For more than two decades naturally presented, human leukocyte antigen (HLA)-restricted peptides (immunopeptidome) have been eluted and sequenced using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Since, identified disease-associated HLA ligands have been characterized and evaluated as potential active substances. Treatments based on HLA-presented peptides have shown promising results in clinical application as personalized T cell-based immunotherapy. Peptide vaccination cocktails are produced as investigational medicinal products under GMP conditions. To support clinical trials based on HLA-presented tumor-associated antigens, in this study the sensitive LC-MS/MS HLA class I antigen identification pipeline was fully validated for our technical equipment according to the current US Food and Drug Administration (FDA) and European Medicines Agency (EMA) guidelines.

The immunopeptidomes of JY cells with or without spiked-in, isotope labeled peptides, of peripheral blood mononuclear cells of healthy volunteers as well as a chronic lymphocytic leukemia and a bladder cancer sample were reliably identified using a data-dependent acquisition method. As the LC-MS/MS pipeline is used for identification purposes, the validation parameters include accuracy, precision, specificity, limit of detection and robustness.

The Centers for Disease Control and Prevention will provide interim guidance to clinicians regarding the coronavirus outbreak during a webinar at 2 p.m. EST Jan. 31.

The ADA said it believes a new policy from the Centers for Medicare and Medicaid could be “detrimental” to the millions of adults who rely on Medicaid for dental care.

The Occupational Safety and Health Administration has issued new guidance for health care providers to prepare workplaces for COVID-19.

The ADA provided its members and their patients detailed guidance on March 18 on what to consider dental emergencies and nonemergencies dental care as part of an effort to curb the spread of the coronavirus disease, COVID-19, and alleviate the burden on hospital and emergency departments.

The American Dental Association is urging the Centers for Disease Control and Prevention to provide immediate guidance on the best way to protect dental patients and staff from the transmission of COVID-19 during emergency and urgent care situations.

The U.S. Department of Labor Wage and Hour Division released new guidance March 26 to help workers and employers understand provisions included in the Families First Coronavirus Response Act.

The American Dental Association has released interim guidance for dentists on how to minimize the risk of COVID-19 transmission before, during and after treating dental emergencies.

The ADA is urging dentists to be cautious about using novel coronavirus diagnostic tests before they have been properly evaluated and made available for dentists.

“To aid dentists who may be reopening their practices when state mandates are lifted,” the ADA issued an updated statement and interim guidance April 18 on the personal protective equipment recommended in order to practice during this pandemic and minimize the risk of virus transmission.

The ADA's Advisory Task Force on Dental Practice Recovery has developed a toolkit to help dentists return to more normal practice operations while taking precautions to protect staff, patients and themselves from COVID-19 as some states reopen.

The American Dental Association is urging the Centers for Disease Control and Prevention to “quickly provide guidance” on how to safely reopen dental practices during the deceleration phase of the COVID-19 outbreak.

The American Dental Association has created a tip sheet with guidance from the National Institute for Occupational Safety and Health group at the Centers for Disease Control and Prevention to help health care professionals avoid buying or using counterfeit N95 respirators, which are often simply referred to as masks.

The Historical Dietary Guidance Digital Collection (HDGDC) combines more than 900 documents on diet and nutrition published by the U.S. Government , representing more than 100 years of history. Materials in this collection include historical nutrition education materials, such as posters, recipes, and radio transcripts, as well as current nutrition education materials reviewed by the Dietary Guidance Review Committee.

But the U.S. Commission on Civil Rights was not unanimous in its support of the findings that students of color were not more likely to commit discipline-worthy offenses.

Childhood obesity occurs in 20% of children before they enter kindergarten. Treatment is difficult, making prevention desirable, but little is known about effective methods using anticipatory guidance to prevent obesity in pediatric primary care.

This study provides a comparison of 2 approaches versus usual care using anticipatory guidance to improve infant feeding during the first year of life, and demonstrates positive specific feeding behavior differences at 1 year in the intervention groups. (Read the full article)

Following a March 19 announcement by Pennsylvania Gov. Tom Wolf to end physical operations at many businesses statewide, Penn State Executive Vice President and Provost Nicholas P. Jones shared the following message with the University community.

Unilever had expected demand to pick up across its markets in H2 of 2020 with a growth of 3%. The company had lowered its guidance for 2020 in December 2019 and now its long-term guidance band for the current year too stands suspended.

SMYRNA (March 14, 2020) – The State of Delaware issued guidance today to assist non-public school child care facilities with their response to the global outbreak of respiratory coronavirus disease-2019 (COVID-19). Based on advice from the Centers for Disease Control and Prevention (CDC), the Delaware Division of Public Health does not recommend closing non-public school […]

Email from Governor John Carney:   This is an uncertain time, and Delawareans have understandable questions about the potential impact of coronavirus (COVID-19) on their families and communities.   We’ve repeatedly heard versions of this question:  Why would the state close schools, but recommend that childcare centers remain open?   The current guidance from the Delaware Division of […]

Delawareans should wear cloth face coverings in public settings where maintaining social distancing is difficult WILMINGTON, Del. – Consistent with guidance from the Centers for Disease Control Prevention (CDC), the Division of Public Health (DPH) recommended on Wednesday that Delawareans should wear cloth face coverings in public settings where social distancing measures are difficult to […]

The Coronavirus Aid, Relief, and Economic Security (CARES) Act recently passed by the United States Congress and signed into law on March 27th provides unemployment assistance to independent contractors and those self-employed who have been affected by the Coronavirus.

NEW CASTLE (March 9, 2020) – The Delaware Division of Public Health (DPH) advises older Delawareans and people with severe chronic health conditions to follow guidance issued by the Centers for Disease Control and Prevention (CDC) encouraging them to “avoid crowds as much as possible” as a way to reduce their risk of contracting coronavirus […]

Dassault Systèmes Reports First Quarter Financial Results With Recurring Software, Operating Margin and EPS At the High End of Its Non-IFRS Guidance

The Final FFIEC Guidance has been issued and its main intent is to reinforce the 2005 Guidance's risk management framework and update the Agencies' expectations regarding customer authentication, layered security, or other controls in the increasingly hostile online environment.

The FDIC has announced a series of steps intended to provide regulatory relief to financial institutions and facilitate recovery in areas of Illinois affected by severe storms, straight-line winds, and tornadoes.

The Final FFIEC Guidance has been issued and its main intent is to reinforce the 2005 Guidance's risk management framework and update the Agencies' expectations regarding customer authentication, layered security, or other controls in the increasingly hostile online environment.

The Final FFIEC Guidance has been issued and its main intent is to reinforce the 2005 Guidance's risk management framework and update the Agencies' expectations regarding customer authentication, layered security, or other controls in the increasingly hostile online environment.

On 7 August 2018, ESMA published a letter from Steven Maijoor, ESMA Chair, to Gabriel Bernardino, EIOPA Chair. The letter addressed the question of whether ESMA would consider borrowing arrangements and derivative arrangements entered into by an Alt...

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In September 2019, the UK government introduced new legislation which will change the way in which food businesses are required to provided allergen information. The new legislation, which comes into force on 1 October 2021, requires food businesses...

Abstract: This articles reviews the Court of Appeal decision in Serafin v Malkiewicz reversing the dismissal at first instance of a libel claim relating to an article which made serious allegations about the claimant.  The ruling makes clear th...

Procuring authorities and private sector contractors have for some years struggled with the application of the Freedom of Information Act to PFI/PPP procurement processes, and to the legal documentation that results from them. Procuring authorities...