Индийский инсайдер Судханшу Амбхоре (Sudhanshu Ambhore)‏ продолжает публиковать подробности о новом смартфоне Realme X3 SuperZoom.

BACKGROUND Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate and compare the immunological features of severe and moderate COVID-19.METHODS In this retrospective study, the clinical and immunological characteristics of 21 patients (17 male and 4 female) with COVID-19 were analyzed. These patients were classified as severe (11 cases) and moderate (10 cases) according to the guidelines released by the National Health Commission of China.RESULTS The median age of severe and moderate cases was 61.0 and 52.0 years, respectively. Common clinical manifestations included fever, cough, and fatigue. Compared with moderate cases, severe cases more frequently had dyspnea, lymphopenia, and hypoalbuminemia, with higher levels of alanine aminotransferase, lactate dehydrogenase, C-reactive protein, ferritin, and D-dimer as well as markedly higher levels of IL-2R, IL-6, IL-10, and TNF-α. Absolute numbers of T lymphocytes, CD4+ T cells, and CD8+ T cells decreased in nearly all the patients, and were markedly lower in severe cases (294.0, 177.5, and 89.0 × 106/L, respectively) than moderate cases (640.5, 381.5, and 254.0 × 106/L, respectively). The expression of IFN-γ by CD4+ T cells tended to be lower in severe cases (14.1%) than in moderate cases (22.8%).CONCLUSION The SARS-CoV-2 infection may affect primarily T lymphocytes, particularly CD4+ and CD8+ T cells, resulting in a decrease in numbers as well as IFN-γ production by CD4+ T cells. These potential immunological markers may be of importance because of their correlation with disease severity in COVID-19.TRIAL REGISTRATION This is a retrospective observational study without a trial registration number.FUNDING This work is funded by grants from Tongji Hospital for the Pilot Scheme Project, and partly supported by the Chinese National Thirteenth Five Years Project in Science and Technology for Infectious Disease (2017ZX10202201).

BACKGROUND Preclinical experiments have shown that donor blood cells, modified in vitro by an alkylating agent (modified immune cells [MICs]), induced long-term specific immunosuppression against the allogeneic donor.METHODS In this phase I trial, patients received either 1.5 × 106 MICs per kg BW on day –2 (n = 3, group A), or 1.5 × 108 MICs per kg BW on day –2 (n = 3, group B) or day –7 (n = 4, group C) before living donor kidney transplantation in addition to post-transplantation immunosuppression. The primary outcome measure was the frequency of adverse events (AEs) until day 30 (study phase) with follow-up out to day 360.RESULTS MIC infusions were extremely well tolerated. During the study phase, 10 treated patients experienced a total of 69 AEs that were unlikely to be related or not related to MIC infusion. No donor-specific human leukocyte antigen Abs or rejection episodes were noted, even though the patients received up to 1.3 × 1010 donor mononuclear cells before transplantation. Group C patients with low immunosuppression during follow-up showed no in vitro reactivity against stimulatory donor blood cells on day 360, whereas reactivity against third-party cells was still preserved. Frequencies of CD19+CD24hiCD38hi transitional B lymphocytes (Bregs) increased from a median of 6% before MIC infusion to 20% on day 180, which was 19- and 68-fold higher, respectively, than in 2 independent cohorts of transplanted controls. The majority of Bregs produced the immunosuppressive cytokine IL-10. MIC-treated patients showed the Immune Tolerance Network operational tolerance signature.CONCLUSION MIC administration was safe and could be a future tool for the targeted induction of tolerogenic Bregs.TRIAL REGISTRATION EudraCT number: 2014-002086-30; ClinicalTrials.gov identifier: NCT02560220FUNDING Federal Ministry for Economic Affairs and Technology, Berlin, Germany, and TolerogenixX GmbH, Heidelberg, Germany.

Regenerative pain medicine, which seeks to harness the body’s own reparative capacity, is rapidly emerging as a field within pain medicine and orthopedics. It is increasingly appreciated that common analgesic mechanisms for these treatments depend on neuroimmune modulation. In this Review, we discuss recent progress in mechanistic understanding of nociceptive sensitization in chronic pain with a focus on neuroimmune modulation. We also examine the spectrum of regenerative outcomes, including preclinical and clinical outcomes. We further distinguish the analgesic mechanisms of regenerative therapies from those of cellular replacement, creating a conceptual and mechanistic framework to evaluate future research on regenerative medicine.

Seizures often herald the clinical appearance of gliomas or appear at later stages. Dissecting their precise evolution and cellular pathogenesis in brain malignancies could inform the development of staged therapies for these highly pharmaco-resistant epilepsies. Studies in immunodeficient xenograft models have identified local interneuron loss and excess glial glutamate release as chief contributors to network disinhibition, but how hyperexcitability in the peritumoral microenvironment evolves in an immunocompetent brain is unclear. We generated gliomas in WT mice via in utero deletion of key tumor suppressor genes and serially monitored cortical epileptogenesis during tumor infiltration with in vivo electrophysiology and GCAMP7 calcium imaging, revealing a reproducible progression from hyperexcitability to convulsive seizures. Long before seizures, coincident with loss of inhibitory cells and their protective scaffolding, gain of glial glutamate antiporter xCT expression, and reactive astrocytosis, we detected local Iba1+ microglial inflammation that intensified and later extended far beyond tumor boundaries. Hitherto unrecognized episodes of cortical spreading depolarization that arose frequently from the peritumoral region may provide a mechanism for transient neurological deficits. Early blockade of glial xCT activity inhibited later seizures, and genomic reduction of host brain excitability by deleting MapT suppressed molecular markers of epileptogenesis and seizures. Our studies confirmed xenograft tumor–driven pathobiology and revealed early and late components of tumor-related epileptogenesis in a genetically tractable, immunocompetent mouse model of glioma, allowing the complex dissection of tumor versus host pathogenic seizure mechanisms.

Amazon is taking up to $100 off the Apple Watch Series 5 this week, with prices starting at $299.99 for the 40mm GPS models. Only the Gold Aluminum Case with Pink Sport Band is available at this price. If you order today, the Apple Watch should arrive sometime next week.

Note: MacRumors is an affiliate partner with Amazon. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.

The Apple Watch Series 5 was released in September 2019 with a new OLED screen that supports an always-on feature, which represents the biggest change to the Series 5 models. The newest Apple Watch is available in 40mm and 44mm sizes, and it has the overall same design as the Series 4 models.

"And you know, we have to stop looking beyond this election cycle and see that this corporate driven ideology, you know, this commodification of the culture, this constant extracting of blood from us as citizens to pay what in essence were private debts of the banks which engaged in casino capitalism, has political consequences. History has taught us that. And Hillary Clinton is only going to further that process." Continue reading →

At the International Supercomputing Conference in Frankfurt, The Weather Company, an IBM Business, today announced a plan to help improve weather prediction globally via a new collaboration with the University Corporation for Atmospheric Research (UCAR) and the National Center for Atmospheric Research (NCAR), a federally funded research and development center for the atmosphere and Earth’s geospace systems.

IBM and West Virginia University’s Center for Disability Inclusion (CDI) today announced they are developing a first generation mobile workplace accommodation case management app to help U.S. businesses create inclusive workplaces for employees with disabilities.

• Con vigencia de 10 años, Banorte e IBM firman alianza estratégica que permitirá establecer las bases de un nuevo modelo de banca enfocado al cliente, y mejorar sustancialmente sus índices de eficiencia para alcanzar niveles cercanos al 40%, así como retornos sobre capital superiores al 20%. El acuerdo incluye servicios de consultoría y de tecnología, investigación y desarrollo. • “Estamos plenamente satisfechos con el acuerdo logrado, pues este suma el mejor talento humano, tanto de IBM, como de Banorte Ixe, y está en línea con nuestra búsqueda de herramientas tecnológicas para servir a nuestros clientes de manera individualizada”: Alejandro Valenzuela.

Seguridad, aplicaciones estratégicas y analítica móvil son clave para que las organizaciones inteligentes mejoren sus resultados

Diltex -empresa mexicana propietaria de las marcas Ilusión y Fiorentina, socios de Vanity Fair Brands y franquiciatarios de David's Bridal en México- e IBM, anunciaron que la compañía dedicada a la industria de la moda está mejorando la experiencia del cliente y fortaleciendo su producción, distribución y comercialización a través de su transformación digital.

La marca de moda urbana DPStreet, filial del corporativo GrupoDP, ha dado a conocer su intención de transformar el modelo comercial y de negocio apoyados en la habilitación de distintas estrategias digitales, una de las principales es una tienda virtual desarrollada por IBM (Digital Commerce) e implementada por Solemti S.A. de C.V., su asociado de negocios en el área digital.

La inteligencia artificial (IA) promete transformar tanto el futuro del trabajo como la función de Recursos Humanos (RRHH). Alineado con esta premisa, IBM (NYSE: IBM) anunció hoy IBM Talent & Transformation, una nueva unidad destinada a ayudar a las organizaciones y a sus empleados a tener éxito en la era de la inteligencia artificial y la automatización.

Enfrenta IBM Desafíos de Big Data con Modelo Innovador de Servidor Abierto

IBM today announced that WesTrac Pty Ltd, an industrial machinery supplier headquartered in Perth, has selected IBM to design and implement a Portable Modular Data Center (PMDC) solution to provide the company with a flexible, cost-effective data centre to meet its immediate business needs as well as support future IT growth.

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In the comments to these weekly posts (and only these posts), it's your chance to go as off topic as you like. Talk about non-comics stuff, thread derail, and just generally chat among yourselves.

The EU hosted a summit where over 40 countries and global organisations promised a starting figure of over $8 billion to the development of a covid-19 vaccine.

Much of the world is starting to experiment with opening up again in a new sort-of-post-Covid19 world, with places like Germany and Spain relaxing, gradually, some of the lockdown protocols, with strong limitations and provisos.

In New Zealand, consistent reminder that competent politicians exist Jacinda Ardern has suggested that the country may not have open borders for a long time to come.

In the UK, a phone app is being developed for contact tracingM and notification of people you may have been in contact with who develop Covid19, though in true current UK style, it's going against every other countries developed app by not using the personalised data storage method (Where your information never leaves your phone), but a centralised database, which is raising some concerns about the storage and disposal (or not) of this data.

The US government is planning on borrowing around 3 TRILLION dollars in the next quarter to pay for pandemic support initiatives. That's 3,000,000,000,000 (Which I only mention because I've never had a reason to type an actual number that big in a real world context!)

The US is also starting to open up in places, though the wisdom of this is being called into question by... well, pretty much everyone else on the planet, and a goodly number of the local population of course.

The Clone Wars seventh and final season came to an end with a frankly spectacular arc which saw Ahsoka Tano facing off against Darth Maul in the sort of iconic fight scene that, truth be told, the sequel trilogy was mostly completely lacking, at least on an emotional level), and giving us a chance to see the impact of General Order 66 from the point of view of Ahsoka, as well as the actual Clone Troopers who we have got to know and care about over the years of this series. THIS is how you do it!

The long overdue, repeatedly delayed, New Mutants movie was briefly appearing as forthcoming video on demand from Amazon, though without a release date, but it has now disappeared again. This DOES seem to suggest it might go straight to digital with no cinema release.

Also a new image of a new baddies form the movie have been released in the shape of the Smiley-Men.

And I've clearly been watching waaaay too much anime, or at least listening to too many anime soundtracks when a random video from something called Argonavis (A games based anime from what I can see) popped up and I thought "Gosh that sounds like Unison Square Garden" (who did "Orion o Nazoru", the belter of an OP for Tiger and Bunny) only to discover it's not, but it was written and arranged by two of the members.

In terms of podcasts, alongside old favourites like "Jay and Miles X-Plain the X-Men" (pretty much what it says on the tin and currently looking at Age of Apocalypse), "The NoSleep Podcast" (Horror fiction) and "The Arkham Sessions" (An actual qualified clinical psychologist, Dr Andrea Letamendi, examined, firstly "Batman the Animated Series" and is now looking at the "Doom Patrol" TV series for their depictions of mental conditions), I've just started Mockery Manor, a horror/mystery/drama set at a gloriously awful (and thankfully fictional) British theme park in the late 1980's.

So today's extra curricular activity for the community: What podcasts are you currently listening to that you'd recommend to others?


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