Tasmania confirms eight more cases of coronavirus, bringing the state's tally to 36, as another college ends classroom teaching, citing "mixed and uncertain medical health advice within the community and from various public health authorities".

Experts say there's no evidence the weather has an impact on the spread of coronavirus — but with restrictions lifting, what you do when it's hot or cold outside might.

Australian gold prices reached an all-time high this week but experts are warning investors not to get too excited.

Cameron Rowland says he can no longer complete his auto electrician training in Tennant Creek because of course cuts.

Hunkered down in Georgia, certain his tomato plants will reach for the sun as the invisible fog of coronavirus begins to recede, Edwin Moses feels blessed. Tilling the red clay of a vegetable garden, Moses is safe at home, a 64-year-old legend filled with gratitude for health as solid as Olympic gold. The greatest hurdler […]

The Denver Post would like to interview you, the 2008/2009 graduate, and you, the 2020 graduate. We would love to hear the 2008/2009 graduate share what it was like being thrust into an economically fraught time, what that experience taught you and where you went from there.

But she’s got an exciting new project to focus on.

The Atlanta rapper reflected on his career.

TRB’s Airport Cooperative Research Program (ACRP) Report 76: Addressing Uncertainty about Future Airport Activity Levels in Airport Decision Making provides a systems analysis methodology that augments standard airport master planning and strategic planning approaches. The methodology includes a set of tools for improving the understanding and application of risk and uncertainty in air traffic forecasts as well as for increasing the overall effectiveness of airport planning and decision making.

Two StarWars.com writers debate Luke’s choice in Star Wars: The Empire Strikes Back.

Short breaks are among the most fundamental services for supporting families with disabled children. By providing breaks from caring and positive experiences for children and young people, they allow parent carers to focus on relationships with other children, or to have time to themselves or with their partner, leading to lower levels of psychological distress, higher levels of life satisfaction and better health. As a result, fewer parent carers reach ‘breaking point’ and fewer children require access to emergency provision or enter the looked after system. This report, commissioned by Every Disabled Child Matters, looks at the current provision of short breaks to families of disabled children in England.

By Leo Babauta The world is in a state of fear and uncertainty right now, and it’s stressful and overwhelming for most of us. This kind of fear, stress, uncertain and overwhelm can have some really strong effects on our lives: Constant fear and stress can cause anxiety problems, worsening sleep and health, depression and […]

We study a novel policy tool—interest rate uncertainty—that can be used to discourage inefficient capital inflows and to adjust the composition of external accounts between short-term securities and foreign direct investment (FDI). We identify the trade-offs faced in navigating between external balance and price stability. The interest rate uncertainty policy discourages short-term inflows mainly through portfolio risk and precautionary saving channels. A markup channel generates net FDI inflows under imperfect exchange rate pass-through. We further investigate new channels under different assumptions about the irreversibility of FDI, the currency of export invoicing, risk aversion of outside agents, and effective lower bound in the rest of the world. Under every scenario, uncertainty policy is inflationary.

My retirement came at the very start of the season so it felt like things had dragged on for quite a while for me before I could attempt to cut ties because I had already kicked off the season with the current group.

Amid the coronavirus outbreak, the NBA hasn't decided when it might restart the season, or if the draft and free agency will be held as scheduled.

About all we do know is that there is almost certainly going to be no minor league baseball at all this year.

MLB scouts can't evaluate college and high school players during the coronavirus shutdown, casting doubt on whether the June amateur draft can be held.

About all we do know is that there is almost certainly going to be no minor league baseball at all this year.

UCLA coach Mick Cronin is waiting to find out what sorts of basketball activities or workouts or team meetings would be allowed once spring quarter begins.

UCLA guard Chris Smith's decision whether to turn pro is uncertain.

University of California regents will not vote on a tuition increase as scheduled this week because the coronavirus crisis has created too much uncertainty, officials said Wednesday.

USC admission rates rose significantly for fall 2020 as the coronavirus outbreak deepens uncertainty over students' college plans.

Beloved NBC sitcom "Parks and Recreation," starring Amy Poehler, returned Thursday during the coronavirus outbreak for a special to benefit Feeding America.

The Virtual Grand National takes placed this evening in the absence of the real race at Aintree.

HARRY Enfield is an enduring British comedy legend. Central to his appeal has been his ability to create a cast of characters who are both hilariously original and instantly recognisable.

Norfolk, Virginia

Two tugs play around the USS Bataan, guiding her out of port, the beginning of her long journey to the Mediterranean off the coast of Libya. Sailors and Marines line her decks, standing to attention while relatives say their goodbyes from another ship on the quayside. One woman rubs her hands up and down the arms of her young son, comforting herself with the repetitive motion as much as him. Another waves as the ship departs, waves as it moves into the open waters, and is still waving as it shrinks into the distance. There are tears, as those who remain behind hug each other in support.

One woman tells me: "Every time they go it is like a little bit taken out of a puzzle. That puzzle is your life. And they never come back the same."

The pain of parting for probably around a year must be great. But this mission is not like Afghanistan, or in the past Iraq, where those leaving would definitely see action. Indeed, no-one seems certain what they are going to do.

Not, as is sometimes the case, because they are unwilling to discuss a military operation. They really don't know.

I ask a couple of Marines if they think they will be landing.

"Couldn't really tell you," says one.

Do they know what the mission is? They shake their heads.

Several tell me they are surprised. They were due to go out to the area soon anyway but the Libyan crisis has cut short their time at home.

"Yes, sir, honestly a little bit surprised, but you're ready for anything in the navy."

"We only got two weeks' notice, it's really sudden," said another.

"I am a little surprised, they're very surprised too, it's a Libyan civil war, I don't quite know what we're doing there," one mother, here to see off her son, tells me.

They are, at least, designed to be ready for anything.

The USS Bataan, along with the USS Mesa Verde and USS Whidbey Island make up an amphibious ready group. The Bataan, which looks to my untutored eye like a small aircraft carrier, is an amphibious assault craft. On board are about 800 Marines (2,200 in the three ships), 26 aircraft, mostly helicopters, and a 600-bed hospital.

They would have been going out to the Med anyway, later in the year, to replace the USS Kearsarge. She's used to being a jack of all trades, delivering troops to the Iraq war, then acting as a Harrier carrier, and helping with the crisis after Hurricane Katrina and the Haiti earthquake. Minutes before he boarded the ship I asked the Commodore of Amphibious Squadron Six, Capt Steven Yoder, if he knew what the mission was.

"Right now it's undetermined. We arrive on station, we will be asked to do any of the missions we're trained to. They run from humanitarian assistance to maritime and security operations," he says.

I ask the Marines' commanding officer, Col Eric Steidl, what their mission will be, given that the UN resolution and President Barack Obama have been quite clear that there will be no boots on the ground, especially not American boots.

"I don't make policy decisions, I do what 'higher' tells me to do. Does that mean they will have nothing to do? That's not for me to say," he tells me.

In any war, the individual fighting men and women and their units don't know exactly what they are going to be doing and how that might change. It is a cliche to say no battle plan survives contact with the enemy. But in the Libyan crisis, there is greater uncertainty. The natural evolution of any conflict is further fogged by the uncertainty of what happens if Col Muammar Gaddafi doesn't lose quickly, and fears that the mission will change.

Nonetheless, those 2,200 Marines had better be prepared for a dull and uneventful trip. If they ever come off the front ramp of this landing craft, if they are ever deployed, it will be in defiance of the UN's resolution.

Mr Obama's words are clear, but the US military likes to be prepared for anything.

Invitation Only Research Event

Event participants

Toby Dodge, Associate Fellow, MENA Programme, Chatham House
Mac Skelton, Director, IRIS, American University of Iraq-Sulaimani
Ahmed Tabaqchali, Chief Investment Officer, AFC Iraq Fund
Hanaa Edwar, Co-founder and Chairperson, Iraqi Al-Amal Association
Chair: Renad Mansour, Senior Research Fellow, MENA Programme, Chatham House

6 February 2014 , Volume 70, Number 1

From the point of view of a Saudi policy-maker, the country, the region and the world look to be increasingly complex places

K. A. Mirzoev and T. A. Safonova
Trans. Moscow Math. Soc. 80 (2020), 133-151.
Abstract, references and article information

I. Arab and P. E. Oliveira
Theor. Probability and Math. Statist. 99 (2020), 19-37.
Abstract, references and article information

The developing nervous system is remarkably sensitive to environmental signals, including disruptive toxins, such as polybrominated diphenyl ethers (PBDEs). PBDEs are an environmentally pervasive class of brominated flame retardants whose neurodevelopmental toxicity mechanisms remain largely unclear. Using dissociated cortical neurons from embryonic Rattus norvegicus, we found here that chronic exposure to 6-OH–BDE-47, one of the most prevalent hydroxylated PBDE metabolites, suppresses both spontaneous and evoked neuronal electrical activity. On the basis of our previous work on mitogen-activated protein kinase (MAPK)/extracellular signal-related kinase (ERK) (MEK) biology and our observation that 6-OH–BDE-47 is structurally similar to kinase inhibitors, we hypothesized that certain hydroxylated PBDEs mediate neurotoxicity, at least in part, by impairing the MEK–ERK axis of MAPK signal transduction. We tested this hypothesis on three experimental platforms: 1) in silico, where modeling ligand–protein docking suggested that 6-OH–BDE-47 is a promiscuous ATP-competitive kinase inhibitor; 2) in vitro in dissociated neurons, where 6-OH–BDE-47 and another specific hydroxylated BDE metabolite similarly impaired phosphorylation of MEK/ERK1/2 and activity-induced transcription of a neuronal immediate early gene; and 3) in vivo in Drosophila melanogaster, where developmental exposures to 6-OH–BDE-47 and a MAPK inhibitor resulted in offspring displaying similarly increased frequency of mushroom-body β–lobe midline crossing, a metric of axonal guidance. Taken together, our results support that certain ortho-hydroxylated PBDE metabolites are promiscuous kinase inhibitors and can cause disruptions of critical neurodevelopmental processes, including neuronal electrical activity, pre-synaptic functions, MEK–ERK signaling, and axonal guidance.

(Oregon State University) Clinical trial data behind drug dose recommendations for elevated cholesterol and chronic obstructive pulmonary disease illustrate how larger doses may not be worth the extra costs for many types of patients.

Abby Joseph Cohen and Alexis Crow share insights on the economic impact of COVID-19 in a discussion moderated by Pierre Yared. 

The developing nervous system is remarkably sensitive to environmental signals, including disruptive toxins, such as polybrominated diphenyl ethers (PBDEs). PBDEs are an environmentally pervasive class of brominated flame retardants whose neurodevelopmental toxicity mechanisms remain largely unclear. Using dissociated cortical neurons from embryonic Rattus norvegicus, we found here that chronic exposure to 6-OH–BDE-47, one of the most prevalent hydroxylated PBDE metabolites, suppresses both spontaneous and evoked neuronal electrical activity. On the basis of our previous work on mitogen-activated protein kinase (MAPK)/extracellular signal-related kinase (ERK) (MEK) biology and our observation that 6-OH–BDE-47 is structurally similar to kinase inhibitors, we hypothesized that certain hydroxylated PBDEs mediate neurotoxicity, at least in part, by impairing the MEK–ERK axis of MAPK signal transduction. We tested this hypothesis on three experimental platforms: 1) in silico, where modeling ligand–protein docking suggested that 6-OH–BDE-47 is a promiscuous ATP-competitive kinase inhibitor; 2) in vitro in dissociated neurons, where 6-OH–BDE-47 and another specific hydroxylated BDE metabolite similarly impaired phosphorylation of MEK/ERK1/2 and activity-induced transcription of a neuronal immediate early gene; and 3) in vivo in Drosophila melanogaster, where developmental exposures to 6-OH–BDE-47 and a MAPK inhibitor resulted in offspring displaying similarly increased frequency of mushroom-body β–lobe midline crossing, a metric of axonal guidance. Taken together, our results support that certain ortho-hydroxylated PBDE metabolites are promiscuous kinase inhibitors and can cause disruptions of critical neurodevelopmental processes, including neuronal electrical activity, pre-synaptic functions, MEK–ERK signaling, and axonal guidance.

Invitation Only Research Event

Event participants

Toby Dodge, Associate Fellow, MENA Programme, Chatham House
Mac Skelton, Director, IRIS, American University of Iraq-Sulaimani
Ahmed Tabaqchali, Chief Investment Officer, AFC Iraq Fund
Hanaa Edwar, Co-founder and Chairperson, Iraqi Al-Amal Association
Chair: Renad Mansour, Senior Research Fellow, MENA Programme, Chatham House

11 March 2020

11 March 2020

The estimation results might be incorrect in PROC PANEL when the RANONE and NOINT options are specified in the MODEL statement.

The METADATA procedure might return an error similar to one of the following: