Neuronal cytotoxic edema is implicated in neuronal injury and death, yet mitigating brain edema with osmotic and surgical interventions yields poor clinical outcomes. Importantly, neuronal swelling and its downstream consequences during early brain development remain poorly investigated, and new treatment approaches are needed. We explored Ca²⁺-dependent downstream effects after neuronal cytotoxic edema caused by diverse injuries in mice of both sexes using multiphoton Ca²⁺ imaging in vivo [Postnatal Day (P)12–17] and in acute brain slices (P8–12). After different excitotoxic insults, cytosolic GCaMP6s translocated into the nucleus after a few minutes in a subpopulation of neurons, persisting for hours. We used an automated morphology-detection algorithm to detect neuronal soma and quantified the nuclear translocation of GCaMP6s as the nuclear to cytosolic intensity (N/C ratio). Elevated neuronal N/C ratios occurred concurrently with persistent elevation in Ca²⁺ loads and could also occur independently from neuronal swelling. Electron microscopy revealed that the nuclear translocation was associated with the increased nuclear pore size. The nuclear accumulation of GCaMP6s in neurons led to neocortical circuit dysfunction, mitochondrial pathology, and increased cell death. Inhibiting calpains, a family of Ca²⁺-activated proteases, prevented elevated N/C ratios and neuronal swelling. In summary, in the developing brain, we identified a calpain-dependent alteration of nuclear transport in a subpopulation of neurons after disease-relevant insults leading to long-term circuit dysfunction and cell death. The nuclear translocation of GCaMP6 and other cytosolic proteins after acute excitotoxicity can be an early biomarker of brain injury in the developing brain.

Senior staff at FAO yesterday briefed a delegation of five U.S. Senators on FAO’s work on resilience, nutrition, fisheries, climate change, [...]

26 October 2022, 09.00-16.00 (CEST)

Water is a fundamental resource enabling the production of over 95% of food on land as well the progress of all sustainable development goals [...]

In this episode, the FAO Food Price Index eased in February, driven mostly by lower cereal prices; FAO calls for restoration of humanitarian space to eliminate the risk of famine [...]

In this episode, FAO is distributing fodder to vulnerable families in Gaza to enhance food production to alleviate the catastrophic food security situation; FAO calls for urgent action to prevent [...]

In this episode, FAO calls for more funding and resources for farmers in Sudan to prevent the escalation of the hunger crisis; FAO’s Director-General emphasized Africa’s potential for development at [...]

In this episode, over 282 million people in 59 countries suffered acute food insecurity in 2023, according to the Global Report on Food Crises; FAO warns about the food insecurity [...]

In this episode, high levels of acute food insecurity in Honduras; FAO’s Regional Conference for Europe; and Earth Map receives the Google impact award.

Deteriorating food insecurity in Haiti, The King Hassan II Great World Water Prize; and an updated action plan for mainstreaming biodiversity. 

In this episode, a new report urges immediate action to prevent famine in Gaza and the Sudan; world fisheries and aquaculture production reaches a record high; and the FPI [...]

In this episode, FAO calls for urgent funding to prevent further starvation and suffering in Haiti; FAO’s Director-General underscores that the world should step up efforts and cooperation to tackle [...]

In this episode, FAO welcomed the 'Pact for the Future' in New York, International Food Loss and Waste Day, and an atlas to combat livestock disease.

In this episode, FAO urges immediate access to Gaza; the UN Climate Summit ; the fourth annual World Food Forum 

Uncover the bittersweet story of this ancient treat. Read more at https://www.smithsonianmag.com/arts-culture/a-brief-history-of-chocolate-21860917/

Book-banning might seem like a relic of less enlightened times, but the practice is back in a big way. The American Library Association reports (https://www.smithsonianmag.com/smart-news/american-library-association-names-2022s-most-banned-books-180982048/) that 2022 saw more attempts to have books removed from public libraries than in any prior year this century — indeed, it documented more than twice as many attempted bans in 2022 than in 2021. In schools, attempts to keep certain books out of the hands of students have been even more aggressive and draconian. What’s new about these efforts is the subject that binds the most-challenged titles: Most of them address themes of LGBT+ identity or gender expression. In this episode, we talk with journalist Colleen Connolly about Thomas Morton’s New English Canaan, the first book ever to be suppressed in North America. What did the Puritans find so threatening about it, and how has this book echoed through subsequent centuries? Then we’re joined by Dr. Carla Hayden, Librarian of Congress, for a wide-ranging conversation about the history of book bans in the United States, how a resurgent wave of book bans in many states differs from those of prior eras, and why organized attempts to prevent specific people from reading specific books usually fail. A transcript of this episode can be found here (http://smithsonianmag.com/history/a-brief-history-of-banned-books-in-america-180983011) . Read Colleen’s Smithsonian story about New English Canaan here (https://www.smithsonianmag.com/history/how-americas-first-banned-book-survived-and-became-an-anti-authoritarian-icon-180982971/) . Find prior episodes of our show here (https://www.smithsonianmag.com/podcast/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Fact-checking by Stephanie Abramson. Episode artwork by Emily Lankiewicz. Music by APM Music.

Two-time Olympian Gabrielle Daleman was victorious in Sunday's free skate to win the women's event at the 2022 Skate Canada Challenge in Regina.

Product, company, and customers earn additional recognition

A report suggests that the $2.5 billion program should focus more on continuous improvement than on scattershot activities.

A collection of news stories from this week.

A collection of stories from the week that you may have missed.

An overview of the biggest business developments in SA and beyond.

A collection of stories from the week that you may have missed.

An overview of the biggest business developments in SA and beyond.

A breakdown of high-profile news stories you may have missed during the week.

[allAfrica]

[allAfrica]

PHY Interface for the PCI Express (PCIe), SATA, USB, DisplayPort, and USB4 Architectures (PIPE) enables the development of the Physical Layer (PHY) and Media Access Layer (MAC) design separately, providing a standard communication interface between these two components in the system.

In recent years, the PIPE interface specification has incorporated many enhancements to support new features and advancements happening in the supported protocols. As the supported features increase, so does the count of signals on PIPE interface. To address the issue of increasing signal count, the message bus interface was introduced in PIPE 4.4 and utilized for PCIe lane margining at the receiver and elastic buffer depth control.

In PIPE 5.0, all the legacy PIPE signals without critical timing requirements were mapped into message bus registers so that their associated functionality could be accessed via the message bus interface instead of implementing dedicated signals. It was decided that any new feature added in the new version of PIPE specification will be available only via message bus accesses unless they have critical timing requirements that need dedicated signals.

Message Bus Interface

The message bus interface provides a way to initiate and participate in non-latency-sensitive PIPE operations using a small number of wires. It also enables future PIPE operations to be added without adding additional wires. The use of this interface requires the device to be in a power state with PCLK running.

Control and status bits used for PIPE operations are mapped into 8-bit registers that are hosted in 12-bit address spaces in the PHY and the MAC. The registers are accessed using read-and-write commands driven over the signals M2P_MessageBus[7:0] and P2M_MessageBus[7:0]. These signals are synchronous with the PCLK and are reset with Reset#.

Message Bus Interface Commands

The 4-bit commands are used for accessing the PIPE registers across the message bus. A transaction consists of a command and any associated address and data.

All the following are time multiplexed over the bus from MAC and PHY:

1. Commands (write_uncommitted, write_committed, read, read completion, write_ack)
2. 12-bit address used for all types and read and writes
3. 8-bit data, either read or written

There can be cases where multiple PIPE interface signals can change on the same PCLK. To address such cases, the concept of write_uncommitted and write_committed is introduced.

The uncommitted write should be saved into a write buffer, and its associated data values are updated into the relevant PIPE register at a future time when a write_committed is received, taking effect during the same PCLK cycle. Once a write_committed is sent, no new writes, whether committed or uncommitted, and any read command may be sent until a write_ack is received. Also, it is allowed to send NOP commands between write uncommitted and write committed. 

A simple timing demonstration of message bus:

Message Address Space

MAC and PHY each implement unique 12-bit address spaces. These address spaces will host registers associated with the PIPE operations. MAC accesses PHY registers using M2P_MessageBus[7:0], and PHY accesses the MAC registers using the M2P_MessageBus[7:0].

The MAC and PHY access specific bits in the registers to: initiate operations, Initiate handshakes, and Indicate status.

Each 12-bit address space is divided into four main regions: the receiver address region, the transmitter address region, the common address region, and the vendor-specific address region.

Each register field has an attribute description of either level or 1-cycle assertion. When a level field is written, the value written is maintained by the hardware until the next write to that field or until a reset occurs. When a 1-cycle field is written to assert the value high, the hardware maintains the assertion for only a single cycle and then automatically resets the value to zero on the next cycle.

Cadence has a mature Verification IP solution for the verification of various aspects and topologies of PIPE PHY design. For more details, you may refer to the Simulation VIP for PIPE PHY | Cadence page, or you may send an email to support@cadence.com.

Today, the latest issue of The Domain Name Industry Brief Quarterly Report was released by DNIB.com, showing the third quarter of 2023 closed with 359.3 million domain name registrations across all top-level domains (TLDs), an increase of 2.7 million domain name registrations, or 0.8%, compared to the second quarter of 2023. Domain name registrations also […]

The post Domain Name Industry Brief Quarterly Report: DNIB.com Announces 359.3 Million Domain Name Registrations in the Third Quarter of 2023 appeared first on Verisign Blog.

Today, the latest issue of The Domain Name Industry Brief Quarterly Report was released by DNIB.com, showing the fourth quarter of 2023 closed with 359.8 million domain name registrations across all top-level domains (TLDs), an increase of 0.6 million domain name registrations, or 0.2%, compared to the third quarter of 2023. Domain name registrations also […]

The post Domain Name Industry Brief Quarterly Report: DNIB.com Announces 359.8 Million Domain Name Registrations in the Fourth Quarter of 2023 appeared first on Verisign Blog.

Today, the latest issue of The Domain Name Industry Brief Quarterly Report was released by DNIB.com, showing the first quarter of 2024 closed with 362.4 million domain name registrations across all top-level domains (TLDs), an increase of 2.5 million domain name registrations, or 0.7%, compared to the fourth quarter of 2023. Domain name registrations also […]

The post Domain Name Industry Brief Quarterly Report: DNIB.com Announces 362.4 Million Domain Name Registrations in the First Quarter of 2024 appeared first on Verisign Blog.

Today, the latest issue of The Domain Name Industry Brief Quarterly Report was released by DNIB.com, showing the second quarter of 2024 closed with 362.4 million domain name registrations across all top-level domains (TLDs), unchanged compared to the first quarter of 2024. Domain name registrations increased by 5.8 million, or 1.6%, year over year. Check […]

The post Domain Name Industry Brief Quarterly Report: DNIB.com Announces 362.4 Million Domain Name Registrations in the Second Quarter of 2024 appeared first on Verisign Blog.

Today, the latest issue of The Domain Name Industry Brief Quarterly Report was released by DNIB.com, showing the third quarter of 2024 closed with 362.3 million domain name registrations across all top-level domains (TLDs), a decrease of 0.1 million domain name registrations, or less than 0.05%, compared to the second quarter of 2024. Domain name […]

The post Domain Name Industry Brief Quarterly Report: DNIB.com Announces 362.3 Million Domain Name Registrations in the Third Quarter of 2024 appeared first on Verisign Blog.

[allAfrica]

Title: Brief Drop in Blood Sugar at Birth Tied to Poorer School Performance
Category: Health News
Created: 8/24/2015 12:00:00 AM
Last Editorial Review: 8/25/2015 12:00:00 AM

Patient expectations of receiving antibiotics for common symptoms can trigger unnecessary use. We conducted a survey (n = 564) between January 2020 to June 2021 in public and private primary care clinics in Texas to study the prevalence and predictors of patients’ antibiotic expectations for common symptoms/illnesses. We surveyed Black patients (33%) and Hispanic/Latine patients (47%), and over 93% expected to receive an antibiotic for at least 1 of the 5 pre-defined symptoms/illnesses. Public clinic patients were nearly twice as likely to expect antibiotics for sore throat, diarrhea, and cold/flu than private clinic patients. Lack of knowledge of potential risks of antibiotic use was associated with increased antibiotic expectations for diarrhea (odds ratio [OR] = 1.6; 95% CI, 1.1-2.4) and cold/flu symptoms (OR = 2.9; 95% CI, 2.0-4.4). Lower education and inadequate health literacy were predictors of antibiotic expectations for diarrhea. Future antibiotic stewardship interventions should tailor patient education materials to include information on antibiotic risks and guidance on appropriate antibiotic indications.

The aim of this work is to test whether the use of a transparent capsule affects the residual capsule weight after inhalation as a surrogate of the inhaled delivered dose for patients with non-reversible chronic airway disease. Researchers conducted an observational cross-sectional study with patients using a single-dose dry powder inhaler. The weight of the capsule was measured with a precision microbalance before and after inhalation. Ninety-one patients were included, of whom 63 (69.2%) used a transparent capsule. Inhalation with a transparent capsule achieved a weight decrease of 30.1% vs 8.6% for devices with an opaque capsule (P <0.001). These data reinforce the need to provide patients with mechanisms that verify the correct inhalation technique.

World-building, identity and decolonising spaces in the digital and offline realms.

The post Interview: Gabriel Massan & LYZZA appeared first on Fact Magazine.

Treat yourself to a Becky Lynch book signing, games with the Dropout stars, Kevin Smith’s Dogma, and so much more!

CIBUS Fresh of Noblesville, IN, is recalling CIBUS Fresh products containing Glenview Farms Spreadable Brie, 2/3lb because of a supplier notification of possible Listeria monocytogenes (products are listed below).  More information regarding the recent Brie recall can be found here. The product was distributed under the following labels: CIBUS Fresh,... Continue Reading

Note to readers: After a period of inactivity CardioBrief is coming back, but with some big differences. This website, CardioBrief.Org, will remain my personal website. A new website, CVCTCardiobrief.com, will be the new home for my “professional” blogging activities. To develop this website I have joined forces with the global CVCT Forum. I look forward to...

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Apr 10, 2023

The following is an event write-up about the recent Future of Diplomacy Project (FDP) seminar on “The Geopolitics of Latin America amid the War in Ukraine and China-U.S. Tensions” moderated by Negah Angha, Fellow at the Institute of Politics, on March 29, 2023.

Apr 18, 2023

The following is an event write-up about the recent Future of Diplomacy Project (FDP) seminar on “The Future of Ukraine: Reconstruction, Energy Security, and Innovation” moderated by Ambassador Paula J. Dobriansky, Senior Fellow with the Future of Diplomacy Project. 

Jun 5, 2024

Harvard Kennedy School hosted Leah Stokes, Anton Conk Associate Professor of Environmental Politics at UC Santa Barbara, to discuss how the historic Inflation Reduction Act succeeded where so many previous climate bills failed.

Mar 18, 2024

Harvard Kennedy School hosted Jahi Wise, Senior Adviser to the Administrator of the U.S. Environmental Protection Agency, to discuss the design and implementation of the Greenhouse Gas Reduction Fund, a historic investment in American clean energy technology finance.

Apr 1, 2024

Harvard Kennedy School hosted Sarah Ladislaw, Special Assistant to the President and Senior Director for Climate and Energy of the U.S. National Security Council, for an Energy Policy Seminar on the U.S. approach to energy and climate issues in its foreign policy.

Apr 26, 2024

Concerns over resource adequacy during periods of peak demand or supply crises are rising with increasing deployment of renewable energy. Conleigh Byers says mandatory forward market contracts could help.

Jun 6, 2024

Emily Grubert, Associate Professor of Sustainable Energy Policy and of Civil and Environmental Engineering and Earth Sciences at the University of Notre Dame, discussed the dangers of an unplanned transition from a fossil-based energy system to a zero-carbon energy system during a talk at Harvard Kennedy School.