Photographer Katie Edwards captures America from the window of a train.

You can install and run Windows 11 on a Mac, without having to overwrite the MacOS operating system, by installing Windows 11 into a virtual machine. Virtual machines are self-contained installations of operating systems that can be used for a variety of purposes, from testing to demonstrations, to running software that runs on Windows but ... Read More

RecQ family helicases are highly conserved from bacteria to humans and have essential roles in maintaining genome stability. Mutations in three human RecQ helicases cause severe diseases with the main features of premature aging and cancer predisposition. Most RecQ helicases shared a conserved domain arrangement which comprises a helicase core, an RecQ C-terminal domain, and an auxiliary element helicase and RNaseD C-terminal (HRDC) domain, the functions of which are poorly understood. In this study, we systematically characterized the roles of the HRDC domain in E. coli RecQ in various DNA transactions by single-molecule FRET. We found that RecQ repetitively unwinds the 3'-partial duplex and fork DNA with a moderate processivity and periodically patrols on the ssDNA in the 5'-partial duplex by translocation. The HRDC domain significantly suppresses RecQ activities in the above transactions. In sharp contrast, the HRDC domain is essential for the deep and long-time unfolding of the G4 DNA structure by RecQ. Based on the observations that the HRDC domain dynamically switches between RecA core- and ssDNA-binding modes after RecQ association with DNA, we proposed a model to explain the modulation mechanism of the HRDC domain. Our findings not only provide new insights into the activities of RecQ on different substrates but also highlight the novel functions of the HRDC domain in DNA metabolisms.

The synthesis of cholesterol requires more than 20 enzymes, many of which are intricately regulated. Post-translational control of these enzymes provides a rapid means for modifying flux through the pathway. So far, several enzymes have been shown to be rapidly degraded through the ubiquitin–proteasome pathway in response to cholesterol and other sterol intermediates. Additionally, several enzymes have their activity altered through phosphorylation mechanisms. Most work has focused on the two rate-limiting enzymes: 3-hydroxy-3-methylglutaryl CoA reductase and squalene monooxygenase. Here, we review current literature in the area to define some common themes in the regulation of the entire cholesterol synthesis pathway. We highlight the rich variety of inputs controlling each enzyme, discuss the interplay that exists between regulatory mechanisms, and summarize findings that reveal an intricately coordinated network of regulation along the cholesterol synthesis pathway. We provide a roadmap for future research into the post-translational control of cholesterol synthesis, and no doubt the road ahead will reveal further twists and turns for this fascinating pathway crucial for human health and disease.

You might see the following error messages: "ERROR: Connection failed. Server returned: SAS Logon Manager authentication failed: Access denied." and "ERROR: Unable to connect to Cloud Analytic Services host-name on port 5570. Veri

Editing and/or saving an action column can take up to a minute to display a window. There are no workarounds identified at this time.

When you log on to the SAS Risk Governance Framework and choose a solution, the web application might fail to load the solution content. When the problem occurs, you continue to see "Loading..." on the screen, an

Three Oregon school employees sued their union in federal court last week, arguing it's unfair that the teachers' union only lets members drop out and stop paying dues during the month of September.

The GHSA football playoffs kick off Friday night with several area teams competing, while the GIAA playoffs move to the state semifinal round, where two local schools look to secure a spot in the championship game. Friday night’s matchups: Luella (5-5) at No. 6 Westover (9-1) Luella travels to Albany after finishing 4-2 in Region 5, capping their regular season with a 35-25 win over ...

Uri Hasson
Mar 5, 2008; 28:2539-2550
BehavioralSystemsCognitive

Yulia Lerner
Feb 23, 2011; 31:2906-2915
BehavioralSystemsCognitive

In this one-minute video, our Ask Smithsonian host, Eric Schulze, explains what causes wind. The answer might blow you away.

Take an animated tour of the future Giant Magellan Telescope

At a new park in Bosnia and Herzegovina, two dozen gardeners have spent years replicating the Dutch artist's masterpiece using the land as their canvas

A clinical social worker explains the vital role of the old-fashioned rotary phone for those dealing with death and loss

Carleton County is getting another wind farm proposal, this time with involvement of First Nations.

A Winnipeg business owner is suing a man she alleges swindled her out of ownership of two properties after promising financial help — the latest in a string of court proceedings against the man, whom a judge previously described as showing the signs of a "predator" who seeks out financially vulnerable clients.

Drivers are being warned to use caution on Saskatchewan's highways after five separate collisions involving moose were reported to RCMP in a 30-minute window on Friday evening.

Officials have issued wind and rainfall warnings for Tuesday night in several regions as another fall storm approaches southwestern B.C.

Malls and transit will operate under regular hours in Windsor, Ont., while museums and libraries will be closed on Remembrance Day.

Windsor's push to tax people that own houses that sit empty in a city dealing with an affordable housing crunch has led to some surprising early results.

Midway through her second term as a public school board trustee in Windsor-Essex, Sarah Cipkar is resigning for what she calls mainly “personal and professional” reasons.

Windsor Light Music Theatre's production of A Christmas Story: The Musical will feature sign language interpreters at the Nov. 22 show to make the entertainment accessible to those who are deaf or hard of hearing.

CBC's Dalson Chen talks to Bob Reaume about a break in that resulted in an estimated $40,000 in merchandise taken just before the busy holiday season.

With hundreds of vessels passing through Windsor's waterways every year, the company that fuels many of them will receive nearly $5 million in new funding to improve their infrastructure for the distribution of lower-carbon fuels — making the shipping industry more sustainable and lower emission. 

Switch to SolidWorks 3D CAD and Simulation Software Delivers Productivity Increase over AutoCAD

Jewers Doors switched to SolidWorks to design products that enclose the world's largest hangars, protect against explosions at weapons depots, and mute sound at large plants

Windsave Turbines are Small, and Can Help Customers Save up to 30 percent on Electricity Costs

SOLIDWORKS Edition for Windows Vista delivers enhanced user experience plus advanced search, preview, and content distribution

The dollar softened on Tuesday as traders squared positions on the day of the US presidential election, after recent polls dented some market bets on a victory for Republican Donald Trump.

Google has announced the silent rollout of its Quick Share app for ARM-powered devices running Windows 11 or later. Users can now easily send and receive photos, documents, and more data between nearby Android devices and ARM-based Windows PCs including the new Snapdragon X Elite laptops.

Here Mudassar Khan has explained

Offshore wind developer US Wind, Inc. has submitted multiple permit applications to the Delaware Department of Natural Resources and Environmental Control for its wind energy project offshore of Maryland. To inform the public and engage Delawareans in the regulatory process, DNREC will host a public information session on Wednesday, June 5, from 4 to 7 p.m. at Beacon Middle School, 19483 John J. Williams Highway, Lewes, Del.

DNREC will hold a joint virtual public hearing Tuesday, July 9 at 6 p.m. on multiple permit applications and authorization requests made to DNREC by wind energy developer US Wind, Inc. involving Delaware aspects of the company’s proposed Maryland offshore wind project.

Mirroring your smartphone’s screen onto a Windows/Mac PC is fairly simple with these apps.

Microsoft Ads on File Explorer were subject to widespread criticism and the company claimed it was “experimental” and “turned off”. But, there are other Windows 10 or Windows 11 ads you may want to get rid of.

Google has seemingly launched the Quick Share app for Windows on ARM PCs, something that was not previously available.

The post Google Quick Share now available for Windows on ARM appeared first on Phandroid.

Wind River, an IoT and industrial operating system owned by Intel will be acquired by TPG, global alternative asset firm. Terms of the deal were not disclosed. Intel had bought Wind River Systems for $884 million in 2009

Wind River operates in several markets, including aerospace and defense, automotive, industrial, medical and networking technologies. Its core products in these markets are operating systems, software infrastructure platforms, device management, and simulation software. The IoT practice of Wind River provides consulting services for customers building IoT applications.

In a statement for Wind River, Nehal Raj, Partner and Head of Technology investing at TPG said “We see a tremendous market opportunity in industrial software driven by the convergence of the Internet of Things (IoT), intelligent devices and edge computing. As a market leader with a strong product portfolio, Wind River is well positioned to benefit from these trends. We are excited about the prospects for Wind River as an independent company, and plan to build on its strong foundation with investments in both organic and inorganic growth.”

Wind River’s main IoT product is Helix Device Cloud, a cloud-offering capable of managing deployed IoT devices and industrial equipment across a machine’s lifecycle. Helix can connect and manage devices remotely.

Helix platform’s key uses cases are gateway management, proactive maintenance, security updates, and device provisioning.

Hi guys,

I see that inside VNC I can’t resize window boxes by mouse. While pressing the arrow at the box edge and dragging it nothing happens:

is it a bug, or setup change require?

Noted, it only happens when trying to resize window box from left and right side..

Thx

Hello,

I am trying to load some of the signals of the design saved in the signals.svwf to the waveform windown via the tcl file, I am using the following commands but nothing works, Can you please help 

 -submit waveform loadsignals -using "Waveform 2" FB1.svwf but it gives me the below error

-submit waveform new -reuse -name Waveforms

Hello..

I'm updating part in part editor in orcad capture, and I wonder how to align pin numbers using menu or tcl/tk command.

Please, let me know. Thank you.

Hello All,

I'm a novice to this forum and probably this subject has been already discussed here.

My company has purchased OrCAD Capture 17.4 tools that have a new GUI if compared to my earlier used OrCAD Capture 9.2. I have been using Capture 9.2 for ~18 years and its GUI is really convenient. The GUI of 17.4 looks to be a modern one with new icons and really has improved features and new capabilities.

However, my main complain about GUI 17.4 is that the schematic windows cannot be cascaded. Although they can be set floating, this is even more annoying because all toolbars remain in the Capture window and when you select a tool, the Capture window pops over already open schematic window and you need a lot of useless extra clicks to return back to the currently edited schematic page. I always used cascading of schematic windows before because my complex designs includes many pages, not speaking about the library windows that are typically open simulatneously. My view is that the lack of CASCADING in Capture GUI 17.4 is critical and unacceptable for complex projects, and I would very highly appreciate if the Cadence guys will return back the CASCADING capability for schematic pages. In case this will be done, this will make the GUI really great and comfortable to use.

Does anybody have opinion on this issue?

Many thanks,

Pavel

Despite its thriving automotive sector, Gothenburg is vulnerable to global economic pressures. However, local authorities are confident that their strategies will see the city ride out the uncertainties related to Brexit and the US-China trade wars.

Birders and organized labor dominated a recent public comment period, while beach towns were mostly mum. The Bureau of Ocean Energy Management will now consider the input ahead of an anticipated auction this spring.

Senators heard three hours of testimony from anti-wind sources and just one hour from proponents of renewable energy

South Fork Wind Farm is a 132 MW project to be located 19 miles southeast of Block Island, Rhode Island. The project is approved to install 12 or fewer wind turbines and will use Siemens-Gamesa’s 11 MW turbines. Kiewit Offshore Services will design and build the project’s substation.