Human-generated noise can reduce the foraging activity of wildlife and should be taken into account during conservation planning, a new study suggests. The test showed that traffic noise decreased the foraging activity of Daubenton’s bat (Myotis daubentonii) by inducing an avoidance response. The new experimental approach could be used to identify how noise disturbs any species capable of detecting noise.

The announcement of a new no-take fishing zone in the Pacific led to a 130% increase in fishing activity ahead of its implementation, satellite data reveal. Although fishing activity dropped to zero once the marine protected area (MPA) came into effect just over a year later, the study warns that the pre-emptive short-term surge in fishing could have caused long-term ecological damage.

Human activities have caused phosphorus to accumulate in soils and water bodies, creating a legacy that could last for decades, new research shows. A study of three major river basins highlights better sewage treatment facilities and reduced fertiliser use as key reasons for an overall decline in phosphorus levels in the Thames River basin, UK, since the late 1990s.

Past economic activity is more likely to explain the current pattern of biological invasions across Europe than recent human activities, according to a new study. It can take several decades before a newly introduced species becomes established and spreads, which may mean that recent invasions caused by current economic activities could create an 'invasion debt' for future generations.

Researchers have demonstrated how the ERICA Integrated Approach can be used to assess the effect of releasing radiation into the environment on local wildlife in a real-world situation. The study applied ERICA to a river in Norway and found that local wildlife was only exposed to low levels of radioactivity from the routine aquatic discharges of a nearby research reactor, although historical exposure was higher.

Gold mining areas in the Peruvian Amazon rainforest expanded from under 10 000 hectares in 1999 to over 50 000 hectares by 2012, and now destroys more forest than agriculture and logging combined, new research has shown. Using high-resolution satellite imaging, researchers estimated gold mining areas to be twice as large as estimated by previous studies, which did not include the combined effects of thousands of small, mainly illicit, mining operations.

Large carnivores play important roles in ecosystems by regulating populations of herbivores and other species. Understanding how human activities affect the role of predators, particularly within human-modified systems such as agricultural landscapes, is therefore important. This study investigated how predator and prey populations were distributed in Transylvania, Romania, and assessed them in relation to human activities. The research highlights how relationships between large carnivores and people need to be considered as part of biodiversity conservation efforts, especially considering the successful recovery of several large carnivore populations within the EU.

Two chemicals used as co-formulants in pesticides have been found to reduce the predatory behaviour of the wolf spider Pardosa agrestis, an insect predator found within agricultural landscapes. A third co-formulant was found not to affect the predatory behaviour of females and increased the prey behaviour of male spiders. This is the first time that pesticide additives have been shown to alter the predatory activity of a potential biological control agent of crop pests.

UV treatment does not always turn hazardous water pollutants into harmless substances. Recent lab tests suggest that the toxicity of the antibiotic linezolid to microorganisms appeared to increase post-treatment. This research did find, however, that UV treatment successfully reduced the antimicrobial activity of four other antibiotics tested, plus four artificial sweeteners.

Global air quality will significantly deteriorate by 2050 unless further steps are taken to cut current emissions from human activities, according to recent research. Most people around the world will be affected by worsening air quality with hotspots of particularly poor air occurring in China, northern India and the Middle East.

Zillow Group Mortgage analysis shows that the mortgage payment on the typical home in most of the country's housing market would increase by $25 or less should interest rates rise to 4.25%

Zillow web traffic on for-sale listings and requests to connect with Premier Agents have ticked up recently after slowing in the early days of the U.S. coronavirus pandemic in mid-March

Natural fluctuations alone do not explain warming in the upper layers of the planet's oceans, confirms a new computer modeling study.

When you share a rescue organization's posts or comment on them, it may not always be what's best for the shelter.

Plucking litter from canals while sightseeing is one of the more singular ways to spend a couple hours in the Dutch city.

Forget the idea that only 10-minute bursts of activity are important. New research finds that even small moments of activity can help you meet your goal.

Walking outside is having a moment, helping us clear our heads of coronavirus worries and breathe some fresh air.

Learn why iron and B vitamins deficiency reduce brain function and what you need to know to counteract these deficiencies. Learn which foods give you iron and B vitamins.

Assisted Living Facility announces new creative space for residents

Real Estate Agents Also Turning to Technology to Facilitate Showings in the Face of Stay-at-Home Orders

It comes as businesses and buyers are increasingly seeking online platforms to continue their trade.

Over the weekend, fire managers in Grand Canyon National Park began ignitions on the Range Prescribed Fire, located on the North Rim of the park. In addition, they resumed work on the Bright Angel Prescribed Fire, also located on the North Rim, which was partially completed earlier this year. https://www.nps.gov/grca/learn/news/2011-10-31_nr-rxs.htm

Warmer, drier weather has led to increased fire activity on the Fuller Fire. https://www.nps.gov/grca/learn/news/fuller-fire-increased-activity.htm

The Ikes Fire moved into the northeast portion of the planning area that has a history of little to no fire activity in over two decades. This wildfire is consuming heavy fuel accumulations on the forest floor and is helping ensure the ecosystem will be healthier and more resilient in the future. https://www.nps.gov/grca/learn/news/ikes-fire-promotes-healthy-forest-regeneration-as-fire-activity-increases-20190807.htm

This report synthesizes the literature on the role of informal economic activity in the United States postindustrial economy. Informal economic activity is expanding in the United States and is likely to continue in the foreseeable future. The formal and informal economic sectors are inextricably intertwined, with individuals and households combining elements of both sectors to construct their livelihoods. Although the informal economy is often thought of as the domain of economically marginal individuals and households, virtually everyone participates in the informal economy to some extent. However, the literature highlights how factors such as social status and household position in the formal economy affect whether participation in informal economic activity is exploitative or empowering. The nontimber forest products sector serves as a case study of why it is important to consider informal economic activity when developing natural resource and economic development policy. We recommend steps policymakers can take to identify and encourage positive aspects of the informal economic activity. We also highlight several areas of research to improve understandings of the role of informal economic activity in postindustrial societies.

Population growth in Oregon, Washington, and Alaska is expected to increase demand for outdoor recreation on public land. This trend will be tempered by changes in the sociodemographic composition of the population. Among sociodemographic characteristics, different ages and incomes correspond to different participation rates. Although older Americans are participating more, participation is still lower among this group for active pursuits. Hence, as the population ages, demand for passive activities may increase. Low-income people participate at a much lower rate than higher income people in outdoor recreation, and the growing disparity between the wealthy and poor may create inequities in opportunities for participation. State recreation planning documents for Oregon, Washington, and Alaska have identified this issue as a significant concern for recreation providers. Another important factor in recreation trends in the region is ethnicity: different ethnic groups participate in outdoor recreation at different rates, exhibit some different preferences for specific activities, and use recreation sites in different ways. In Alaska, the number of Asian/Pacific Islanders is expected to quadruple by 2025; in Oregon, the Hispanic population may triple by 2025; and in Washington, both these segments of the population may double.

Research Highlights: People with recent heart attacks have significantly higher activity in a brain area (the amygdala) involved in stress perception and emotional response. They also have more inflammation in key arteries and increased bone marrow ...

American Geophysical Union (AGU) Press Release A new study finds human-caused global warming is significantly increasing the rate at which hot temperature records are being broken around the world. Global annual temperature records show there were 17 record hot years … Continue reading →

Monitoring users on large computing platforms such as high performance computing (HPC) and cloud computing systems is non-trivial. Utilities such as process viewers provide limited insight into what users are running, due to granularity limitation, and other sources of data, such as system call tracing, can impose significant operational overhead. However, despite technical and procedural measures, instances of users abusing valuable HPC resources for personal gains have been documented in the past cite{hpcbitmine}, and systems that are open to large numbers of loosely-verified users from around the world are at risk of abuse. In this paper, we show how electrical power consumption data from an HPC platform can be used to identify what programs are executed. The intuition is that during execution, programs exhibit various patterns of CPU and memory activity. These patterns are reflected in the power consumption of the system and can be used to identify programs running. We test our approach on an HPC rack at Lawrence Berkeley National Laboratory using a variety of scientific benchmarks. Among other interesting observations, our results show that by monitoring the power consumption of an HPC rack, it is possible to identify if particular programs are running with precision up to and recall of 95\% even in noisy scenarios.

The present application describes modulators of MCP-1 or CCR-2 of formula or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, n, W, X, R1 and R6, are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.

The invention relates compounds of general formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1 is halogen, vinylene-aryl, substituted aryl, heteroaryl or a benzo[1,3]dioxolil group,W is a group of formula —NH—SO2—R2 or heteroaryl group or NHR3 group where R3 is hydrogen or heteroaryl; and n is 1, 2, 3 or 4. Furthermore, the present invention is directed to pharmaceutical composition containing at least one compound of general formula (I) and/or pharmaceutically acceptable salts or solvates thereof and for the use of them for the preparation of pharmaceutical compositions for the prophylaxis and/or the treatment of protein kinase related, especially CDK9-related diseases e.g. cell proliferative disease, infectious disease, pain, cardiovascular disease and inflammation.

An array of a plurality of processing elements (PEs) are in a data packet-switched network interconnecting the PEs and memory to enable any of the PEs to access the memory. The network connects the PEs and their local memories to a common controller. The common controller may include a shared load/store (SLS) unit and an array control unit. A shared read may be addressed to an external device via the common controller. The SLS unit can continue activity as if a normal shared read operation has taken place, except that the transactions that have been sent externally may take more cycles to complete than the local shared reads. Hence, a number of transaction-enabled flags may not have been deactivated even though there is no more bus activity. The SLS unit can use this state to indicate to the array control unit that a thread switch may now take place.

A mechanism for generating gate-level activity data for use in clock gating efficiency analysis of an integrated circuit (IC) design is provided. Generating the gate-level activity data includes generating a signal behaviour description for inter-register signals, generating a gate-level netlist for the IC design, generating gate-level stimuli based at least partly on the generated signal behaviour description, and performing gate-level simulation using the generated gate-level stimuli to generate gate-level activity data for the IC design. In one embodiment, generating the signal behaviour description includes performing Register Transfer Level (RTL) simulation of the IC design, and generating the gate-level netlist includes performing RTL synthesis. The RTL simulation and RTL synthesis are performed on RTL data for the IC design.

Apparatus and methods are provided for forming and processing multiphasic systems. In one embodiment, the invention provides a process for the manufacture of an epoxide, including reacting an olefinically unsaturated compound with an oxidant in the presence of a buffer component and a water-soluble manganese complex disposed in an aqueous phase having a first pH level in a first multiphasic system, adjusting the pH of the aqueous phase to a second pH level less than the first pH level, isolating at least a portion of the aqueous phase from the first multiphasic system, adjusting the pH of the at least a portion of the aqueous phase to a third pH level greater than the second pH level, and introducing the at least a portion of the aqueous phase into a second multiphasic system.

A substituted phenoxyethyl(isopropyl)acyloxyalkyl phosphonate having phosphorusheterocyclic ring and having herbicidal activity, with a general formula of I, wherein R represents 5,5-dimethyl-1,3,2-dioxaphosphorinan-2-one-2-yl, or 1-oxo-1-phospha-2,6,7-trioxabicyclo[2,2,2]octan-4-yl, or 1-sulfo-1-phospha-2,6,7-trioxabicyclo 2,6,7-trioxabicyclo[2,2,2]octan-4-yl; R1 represents H, C1-C4 alkyl, phenyl, furyl, pyridyl, or phenyl substituted with methyl, methoxyl, nitro or chloro; R2 represents H, methyl, and methyl only if R in the general formula I is 1-sulfo-1-phospha-2,6,7-trioxabicyclo[2,2,2]octan-4-yl as phosphorusheterocyclic ring; X and Y represent H, halogen, C1-C4 alkyl or trifluoromethyl, and X and Y are the same or different. The compounds according to the present invention may be used as active component of dicotyledonous broadleaf weed herbicides.

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 bicyclic amines of triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-3 cycloalkenyl triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV: wherein X can be a C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6-9 oxaspirocycloalkyl, or C6-9 oxaspirocycloalkenyl ring. These compounds are useful for the treatment of HIV and AIDS.

The present invention provides a compound which functions as a selective vitamin D receptor modulator and has action-selectivity or tissue-selectivity such that it does not induce hypercalcemia but causes other effects. There is provided a compound represented by formula (I), a solvate thereof or a prodrug thereof. wherein m and n each independently represent 1 or 0;R represents a hydrogen atom or an alkyl group;Y represents an ethane-1,1-diyl group or an ethyne-1,2-diyl group; andZ1 represents a hydrogen atom and Z2 represents a hydroxyalkoxy group, orZ1 and Z2 jointly form a methylene group.

New phenylamidines are described, having general formula (I): and their use for the control of phytopathogenic fungi.

The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through metabolic pathways of interest.

A regenerated spent hydroprocessing catalyst treated with a chelating agent and having incorporated therein a polar additive.

Activities, actions and events during user performance of physical activity may be detected using various algorithms and templates. Templates may include an arrangement of one or more states that may identify particular event types and timing between events. Templates may be specific to a particular type of activity (e.g., types of sports, drills, events, etc.), user, terrain, time of day and the like.

The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.

Monitoring user activity on a mobile device is described. In one aspect, video content is received and played to a user of the mobile device. The monitoring activity detects an interruption of playback of the video content and determines an event associated with the interruption. The event is stored in the mobile device and communicated to a remote device.

Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.

The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a variant signal peptide or a variant prepropeptide; and (b) isolating the secreted polypeptide having biological activity from the cultivation medium.

The instant invention is the storage of Type II collagen containing tissue in carbonated water. Such Type II collagen is useful for alleviating the symptoms of arthritis in mammals as well as the treatment of arthritis in mammals. Such Type II collagen is also useful for the prevention of arthritis in mammals. The instant invention is also a method for the preparation of a nutritional supplement that includes the steps of: (a) separating water-insoluble undenatured Type II collagen containing animal tissue from animal tissue not containing Type II collagen; (b) subdividing and sterilizing said tissue under conditions which do not change the original structure of the Type II collagen to produce a subdivided and sterilized product; (c) packaging the subdivided and sterilized product in carbonated water.

A developmental toy for infants including an infant support surface having an open and a folded operative orientation, a first pair of circumferential elements associated therewith and having an open and a folded operative orientation and a second pair of elements, generally similar in configuration to the first pair of circumferential elements, arranged to support toy objects above the infant support surface and having an open and a folded operative orientation and a locking assembly for selectably locking the first and second pairs of circumferential elements in their respective open operative orientations, the open operative orientation of the infant support surface being an angular separation of 180 degrees, the open operative orientation of the first pair of circumferential elements being an angular separation of 180 degrees and the open operative orientation of the first pair of circumferential elements being an angular separation of substantially less than 180 degrees.

Methods, systems and devices are provided for displaying monitored activity data in substantial real-time on a screen of a computing device. One example method includes capturing motion data associated with activity of a user via an activity tracking device. The motion data is quantified into a plurality of metrics associated with the activity of the user. The method includes connecting the activity tracking device with a computing device over a wireless data connection, and sending motion data from the activity tracking device to the computing device for display of one or more of the plurality of metrics on a graphical user interface of the computing device. At least one of the plurality of metrics displayed on the graphical user interface is shown to change in substantial real-time based on the motion data.