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Review: Beethoven's Fifth is the music of our moment. How Teodor Currentzis makes it so

The last thing we need is another Beethoven's Fifth Symphony — unless Teodor Currentzis is conducting. His new recording brings much-needed catharsis.




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New fire commissioner signs covenant with UK Armed Forces

London Fire Brigade’s first Commissioner in 75 years to have served as a commissioned officer in the British army has today sign a covenant with the UK armed forces.




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Where is the Ark of the Covenant? How holy relic could be hidden below Jerusalem



THE Ark of the Covenant has been lost for more than 2,000 years but one expert believes the holy relic could be lurking deep beneath Jerusalem.




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Slovenia timeline

A chronology of key events




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Slovenia country profile

Key facts, figures and dates




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Coronavirus: I'm using my pizza oven to toss masks for nurses

Chicagoans are racing to make personal protective equipment for frontline workers.




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How Carrie Fisher’s role was woven into ‘Rise of Skywalker’

It was "heartbreaking" not to have Fisher on set for the new Star Wars film, says director J.J. Abrams.




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AT#162 - Travel to Slovenia

The Amateur Traveler talks to Shel Holtz (from the For Immediate Release podcast) about his trip to Slovenia. Here about the food, the wine, the lake and the cake as Shel describes his visit to the capital of Ljubjana, the caves at Postojna, Portoroz castle and Lake Bled. Slovenia is one of Europe’s best kept secrets.




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AT#373 Travel to Slovenia

Hear about travel to Slovenia as the Amateur Traveler talks again to Michael Soncina about his visit to the country. The country is independent, beautiful and deserves to see more tourists than it gets.




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AT#510 - Travel to Provence, France

Hear about travel to Provence, France as the Amateur Traveler talks to Wendy Jaeger from blisstravels.com about her adopted home in the south of France.




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AT#656 - Travel to Slovenia

Hear about travel to Slovenia as Chris Christensen (the Amateur Traveler) talks about his recent solo road trip through western Slovenia as a guest of the Slovenia Tourism board. 




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This solar oven can cook using the power of the sun, and it's on sale

TL;DR: Have a hot meal wherever you go with the Go portable solar oven for $119, a 14% savings as of May 9.


As we look toward upcoming summer festivities, our calendars are looking pretty bleak. Nearly every event has been postponed. Festival season was straight-up canceled. And gatherings in public places are basically extinct. With fewer options on the table, you're probably going to be spending a lot of time enjoying the great outdoors in small groups or on your own as the weather warms up. By then, you'll be sick of staying home, so it's a good thing nature isn't canceled.

As you head outside for your camping, hiking, biking, and beach excursions, you'll probably need a way to cook your own food, especially if restaurants are still closed or operating on abbreviated hours. We've got just thing, and it's on sale: the Go Portable Solar Oven. All you need is a little bit of sun and this lightweight grill can cook just about anything. Read more...

More about Cooking, Camping, Mashable Shopping, Tech, and Consumer Tech




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Five of the Best B2B Content Marketing Trends That Are Proven Effective To Gain New Clients

Digital marketing is fast-paced with trends and new updates to existing systems continuously popping out. That’s why it is important to stay up-to-date with the latest strategies that can be beneficial in reaching new audiences. Keeping up to date with the marketing trends will also help a business stay ahead of their competition. The best […]

The post Five of the Best B2B Content Marketing Trends That Are Proven Effective To Gain New Clients appeared first on Dumb Little Man.




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Source Murray Model - method for determining permitted take in the Victorian Murray, Kiewa and Ovens SDL resource units.




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#m720 Jail & "In the Oven"




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Madagascar ships unproven herbal remedy for COVID-19 to several African nations

Madagascar is putting its self-proclaimed, plant-based "cure" for COVID-19 on sale and several countries in Africa have already put in orders for purchase, despite warnings from the World Health Organization that its efficacy is unproven.




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Special Olympics in Slovenia

We look at how the Slovenian FA is tackling disability football.




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Slovenia's Roma clubs

We find out about the importance of equal opportunities for Roma players in Slovenian football.




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Slovenia make history with Spain futsal success

Slovenia's 1-0 first-leg defeat of Spain ended a string of streaks held by the European champions, including 27 straight wins and unbeaten runs of more than a decade.




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Steel-Woven Wallet Pledges To Keep RFID Credit Cards Safe




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This solar oven can cook using the power of the sun, and it's on sale

TL;DR: Have a hot meal wherever you go with the Go portable solar oven for $119, a 14% savings as of May 9.


As we look toward upcoming summer festivities, our calendars are looking pretty bleak. Nearly every event has been postponed. Festival season was straight-up canceled. And gatherings in public places are basically extinct. With fewer options on the table, you're probably going to be spending a lot of time enjoying the great outdoors in small groups or on your own as the weather warms up. By then, you'll be sick of staying home, so it's a good thing nature isn't canceled.

As you head outside for your camping, hiking, biking, and beach excursions, you'll probably need a way to cook your own food, especially if restaurants are still closed or operating on abbreviated hours. We've got just thing, and it's on sale: the Go Portable Solar Oven. All you need is a little bit of sun and this lightweight grill can cook just about anything. Read more...

More about Cooking, Camping, Mashable Shopping, Tech, and Consumer Tech




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God’s Eternal Covenant of Promise (Galatians 3:15–18)

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.




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Lawbite: No modification of restrictive covenant

The Alexander Devine Children's Cancer Trust v Millgate Developments Ltd and others [2018] EWCA Civ 2679 The Court of Appeal has refused to allow a property developer to modify a set of restrictive covenants, reversing the decision of the Upper Trib...




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Repairing covenants - does aesthetic appearance matter?

Blue Manchester LTD v North West Ground Rents LTD [2019] EWHC 142 (TCC) The High Court confirmed earlier this year that landlords must consider aesthetic appearance when assessing repairs as they may be obliged to reinstate original design features....




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Lawbite: Don’t make a dog’s dinner over restrictive covenants!

Modification and discharge of restrictive covenants! In the matter of an application by Paul Holden (2018) Many properties are bound by restrictive covenants, which restrict the use to which the property in question may be put.  Restrictive cov...




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Billy’s Biscuits for Countertop Convection Ovens

I Love Biscuits and I have been searching for a quick and easy recipe to make in my countertop convection oven. Living in a hot climate – I don’t want to heat up the house with the regular oven and besides, I only want a small batch. This is a quick and easy Drop-Biscuit recipe that makes six biscuits. Plus, you can make it Vegan if you like! -- posted by Billy R.




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New Jersey Resources Corporation (NJR) CEO Steve Westhovenon Q2 2020 Results - Earnings Call Transcript




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Enforcing restrictive covenants

The litigation in City Inn (Jersey) Ltd v Ten Trinity Square Ltd, between rival hoteliers next to the Tower of London, concerned restrictive covenants imposed by the Port of London Authority (PLA). The parties asked the court to decide whether the c...




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Easements, covenants and profits à prendre: reform is in the air

The Law Commission has published a consultation paper proposing wide-ranging reforms to the law governing easements, covenants and profits à prendre. The changes suggested by the Law Commission include: the creation of a single new method ...




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Discharging restrictive covenants

In Re Alisha House, the Lands Tribunal discharged a restrictive covenant preventing a developer from using land for residential development in circumstances where: the developer had entered into the restrictive covenant with the local authority r...




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Slovenian cyclists stage anti-government coronavirus protest

Thousands of cyclists took over streets in the center of the Slovenian capital Ljubljana on Friday evening to protest against the government of Prime Minister Janez Jansa and the restrictions it has imposed to fight the coronavirus.




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Slovenian cyclists stage anti-government coronavirus protest

Thousands of cyclists took over streets in the center of the Slovenian capital Ljubljana on Friday evening to protest against the government of Prime Minister Janez Jansa and the restrictions it has imposed to fight the coronavirus.




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Provenge Approved for Advanced Prostate Cancer

Title: Provenge Approved for Advanced Prostate Cancer
Category: Health News
Created: 4/29/2010 2:10:00 PM
Last Editorial Review: 4/30/2010 12:00:00 AM




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Interest in Unproven COVID Drugs Soared After Trump Gave Thumbs Up

Title: Interest in Unproven COVID Drugs Soared After Trump Gave Thumbs Up
Category: Health News
Created: 4/29/2020 12:00:00 AM
Last Editorial Review: 4/30/2020 12:00:00 AM




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Atorvastatin Reduces In Vivo Fibrin Deposition and Macrophage Accumulation, and Improves Primary Patency Duration and Maturation of Murine Arteriovenous Fistula

Background

Arteriovenous fistulas placed surgically for dialysis vascular access have a high primary failure rate resulting from excessive inward remodeling, medial fibrosis, and thrombosis. No clinically established pharmacologic or perisurgical therapies currently address this unmet need. Statins’ induction of multiple anti-inflammatory and antithrombotic effects suggests that these drugs might reduce arteriovenous fistula failure. Yet, the in vivo physiologic and molecular effects of statins on fistula patency and maturation remain poorly understood.

Methods

We randomized 108 C57Bl/6J mice to receive daily atorvastatin 1.14 mg/kg or PBS (control) starting 7 days before end-to-side carotid artery–jugular vein fistula creation and for up to 42 days after fistula creation. We then assessed longitudinally the effects of statin therapy on primary murine fistula patency and maturation. We concomitantly analyzed the in vivo arteriovenous fistula thrombogenic and inflammatory macrophage response to statin therapy, using the fibrin-targeted, near-infrared fluorescence molecular imaging agent FTP11-CyAm7 and dextranated, macrophage-avid nanoparticles CLIO-VT680.

Results

In vivo molecular-structural imaging demonstrated that atorvastatin significantly reduced fibrin deposition at day 7 and macrophage accumulation at days 7 and 14, findings supported by histopathologic and gene-expression analyses. Structurally, atorvastatin promoted favorable venous limb outward remodeling, preserved arteriovenous fistula blood flow, and prolonged primary arteriovenous fistula patency through day 42 (P<0.05 versus control for all measures).

Conclusions

These findings provide new in vivo evidence that statins improve experimental arteriovenous fistula patency and maturation, indicating that additional clinical evaluation of statin therapy in patients on dialysis undergoing arteriovenous fistula placement is warranted.




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Facial Nerve Arterial Arcade Supply in Dural Arteriovenous Fistulas: Anatomy and Treatment Strategies [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

Endovascular treatment of petrous dural AVFs may carry a risk of iatrogenic facial nerve palsy if the facial nerve arterial arcade, an anastomotic arterial arch that supplies the geniculate ganglion, is not respected or recognized. Our purpose was to demonstrate that the use of a treatment strategy algorithm incorporating detailed angiographic anatomic assessment allows identification of the facial nerve arterial arcade and therefore safe endovascular treatment.

MATERIALS AND METHODS:

This was a retrospective cohort study of consecutive petrous dural AVF cases managed at Toronto Western Hospital between 2006 and 2018. Our standard of care consists of detailed angiographic assessment followed by multidisciplinary discussion on management. Arterial supply, primary and secondary treatments undertaken, angiographic outcomes, and clinical outcomes were assessed by 2 independent fellowship-trained interventional neuroradiologists.

RESULTS:

Fifteen patients had 15 fistulas localized over the petrous temporal bone. Fistulas in all 15 patients had direct cortical venous drainage and received at least partial supply from the facial nerve arterial arcade. Following multidisciplinary evaluation, treatment was performed by endovascular embolization in 8 patients (53%) and microsurgical disconnection in 7 patients (47%). All patients had long-term angiographic cure, and none developed iatrogenic facial nerve palsy.

CONCLUSIONS:

By means of our treatment strategy based on detailed angiographic assessment and multidisciplinary discussion, approximately half of our patients with petrous AVFs were cured by endovascular treatment, half were cured by an operation, and all had preserved facial nerve function.




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Treatment Outcomes of Endovascular Embolization Only in Patients with Unruptured Brain Arteriovenous Malformations: A Subgroup Analysis of ARUBA (A Randomized Trial of Unruptured Brain Arteriovenous Malformations) [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

Endovascular embolization only has been advocated for treatment of brain arteriovenous malformations in recent trials. Our aim was to evaluate the results of embolization only in a cohort of patients who were enrolled in the A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) study at 39 clinical sites in 9 countries.

MATERIALS AND METHODS:

We analyzed the rates and severity of stroke and death in patients who underwent embolization only. Events were identified through in-person neurologic follow-up visits performed at 6-month intervals during the first 2 years and annually, with telephone contact every 6 months thereafter. All event-related data were reviewed by independent adjudicators.

RESULTS:

Among 30 patients who had embolization planned, 26 underwent embolization only. A total of 13 stroke events were reported in the follow-up period among 26 subjects (ischemic, hemorrhagic, or both in 4, 7, and 2 subjects, respectively). The adverse event occurred after the first embolization in 11 of 13 patients. One patient had a major motor deficit, and 2 patients developed major visual field deficits. One event was fatal. The modified Rankin Scale score was 0–2 at last follow-up in 11 of the 12 stroke survivors. Estimated stroke-free survival was 46% at 12 months.

CONCLUSIONS:

Although the rates of stroke and/or death were high in patients treated with embolization only in ARUBA, the rates of favorable outcomes following stroke were high during follow-up.




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Complications of Endovascular Treatments for Brain Arteriovenous Malformations: A Nationwide Surveillance [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

Embolization is widely performed to treat brain arteriovenous malformations, but little has been reported on factors contributing to complications. We retrospectively reviewed a nationwide surveillance to identify risk factors contributing to complications and short-term clinical outcomes in the endovascular treatment of brain arteriovenous malformations.

MATERIALS AND METHODS:

Data for endovascular treatment of brain arteriovenous malformations were extracted from the Japanese nationwide surveillance. Patient characteristics, brain arteriovenous malformation features, procedures, angiographic results, complications, and clinical outcomes at 30 days postprocedure were analyzed.

RESULTS:

A total of 1042 endovascular procedures (788 patients; mean, 1.43 ± 0.85 procedures per patient) performed in 111 institutions from 2010 to 2014 were reviewed. Liquid materials were used in 976 procedures (93.7%): to perform presurgical embolization in 638 procedures (61.2%), preradiosurgical embolization in 160 (15.4%), and as sole endovascular treatment in 231 (22.2%). Complete or near-complete obliteration of brain arteriovenous malformations was obtained in 386 procedures (37.0%). Procedure-related complications occurred in 136 procedures (13.1%), including hemorrhagic complications in 59 (5.7%) and ischemic complications in 57 (5.5%). Univariate analysis identified deep venous drainage, associated aneurysms, infratentorial location, and preradiosurgical embolization as statistically significant risk factors for complications. Multivariate analysis showed that embolization of brain arteriovenous malformations in the infratentorial location was significantly associated with complications. Patients with complications due to endovascular procedures had worse clinical outcomes 30 days after the procedures than those without complications.

CONCLUSIONS:

Complications arising after endovascular treatment of brain arteriovenous malformations are not negligible even though they may play a role in adjunctive therapy, especially in the management of infratentorial brain arteriovenous malformations.




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Slovenian cyclists stage anti-government coronavirus protest

Thousands of cyclists took over streets in the centre of the Slovenian capital Ljubljana on Friday evening to protest against the government of Prime Minister Janez Jansa and the restrictions it has imposed to fight the coronavirus.




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Trump administration &apos;ignored coronavirus warnings and pushed unproven drug&apos;, says senior scientist

The Trump administration failed to prepare for the onslaught of coronavirus, then sought a quick fix by trying to rush an unproven drug to patients, a senior government scientist has alleged in a whistleblower complaint.




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Coronavirus: Surge in people trying to buy unproven &apos;cures&apos; promoted by Trump and Elon Musk, study finds

Even deaths did not stop interest in buying potentially dangerous drugs, researchers find




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Charlton urge EFL to take action against ousted chairman Matt Southall if misconduct allegations are proven

Charlton have called on the EFL to sanction ousted chairman Matt Southall, rather than the club, if the League's investigation finds evidence of misconduct.




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Why 3D printing has proven to be the ‘true hero’ during this pandemic

John Dogru, CEO of 3DPrinterOS, spoke to MPN’s editor Laura Hughes about the pivotal role of 3D printing during the Covid-19 pandemic.




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Covenant Medical Center to Pay U.S. $4.5 Million to Resolve False Claims Act Allegations

Covenant Medical Center in Waterloo, Iowa has agreed to pay the United States $4.5 million to resolve allegations that it violated the False Claims Act. This settlement resolves allegations that Covenant submitted false claims to Medicare by having financial relationships with five physicians that violated the Stark Law.



  • OPA Press Releases

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Electrolux Agrees to Pay $750,000 Civil Penalty for Delay in Reporting Oven Hazard

The Justice Department’s Civil Division announced today that Electrolux Home Products Inc., of Charlotte, North Carolina, has agreed to pay a civil penalty of $750,000 to settle allegations that it knowingly failed to report immediately to the U.S. Consumer Product Safety Commission a safety hazard associated with certain wall ovens sold to consumers.



  • OPA Press Releases

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FDA approves Proventil and Daraprim generics

The US Food and Drug Administration (FDA) has approved the first generic version of a commonly used inhaler, marketed as Proventil, and the anti-parasitic Daraprim, which has previously been the subject of a price gouging scandal.




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China is promoting coronavirus treatments based on unproven traditional medicines




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Just what we needed dept: a $10,000 home pizza oven

It can cook a pizza in two minutes? But I want it now.




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5 ways to make fruit cobbler without an oven

It's win-win: you don't heat up the kitchen and you still get the best dessert ever.




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Stool ZERO: Handwoven seating made from recycled fans & wire

Vibrantly colored wire is saved from the landfill and woven into recycled fan cages to produce these fresh pieces of furniture.