new collection of funny science cartoons

Tom Gauld’s science cartoons appear weekly in New Scientist. He explains how he gets his ideas as his latest collection, Department of Mind-Blowing Theories, hits the shelves




sci

Science Diction review: The origins of jargon in bite-sized chunks

A podcast called Science Diction looks at the stories behind scientific terms and phrases. Each episode is short and nicely put together, says David Silverberg




sci

Seagulls aren't menaces – they are fascinating and complex creatures

Gulls are often misunderstood. Many people think of them as chip-stealing pests, but that's just because they haven't spent the time to get to know them, says Madeleine Goumas




sci

The science of how 'wok hei' makes stir-fried food taste so good

Getting your wok scorching hot and preparing your ingredients in advance is the best way to make a tasty stir-fry, says Sam Wong




sci

Naomi Oreskes: Turn your anger at science denial into political action

Rejection of science is rampant, but scientists can do better at countering doubt and there are grounds for optimism every day, says Naomi Oreskes, author of Why Trust Science?




sci

Altruism 2.0: How to use science to make charitable acts go further

Effective altruists use evidence and reason to maximise the impact of their kindness. Joshua Howgego follows their lead to see if it can help him do good better




sci

From Star Wars to Hitchhiker's – how to make the best drinks in sci-fi

New Scientist combines mixology with science fiction to produce recipes for the finest drinks in this – or any other – universe, from Bantha Milk to Ambrosia




sci

The big guide to small talk – a scientific masterclass on conversation

Ditch the phone, don't stand too close and strive for optimal eye contact: the evidence-based approach to painless holiday schmoozing




sci

Einstein's jacket and Apollo 11 tapes: Inside the science auction

Fancy bidding on a Christmas present steeped in science history? Find out what they'll set you back, and which present-day artefacts might be worth investing in




sci

Jess Wade's one-woman mission to diversify Wikipedia's science stories

Our largest encyclopedia overwhelmingly recognises the achievements of white men. For physicist Jess Wade, fighting this bias has been an uphill battle




sci

Don't stress: The scientific secrets of people who keep cool heads

Studies of the world's most unflappable people point to ways we can all better manage stress – and are even inspiring the first stress vaccine




sci

Is running or walking better for you? Here’s what the science says

Does pounding the pavement damage your joints? Can you get away with just walking? Sports engineer Steve Haake pits running against walking and dispels some abiding myths




sci

Is the universe conscious? It seems impossible until you do the maths

The question of how the brain gives rise to subjective experience is the hardest of all. Mathematicians think they can help, but their first attempts have thrown up some eye-popping conclusions




sci

Science Diction review: The origins of jargon in bite-sized chunks

A podcast called Science Diction looks at the stories behind scientific terms and phrases. Each episode is short and nicely put together, says David Silverberg




sci

Names of UK's coronavirus science advisers to be revealed

The membership of the UK's Scientific Advisory Group for Emergencies has so far been kept secret, but a list of names will soon be published, the UK's chief scientific adviser has said




sci

Is the universe conscious? It seems impossible until you do the maths

The question of how the brain gives rise to subjective experience is the hardest of all. Mathematicians think they can help, but their first attempts have thrown up some eye-popping conclusions




sci

Devs: Here's the real science behind the quantum computing TV show

In TV series Devs, a tech company has built an extremely powerful quantum computer. The show is both beautiful and captivating, says Rowan Hooper




sci

The science of how 'wok hei' makes stir-fried food taste so good

Getting your wok scorching hot and preparing your ingredients in advance is the best way to make a tasty stir-fry, says Sam Wong




sci

Pondering the big question of consciousness is a welcome distraction

Our best mathematical theory of consciousness is sparking a rethink of one of science’s hardest problems – how simple matter gives rise to a complex mind




sci

Covid-19 shows why an infodemic of bad science must never happen again

Once the coronavirus pandemic is over, we must work out how to stop the spread of poor information that has helped make a bad situation that much worse




sci

How the covid-19 pandemic has led to a flood of misleading science

Amid the global coronavirus outbreak, a second epidemic of preliminary, unverified and misinterpreted research has broken out. Can it be fixed?




sci

Scientists Find Way to Heal Broken Bones Faster

Title: Scientists Find Way to Heal Broken Bones Faster
Category: Health News
Created: 4/28/2010 2:10:00 PM
Last Editorial Review: 4/29/2010 12:00:00 AM




sci

Scientists Discover Substance That Causes Pain

Title: Scientists Discover Substance That Causes Pain
Category: Health News
Created: 4/28/2010 2:10:00 PM
Last Editorial Review: 4/29/2010 12:00:00 AM




sci

Scientists Find Cause of Involuntary Mirror Movements

Title: Scientists Find Cause of Involuntary Mirror Movements
Category: Health News
Created: 4/29/2010 2:10:00 PM
Last Editorial Review: 4/30/2010 12:00:00 AM




sci

Scientists Spot How Cox-2 Painkillers Raise Heart Risks

Title: Scientists Spot How Cox-2 Painkillers Raise Heart Risks
Category: Health News
Created: 5/2/2012 4:05:00 PM
Last Editorial Review: 5/3/2012 12:00:00 AM




sci

HIV 'Cure' Looks 'Promising,' Danish Scientists Contend

Title: HIV 'Cure' Looks 'Promising,' Danish Scientists Contend
Category: Health News
Created: 4/29/2013 12:35:00 PM
Last Editorial Review: 4/30/2013 12:00:00 AM




sci

Sampling New York Subway Air for Science

Title: Sampling New York Subway Air for Science
Category: Health News
Created: 4/29/2013 12:35:00 PM
Last Editorial Review: 4/30/2013 12:00:00 AM




sci

Scientists Pinpoint Brain's 'Hunger Circuit' in Mice

Title: Scientists Pinpoint Brain's 'Hunger Circuit' in Mice
Category: Health News
Created: 4/28/2015 12:00:00 AM
Last Editorial Review: 4/28/2015 12:00:00 AM




sci

Scientists Pinpoint Dozens of Genes That Increase Risk of Depression

Title: Scientists Pinpoint Dozens of Genes That Increase Risk of Depression
Category: Health News
Created: 4/27/2018 12:00:00 AM
Last Editorial Review: 4/30/2018 12:00:00 AM




sci

Scientists Probe Mystery of How Hair Prematurely Goes Gray

Title: Scientists Probe Mystery of How Hair Prematurely Goes Gray
Category: Health News
Created: 5/3/2018 12:00:00 AM
Last Editorial Review: 5/4/2018 12:00:00 AM




sci

Scientists Develop Blood Test for Peanut Allergy

Title: Scientists Develop Blood Test for Peanut Allergy
Category: Health News
Created: 5/3/2018 12:00:00 AM
Last Editorial Review: 5/4/2018 12:00:00 AM




sci

Don't Believe All the 'Science' on CBD Products

Title: Don't Believe All the 'Science' on CBD Products
Category: Health News
Created: 3/16/2020 12:00:00 AM
Last Editorial Review: 3/17/2020 12:00:00 AM




sci

What Works Best to Ease the Pain of Sciatica?

Title: What Works Best to Ease the Pain of Sciatica?
Category: Health News
Created: 3/18/2020 12:00:00 AM
Last Editorial Review: 3/19/2020 12:00:00 AM




sci

Lexapro (escitalopram)

Title: Lexapro (escitalopram)
Category: Medications
Created: 3/16/2003 12:00:00 AM
Last Editorial Review: 2/24/2020 12:00:00 AM




sci

Challenges with Adherence to Clinical Practice Guidelines: Lessons for Implementation Science




sci

COVID-19: APHA serves as trusted voice on outbreak science, funding

Since December, when cases of a then-unknown respiratory disease were first reported in Wuhan, China, APHA has working to share information and ensure that public health has the resources it needs to address COVID-19.




sci

Forced oscillation technique for optimising PEEP in ventilated extremely preterm infants

Ventilatory settings are critical in mechanically ventilated extremely preterm newborn infants due to the risk of ventilation-induced lung injury (VILI) and the subsequent development of bronchopulmonary dysplasia (BPD) [1]. Positive end-expiratory pressure (PEEP) settings usually rely on blood gases, oxygen requirement, lung auscultation, evaluation of chest radiograph and assessment of the pressure/volume curves provided by ventilators. Studies of optimal PEEP settings in the surfactant-treated preterm infant in need of mechanical ventilation are limited and evidence-based clinical guidelines are sparse [2, 3]. A bedside method identifying the PEEP value that comprises maximal lung volume recruitment and minimising tissue overdistension could improve real-time optimisation of PEEP and potentially minimise the risk of VILI and BPD [4, 5].




sci

Apraxia of speech involves lesions of dorsal arcuate fasciculus and insula in patients with aphasia

Objective

To determine the contributions of apraxia of speech (AOS) and anomia to conversational dysfluency.

Methods

In this observational study of 52 patients with chronic aphasia, 47 with concomitant AOS, fluency was quantified using correct information units per minute (CIUs/min) from propositional speech tasks. Videos of patients performing conversational, how-to and picture-description tasks, word and sentence repetition, and diadochokinetic tasks were used to diagnose AOS using the Apraxia of Speech Rating Scale (ASRS). Anomia was quantified by patients' scores on the 30 even-numbered items from the Boston Naming Test (BNT).

Results

Together, ASRS and BNT scores accounted for 51.4% of the total variance in CIUs/min; the ASRS score accounted for the majority of that variance. The BNT score was associated with lesions in the left superior temporal gyrus, left inferior frontal gyrus, and large parts of the insula. The global ASRS score was associated with lesions in the left dorsal arcuate fasciculus (AF), pre- and post-central gyri, and both banks of the central sulcus of the insula. The ASRS score for the primary distinguishing features of AOS (no overlap with features of aphasia) was associated with less AF and more insular involvement. Only ~27% of this apraxia-specific lesion overlapped with lesions associated with the BNT score. Lesions associated with AOS had minimal overlap with the frontal aslant tract (FAT) (<1%) or the extreme capsule fiber tract (1.4%). Finally, ASRS scores correlated significantly with damage to the insula but not to the AF, extreme capsule, or FAT.

Conclusions

Results are consistent with previous findings identifying lesions of the insula and AF in patients with AOS, damage to both of which may create dysfluency in patients with aphasia.




sci

Machine learning as a diagnostic decision aid for patients with transient loss of consciousness

Background

Transient loss of consciousness (TLOC) is a common reason for presentation to primary/emergency care; over 90% are because of epilepsy, syncope, or psychogenic non-epileptic seizures (PNES). Misdiagnoses are common, and there are currently no validated decision rules to aid diagnosis and management. We seek to explore the utility of machine-learning techniques to develop a short diagnostic instrument by extracting features with optimal discriminatory values from responses to detailed questionnaires about TLOC manifestations and comorbidities (86 questions to patients, 31 to TLOC witnesses).

Methods

Multi-center retrospective self- and witness-report questionnaire study in secondary care settings. Feature selection was performed by an iterative algorithm based on random forest analysis. Data were randomly divided in a 2:1 ratio into training and validation sets (163:86 for all data; 208:92 for analysis excluding witness reports).

Results

Three hundred patients with proven diagnoses (100 each: epilepsy, syncope and PNES) were recruited from epilepsy and syncope services. Two hundred forty-nine completed patient and witness questionnaires: 86 epilepsy (64 female), 84 PNES (61 female), and 79 syncope (59 female). Responses to 36 questions optimally predicted diagnoses. A classifier trained on these features classified 74/86 (86.0% [95% confidence interval 76.9%–92.6%]) of patients correctly in validation (100 [86.7%–100%] syncope, 85.7 [67.3%–96.0%] epilepsy, 75.0 [56.6%–88.5%] PNES). Excluding witness reports, 34 features provided optimal prediction (classifier accuracy of 72/92 [78.3 (68.4%–86.2%)] in validation, 83.8 [68.0%–93.8%] syncope, 81.5 [61.9%–93.7%] epilepsy, 67.9 [47.7%–84.1%] PNES).

Conclusions

A tool based on patient symptoms/comorbidities and witness reports separates well between syncope and other common causes of TLOC. It can help to differentiate epilepsy and PNES. Validated decision rules may improve diagnostic processes and reduce misdiagnosis rates.

Classification of evidence

This study provides Class III evidence that for patients with TLOC, patient and witness questionnaires discriminate between syncope, epilepsy and PNES.




sci

Initial Resuscitation Algorithm for Children




sci

LuxS/AI-2 Quorum Sensing System in Edwardsiella piscicida Promotes Biofilm Formation and Pathogenicity [Bacterial Infections]

LuxS/AI-2 is an important quorum sensing system which affects the growth, biofilm formation, virulence, and metabolism of bacteria. LuxS is encoded by the luxS gene, but how this gene is associated with a diverse array of physiological activities in Edwardsiella piscicida (E. piscicida) is not known. Here, we constructed an luxS gene mutant strain, the luxS strain, to identify how LuxS/AI-2 affects pathogenicity. The results showed that LuxS was not found in the luxS gene mutant strain, and this gene deletion decreased E. piscicida growth compared to that of the wild-type strain. Meanwhile, the wild-type strain significantly increased penetration and motility in mucin compared to levels with the luxS strain. The 50% lethal dose (LD50) of the E. piscicida luxS strain for zebrafish was significantly higher than that of the wild-type strain, which suggested that the luxS gene deletion could attenuate the strain’s virulence. The AI-2 activities of EIB202 were 56-fold higher than those in the luxS strain, suggesting that the luxS gene promotes AI-2 production. Transcriptome results demonstrated that between cells infected with the luxS strain and those infected with the wild-type strain 46 genes were significantly differentially regulated, which included 34 upregulated genes and 12 downregulated genes. Among these genes, the largest number were closely related to cell immunity and signaling systems. In addition, the biofilm formation ability of EIB202 was significantly higher than that of the luxS strain. The supernatant of EIB202 increased the biofilm formation ability of the luxS strain, which suggested that the luxS gene and its product LuxS enhanced biofilm formation in E. piscicida. All results indicate that the LuxS/AI-2 quorum sensing system in E. piscicida promotes its pathogenicity through increasing a diverse array of physiological activities.




sci

Opinion: We need a global movement to transform ocean science for a better world [Sustainability Science]

The ocean is our planet’s largest life-support system. It stabilizes climate; stores carbon; produces oxygen; nurtures biodiversity; directly supports human well-being through food, mineral, and energy resources; and provides cultural and recreational services. The value of the ocean economy speaks to its importance: The Organization for Economic Cooperation and Development...




sci

Procedural justice training reduces police use of force and complaints against officers [Social Sciences]

Existing research shows that distrust of the police is widespread and consequential for public safety. However, there is a shortage of interventions that demonstrably reduce negative police interactions with the communities they serve. A training program in Chicago attempted to encourage 8,480 officers to adopt procedural justice policing strategies. These...




sci

Demographic science aids in understanding the spread and fatality rates of COVID-19 [Social Sciences]

Governments around the world must rapidly mobilize and make difficult policy decisions to mitigate the coronavirus disease 2019 (COVID-19) pandemic. Because deaths have been concentrated at older ages, we highlight the important role of demography, particularly, how the age structure of a population may help explain differences in fatality rates...




sci

Asking young children to &#x201C;do science&#x201D; instead of &#x201C;be scientists&#x201D; increases science engagement in a randomized field experiment [Psychological and Cognitive Sciences]

Subtle features of common language can imply to young children that scientists are a special and distinct kind of person—a way of thinking that can interfere with the development of children’s own engagement with science. We conducted a large field experiment (involving 45 prekindergarten schools, 130 teachers, and over 1,100...




sci

Reduced perceptual narrowing in synesthesia [Psychological and Cognitive Sciences]

Synesthesia is a neurologic trait in which specific inducers, such as sounds, automatically elicit additional idiosyncratic percepts, such as color (thus “colored hearing”). One explanation for this trait—and the one tested here—is that synesthesia results from unusually weak pruning of cortical synaptic hyperconnectivity during early perceptual development. We tested the...