Between the infamous Peloton commercial, the wild Boyhood wannabe that ended up being a Subway ad, and the endless #girlboss marketing reminding you that even women can be part of the capitalist machine, 2019 was a year for advertising. 

But nothing quite tops this one, which was released in September but resurfaced in a viral tweet on Friday.  

The ad starts off with a bleak statistic: women hold just 10 percent of all patented inventions. Then, it pans over to a delightful montage of ambitious young women. Each one is filmed preparing for their career goals, from mixing delicate chemicals in a laboratory to carefully testing the consistency of soil.  Read more...

Yesterday saw the online premier of a mini-episode of a new animated comic series based on the classic Gilbert Shelton underground comic, the Fabulous Furry Freak Brothers. As a hippie wannabe teen in the 70s, this (and Zap! Comics) was everything to me.

In 1969, life in San Francisco consists of free love, communal living, and political protest. Freewheelin’ Franklin Freek (Harrelson), Fat Freddy Freekowtski (Goodman), Phineas T. Phreakers (Davidson) and their mischievous, foul-mouthed cat, Kitty (Haddish) spend their days dodging many things —- the draft, the narcs, and steady employment -– all while searching for an altered state of bliss.

But after partaking of a genetically-mutated strain of marijuana, the Freaks wake up 50 years later to discover a much different society. Quickly feeling like fish out of water in a high-tech world of fourth-wave feminism, extreme gentrification and intense political correctness, the Freaks learn how to navigate life in 2020 -— where, surprisingly, their precious cannabis is now legal.

OK, sounds good. But is it? If the reaction to the first mini-episode is any indication, maybe the Freaks should have remained in their drug-induced coma. As one Facbooker commented: "Get yourself a collected set of the original comic and skip this drivel!"

Read the rest

Other Space Synopsis Other Space is a Science Fiction comedy television series produced by Yahoo that premiered in April of 2015. Created by Paul Feig (Freaks and Geeks) Other Space is set in the early 22nd century and follows the story of the inexperienced crew aboard UMP Cruiser on a routine space exploratory mission. In […]

Mother’s Day is just around the corner and finding the perfect gift for such a special occasion can be a really overwhelming task, particularly if you’re a last minute shopper. That’s why, to help you out, we’re sharing with you the best Mother’s Day gift ideas you can give to every supermom on your list. […]

The post DumbLittleMan’s Ultimate Gift Guide for Mother’s Day 2020 appeared first on Dumb Little Man.

The calendar may say May, but that didn't stop Mother Nature from blasting some wintry weather in Muskoka on Friday.

The following article, 77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO], was first published on 100PercentFedUp.com.

Emergency orders that “non-essential businesses” remain closed during the Covid-19 crisis have devastated small business owners across America. A wave of business owners across the nation are defying executive orders by their governors and opening their businesses anyhow. Yesterday, we reported about a small business owner in the state of Michigan, where Governor Gretchen Whitmer […]

Continue reading: 77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO] ...

The following article, Mother of the Year, Michelle Obama Explains How Having Kids Was A “Concession”… Had To Give Up Her “Aspirations and Dreams” [VIDEO], was first published on 100PercentFedUp.com.

While campaigning for her community organizer turned presidential candidate husband, Barack, Michelle Obama told a crowd of his supporters in Milwaukee, Wisconsin that for the first time in her life, she was proud to be an American. Four years later, Michelle Obama was a keynote speaker at the DNC convention, where she told Democrats how […]

Continue reading: Mother of the Year, Michelle Obama Explains How Having Kids Was A “Concession”… Had To Give Up Her “Aspirations and Dreams” [VIDEO] ...

The following article, BREAKING: President Trump’s Fiery Interview On Fox & Friends…”These are dirty politicians and dirty cops…They put our nation in danger with other nations, including Russia” [VIDEO], was first published on 100PercentFedUp.com.

This morning during a nearly one hour interview with Fox & Friends, President Trump addressed the decision by the DOJ to drop the case against the innocent General Michael Flynn. Trump ripped into the “dirty politicians and dirty cops” who went after General Michael Flynn. President Trump called the players involved in the horrible plot […]

Continue reading: BREAKING: President Trump’s Fiery Interview On Fox & Friends…”These are dirty politicians and dirty cops…They put our nation in danger with other nations, including Russia” [VIDEO] ...

Mother's Day is Sunday, but with COVID-19, it's forcing many to change their plans.

A beverage company in the U.S. is inviting moms to let out a ‘quaranscream’ this Mother’s Day on a designated ‘zero-judgement venting hotline’ for a chance to win its wine spritzers.

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

28 February 2020

Membrane-bound proteins have been proposed to mediate the transport of long-chain FA (LCFA) transport through the plasma membrane (PM). These proposals are based largely on reports that PM transport of LCFAs can be blocked by a number of enzymes and purported inhibitors of LCFA transport. Here, using the ratiometric pH indicator (2',7'-bis-(2-carboxyethyl)-5-(and-6-)-carboxyfluorescein and acrylodated intestinal FA-binding protein-based dual fluorescence assays, we investigated the effects of nine inhibitors of the putative FA transporter protein CD36 on the binding and transmembrane movement of LCFAs. We particularly focused on sulfosuccinimidyl oleate (SSO), reported to be a competitive inhibitor of CD36-mediated LCFA transport. Using these assays in adipocytes and inhibitor-treated protein-free lipid vesicles, we demonstrate that rapid LCFA transport across model and biological membranes remains unchanged in the presence of these purported inhibitors. We have previously shown in live cells that CD36 does not accelerate the transport of unesterified LCFAs across the PM. Our present experiments indicated disruption of LCFA metabolism inside the cell within minutes upon treatment with many of the "inhibitors" previously assumed to inhibit LCFA transport across the PM. Furthermore, using confocal microscopy and a specific anti-SSO antibody, we found that numerous intracellular and PM-bound proteins are SSO-modified in addition to CD36. Our results support the hypothesis that LCFAs diffuse rapidly across biological membranes and do not require an active protein transporter for their transmembrane movement.

A triple cork is a spinning jump in which the snowboarder is parallel to the ground three times while in the air. Such a jump had never been performed in a competition before 2011, which prompted ESPN.s Sport Science program to ask math professor Tim Chartier if it could be done under certain conditions. Originally doubtful, he and a recent math major graduate used differential equations, vector analysis, and calculus to discover that yes, a triple cork was indeed possible. A few days later, boarder Torstein Horgmo landed a successful triple cork at the X-Games (which presumably are named for everyone.s favorite variable). Snowboarding is not the only sport in which modern athletes and coaches seek answers from mathematics. Swimming and bobsledding research involves computational fluid dynamics to analyze fluid flow so as to decrease drag. Soccer and basketball analysts employ graph and network theory to chart passes and quantify team performance. And coaches in the NFL apply statistics and game theory to focus on the expected value of a play instead of sticking with the traditional Square root of 9 yards and a cloud of dust.

A triple cork is a spinning jump in which the snowboarder is parallel to the ground three times while in the air. Such a jump had never been performed in a competition before 2011, which prompted ESPN.s Sport Science program to ask math professor Tim Chartier if it could be done under certain conditions. Originally doubtful, he and a recent math major graduate used differential equations, vector analysis, and calculus to discover that yes, a triple cork was indeed possible. A few days later, boarder Torstein Horgmo landed a successful triple cork at the X-Games (which presumably are named for everyone.s favorite variable). Snowboarding is not the only sport in which modern athletes and coaches seek answers from mathematics. Swimming and bobsledding research involves computational fluid dynamics to analyze fluid flow so as to decrease drag. Soccer and basketball analysts employ graph and network theory to chart passes and quantify team performance. And coaches in the NFL apply statistics and game theory to focus on the expected value of a play instead of sticking with the traditional Square root of 9 yards and a cloud of dust.

updated April 1, 2020

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