losing Kings snap losing streak with victory over Flames By www.latimes.com Published On :: Thu, 13 Feb 2020 01:45:39 -0500 The Kings' weeks-long scoring struggles finally subsided, as 12 players got on the scoresheet in a 5-3 victory over the Calgary Flames that ended the team's losing streak at five games. Full Article
losing Kern County city gets hit with triple whammy: Lockdowns, oil slump and prison closing By www.latimes.com Published On :: Wed, 6 May 2020 08:00:04 -0400 A small oil town in Southern California is pummeled by the economy during the coronavirus outbreak and economic downturn Full Article
losing Elliott: Olympian Mirai Nagasu finds hope in fight to keep parents' restaurant from closing By www.latimes.com Published On :: Wed, 22 Apr 2020 17:05:19 -0400 Olympic figure skater Mirai Nagasu, who grew up in her parents' restaurant in Arcadia, is determined not to let the coronavirus close the family business. Full Article
losing Column: As an L.A. newcomer, I adored Souplantation. I'm grieving its closing By www.latimes.com Published On :: Thu, 7 May 2020 22:57:45 -0400 Los Angeles magazine called it 'aggressively mediocre,' but its simple food and family-style seating reminded me of my Queens childhood. Full Article
losing Letters to the Editor: The Postal Service helps define our nation. Losing it would be devastating By www.latimes.com Published On :: Sun, 19 Apr 2020 06:00:40 -0400 The Postal Service is as important to the United States as its language and its highways. Losing it would forever change the country for the worse. Full Article
losing Film academy considers Oscar eligibility rules change with coronavirus theater closings By www.latimes.com Published On :: Fri, 20 Mar 2020 20:17:41 -0400 The coronavirus pandemic has shut down theaters, which may result in big changes for the Oscars. Full Article
losing British Airways: closing Gatwick solves the Heathrow problem By www.independent.co.uk Published On :: 2020-05-01T14:33:00Z The Man Who Pays His Way: will happen to the Sussex airport? Full Article
losing Tesla returns to losing money as revenue, cash and other key numbers tumble By www.latimes.com Published On :: Wed, 24 Apr 2019 17:47:56 -0400 Elon Musk envisions a glorious future when fleets of Tesla robo-taxis earn money for Tesla owners and make all other automobiles instantly obsolete. Full Article
losing Southwest Utah gains two cases, state closing in on 5,000 total cases By rssfeeds.thespectrum.com Published On :: Sun, 03 May 2020 03:30:17 +0000 Southwest Utah passed 100 positive cases of COVID-19 on Friday and the total tally sits at 103 cases on Saturday as Utah nears 5000 cases statewide Full Article
losing LGBTQ Americans are getting coronavirus, losing jobs. Anti-gay bias is making it worse for them. By rssfeeds.usatoday.com Published On :: Sat, 09 May 2020 11:07:16 +0000 The coronavirus outbreak is pummeling LGBTQ Americans, leaving a population already vulnerable to health care and employment discrimination suffering. Full Article
losing Cartoonist Gary Varvel: GM workers losing jobs By rssfeeds.indystar.com Published On :: Thu, 29 Nov 2018 17:32:59 +0000 General Motors announces 14,000 job cuts Full Article
losing Avon Schools is closing due to coronavirus concerns. Here's what parents need to know. By rssfeeds.indystar.com Published On :: Sat, 21 Mar 2020 03:54:25 +0000 After a coronavirus update that a second student was showing symptoms, Avon schools decided to close all buildings ahead of spring break. Full Article
losing List of Indianapolis-area coronavirus school closings By rssfeeds.indystar.com Published On :: Tue, 17 Mar 2020 16:49:05 +0000 As national, state and local officials consider ways to slow the spread of COVID-19, many are closing schools. Full Article
losing Donnie Walsh on losing basketball game to Dr. Anthony Fauci: 'How did that happen?' By rssfeeds.indystar.com Published On :: Thu, 02 Apr 2020 21:01:18 +0000 Donnie Walsh has been plopped in the middle of America's most famous infectious disease doctor's basketball claim to fame. Full Article
losing The Nashville House announces it's closing By rssfeeds.indystar.com Published On :: Wed, 17 Oct 2018 20:02:38 +0000 Landmark restaurant has been in business since 1927. Full Article
losing Stacked Pickle closing all restaurants due to impact of coronavirus restrictions By rssfeeds.indystar.com Published On :: Thu, 07 May 2020 11:44:49 +0000 The sports bar and restaurant owned by former Colts football player and Super Bowl champion Gary Brackett is closing. Full Article
losing Tie Dye Grill is closing, for good this time; say goodbye to one of Indy's best tenderloins By rssfeeds.indystar.com Published On :: Tue, 17 Jul 2018 23:42:27 +0000 A new location couldn't save the east-side restaurant. Full Article
losing He wrote a graphic novel about losing his home to a wildfire. Now Kincade is threatening it again. By www.washingtonpost.com Published On :: Wed, 30 Oct 2019 15:55:14 +0000 Eisner-winning cartoonist Brian Fies faces down another fire two years after losing his Northern California home. "I'm mostly numb," he says. Full Article
losing ‘Real Housewives’ stars Ashley and Michael Darby are closing their Virginia restaurant By www.washingtonpost.com Published On :: Wed, 26 Jun 2019 16:46:54 +0000 The couple ran Oz, an Australian-themed eatery in Clarendon. Full Article
losing Stop Losing Sleep: 7 Steps for Stress-free Decision-making By feedproxy.google.com Published On :: Mon, 27 Apr 2020 12:30:49 +0000 Decision-making can be tough especially when the best choice isn’t glaringly obvious. We’re faced with this process every minute of the day. When do I wake up? What’s for lunch? Do I want to go out on a date with this person? What do I want to do with my life? Can I stay in […] The post Stop Losing Sleep: 7 Steps for Stress-free Decision-making appeared first on Dumb Little Man. Full Article Stress Success
losing 'Where is that compassion?': Closing tent cities a chance to change housing policy, advocates say By bc.ctvnews.ca Published On :: Fri, 8 May 2020 06:49:00 -0700 T.J. Lovell had just 30 minutes to pack up his belongings from the tent city in Oppenheimer Park if he wanted access to a hotel room that he could share with his father. Full Article
losing After Latest Turn, Is Muqtada al-Sadr Losing Influence in Iraq? By feedproxy.google.com Published On :: Wed, 12 Feb 2020 14:23:04 +0000 12 February 2020 Dr Renad Mansour Senior Research Fellow, Middle East and North Africa Programme; Project Director, Iraq Initiative @renadmansour Ben Robin-D'Cruz Researcher on Iraqi Politics, University of Edinburgh The populist cleric has repositioned himself in Iraqi politics multiple times, but his recent shift against youth-led protestors may signal his decline as an autonomous political force. 2020-02-12-Sadr.jpg Muqtada al-Sadr in Najaf in October. Photo: Getty Images. Following the US strike on Qassem Solaimani and Abu Mehdi al-Muhandis, populist cleric Muqtada al-Sadr has violently cracked down on youth-led protests in Iraq.His paramilitaries and ‘blue hats’ – supposedly created to protect protestors from state and allied parastatal security forces – sought to end the months-long demonstrations by attacking the places where protesters have camped since October. In Baghdad’s Tahrir Square, they successfully captured the famous Turkish restaurant which had become a symbol of Iraq’s ‘October revolution’. Once the champion of Iraq’s protest movement, Sadr has seemingly changed course and now leads the counter-protests. This reversal has mystified many, from Iraqis who saw Sadr as an ally in their struggle for reform against an impenetrable elite to foreign diplomats who hoped Sadr could help pushback against Iranian influence in Iraq. Yet this is not the first time that Sadr has drastically redefined his position. Since 2003, he has gone from Shia sectarian militia leader to pro-democracy reformist and Iraqi nationalist.And in the past few months, he has given mixed signals, both supporting and criticising the protesters. The most recent incidents of Sadrist violence targeting demonstrators provoked a societal backlash, prompting Sadr to change tack once more and announce that he would disband the blue hats and investigate their crimes against protesters.Sadr and the paramilitariesSadr’s latest change of course may seem to flow directly from the US assassination of Qassem Soleimani and Abu Mahdi al-Muhandis and the ensuing vacuum in the Shia paramilitary sphere. Prior to this move, the Sadrists were on the defensive, outflanked and outgunned by the growing coercive and political power of a constellation of Shia armed groups coalescing under Muhandis’s de facto leadership. Many of these groups competed for Sadr’s base, including Qais al-Khazali’s Asa’ib ahl al-Haq and Akram al-Kaabi’s Harakat Hezbollah al-Nujaba. With Muhandis out of the picture, Sadr could reclaim the space by pushing his own right hand, Kadhem al-Issawi (Abu Do’a), to be the new centre of the paramilitary field and forcing competitors, including Khaza’li and Kaabi, to rally around his leadership.Iran, in the short term, appears to be going along with this solution to bring more coherence to its allied forces in Iraq as it seeks to counter what it regards as US aggression. Iran also hopes that bringing Sadr back in will help neutralize the protest movement which threatens its stake in Iraqi politics. The most visible sign of this Iran-brokered rapprochement was the 13 January meeting in Qom attended by Sadr, Issawi and several senior militia commanders including Laith al-Khazali (Qais al-Khazali’s brother). Following the Qom meeting, a pattern of tit-for-tat violence and assassinations between the Sadrists’ Saraya al-Salam and Asa’ib Ahl al-Haq – ongoing since the start of the October protests in Iraq – ceased.A fragmented movement?However, while the US strikes certainly changed Sadr’s political calculations, there are more persistent fundamentals at work that help explain his change of course. The first of these relates to long-standing fragmentation within the movement. This exists not only within Sadrist paramilitaries, but within the movement’s clerical networks, and also applies to the ties that bind the Sadrist leadership to its popular base. This fragmentation makes it difficult for Sadr to impose a coherent politics on his followers from the top down.There are signs that Sadr’s recent shift in position has exacerbated this fragmentation. His attempt to reposition the movement’s base within the ‘resistance axis’ that supports the Shia militias in Iraq has only been partially successful. On 24 January, responding to the US assassinations, Sadr called for a million-man march focused on expelling US forces from Iraq. However, turnout was poor, especially given the huge logistical support for the march, and it lasted only a few hours.Equally revealing, when Sadr called on his supporters to vacate the squares, many refused. One Sadrist protester in Baghdad’s Tahrir Square told the authors: ‘We’ve been camping with our brothers and sisters for four months. Why should we leave them to die?’Meanwhile, fissures have also opened up within the Sadrists’ clerical elite. One senior Sadrist cleric, for example, is openly defying Sadr’s authority and siding with the revolutionaries in Nasiriyah. Sadr’s attempt to dominate the paramilitary sphere is also unlikely to prove any more successful than his many previous failed attempts since 2003. He is neither trusted nor respected by the leaders of other groups. The Iran-brokered rapprochement is already showing signs of weakness. Two recent assassinations of Saraya al-Salam leaders in Basra and Maysan indicate a potential renewal of power struggles between the Sadrist militia and Asa’ib Ahl al-Haq. Sadr is not a revolutionarySadr has never been a revolutionary, but someone who seeks to leverage a role as both ‘spoiler’ and ‘stabilizer’ to maximise his political leverage. This strategy is ultimately oriented towards sustaining Iraq’s extant political system, not its overthrow. Forced to choose between the roles of revolutionary or maintainer of the status quo, he has opted for the latter. The protests that erupted in 2019 were not the same movement that Sadr led from 2015. The 2015 protests were an elite-driven phenomenon, integrated into the political field and carefully calibrated to exert pressure on the elite towards gradual reform. By contrast, the 2019 demonstrations spring from a youth-led, bottom-up mobilization that rejects politicization and seeks a more radical form of change. Chatham House surveys in a forthcoming paper reveal that the protesters are younger that those who protested in 2015-16. Fewer have permanent employment. Instead of demanding better services or jobs, they are focusing wholesale transformation of the post-2003 political system.A Sadrist official told the authors that their movement initially joined the protests in October 2019 expecting a similar reform-orientation to the protests which Sadr had previously led. However, according to him, the protesters failed to come forward with reasonable demands or alternative names for prime minister. He believed the protests would fade, and many would regret the ‘wasted time and blood’. Sadr’s relations with IranA final long-term factor at play is Sadr’s receding autonomy from Iran. Ever since his movement’s electoral victory in May 2018, Sadr came under enormous pressure to reconcile with the political wing of the Iranian-allied parastatal armed groups in the formation of a new government acceptable to Iran.Over the last year, Sadr has moved even closer to Iran, spending more time in Qom. Iran has offered Sadr security from his paramilitary rivals (such as Asa’ib ahl al-Haq), convincing Sadr that he is safer in Iran than Iraq. Moreover, Sadr is undertaking religious training in Qom, and may see this as a chance to enhance his standing in the Shia religious field as many look towards a future beyond the elderly Najaf-based marja Ali al-Sistani.By keeping Sadr in Qom, Iran appears to be trying to isolate him from what they regard as negative influences. As tensions between the Sadrists and other protest groups intensified, efforts were made by some protest leaders and allied political groups to reach Sadr in Qom and try to persuade him to change course or restrain the worst abuses of his forces. However, this delegation was unable to make contact with Sadr. Those involved told the authors they have resorted to communicating with local Sadrist leaders in Najaf, Babil, Basra and Baghdad. Crossing a lineThis is a transformative moment for the Sadrists. Sadr is now defying the popular sentiments driving protests across central and southern Iraq. The sense of betrayal among former allies and friends of the Sadrists is palpable. One senior activist involved in cooperation with the Sadrists wrote that, no matter what moves Sadr makes next, the cleric has ‘terminated all partnership with the protesters,’ and ‘shattered the framework for cooperation’. A line has thus been crossed that Sadr cannot reverse; he will not be able to recover what he has now lost. Iran, also, does not see Sadr as a dependable ally, and will look to isolate and side-line the cleric when the opportunity arises. Thus, in seeking to exploit a crisis for short-term gain, Sadr may well have sealed his fate – in the long term – as a declining force in Iraqi politics. Full Article
losing Britain should treat Europe as its ‘inner circle’ or risk losing international influence By feedproxy.google.com Published On :: Mon, 19 Oct 2015 09:05:23 +0000 13 October 2015 20151019BritanEuropeWorld.jpg British Prime Minister David Cameron sits with other world leaders at the G20 summit in Brisbane, Australia on 15 November 2014. Photo by Getty Images. Given the international context, it is in Britain’s best interests to treat Europe as the ‘inner circle’ of its foreign, security and international economic policy, argues Dr Robin Niblett, director of Chatham House, in a new paper.The British government’s approach since 2010 of seeking to enhance the UK's relations with the world’s emerging powers while balancing these with relationships with the United States and Europe has had only limited success. With constrained resources, and in the face of intense global economic competition, mounting security challenges and decaying international institutions, trying to commit the UK equally on all three fronts will not succeed in the future.Britain, Europe and the World: Rethinking the UK’s Circles of Influence calls for a different mindset and strategy towards the UK’s place in the world – one in which Britain is surrounded by three concentric circles of influence:The first or ‘inner circle’ is the EU, the region with which the UK’s relationships need to be strongest and most active.The ‘second circle’ consists of the protective and enabling set of economic and security relationships with the US.Finally, an ‘outer circle’ comprises the UK’s other key bilateral and institutional relationships.Should the UK vote to remain in the EU, policy-makers should commit to placing the EU at the centre of Britain's foreign policy, using the country’s economic weight, diplomatic skills and networks to play a leading role in leveraging more effective EU-wide policies. Should the country vote to leave, the UK and the EU would enter an extended period of dislocation before arriving at a new, mutually diminished settlement. British policy-makers would be forced to deal and negotiate with the EU on critical policy issues from the outside. It is hard to see, argues Dr Niblett, how that could lead to EU policies or an international context more in line with British interests. Despite its structural flaws and competing national interests, the EU offers the best prospects for managing the rapidly changing global context, for three main reasons:First, it allows the UK to leverage the EU’s global economic weight to enhance the UK’s economic interests internationally, including securing beneficial trade agreements and contributing to EU and global standard-setting and rule-writing. Conversely, leaving would require the UK to renegotiate over 100 trade agreements, and would disadvantage UK interests in EU markets, including making EU governments less likely to liberalize services. Second, it gives the UK a say in designing new EU initiatives to strengthen both British and European security in the face of diverse threats, whether managing the flow of refugees and other emigrants; combatting terrorism; or managing a more assertive Russia and the fallout from a disintegrating Middle East. Third, cooperating with other EU members offers a way of maximizing opportunities to find joint solutions to shared problems, whether in terms of responding to climate change; managing growing cyber insecurity; reversing the decay of governance in failing states; or combating the rise of dangerous non-state actors.Dr Robin Niblett said:‘Britain is likely to be richer, safer and more influential in the coming decades if it treats Europe as the ‘inner circle’ of its foreign policy. For a mid-sized country like the UK, being a major player in a strong regional institution can offer a critical lever for international influence. In the UK’s case, this means choosing to be a leading player in the world’s principal civilian power, the European Union.’ Editor's notes Read Britain, Europe and the World: Rethinking the UK's Circles of InfluenceChatham House will host a press briefing with Dr Robin Niblett on Monday 19 October at 11:00-11:45 BST. To register, or for interview requests, please contact the press office.The views expressed in this paper are those of the author. Chatham House experts will publish a series of papers and commentaries in the run up to the UK’s referendum on its membership of the EU. The institute will also offer a platform for debate on the referendum and Britain’s role in Europe via a series of events and meetings.Read more about the EU referendum. Contacts Press Office +44 (0)20 7957 5739 Email Full Article
losing Chatham House Forum: Is the West Losing its Power on the Global Stage? By feedproxy.google.com Published On :: Wed, 11 Apr 2018 00:00:00 +0100 Full Article
losing Closing the Global Access Gap in Palliative Care and Pain Relief: A Top Priority in Achieving Universal Health Coverage By feedproxy.google.com Published On :: Wed, 26 Jun 2019 13:50:01 +0000 Invitation Only Research Event 17 July 2019 - 12:30pm to 5:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Dr Tedros Adhanom Ghebreyesus, Director-General, World Health Organization The Lancet Commission on Palliative Care and Pain Relief estimated that in 2015, 61 million people experienced serious health-related suffering (SHS) that could have been ameliorated by palliative care. A large proportion of this burden – more than 80 per cent – fell on low- and middle-income countries (LMICs) despite an essential package of palliative care and pain relief services being cost-effective and affordable. As the director general of the World Health Organization (WHO) argues, there cannot be UHC without palliative care and thus, closing this coverage gap should be a top priority for the global UHC movement.The Centre on Global Health Security at Chatham House, building on the momentum of the Lancet Commission, is hosting a roundtable focused on the global unmet need for palliative care and effective pain relief. The primary purpose of this roundtable is to convene leading experts, palliative care service users and advocates with key figures from the UHC movement and global health to highlight the importance of prioritizing this vital part of the continuum of care in UHC reform processes. The roundtable will serve as a scholarly discourse in translating the recommendations of the Lancet Commission into concrete actions, focusing on the political and economic dimensions. Department/project Global Health Programme, Universal Health Coverage Policy Forum Alexandra Squires McCarthy Programme Coordinator, Global Health Programme +44 (0)207 314 2789 Email Full Article
losing CBD News: Statement by Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity at the closing session of the Ninth Meeting of the Parties to the Convention on Biological Diversity, Bonn, 30 May 2008. By www.cbd.int Published On :: Fri, 30 May 2008 00:00:00 GMT Full Article
losing CBD News: Statement by Ahmed Djoghlaf, CBD Executive Secretary, at the Closing Session of the Expert Meeting on Mainstreaming Biodiversity in Development Cooperation, Montreal, 15 May 2009. By www.cbd.int Published On :: Fri, 15 May 2009 00:00:00 GMT Full Article
losing CBD News: Statement by Mr Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, at the closing session of the Sixth Meeting of the Ad Hoc Open-Ended Working Group on Article 8(j) and Related Provisions of the Convention on Biologi By www.cbd.int Published On :: Fri, 06 Nov 2009 00:00:00 GMT Full Article
losing CBD News: Statement by Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, at the Closing Session of the Eighth Meeting of the Ad Hoc Open-Ended Working Group on Access and Benefit-Sharing, Montreal, 15 November 2009. By www.cbd.int Published On :: Sun, 15 Nov 2009 00:00:00 GMT Full Article
losing CBD News: The UN Secretary-General Message to Closing Ceremony for the International Year of Biodiversity, Kanazawa, 18 December 2010. The UNSG Message is also available in Japanese on the Countries Celebrations page www.cbd.int/2010/country/?country=jp By www.cbd.int Published On :: Sat, 18 Dec 2010 00:00:00 GMT Full Article
losing CBD News: Statement by CBD Executive Secretary, Braulio Ferreira de Souza Dias, at the Closing of the High-Level Segment of the 2016 United Nations Biodiversity Conference, Cancun, Mexico, 3 December 2016 By www.cbd.int Published On :: Sat, 03 Dec 2016 00:00:00 GMT Full Article
losing CBD News: Statement of the Executive Secretary, Ms. Cristiana Pasca Palmer, at the closing of the United Nations Biodiversity Conference 2018, Sharm el-Sheikh, Egypt, 29 November 2018 By www.cbd.int Published On :: Thu, 29 Nov 2018 00:00:00 GMT Full Article
losing CBD News: Statement by Ms. Cristiana Pasca Palmer, Executive Secretary, Convention on Biological Diversity, at the closing of the Plenary of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services, 4 May 2019 By www.cbd.int Published On :: Wed, 08 May 2019 00:00:00 GMT Full Article
losing CBD News: Statement by Ms. Cristiana Pas?ca Palmer, Executive Secretary, Convention on Biological Diversity, at the closing of the first meeting of the Open-ended Working Group on the Post-2020 Global Biodiversity Framework, Nairobi, 30 August 2019 By www.cbd.int Published On :: Fri, 30 Aug 2019 00:00:00 GMT Full Article
losing CBD News: Statement by Ms. Elizabeth Maruma Mrema, Officer-in-Charge, Secretariat of the Convention on Biological Diversity, at the closing of the twenty-third meeting of the Subsidiary Body on Scientific, Technical and Technological Advice, 29 November 2 By www.cbd.int Published On :: Fri, 29 Nov 2019 00:00:00 GMT Full Article
losing Modulation of natural HLA-B*27:05 ligandome by ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 2 (ERAP2) By feedproxy.google.com Published On :: 2020-04-07 Elena LorenteApr 7, 2020; 0:RA120.002014v1-mcp.RA120.002014Research Full Article
losing Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays [11. Microarrays/Combinatorics/Display Technology] By feedproxy.google.com Published On :: 2010-02-01T14:51:46-08:00 Ankylosing Spondylitis (AS) is a common, inflammatory rheumatic disease, which primarily affects the axial skeleton and is associated with sacroiliitis, uveitis and enthesitis. Unlike other autoimmune rheumatic diseases, such as rheumatoid arthritis or systemic lupus erythematosus, autoantibodies have not yet been reported to be a feature of AS. We therefore wished to determine if plasma from patients with AS contained autoantibodies and if so, characterize and quantify this response in comparison to patients with Rheumatoid Arthritis (RA) and healthy controls. Two high-density nucleic acid programmable protein arrays expressing a total of 3498 proteins were screened with plasma from 25 patients with AS, 17 with RA and 25 healthy controls. Autoantigens identified were subjected to Ingenuity Pathway Analysis in order to determine patterns of signalling cascades or tissue origin. 44% of patients with Ankylosing Spondylitis demonstrated a broad autoantibody response, as compared to 33% of patients with RA and only 8% of healthy controls. Individuals with AS demonstrated autoantibody responses to shared autoantigens, and 60% of autoantigens identified in the AS cohort were restricted to that group. The AS patients autoantibody responses were targeted towards connective, skeletal and muscular tissue, unlike those of RA patients or healthy controls. Thus, patients with AS show evidence of systemic humoral autoimmunity and multispecific autoantibody production. Nucleic Acid Programmable Protein Arrays constitute a powerful tool to study autoimmune diseases. Full Article
losing Modulation of natural HLA-B*27:05 ligandome by ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 2 (ERAP2) [Research] By feedproxy.google.com Published On :: 2020-04-07T08:35:14-07:00 The human leucocyte antigen (HLA)-B*27:05 allele and the endoplasmic reticulum-resident aminopeptidases are strongly associated with ankylosing spondylitis (AS), a chronic inflammatory spondyloarthropathy. This study examined the effect of endoplasmic reticulum aminopeptidase 2 (ERAP2) in the generation of the natural HLA-B*27:05 ligandome in live cells. Complexes of HLA-B*27:05-bound peptide pools were isolated from human ERAP2-edited cell clones and the peptides were identified using high throughput mass spectrometry analyses. The relative abundance of thousand ligands was established by quantitative tandem mass spectrometry and bioinformatics analysis. The residue frequencies at different peptide position, identified in presence or absence of ERAP2, determined structural features of ligands and their interactions with specific pockets of antigen binding site of HLA-B*27:05 molecule. Sequence alignment of ligands identified with species of bacteria associated with HLA-B*27-dependent reactive arthritis was performed. In the absence of ERAP2, peptides with N-terminal basic residues, and minority canonical P2 residues are enriched in the natural ligandome. Further, alterations of residue frequencies and hydrophobicity profile at P3, P7, and P positions were detected. In addition, several ERAP2-dependent cellular peptides were highly similar to protein sequences of arthritogenic bacteria, including one human HLA-B*27:05 ligand fully conserved in a protein from Campylobacter jejuni. These findings highlight the pathogenic role of this aminopeptidase in the triggering of AS autoimmune disease. Full Article
losing Is the Door Closing? Latin American and Caribbean Responses to Venezuelan Migration By www.migrationpolicy.org Published On :: Fri, 31 Jan 2020 16:30:49 -0500 This webinar marks the release of MPI's Latin American and Caribbean Migration Portal that offers up-to-date, authoritative research and data on migration trends and policies, and a report examining the policy responses of 11 countries in Latin America and the Caribbean to increased Venezuelan and Nicaraguan migration. Full Article
losing Is the Door Closing? Latin American and Caribbean Responses to Venezuelan Migration By www.migrationpolicy.org Published On :: Thu, 13 Feb 2020 11:40:37 -0500 Fleeing crisis, nearly 4 million Venezuelans have moved to other Latin American and Caribbean countries over the past few years. This webinar marked the launch of a Latin American and Caribbean Migration Portal, and a report examining the migration and integration policy responses in the region. Full Article
losing Maryland extends school closings through May 15 due to virus By feedproxy.google.com Published On :: Mon, 20 Apr 2020 00:00:00 +0000 Full Article Maryland
losing A fight between two men is interrupted by a woman representing mercy, pleading on behalf of the losing party. Engraving by G.T. Doo, 1848, after W. Etty. By feedproxy.google.com Published On :: London (5 Haymarket) : Published ... by J. Hogarth, June 1 1849. Full Article
losing Wintrust Financial Corporation Announces the Closing of the Acquisition of Countryside Bank By www.snl.com Published On :: Fri, 01 Nov 2019 20:10:00 GMT To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452. Full Article
losing Wintrust Financial Corporation Announces Precautionary Decision to Help Achieve Community Health Objectives By Temporarily Closing Selected Branches By www.snl.com Published On :: Tue, 17 Mar 2020 11:00:00 GMT To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452. Full Article
losing Closing arguments presented at trial of Regina man accused of sexually assaulting 14-year-old By www.cbc.ca Published On :: Fri, 8 May 2020 17:28:37 EDT Closing arguments were presented at the trial of Phillip Lionel Levac on Friday at Regina Court of Queen's Bench. Full Article News/Canada/Saskatchewan
losing Closing of First Nation borders to keep out COVID-19 reinforcing racial divisions on Manitoulin Island By www.cbc.ca Published On :: Thu, 7 May 2020 08:25:22 EDT Tensions are rising on Manitoulin Island because a First Nation is stopping travellers on provincial highways that go through the community. But opinions on M'Chigeeng's attempt to protect its people from COVID-19 are not divided along racial lines. Full Article News/Canada/Sudbury
losing Port of Sydney takes hit after losing more than 50 cruise visits this season By www.cbc.ca Published On :: Fri, 8 May 2020 13:55:07 EDT Holland America and Princess cruise lines issued notices this week cancelling the remainder of the season in Atlantic Canada, citing global health concerns, and that's taking a huge bite out of the Port of Sydney's budget. Full Article News/Canada/Nova Scotia
losing Michael Marinaro opens up about losing his grandmother to COVID-19 By www.cbc.ca Published On :: Sat, 25 Apr 2020 15:25:00 EDT Figure skater Michael Marinaro gets emotional as he talks about his grandmother who passed away from COVID-19. Marinaro and his partner Kirsten Moore-Towers joined fellow Canadian Kaitlyn Weaver who was hosting a livestream with figure skating legends to raise money for the UN Foundation's COVID-19 Solidarity Response Fund. Full Article Sports
losing Sask. economy has hopefully 'bottomed out' after losing 53,000 jobs in April, says economist By www.cbc.ca Published On :: Fri, 8 May 2020 11:30:15 EDT Saskatchewan's unemployment rate soared in April due to the COVID-19 economic shutdown but an economist says it's not likely to get much worse. Full Article News/Canada/Saskatoon
losing 'I can't get up without losing my breath': Former Habs enforcer Laraque on COVID-19 By www.cbc.ca Published On :: Sun, 3 May 2020 13:02:12 EDT Former Montreal Canadiens enforcer Georges Laraque's biggest challenge is trying to breathe clearly as he fights COVID-19 at a Montreal hospital. "The nights are the worst. I have fevers a couple times a night. I have to get up and take pills." Full Article Sports/Hockey/NHL