A five-member fishing crew is relieved to be back on land after enduring 12 days adrift off South Australia's coast, coming up against personal tragedy, a failed rescue attempt and a shortage of food.

A veteran helicopter pilot recalls the rescues from Uluru he took part in and says he is surprised the climb has not been closed sooner.

Four children are among eight people rescued from cars trapped in snow as Victoria is hit by unusually heavy May falls.

ACT water police spent Wednesday morning trying to tie up an unwilling Canberran that had found itself in Lake Burley Griffin. According to a witness, the roo was eventually rescued and hopped off towards the High Court.

This startled eastern grey kangaroo was a bit miffed when two police officers on a jetski tried to haul it back on to the shore of Lake Burley Griffin.

Helicopter vision shows a catamaran burning and sinking off Main Beach on the Gold Coast after eight people are rescued while whale watching.

An incredible show of community spirit brings locals together in the Gold Coast Hinterland with dozens of Canungra residents rescuing animals from the fire front at nearby Binna Burra.

A singed and injured koala and her joey, who have become a symbol of hope and resilience amid Queensland's bushfire emergency, are slowly recovering in a Brisbane wildlife hospital.

Two people are treated for hypothermia after being plucked from the hull of their overturned boat in waters off the Gold Coast overnight.

Two men are rescued after being stranded when their six-metre yacht crashed on the shore of a remote island off the Central Queensland coast.

She's been described as "the friendliest dog in the world", but Lucy was rejected by three families before she found her forever home. The affectionate labrador is now helping others face their own stressful situations.

Weighing no more than a bag of sugar, Wendy the orphaned wallaby is a true survivor — all thanks to her tiny tail and an eagle-eyed motorist­.

The restaurant industry predicts that as many as 30% of all Denver restaurants and 22% statewide may permanently go out of business if they can’t open before the end of May.

The restaurant industry predicts that as many as 30% of all Denver restaurants and 22% statewide may permanently go out of business if they can’t open before the end of May.

The restaurant industry predicts that as many as 30% of all Denver restaurants and 22% statewide may permanently go out of business if they can’t open before the end of May.

How can people be so mean to helpless animals?  While visiting my friends on Earth over Thanksgiving, I was taking a walk and Tra and I saw a dog abandoned in a box in the cold.  She had finished nursing her puppies and so the people who owned her just turned her out in the […]

With COVID-19 “stay at home” advisories in effect across the globe, an unlikely technology has come to the aid of public safety agencies responsible for enforcement measures: drones. Government officials everywhere have asked citizens to

A Brooklyn woman discovered a wayward rooster living on the streets in Park Slope, and took it home in hopes of finding out who he belonged to.

The stimulus plan passed the Senate. Now it's up to government to get the money flowing quickly and transparently.

The Lakers have paid back $4.6 million in federal coronavirus relief the franchise applied for as part of the Paycheck Protection Program.

Crews freed the injured bird which had got trapped behind a fence

If employers aren't providing contraceptive coverage, there is no burden on their religious beliefs.

Firefighter Jessica New celebrated her 21st birthday by rescuing a kitten from a house fire in Wembley.

London Fire Brigade will continue to provide a full emergency fire and rescue service to the capital.

Confusion and frustration bedevil attempts to keep employees on the job while getting a Payroll Protection Program loan.

Deborah Borda, now head of the New York Philharmonic, talks leadership in the coronavirus crisis. Her strategy: Invest in a future that people want.

TWENTY-three British citizens left stranded in Morocco as a result of the coronavirus pandemic have been returned to their homes in Gibraltar on two specially commissioned vessels.

Oinking Acres Pig Rescue and Sanctuary is making a difference in the Brownsburg community by saving more than 150 potbellied pigs.

Olivia Head discovered there was a high demand for fostering and adopting potbellied pigs. Thus, Oinking Acres Pig Rescue and Sanctuary was born.

Crews attended 16 call outs across Scotland on the VE Day holiday as the number of UK rescues rose by 54%.

And how Congress can rein him in.

strataconf: Can data rescue the forest elephant? Yes, with your help. http://t.co/DZBXKRdUcA Read about Elephant Listening Project & send us your ideas

Mobilization of hematopoietic stem/progenitor cells (HSPCs) from the bone marrow (BM) is impaired in diabetes. Excess oncostatin M (OSM) produced by M1 macrophages in the diabetic BM signals through p66Shc to induce Cxcl12 in stromal cells and retain HSPCs. BM adipocytes are another source of CXCL12 that blunts mobilization. We tested a strategy of pharmacologic macrophage reprogramming to rescue HSPC mobilization. In vitro, PPAR- activation with pioglitazone switched macrophages from M1 to M2, reduced Osm expression, and prevented transcellular induction of Cxcl12. In diabetic mice, pioglitazone treatment downregulated Osm, p66Shc and Cxcl12 in the hematopoietic BM, restored the effects of granulocyte-colony stimulation factor (G-CSF), and partially rescued HSPC mobilization, but it increased BM adipocytes. Osm deletion recapitulated the effects of pioglitazone on adipogenesis, which was p66Shc-independent, and double knockout of Osm and p66Shc completely rescued HSPC mobilization. In the absence of OSM, BM adipocytes produced less CXCL12, being arguably devoid of HSPC-retaining activity, whereas pioglitazone failed to downregulate Cxcl12 in BM adipocytes. In diabetic patients under pioglitazone therapy, HSPC mobilization after G-CSF was partially rescued. In summary, pioglitazone reprogrammed BM macrophages and suppressed OSM signaling, but sustained Cxcl12 expression by BM adipocytes could limit full recovery of HSPC mobilization.

COVID-19-ravaged regional economies, including Jamaica, will need the united strength of the Caribbean Single Market and Economy (CSME) to help revive their micro, small and medium enterprise (MSME) sectors, many of which have been decimated. That...

Firefighters in Arizona came to the rescue of a puppy that plunged into a 15-foot-deep hole at a construction site.

Police and public works employees in Wisconsin came to the rescue of a deer that found itself struggling to escape a soccer net.

Animal rescuers in California said they reached over the side of a freeway on-ramp to rescue a raccoon seen dangling from a metal beam under the ramp.

Animal rescuers in Britain said a fox was rescued from the narrow gap between the external walls of a house and its garage.

[19--?]

London : Stacy Bias, 2019.

Sibylle Béchet
Apr 8, 2020; 40:3104-3118
Neurobiology of Disease

Op-ed by Agustín Carstens published in the Financial Times on 29 March 2020.

Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist fingolimod (FTY720) attenuates psychosine-induced glial cell death and demyelination both in vitro and ex vivo models. These data, together with a lack of therapies for Krabbe's disease, prompted the current preclinical study examining the effects of fingolimod in twitcher mice, a murine model of Krabbe's disease. Twitcher mice, both male and female, carrying a natural mutation in the galc gene were given fingolimod via drinking water (1 mg/kg/d). The direct impact of fingolimod administration was assessed via histochemical and biochemical analysis using markers of myelin, astrocytes, microglia, neurons, globoid cells, and immune cells. The effects of fingolimod on twitching behavior and life span were also demonstrated. Our results show that treatment of twitcher mice with fingolimod significantly rescued myelin levels compared with vehicle-treated animals and also regulated astrocyte and microglial reactivity. Furthermore, nonphosphorylated neurofilament levels were decreased, indicating neuroprotective and neurorestorative processes. These protective effects of fingolimod on twitcher mice brain pathology was reflected by an increased life span of fingolimod-treated twitcher mice. These in vivo findings corroborate initial in vitro studies and highlight the potential use of S1P receptors as drug targets for treatment of Krabbe's disease.

SIGNIFICANCE STATEMENT This study demonstrates that the administration of the therapy known as fingolimod in a mouse model of Krabbe's disease (namely, the twitcher mouse model) significantly rescues myelin levels. Further, the drug fingolimod also regulates the reactivity of glial cells, astrocytes and microglia, in this mouse model. These protective effects of fingolimod result in an increased life span of twitcher mice.

A collection of 14 restored wooden statues, including a two-ton William IV, will be shown at the Box Museum in England

Precious data points logged on paper are in dire need of a hero. Could it be you?

As 'Fitspo' turns off many women, it's Bollywood dance to the rescue  The Age