1 Fiji Dollar = 6.3303 Estonian Kroon

1 Fiji Dollar = 56.9613 Algerian Dinar

1 Fiji Dollar = 24.4294 Dominican Peso

1 Fiji Dollar = 3.0541 Danish Krone

1 Fiji Dollar = 11.155 Czech Republic Koruna

1 Fiji Dollar = 252.5197 Costa Rican Colon

1 Fiji Dollar = 1729.4411 Colombian Peso

1 Fiji Dollar = 3.1398 Chinese Yuan Renminbi

1 Fiji Dollar = 366.5288 Chilean Peso

1 Fiji Dollar = 0.431 Swiss Franc

1 Fiji Dollar = 0.6222 Canadian Dollar

1 Fiji Dollar = 5.3902 Botswana Pula

1 Fiji Dollar = 2.5443 Brazilian Real

1 Fiji Dollar = 3.0606 Bolivian Boliviano

1 Fiji Dollar = 0.6273 Brunei Dollar

1 Fiji Dollar = 0.1679 Bahraini Dinar

1 Fiji Dollar = 0.8014 Bulgarian Lev

1 Fiji Dollar = 37.7244 Bangladeshi Taka

1 Fiji Dollar = 0.6793 Australian Dollar

1 Fiji Dollar = 29.5036 Argentine Peso

1 Fiji Dollar = 0.7968 Netherlands Antillean Guilder

1 Fiji Dollar = 1.6303 United Arab Emirates Dirham

1 New Zealand Dollar = 1.3829 Fiji Dollar

1 Croatian Kuna = 0.3247 Fiji Dollar

1 Peruvian Nuevo Sol = 0.6628 Fiji Dollar

1 Dominican Peso = 0.0409 Fiji Dollar

1 Papua New Guinean Kina = 0.6568 Fiji Dollar

1 Brunei Dollar = 1.5942 Fiji Dollar

પોલીસ હજુ ધારાસભ્યને શોધી શકી નથી. એવામાં પોલીસ મોબાઈલ સર્વિલન્સના સહારે પણ ધારાસભ્યને શધી રહી છે

ABSTRACT

Insights into the interaction between phages and their bacterial hosts are crucial for the development of phage therapy. However, only one study has investigated global gene expression of Clostridioides (formerly Clostridium) difficile carrying prophage, and transcriptional reprogramming during lytic infection has not been studied. Here, we presented the isolation, propagation, and characterization of a newly discovered 35,109-bp phage, JD032, and investigated the global transcriptomes of both JD032 and C. difficile ribotype 078 (RT078) strain TW11 during JD032 infection. Transcriptome sequencing (RNA-seq) revealed the progressive replacement of bacterial host mRNA with phage transcripts. The expressed genes of JD032 were clustered into early, middle, and late temporal categories that were functionally similar. Specifically, a gene (JD032_orf016) involved in the lysis-lysogeny decision was identified as an early expression gene. Only 17.7% (668/3,781) of the host genes were differentially expressed, and more genes were downregulated than upregulated. The expression of genes involved in host macromolecular synthesis (DNA/RNA/proteins) was altered by JD032 at the level of transcription. In particular, the expression of the ropA operon was downregulated. Most noteworthy is that the gene expression of some antiphage systems, including CRISPR-Cas, restriction-modification, and toxin-antitoxin systems, was suppressed by JD032 during infection. In addition, bacterial sporulation, adhesion, and virulence factor genes were significantly downregulated. This study provides the first description of the interaction between anaerobic spore-forming bacteria and phages during lytic infection and highlights new aspects of C. difficile phage-host interactions.

IMPORTANCE C. difficile is one of the most clinically significant intestinal pathogens. Although phages have been shown to effectively control C. difficile infection, the host responses to phage predation have not been fully studied. In this study, we reported the isolation and characterization of a new phage, JD032, and analyzed the global transcriptomic changes in the hypervirulent RT078 C. difficile strain, TW11, during phage JD032 infection. We found that bacterial host mRNA was progressively replaced with phage transcripts, three temporal categories of JD032 gene expression, the extensive interplay between phage-bacterium, antiphage-like responses of the host and phage evasion, and decreased expression of sporulation- and virulence-related genes of the host after phage infection. These findings confirmed the complexity of interactions between C. difficile and phages and suggest that phages undergoing a lytic cycle may also cause different phenotypes in hosts, similar to prophages, which may inspire phage therapy for the control of C. difficile.

The histone demethylase JMJD1A plays a key functional role in spermatogenesis, sex determination, stem cell renewal, and cancer via removing mono- and di-methyl groups from H3K9 to epigenetically control gene expression. However, its role in prostate cancer progression remains unclear. Here, we found JMJD1A was significantly elevated in prostate cancer tissue compared with matched normal tissue. Ectopic JMJD1A expression in prostate cancer cells promoted proliferation, migration, and invasion in vitro, and tumorigenesis in vivo; JMJD1A knockdown exhibited the opposite effects. Mechanically, we revealed that JMJD1A directly interacted with the Snail gene promoter and regulated its transcriptional activity, promoting prostate cancer progression both in vitro and in vivo. Furthermore, we found that JMJD1A transcriptionally activated Snail expression via H3K9me1 and H3K9me2 demethylation at its special promoter region. In summary, our studies reveal JMJD1A plays an important role in regulating proliferation and progression of prostate cancer cells though Snail, and thus highlight JMJD1A as potential therapeutic target for advanced prostate cancer.

OBJECTIVE

Nonalbuminuric diabetic kidney disease (DKD) has become the prevailing phenotype in patients with type 2 diabetes. However, it remains unclear whether its prognosis is poorer than that of other DKD phenotypes.

The ruling JD(U) on Saturday slammed AAP for claiming that it bore the cost of ferrying migrant workers from Delhi to their home in Bihar, saying the party was speaking "half-truth" as the Arvind Kejriwal government has sought reimbursement of the payment.

Is shopping so important that people have to die or get pepper sprayed?

The point of taxation in the present case would be the date of JDA itself and service tax would be applicable as the JDA was entered before 01.07.2017 and the time to discharge such liability would be the month following the month in which SA was entered or handover of flats to the landowner has tak

On Monday, JD Majethia, chairman of the TV wing of the Indian Film and TV Producers' Council (IFTPC), stated that he intends to approach the government to seek permission to resume shoots of television shows with small crews from May 4. The move has sent the daily-wage workers of the television industry into a tizzy as they have been relentlessly calling the Federation of Western India Cine Employees (FWICE) to enquire whether they can report to work post-May 3.

BN Tiwari, president, FWICE, says, "[With his statement], JD Majethia has sent a wrong message to the daily wagers who now feel that producers are willing to work, but the FWICE is imposing unnecessary restrictions. That is not the case. Maharashtra is at high risk, and we are only concerned about our workers' safety. We have issued a letter to Majethia, asking him not to make such statements."

BN Tiwari

On March 15, various cine bodies had unanimously decided to suspend all shoots in the wake of the pandemic. "Similarly, the decision to resume work will have to be collectively taken by IFTDA, FWICE, Producers' Guild, and other associations," insists Tiwari.

Majethia was keen to propose the resumption of shoots as it would bring relief to the daily wagers. However, Tiwari points out that the associations are standing by those in need. "The industry — including Salman Khan, Ajay Devgn, Rohit Shetty and Yash Raj Films — has come together to help the workers. Even if the lockdown is lifted on May 3, we may not begin work until May 25. In case the stay-at-home orders are extended to June, we will continue to take care of our workers."

When mid-day reached out to Majethia, he agreed that the recommencement of shoots will be "a collective decision of the industry" with the approval of the government. "It is not as if we have already taken a call. We will start shooting only when it is safe for everyone, but we must start planning for it in advance."

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Ujda Chaman is about a 30 -year-old bachelor Chaman Kohli, a Hindi lecturer with Premature Balding & in quest of a beautiful wife. After facing several rejections as a prospective groom because of his baldness, Chaman hits rock bottom when an astrologer gives him a deadline to find himself a wife or remain a celibate forever. This leads Chaman on a Funny & emotional roller coaster ride of self-discovery and acceptance.

Over the years, there have been several films that have tackled various conditions that lower a person’s self-esteem like skin colour, obesity, stunted growth etc. Premature balding, however, has rarely been the central plot point of a film. Two very lesser known films like I M 24 [2012], HAIR IS FALLING [2011] etc have dealt with the issue but they sank without a trace. Producer Abhishek Pathak for his directorial debut, UJDA CHAMAN, tackles this idea in the romcom space. So does UJDA CHAMAN manage to entertain and move audiences? Or does it fail to entertain? Let’s analyse. <img class="aligncenter wp-image-1036216 size-full" title="Movie Review: Ujda Chaman" src="https://www.bollywoodhungama.com/wp-content/uploads/2019/11/Movie-Review-Ujda-Chaman.jpg" alt="Movie Review: Ujda Chaman" width="750" height="450" /> UJDA CHAMAN is the story of a man in search of a life partner. Chaman Kohli (Sunny Singh) is a 30-year-old lecturer in Delhi’s Hansraj College. He has faced acute hair loss in the last five years, affecting his self-esteem and also his marriage prospects. His parents, Shashi Kohli (Atul Kumar) and Sushma Kohli (Grusha Kapoor) put his five-year-old picture in his marriage bio-data and when he goes to see a prospective bride, he wears a cap. Sadly, the cap comes off and the prospective bride and her family kick the Kohli’s from their house. Their family astrologer (Saurabh Shukla) adds to their tension as he claims that if Chaman doesn’t get married before his 31^st birthday, he’ll remain celibate for life. Chaman tries to find love, first at the marriage ceremony of a friend but it proves futile. Later, he tries to woo a fellow lecturer, Ekta (Aishwarya Sakhuja) but she rejects him as she is already dating someone. All of a sudden, a first-year student, Aaina Ali Khan (Karishma Sharma) shows interest in Chaman. Chaman falls for her but in no time, he realizes that she hung out with him for vested interests. With no other option, Chaman accepts his father’s suggestion and downloads Tinder. He uploads his picture, but by cropping his bald patch. In no time, he matches with Apsara (Maanvi Gagroo), who is overweight and just like Chaman, she too puts a close up picture to hide her so-called imperfection. Both decide to meet and obviously get shocked looking at each other. What happens next forms the rest of the film. UJDA CHAMAN is an official remake of the 2017 Kannada film, ONDU MOTTEYA KATHE (Writer: Raj B Shetty). Danish J Singh's adapted story has immense potential as a lot of people can relate to the goings on shown in the film. But Danish J Singh's screenplay plays spoilsport. The narrative is engaging but only in parts. Danish J Singh's dialogues are funny and matter-of-fact. Abhishek Pathak's direction is not worthy enough. The execution seems a bit amateurish and over-the-top. The manner in which Chaman is ridiculed almost on a daily basis by the students because of his receding hairline is too much. Moreover, the direction style is not consistent. The second half looks very different from the first half. Also, with nothing unique happening in the film, the narrative becomes extremely predictable. On the positive side, a few scenes work like the track of Aaina and the hospital scene. UJDA CHAMAN begins on a fun but very loud note with the initial portions being mildly engaging. The humour looks forced in the scene where Chaman attempts to assault his brother Goldy (Gagan Arora). The track of Aaina is thankfully better but still, the film doesn’t reach a high. The intermission point is interesting and the film seems promising from here on. And the initial portions of the second half are very entertaining as Chaman and Apsara get close. But after a point, nothing novel or interesting happens. The film gets dragging and predictable. The final scene is cute but comes too late in the film. <span style="text-decoration: underline;"><strong>Ujda Chaman: Public Review | First Day First Show | Sunny Singh Nijjar | Maanvi Gagroo</strong></span> <iframe id="jwiframe" class="playerFrame" src="https://www.bollywoodhungama.com/videos/first-day-first-show/ujda-chaman-public-review-first-day-first-show-sunny-singh-nijjar-maanvi-gagroo/?jwembed=1" width="800" height="340" frameborder="0" allowfullscreen="allowfullscreen"></iframe> Sunny Singh gives his best but the desired impact is not made. The manner in which he seems so serious and lifeless throughout the film is difficult to digest. Even his narration in the beginning is needlessly done in a sombre tone. Maanvi Gagroo does quite better and is a natural. Her issues and predicaments seem very relatable and she plays the part nicely. Atul Kumar also does a genuinely good job. Grusha Kapoor is very loud. Gagan Arora is passable. Karishma Sharma plays her part as per the requirement. Aishwarya Sakhuja has a great screen presence. Sharib Hashmi (Raj) is good but sadly his track is predictable. Saurabh Shukla is strictly okay. Music is disappointing. Only <em>'Chand Nikla'</em> gets registered. The rest of the songs like <em>'Twinkle Twinkle', 'Outfit'</em> and <em>'Oh Bandeya'</em> are forgettable. Hitesh Sonik's background score is too loud and dramatic. Sudhir K Chaudhary's cinematography is neat. Tarpan Srivastav's production design is in sync with the film’s setting. Preetisheel Singh's make up and prosthetics are flawless. Rahil Raja and Himanshi Nijhawan's costumes are realistic. Mitesh Soni's editing is sans complaint and the film’s length is appropriate at 120 minutes. On the whole, UJDA CHAMAN has a promising and relatable story but the inconsistent execution and predictable narrative spoils the show. At the box office, thanks to limited buzz and lack of popular names, the film will have a difficult time.

India cricketer Rohit Sharma turned 33 yesterday and wife Ritika wrote him a sweet message accompanying this picture she Instagrammed to her 1.8 million followers:

Ritika Sajdeh wrote, “Happiest birthday to the one that makes me laugh till I can’t breathe, to my favourite travel companion, to my best friend, to the best dad, to the one that can’t sing even if his life depended on it. To the best I could ever wish for, happy birthday, Love you, Ro.” The post received a whopping 250,000-plus ‘likes’ within a few hours.  

 

 

 

View this post on Instagram

Happiest birthday to the one that makes me laugh till I can’t breathe, to my favourite travel companion, to my best friend, to the best dad, to the one that can’t sing even if his life depended on it. To the best I could ever wish for, happy birthday ❤️ love you Ro

A post shared by Ritika Sajdeh (@ritssajdeh) onApr 29, 2020 at 11:02pm PDT

Ritika Sajdeh and Rohit Sharma were dating for a few years after they met via a mutual friend in none other than Yuvraj Singh. Rohit and Ritika got married on December 13, 2015. Three years later, in 2018, they welcomed their child Samaira into the world.

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Chairman accuses Sports Direct of participating in process for ‘own commercial interests’

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Cloudflare today announced a new partnership with JD Cloud & AI that will see the company expand its network in Chinato an additional 150 data centers. Currently, Cloudflare is available in 17 data centers in mainland China, thanks to a long-standing partnership with Baidu, but this new deal is obviously significantly larger. CloudFlare’s original partnership […]

The 35-year-old had been playing for Al-Gharafa in Qatar but images of him attending Utrecht's clash against VVV-Venlo caused a stir after they showed him to be carrying a few extra pounds.

I ordered a pair of £170 trainers from JD Sports to be delivered by Hermes. I hadn't received them so I contacted Hermes which said they had lost the shoes but I still haven't got them. What can I do?

Shocking footage posted on Snapchat showed the youths looting a JD Sports store in Tottenham. Dozens of youths piled into the shop before grabbing items from shelves.

Bihar Information and Public Relations Minister Niraj Kumar on Saturday hit back at the Congress for demanding his resignation due to the expiry of his MLC tenure, asserting he is holding his ministerial post as per constitutional provisions. Congress national spokesperson and Bihar MLC Prem Chandra Mishra Mishra had on Friday termed as "unethical and against constitutional norms" the continuance of Bihar ministers Niraj Kumar and Ashok Choudhary in their posts despite the expiry of their tenures in the legislative council earlier this week. Both the JD(U) leaders were sworn-in as ministers a year ago, during a Cabinet expansion by Chief Minister Nitish Kumar shortly after the NDA's stupendous victory in the Lok Sabha elections. They are among 17 members of the 75-strong legislative council whose tenure ended on Wednesday. The Election Commission is yet to announce a poll schedule for the Upper House. Building Construction Minister Ashok Choudhary and IPRD Minister ...