Scientists at the Smithsonian’s National Zoo detected a secondary rise in urinary progesterone levels in the Zoo’s female giant panda Mei Xiang (may-SHONG). This hormone rise indicates that it should be 40 to 50 days before Mei Xiang either gives birth to a cub or comes to the end of a pseudopregnancy, or false pregnancy, which is common in giant pandas.

The post Hormone tests show Mei Xiang, the National Zoo’s female giant panda, may be pregnant appeared first on Smithsonian Insider.

In 1987, light from an exploding star in a neighboring galaxy, the Large Magellanic Cloud, reached Earth. Named Supernova 1987A, it was the closest supernova explosion witnessed in almost 400 years, allowing astronomers to study it in unprecedented detail as it evolves.

The post New supernova remnant lights up! appeared first on Smithsonian Insider.

Astronomers using NASA's Chandra X-ray Observatory have detected X-rays emitted by the debris from the explosion of supernova 1957D.

The post Astronomers discover X-rays from a young supernova remnant appeared first on Smithsonian Insider.

A new study finds that since 1985, half of Australia's Great Barrier Reef coral has died.

The post Smithsonian marine biologist Nancy Knowlton discusses Great Barrier Reef coral dieoff on PBS NewsHour appeared first on Smithsonian Insider.

New data from NASA's Chandra X-ray Observatory suggest a highly distorted supernova remnant (shown here) may contain the most recent black hole formed in the Milky Way galaxy.

The post Highly distorted supernova remnant seen by Chandra X-ray Observatory appeared first on Smithsonian Insider.

Using data from NASA’s Chandra X-ray Observatory, astronomers have discovered an unprecedented bonanza of black holes in the Andromeda Galaxy, one of the nearest galaxies […]

The post Chandra X-ray Observatory turns up black hole bonanza in galaxy next door appeared first on Smithsonian Insider.

Rooting through the garbage for a late-night snack or stealing food from the cat’s bowl, the suburban raccoon is a nocturnal, intelligent animal. Yet life […]

The post Suburban raccoons more social yet dominance behavior remains that of a solitary animal appeared first on Smithsonian Insider.

Why is the Sun’s million-degree corona, or outermost atmosphere, so much hotter than the Sun’s surface? This question has baffled astronomers for decades. Today, a […]

The post Tiny ‘nanoflares’ might heat the Sun’s corona appeared first on Smithsonian Insider.

Cassiopeia A, or Cas A for short, is one of the most well studied supernova remnants in our galaxy. But it still holds major surprises.  […]

The post 3-D Map of Supernova Remnant Reveals Frothy Interior appeared first on Smithsonian Insider.

For more than 60 years, researchers have tried to successfully cryopreserve (or freeze) the embryo of zebrafish, a species that is an important medical model […]

The post Gold nanotechnology and lasers used to successfully freeze fish embryos appeared first on Smithsonian Insider.

A new study from the Smithsonian Conservation Biology Institute (SCBI) is helping make headway in an area of animal management that has historically proven challenging: […]

The post Early indicator of cheetah pregnancy identified appeared first on Smithsonian Insider.

Mycoplasma hyopneumoniae is a prokaryotic pathogen that colonizes the respiratory ciliated epithelial cells in swine. Infected animals suffer respiratory lesions, causing major economic losses in the porcine industry. Characterization of the immunodominant membrane-associated proteins from M. hyopneumoniae may be instrumental in the development of new therapeutic approaches. Here, the crystal structure of P46, one of the main surface-antigen proteins, from M. hyopneumoniae is presented and shows N- and C-terminal α/β domains connected by a hinge. The structures solved in this work include a ligand-free open form of P46 (3.1 Å resolution) and two ligand-bound structures of P46 with maltose (2.5 Å resolution) and xylose (3.5 Å resolution) in open and closed conformations, respectively. The ligand-binding site is buried in the cleft between the domains at the hinge region. The two domains of P46 can rotate with respect to each other, giving open or closed alternative conformations. In agreement with this structural information, sequence analyses show similarities to substrate-binding members of the ABC transporter superfamily, with P46 facing the extracellular side as a functional subunit. In the structure with xylose, P46 was also bound to a high-affinity (Kd = 29 nM) Fab fragment from a monoclonal antibody, allowing the characterization of a structural epitope in P46 that exclusively involves residues from the C-terminal domain. The Fab structure in the complex with P46 shows only small conformational rearrangements in the six complementarity-determining regions (CDRs) with respect to the unbound Fab (the structure of which is also determined in this work at 1.95 Å resolution). The structural information that is now available should contribute to a better understanding of sugar nutrient intake by M. hyopneumoniae. This information will also allow the design of protocols and strategies for the generation of new vaccines against this important swine pathogen.

The Cullinan Blue Diamond Necklace, featuring a bow motif with nine sparkling and extremely rare blue diamonds, recently joined the National Gem Collection in the […]

The post Cullinan Blue Diamond Necklace appeared first on Smithsonian Insider.

Structural investigations of amorphous and nanocrystalline phases forming in solution are historically challenging. Few methods are capable of in situ atomic structural analysis and rigorous control of the system. A mixed-flow reactor (MFR) is used for total X-ray scattering experiments to examine the short- and long-range structure of phases in situ with pair distribution function (PDF) analysis. The adaptable experimental setup enables data collection for a range of different system chemistries, initial supersaturations and residence times. The age of the sample during analysis is controlled by adjusting the flow rate. Faster rates allow for younger samples to be examined, but if flow is too fast not enough data are acquired to average out excess signal noise. Slower flow rates form older samples, but at very slow speeds particles settle and block flow, clogging the system. Proper background collection and subtraction is critical for data optimization. Overall, this MFR method is an ideal scheme for analyzing the in situ structures of phases that form during crystal growth in solution. As a proof of concept, high-resolution total X-ray scattering data of amorphous and crystalline calcium phosphates and amorphous calcium carbonate were collected for PDF analysis.

A novel approach for finding and evaluating structural models of small metallic nanoparticles is presented. Rather than fitting a single model with many degrees of freedom, libraries of clusters from multiple structural motifs are built algorithmically and individually refined against experimental pair distribution functions. Each cluster fit is highly constrained. The approach, called cluster-mining, returns all candidate structure models that are consistent with the data as measured by a goodness of fit. It is highly automated, easy to use, and yields models that are more physically realistic and result in better agreement to the data than models based on cubic close-packed crystallographic cores, often reported in the literature for metallic nanoparticles.

The cationic cyclo­metallated iridium(III) complex [Ir(C9H7N2)2(C12H8N2)](PF6) has been synthesized and crystallized by the inter-diffusion method. It contains an unknown number of solvent mol­ecules and has a different space-group symmetry (C2/c) structure than its solvatomorph (P21/c).

The cationic complex in the title compound, [Ir(C9H7N2)2(C12H8N2)]PF6, comprises two phenylpyrazole (ppz) cyclometallating ligands and one 1,10-phenanthroline (phen) ancillary ligand. The asymmetric unit consists of one [Ir(ppz)2(phen)]+ cation and one [PF6]− counter-ion. The central IrIII ion is six-coordinated by two N atoms and two C atoms from the two ppz ligands as well as by two N atoms from the phen ligand within a distorted octahedral C2N4 coordination set. In the crystal structure, the [Ir(ppz)2(phen)]+ cations and PF6− counter-ions are connected with each other through weak intermolecular C—H...F hydrogen bonds. Additional C—H...π interactions between the rings of neighbouring cations consolidate the three-dimensional network. Electron density associated with additional disordered solvent molecules inside cavities of the structure was removed with the SQUEEZE procedure in PLATON [Spek (2015). Acta Cryst. C71, 9–18]. The given chemical formula and other crystal data do not take into account the unknown solvent molecule(s). The title compound has a different space-group symmetry (C2/c) from its solvatomorph (P21/c) comprising 1.5CH2Cl2 solvent molecules per ion pair.

The enanti­opure monopyrrolidine derivative (2S)-methyl (Z)-5-(2-tert-but­oxy-1-cyano-2-oxo­ethyl­idene)pyrrolidine-2-carboxyl­ate, C13H18N2O4, (1), represents a potential ligand and an attractive inter­mediate for the synthesis of chiral metal com­plexes. At the mol­ecular level, the com­pound features an intra­molecular N—H⋯O hydrogen bond; neighbouring mol­ecules inter­act via N—H⋯N contacts to form chains along [100]. Due to its elemental com­position, resonant scattering of the target com­pound is entirely insignificant for diffraction experiments with Mo Kα and small even for Cu Kα radiation. A preliminary study with the harder radiation type confirmed the chiral space group and the suitability of the single crystal chosen; as expected, the results concerning the absolute structure remained com­pletely inconclusive. A second data collection with the longer wavelength gave satisfactory quality indicators for the correct handedness of the mol­ecule, albeit with high standard uncertainties. The absolute configuration has been assessed independently: CD spectra for both enanti­omers of the target mol­ecule were calculated and the spectrum for the S-configured stereoisomer was in agreement with the experiment. The Cotton effect of (1) may be ascribed to π–π* transitions from HOMO to LUMO and from HOMO to LUMO+1. As both independent techniques agree with respect to the handedness of the target mol­ecule, the absolute structure may be assigned with a high degree of confidence.

(The Paypers) Fenergo, a provider of digital Client Lifecycle Management (CLM) software solutions for...

(The Paypers) AML data and tech company Vital4 has revealed its partnership with UK-based

A growing amount of scientific evidence indicates that how much weight women gain during pregnancy and their starting weight at conception can affect their health and that of their babies, says a new report from the Institute of Medicine and the National Research Council.

Consumer access to effective and affordable medicines is an imperative for public health, social equity, and economic development, but this need is not being served adequately by the biopharmaceutical sector, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The U.S. is losing ground in a second laser revolution of highly intense, ultrafast lasers that have broad applications in manufacturing, medicine, and national security, says a new report from the National Academies of Sciences, Engineering, and Medicine.

High-quality early care and education (ECE) is critical to positive child development and has the potential to generate economic returns, but the current financing structure of ECE leaves many children without access to high-quality services and does little to strengthen the ECE workforce, says a new report from the National Academies of Sciences, Engineering, and Medicine.

A commentary published in Nature calls for a moratorium on clinical uses of heritable human genome editing and the establishment of an international governance framework.

The opioid epidemic in the U.S. is driving a simultaneous epidemic of infectious diseases — including HIV, hepatitis C virus (HCV) and bacterial infections, and sexually transmitted infections — but workforce shortages, stigma, and financial and policy barriers are preventing the integration of opioid use disorder (OUD) and infectious disease services, says a new report from the National Academies of Sciences, Engineering, and Medicine.

A new report from the National Academies of Sciences, Engineering, and Medicine says that enhancements to the geodetic infrastructure are needed to answer important questions about sea level rise, water resources, geological hazards, and more over the next decade.

; Credit: J. Scott Applewhite/AP

What does the right to a unanimous jury verdict have to do with abortion, or school prayer, or federal environmental regulations? Stay tuned.

The U.S. Supreme Court Monday struck down state laws in Louisiana and Oregon that allowed people accused of serious crimes to be convicted by a non-unanimous jury vote. The 6-to-3 decision overturned a longstanding prior ruling from 1972, which had upheld such non-unanimous verdicts in state courts.

And these days, any decision to overturn a longstanding precedent rings the alarm bells in the Supreme Court.

In the short run, Monday's decision was a victory for Evangelisto Ramos, who in 2016 was convicted of second-degree murder by a jury vote of 10-to-2 in Louisiana.

Only two states--Louisiana and Oregon--had provisions allowing non-unanimous verdicts, and Louisiana just recently changed its law to be like those in 48 other states and the federal government.

Justice Neil Gorsuch, writing for the majority, laid out the history behind the laws in both states. Gorsuch noted that the measure was first added to the Louisiana state constitution in 1898, after the Supreme Court ruled that racial minorities could not be barred from juries; that same year, Louisiana added the non-unanimous jury provision to its state constitution as part of a package of amendments that deliberately made it difficult for black citizens to vote or otherwise participate meaningfully in the state's governance. Specifically, Gorsuch said, the non-unanimous jury provision was a way to ensure that even if one or two African Americans made it on to a jury, their participation would be "meaningless."

The adoption of the non-unanimous jury rule in Oregon, Gorsuch wrote, "can similarly be traced to the rise of the Ku Klux Klan and efforts to dilute the influence of racial and ethnic and religious minorities on Oregon juries."

Despite these state provisions, there has never been any dispute that the unanimous jury requirement applies to the federal government. The question in this case was whether that aspect of the Sixth Amendment right to a jury trial applied to the states as well.

Over the last 75 years or so, the court has applied just about every other provision of the Bill of Rights to the states, but in 1972 it deviated from that practice, declining to apply the unanimous jury requirement in a similar fashion.

On Monday, however, the 1972 decision came tumbling down. The six-justice court majority — composed of conservatives and liberals — said the earlier ruling was a mistake.

The decision, written by the conservative Gorsuch, was joined in whole or in part by liberal Justices Ruth Bader Ginsburg, Stephen Breyer, Sonia Sotomayor, and conservative Justice Brett Kavanaugh. Justice Clarence Thomas, another conservative, agreed with the result, but on entirely different grounds.

Writing for the dissenters, Justice Samuel Alito — joined by Chief Justice John Roberts and for the most part, Justice Elena Kagan — maintained that the principle of adhering to precedent should be followed in this case because to do otherwise would require "a potentially crushing" number of new trials for people currently imprisoned under the old rule.

"Where is the justice in that?" replied Justice Gorsuch. "Not a single member of this court" is prepared to say that the 1972 decision was correct, he noted. "Every judge must learn to live with the fact that he or she will make mistakes ... But it is something else entirely to perpetuate" a wrong "only because we fear the consequences of being right."

The consequences of Monday's decision will likely be felt more in Louisiana, which allowed non-unanimous verdicts for more serious crimes than Oregon. The court's decision will require retrials for any prisoner who still has appeals pending.

There are about 100 of those cases in Louisiana, says Jamila Johnson, the managing attorney at the Promise of Justice Initiative, which represented Ramos. But there are also at least 1,700 prisoners in the state who might qualify for a new trial if the court eventually holds that Monday's decision is retroactive.

The high court left that question open for another day.

Altogether the majority, concurring, and dissenting opinions totaled a whopping 86 pages and reflected an important subtext--divergent views about when the court should follow its usual rule of adhering to precedent and when it should not.

It's important because, the new ultra-conservative court majority has very different views than the courts of the last 75 years on topics as diverse as abortion, voting rights, federal regulation, and the clash between religious views and generally applicable laws.

"The court's views about when it's OK to overrule prior precedent have always been more about the eye of the beholder than they have been about a rule that is easy or straightforward to apply," says Deborah Pearlstein, professor and co-director of the Floersheimer Center for Constitutional Democracy at Cardozo School of Law. Ultimately, she said, "all of these major questions that are coming before the court are going to be fought along these lines."

This content is from Southern California Public Radio. View the original story at SCPR.org.

KJ Apa and Britt Robertson in "I Still Believe" ; Credit: Lionsgate/I Still Believe (2020)

Larry Mantle and KPCC film critics Amy Nicholson and Wade Major review this weekend’s new movie releases.

• "I Still Believe" on VOD

• "Banana Split" on VOD 

• "Vivarium" on VOD

• "Resistance" on VOD

• "Vitalina Varela" on GrasshopperFilm.com

• "Uncorked" on Netflix

• "Dosed" on film's website

• "The Occupant" on Netflix

• "Tape" on VOD

• "There's Something In The Water" on Netflix

Guests:

Amy Nicholson, film critic for KPCC, film writer for The Guardian and host of the podcasts ‘Unspooled’ and the podcast miniseries “Zoom”; she tweets @TheAmyNicholson

Wade Major, film critic for KPCC and CineGods.com

This content is from Southern California Public Radio. View the original story at SCPR.org.

Director Eliza Hittman on the set of her film "Never Rarely Sometimes Always".
; Credit: Focus Features/Never Rarely Sometimes Always (2020)

The film “Never Rarely Sometimes Always” was slated for a theatrical release in March, but due to COVID-19 screenings were postponed. Instead, the film is out on digital this week, currently sporting a 98 percent rating on Rotten Tomatoes and receiving critical acclaim both here on FilmWeek and nationwide as one of the best films of 2020 so far.

Writer-director Eliza Hittman’s third feature-length film is about two teenage girls Skylar (Talia Ryder) and Autumn (Sidney Flanagan) from rural Pennsylvania who travel to New York City for medical help after an unplanned pregnancy. Hittman says the idea for the film came to her when she read in a book about how some women in Ireland, which up until recently had very strict laws against abortions, would travel from Ireland to London in 24 hours just to get a procedure. It struck her as worthy of a screenplay, and the idea was born. As part of her research for the film Hittman went to a small coal-mining community in rural Pennsylvania and, even though she wasn’t pregnant, visited pregnancy centers, got tested, and talked with women getting treatment and counseling so she could, as she says, “write the scenes with credibility.”

Today on FilmWeek, we’ll air “The Frame” host John Horn’s interview with “Never Rarely Sometimes Always” director Eliza Hittman where the two discuss how Hittman came up with the idea for the film, her journey to rural America to find out what visiting pregnancy centers there is like, and how that informed the way she conceived and wrote the film.

Guest:

Eliza Hittman, writer and director of “Never Rarely Sometimes Always”

This content is from Southern California Public Radio. View the original story at SCPR.org.

We reported last week that layoffs were coming soon to Warner Brothers, but how many positions will be cut is still unknown.  

A spokesman for Warner Brothers Entertainment, Paul McGuire, told KPCC there's no exact number yet. "There is no headcount reduction target, but there is a substantial financial target," Maguire said. 

“This is a budget issue, not a head count issue,” Dee Dee Myers, Warner Brothers Vice President of Corporation Communications told Variety.  The trade publication reports that Warner Brothers is expected to eliminate as many as 1,000 positions worldwide - or about 10 percent of its workforce:

Senior managers are currently assessing their businesses to come up with ways to trim overhead. Only at the end of that process will an exact reduction figure be known. It could be somewhat lower than the current numbers being speculated, but cuts are expected to be substantial.  

News of coming layoffs became public two weeks ago, when KPCC and other media outlets obtained an internal memo written by Warner Bros. Chairman and Chief Executive Officer Kevin Tsujihara.   

"It pains me to say this, positions will be eliminated—at every level—across the Studio," Tsujihara wrote in the memo. 

Morningstar Analyst Neil Macker told KPCC that management at Warner Brothers is trying to protect the company from another takeover play by Rupert Murdoch.  In July, Murdoch offered to buy parent company Time Warner for $80 billion. He withdrew the offer in August. 

Shares of Tronox Holdings traded higher after the company released preliminary Q1/20 earnings data and provided an update on its ongoing operations.

Tradeshift, a supply...

As the development of nanomaterials increases, a recent study recommends combining life cycle analysis and risk assessment to improve our understanding of the potential environmental and human health impacts of products containing nanomaterials.

For the first time, abnormal brain development following a Zika infection during pregnancy has been documented experimentally in the offspring of a non-human primate.

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Nanomaterials – at a scale of one thousand times smaller than a millimetre – offer the promise of radical technological development. Many of these will improve our quality of life, and develop our economies, but all will be measured against the overarching principle that we do not make some error, and harm ourselves and our environment by exposure to new forms of hazard. This Thematic Issue explores recent developments in nanomaterials research, and possibilities for safe, practical and resource-efficient applications.

A recent report has reviewed research on the effectiveness of low-noise road surfaces, taking into account acoustic performance, safety, skidding resistance and cost. It concludes they could have substantial acoustic and financial benefits, but their durability and safety must be taken into account.

‘Dye-sensitised solar cells’ (DSSCs) are an alternative to traditional silicon photovoltaic (PV) cells. They have a number of advantages over traditional PV solar cells, including greater flexibility and lower manufacturing cost, but they are less efficient at turning sunlight into electricity. Taking inspiration from nature, new research has doubled their efficiency using pine tree-shaped nanotubes.

Researchers have summarised the most effective ways that nanostructures can improve the efficiency and lower costs of photovoltaic (PV) solar cells in a recent analysis. Sculpting ultra-thin solar cell surfaces at the nano-scale has been found to effectively boost their efficiency.

A nanoscale 3D printing technique could be useful for nanomanufacturing processes with environmental applications. The authors of a new study have found a way to control their printing process by incorporating a simple pattern into the printing surface. They say their technique could reduce costs for nanoscale printing.

A new review examines the potential uses and scientific, technical and manufacturing problems facing ‘van der Waals heterostructures’ - an emerging science which uses building block-like nanomaterials. Van der Waals heterostructures are nanomaterials built by layering different materials, each one atom thick, on top of each other, to create materials with unique properties and uses.

A new study has found evidence for lung toxicity of different forms of ‘cellulose nanocrystals’ (CNCs) in mice. The study suggests that physical characteristics, such as length, of the CNC relates to the type of effect it has on the lung. These nanosized crystals, made from plant-derived materials, are increasingly being used in novel applications, such as cleaning up oil spills in water and flexible electronic displays, and consumer products, which raises concerns about their potential health impacts.

Adding nanoparticles to water in solar collectors, which are used to capture the sun’s energy, can considerably improve their performance, a recent study on nanofluids has found. The energy efficiency of the collector can be increased by up to 76.6% when using water containing 0.1% by volume of titanium dioxide nanoparticles, compared with water alone.

Amid the covid 19 crisis, the Global Inhouse Centre of Canadian financial services company, Sun Life Financial Asia Service Centre India, is baselining projects that can be accelerated, re-scoped and deferred.

New research on a major UK airport (Heathrow) has estimated that a night-time ban on flights could produce up to £860 million (1 billion euros) in financial savings over a 20 year period. Economic costs caused by the ban could be outweighed by savings from reduced health costs of sleep disturbance and stress caused by the noise of night flights.