A device (1) for extracting an ingredient in a cartridge (9) by supplying an extraction liquid such as heated water into such cartridge, includes upstream and downstream cartridge enclosing parts (7,8) relatively movable between an open position for inserting and/or removing such cartridge and a closed position for forming an extraction chamber (11) enclosing such cartridge during extraction; and a cartridge handling arrangement including a cartridge holder (10), in particular a holder fixed to or integral with the upstream part or the downstream part, for receiving and holding such cartridge against gravity when inserted and descending under gravity between the enclosing parts in the open position prior to forming the extraction chamber (11). The handling arrangement further includes at least one cartridge positioning element (39), in particular a pair of positioning elements, that horizontally guides such cartridge (9) upon reception by the holder (10) in a cartridge extraction alignment (3,3') between the upstream and downstream parts (7,8), optionally the positioning element (s) (39) being fixed to or integral with the downstream part (8) and/or having an arched portion (39') for contacting such cartridge.

A system and method for displaying the actual position of one or more food items on a conveyorized oven system on a display monitor. Digital images of each food item are captured, stored and processed into positional imaging data using data transmitted from sensors adjacent to the conveyorized oven system. Characteristic data for each food item may be associated with the positional imaging data. The characteristic and positional imaging data of the food items may be stored or communicated to a display monitor for the user to view.

The disclosure provides methods and compositions for suppressing retroviruses, including novel methods for treating a retroviral infection in a human in need of such treatment, comprising delivering a functional meiosis arrest female protein 1 (MARF1) to cells containing a retroviral provirus, together with novel expression constructs comprising a coding sequence encoding a functional MARF1 operatively linked to a promoter, vectors comprising such constructs, and packaging cell lines for use in making such vectors.

Specific binding members that bind the ED-A isoform of fibronectin for use in methods of diagnosis, detection, imaging and/or treatment of endometriosis, and/or for use in delivery to the neovasculature of endometriotic tissue of a molecule conjugated to the specific binding member. Specific binding members that bind tenascin-C, especially the A1, A2, A3, A4 and/or D domain tenascin-C large isoform, for use in methods of diagnosis, detection, imaging and/or treatment of endometriosis, psoriatic arthritis or psoriasis, and/or for use in delivery to the neovasculature of endometriotic, psoriatic arthritic or psoriatic tissue of a molecule conjugated to the specific binding member.

The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.

The present invention relates to the use of the miRNA expression profile, particularly of miR-199a-5p, and the target genes regulated thereby for the diagnosis, prognosis and use of miR-199a-5p inhibitors for treating fibroproliferative disorders.

Provided herein are compositions and methods for modifying a predetermined nucleic acid sequence. A programmable nucleoprotein molecular complex containing a polypeptide moiety and a specificity conferring nucleic acid (SCNA) which assembles in-vivo, in a target cell, and is capable of interacting with the predetermined target nucleic acid sequence is provided. The programmable nucleoprotein molecular complex is capable of specifically modifying and/or editing a target site within the target nucleic acid sequence and/or modifying the function of the target nucleic acid sequence.

The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

Provided herein are methods for the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient. In particular, gene expression levels of GCOM1, MEX3D, TRPM4, ATPAF1, PTRF, GLYATL1, FLNA, OBSCN, STRA13, WHSCl, ARFGAP3, KDM2A, FAM83H, CLDN7, CNOT6, and B3GNT9 are measured. Kits containing means for the measurement of gene expression as described herein and methods for treatment of prostate cancer are also provided.

The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether PD has progressed in a subject afflicted with PD, assessing whether a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit from a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.

A machine for automatically joining front and back parts of buttons employs a turntable with nests that are rotated through a series of stations at which the parts are placed in the nests in a desired orientation, joined, and checked for defects. Orientation of the parts is achieved by video imaging of a first part as it is randomly placed in a nest, and computer-controlled placement of the second part based on the ascertained position of the first part.

A method and apparatus for substantially automatically joining front and back parts of buttons employs a turntable with retaining means that are rotated through a series of stations at which the parts are placed in the retaining means in a desired orientation, joined, and checked for defects. A human operator places button front parts at a first station, and the remaining stations carry out the assembly and quality control steps automatically. Placement at the first station determines the alignment and orientation of the two buttons.

Rebaudioside M compositions with improved aqueous solubility and methods for preparing the same are provided herein. The rebaudioside M compositions include (i) disordered crystalline compositions comprising rebaudioside M and rebaudioside D, (ii) spray-dried compositions comprising rebaudioside M, rebaudioside D and steviol glycoside mixtures and/or rebaudioside B and/or NSF-02, (iii) spray-dried compositions comprising rebaudioside M, rebaudioside D and at least one surfactant, polymer, saponin, carbohydrate, polyol, preservative or a combination thereof. Sweetened compositions, such a beverages, containing the rebaudioside M compositions with improved water solubility are also provided herein.

Gender specific synthetic nutritional compositions for female or male infants up to 1 month of age wherein, the concentration of alanine, and/or histidine, and/or isoleucine, and/or proline, and/or valine is adapted based on that found in HM produced for an infant of the same gender and age, and nutritional systems comprising them.

The present invention is directed to novel organoleptic compounds, a process of augmenting, enhancing or imparting taste to a material selected from the group consisting of a foodstuff, a chewing gum, a dental product, an oral hygiene product and a medicinal product comprising the step of incorporating an olfactory acceptable amount of such novel organoleptic compounds, and a process of improving, enhancing or modifying a fragrance composition through the addition of an olfactory acceptable amount of such novel organoleptic compounds.

The invention concerns a sweetened dairy product comprising a dairy material, at least one steviol glycoside, at least one additive selected from a polysaccharide of fructose units and a salt.

The present invention relates to protein compositions. In particular, the invention relates to a method for the production of a composition comprising casein fibrils. Further aspects of the invention area composition comprising casein fibrils, the use of such a composition and a food product comprising the composition.

A storage-stable, flavour composition, wherein said composition comprises a plurality of particles dispersed in a non-aqueous dispersing medium, said particles consisting of a first particle population of encapsulated flavour oil, and a second particle population of micronized acidulant particles.

Gender specific synthetic nutritional compositions for infants up to 1 month of age wherein, the total protein content is adapted based on that found in HM produced for infants of the same gender and age, and nutritional systems comprising them.

The present invention relates to an emulsified flavor composition for an alcoholic beverage that does not generate a floating matter or a sediment, that maintains a stable emulsified state, that imparts transparent appearance to the alcoholic beverage and that does not impair the taste/flavor of the alcoholic beverage, even when mixed with a concentrated syrup that has an alcohol concentration several times higher than that of the alcoholic beverage during the steps for producing the alcoholic beverage. The emulsified flavor composition for alcoholic beverages of the present invention comprises: (a) an oil-soluble component containing a flavor; (b) a polyglycerol fatty acid ester whose 1% by weight aqueous solution has transmittance of 65% or higher at 600 nm; and (c) lecithin.

The present invention is directed to recombinant thraustochytrids that grow on sucrose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.

A socket wrench with a positioning device contains: a body including an accommodating cavity, a first face, and a second face. A toothed holder is accommodated in the accommodating cavity and has a polygonal groove, a first circular portion, a second circular portion, and a ratchet protrusion between the first circular portion and the second circular portion. The first circular portion is inserted to the first face, the second circular portion is inserted to the second face, and the ratchet protrusion engages with a ratchet device. A positioning device includes at least one retaining element disposed on the first circular portion and horizontally moving in the polygonal groove. The first circular portion has a resilient element and a pressing loop which are fitted on the first circular, and the pressing loop has a recess defined on an inner face thereof to correspond to the at least one retaining element.

A composite material includes a composite body having a composite surface, and a reinforcing element extending through the composite body in a first plurality of stitches and a second plurality of stitches. The first plurality of stitches are aligned relative to the composite surface substantially similarly to each other. The second plurality of stitches are aligned relative to the composite surface substantially dissimilarly to each other.

A method for fabricating a repair laminate for a composite part having an exposed surface includes applying a bonding material to the exposed surface and forming an uncured ply stack assembly on the bonding material. The uncured ply stack assembly is formed by forming and compacting a series of uncured ply stacks. The ply stack assembly and bonding material are then cured.

Positioning system of sectors of a device for producing an airplane fuselage in which a lamination mandrel comprises a plurality of sectors borne by a supporting structure and mobile along guides between: an expanded lamination position and a contracted disassembling position. Each guide comprises a fixed part borne by the supporting structure and a mobile part sliding along/with respect to the fixed part in a rectilinear direction H. Between a portion of each mobile part facing towards the respective sector and a stiffening structure of the sector a positioning device is provided which allows adjustment of the position of the sector with respect to the guide in two directions which lie in a plane RP perpendicular to the axis H of the guide.

A composite strip and a method of manufacturing a pre-cured composite strip. A pre-cured composite strip having a thermoset resin may be placed on a surface of a portion of a composite component where a caul plate seam may be expected. Caul plates may be placed on the composite component after placing the pre-cured composite strip to form the caul plate seam. The composite component may be cured after placing the caul plates on the composite component.

The invention relates to low-viscosity, low-monomer aqueous polymer dispersions based on polychloroprene, and a process for the preparation thereof and the use thereof as a contact adhesive.

A ‘bioactive’ composition that has one or more oligogalacturonans ((1→4)-α-D-galacturonan) or any other oligosaccharides (oligoguluronans) that may present an ‘egg box’ conformation, this conformation being further stabilized by one or more polycationic saccharide(s), preferably either a chitosan oligosaccharide or a chitosan polysaccharide. A method prepares this composition and it is used, in medical, pharmaceutical, agricultural, nutraceutical, food, feed, textile, cosmetic, industrial and/or environmental applications.

A composition comprising at least one nutrient element, wherein the at least one nutrient element possesses a relative energy-state value greater than the relative energy-state value of the at least one nutrient element in a preexisting state, the composition being effective, perhaps because of the greater energy-state value, to improve the ability of a soil, when combined with the composition, to support plant growth better than the soil, when not combined with the composition. Also a composition comprising at least one nutrient element, wherein the composition possesses an energy spectrum more positive than the energy spectrum of the composition in a preexisting state, the composition being effective, perhaps because of the more positive energy spectrum, to improve the ability of a soil, when combined with the composition, to support plant growth better than the soil, when not combined with the composition. Methods of making and using the same for improving soil, plants, plant growth, seeds, and/or plant products, including quality of plant products, are also disclosed, as well as improved soil, seeds, including quality of seeds, plants, and/or plant products, including quality of plant product.

The invention relates to novel compositions for preventing caking and crust formation in several types of manures or fertilizers in the form of granular solids. Said compositions comprise at least one phosphoric ester and at least one fatty trialkylamine of formula (III) whereinR1 represents a linear or branched alkyl, alkenyl or alkynyl group containing between 6 and 24 carbon atoms,R2 represents an alkyl group containing between 1 and 5 carbon atoms,R3 represents a linear or branched alkyl group containing between 1 and 5 carbon atoms, or alkyl, alkenyl or alkynyl group containing between 6 and 24 carbon atoms.

The present disclosure is directed toward a composition and method of treating and preventing infection of pathogenic microorganisms and endopyhtic microorganisms in a plant through the use of phosphite compositions.

Method for the stabilization of contaminants within a material selected from soils, mining tailings and by-products, sludge wastes and industrial wastes, by mixing the material with an alum sludge composition. The composition includes one or more aluminum compound(s) and/or complex(es) together with a reactive carbon material.

The invention employs composites of zeolite and ferric oxide hydroxide for removal of inorganic nitrogen and phosphorus wastes from animal environments.

The present invention relates to compositions comprising an effective amount of sulphur, an effective amount of zinc sulphate or zinc oxide and at least one agrochemically acceptable excipient.

Fertilizer granules and methods of producing fertilizer granules. The fertilizer granules are formed from a fertilizer composition, such as a phosphate fertilizer, includes a fibrous material for the purpose of increasing the granule strength preventing or reducing attrition or dusting formation during storage, transport, and/or handling of the fertilizer. Dust formation can be reduced fifty percent or more. The base fertilizer composition can include a phosphate fertilizer, such as monoammonium phosphate (MAP) or diammonium phosphate (DAP), and optionally one or more micronutrients or secondary nutrients, such as elemental sulfur. The fibrous material is pulp or paper sludge, for example.

Disclosed are methods of enhancing plant growth, comprising treating seed at least one month prior to planting with an effective amount of a plant signal molecule, wherein upon harvesting the plant exhibits at least one of increased plant yield measured in terms of bushels/acre, increased root number, increased root length, increased root mass, increased root volume and increased leaf area, compared to plants harvested from untreated seed, or compared to plants harvested from seed treated with the signal molecule just prior to or within a week or less of planting.

A granular agrochemical composition is disclosed including a granular core material having a water soluble portion with a first coating layer applied on the surface of the core material and a second coating layer applied on the surface of the first coating layer. The first coating layer includes a wax composition having a biologically active ingredient incorporated therein and the second coating layer includes a polymeric composition. The granular agrochemical composition exhibits a controlled rate of release of the biologically active ingredient therefrom over a period greater than about 30 days from the date of initial exposure of the granular composition to moisture whereby essentially all of the biologically active ingredient incorporated in the wax material of the first coating layer is released from the granular composition before the water soluble portion of the granular core material is released from the granular composition.

The present invention is related to the field of environmental protection, more specifically, to a foliage silicon fertilizer and a method for production of the fertilizer, which is a molybdenum-silica compound sol used for reducing heavy metal and nitrates in vegetables. The fertilizer, which is a molybdenum-silica compound sol, comprises 10-25 wt % silica, 0.05-5.5 wt % molybdenum ions. More preferably, the fertilize, which is a rare earth-molybdenum-silica compound sol, comprises 10-25 wt % silica, 0.05-5.5 wt % molybdenum ions and 0.1-7.5 wt % rare earth ions. By the combination of silica with molybdenum in the present invention, it is effective for preventing the absorption/accumulation of nitrates in vegetables. In addition, by the further combination with rare earth element, the prevention ability of the fertilizer from absorbing heavy metal and nitrates into vegetables is even enhanced. With a preparation method with normal pressure and relatively, low temperature, that is, with mild condition, simple process and high operability, large scale production of the present invention may be readily executed.

A composition includes a first chelating agent, a second chelating agent, and a plurality of metal ions. In one embodiment, the second chelating agent includes citric acid and is different than the first chelating agent. A method for forming a composition includes mixing a first chelating agent, a second chelating agent, and a metal salt together to form a mixture and processing the mixture to form at least one of a granulated composition and a powdered composition. In some embodiments, the second chelating agent includes citric acid and is different than the first chelating agent.

An improved composition comprising substantial spherical UFP particles and an active agent, such as NBPT, and optionally other components is used as an additive for liquid and solid fertilizers, typically containing urea. Methods of making the compositions and their use are also disclosed.

A position information correcting device includes a reception processing unit receiving position information transmitted from a nearby mobile object, a position correcting unit performing a position correcting process for correcting, based on map data, the position information of the nearby mobile object such that a corrected position of the nearby mobile object is on a running area of a road, a nearby mobile object type acquiring unit acquiring a mobile object type of the nearby mobile object, and a correction performance determining unit determining, based on the mobile object type acquired by the nearby mobile object type acquiring unit, whether the position correcting process needs to be performed to the position information of the nearby mobile object. The position correcting process is performed to the position information of the nearby mobile object only when the correction performance determining unit determines that the position correcting process needs to be performed.

A positive electrode active material includes: secondary particles obtained by aggregation of a plurality of primary particles. The primary particles include, core particles including a lithium composite oxide, and a layer that is provided on surfaces of the core particles and includes a lithium composite oxide. The lithium composite oxide included in the core particles and the lithium composite oxide included in the layer have the same composition or almost the same composition, and crystallinity of the lithium composite oxide included in the layer is lower than crystallinity of the lithium composite oxide included in the core particles.

The invention provides dispersed inorganic mixed metal oxide pigment compositions utilizing a carboxylic acid, containing dispersant and a mixed metal oxide pigment. The metal oxide pigment is of the type used to colour ceramic or glass articles. The dispersant, in addition to at least one carboxylic acid group, comprises at least one 300-3000 g/mole solubilizing chain of repeating units from hydrocarbylene or repeating units from C3 or C4 alkylene ethers or mixtures of said ethers. A milling process using beads is also described to reduce the mixed metal oxide particle size to the desired range. A method of using the mixed metal oxide dispersion to digitally print an image on a ceramic or glass article using the dispersion jetted through a nozzle and firing the coloured article is also described.

A method and apparatus for inspecting a composite structure. A response sound signal to a sound signal sent into the composite structure at a location on the composite structure is detected. An attenuation is identified in the response sound signal detected in response to the sound signal sent into the composite structure at the location on the composite structure. An indication of whether additional evaluation of the location is needed based on a comparison of the attenuation in the response sound signal to a baseline attenuation value for porosity for the location on the composite structure is generated.

Remotely readable valve position indicators and related methods are described. An example apparatus in accordance with the teachings of this disclosure includes a valve body, a valve stem and a fluid flow control apparatus coupled to the valve stem. The fluid flow control apparatus is longitudinally displaceable between a first position and a second position to control fluid flow through a flow aperture of the valve body. The apparatus also includes a valve position indicator including an identifier device coupled to the valve stem. In the first position, the wireless identifier device associated with a first value indicative of the first position of the fluid flow control apparatus. In the second position, the wireless identifier device associated with a second value indicative of the second position of the fluid flow control apparatus.

An arrangement and a method for implosion mitigation, and in particular a structural arrangement of a water vessel and a method thereof for mitigating implosion loads. The water vessel includes first and second end portions connected by a middle portion, with one portion structurally weaker than the others so that when the vessel experiences an overmatching load, only the structurally weaker portion of the vessel fails. The vessel may further include energy absorbing structures.

A multiple position locking handle for an exercise machine for that is movable into a plurality of different positions when unlocked and that is retained in a single secure position when locked. The multiple position locking handle for an exercise machine generally includes a tubular base having a lower end and an upper end, an elongated member extending through the opening of the upper end of the tubular base and extending downwardly through at least a portion of the tubular base, a handle extending outwardly from the elongated member at an angle, and a locking device. The elongated member is movable within the tubular base when the locking device is in the unlocked state and is substantially not movable within the tubular base when the locking device is in the locked state.

A composite trampoline enclosure system has a trampoline with a trampoline frame and a trampoline bed. The trampoline enclosure is mounted to the trampoline. The trampoline enclosure further includes an enclosure pole formed as a tubular post, and an endcap. The endcap fits over the tubular post. A flexible top line is made of polyethylene or polypropylene. The flexible top line connects to the endcap. The flexible top line supports the trampoline enclosure netting. An extended coil spring is whipped in a helical orientation around an external circumferential periphery of the flexible top line. The trampoline enclosure netting is extended around the trampoline bed. The trampoline enclosure netting is supported by the trampoline pole. The extended coil spring is preferably made of spring steel. The flexible top line is preferably made of a high density polyethylene tube.

A insensitive explosive comprises: 34.9 wt % diethylenetriamine trinitrate (DETN),33.4 wt % ethylenediamine dinitrate (EDD),25.4 wt % methyl-guanidine (MeNQ), and6.3 wt % guanidine (NQ). This quaternary eutectic is used in combination with a sensitive explosive. A low melting temperature facilitates melt casting to fill 155 mm artillery shells.

The invention relates to the field of explosives, and more particularly relates to particles of an explosive, wherein they are in crystalline form, have a rounded shape and a majority of them contain no internal defect. Particles of an explosive in crystalline form include a volume fraction of closed pores of less than or equal to 0.05%. A method for preparing explosive particles includes preparing crystalline particles, a majority of which are without an internal defect; and rounding the crystalline particles.