"I fell into transportation domain by chance, pursuing my interests in software and data. And although I kept working in these fields, TRB taught me about transportation and how my software and data expertise could help solve transportation problems," says Nikola Ivanov, Director of Operations at the University of Maryland’s Center for Advanced Transportation Technology (CATT) Laboratory. "Through TRB, I’ve met hundreds of brilliant experts, all of whom help me make a difference in people’s everyday live...

In 2017, when leadership at Seattle–Tacoma International Airport (Sea-Tac) decided to build a new International Arrivals Facility (IAF), they knew they had to leverage airport resources in a cost-effective manner to enhance customer experience. At nearly 50 years old, the existing facility could no longer accommodate Sea-Tac’s demand for international travel, which grew 107 percent from 2007 to 2017. The latest issue of the  TRB Airport Cooperative Research Program's (ACRP) Impacts on Practice serie...

There are opportunities and challenges in implementing public–private partnerships at airports. The TRB Airport Cooperative Research Program's Conference Proceedings on the Web 26: Public–Private Partnerships: What Are the Lessons Learned? is a summary of the presentations and discussions at an ACRP Insight Event held July 10-11, 2019, in Washington, DC.  These in-depth, face-to-face gatherings are designed to promote communication and collaboration, foster innovation, and help identify areas of fut...

There are opportunities and challenges in implementing public–private partnerships at airports. The TRB Airport Cooperative Research Program's Conference Proceedings on the Web 26: Public–Private Partnerships: What Are the Lessons Learned? is a summary of the presentations and discussions at an ACRP Insight Event held July 10-11, 2019, in Washington, DC.  These in-depth, face-to-face gatherings are designed to promote communication and collaboration, foster innovation, and help identify areas of fut...

Although general aviation airports have historically been funded by federal, state, and local entities, the private sector is increasingly playing a larger role. This involvement has ranged on a continuum from service and management contracts to singular projects at airports that involve leasing mechanisms to long-term leases and the whole-scale private development of general aviation airports. In an era of declining resources and increasingly scrutinized public expenditures, private-sector involvement i...

Will Smith, Will Ferrell, Wanda Sykes, Stephen Colbert and Colin Quinn are among the latest additions.

There is great confusion among Christians about the unforgivable sin. Jesus talks about it in Matthew 12:31-32. This brief study summarizes what the unforgivable sin is, and how you can know you have not committed it. This study is an excerpt from my Gospel Dictionary online course.

In Matthew 12:33-37, in the context of warning the religious leaders about the sin of blasphemy against the Holy Spirit, Jesus talks about good fruit and bad fruit. Is Jesus telling people to look at the lives of other teachers to see if they have good works? No! Not at all. Listen to the study to see what Jesus IS teaching and why this is important for properly understanding the gospel.

Just posted to Slate, by Isaac Butler: The Disappearance of John M. Ford. Key takeaway to Making Light readers who...

Politicos watered down earlier efforts, so data defenders will fight to the end

The small group of policy wonks that forced California’s legislature to rush through privacy legislation two years ago are back – and this time they want a ballot.…

High-frequency audio could be used to stealthily track netizens

Technical folks looking to improve web privacy haven't been able to decide whether sound beyond the range of human hearing poses enough of a privacy risk to merit restriction.…

-Album Details- Title: NJBP Concert Archives I ~ANCIENT FESTIVAL~ Publisher: SuperSweep Catalog Number: SRVD-5001 Release Date: July 6th, 2019 Ripped by: Razakin -Info- Recording of the New Japan BGM Philharmonic Orchestra’s Ancient Festival concert, which was full of Yuzo Koshiro goodness from the Scheme to Streets of Rage and Etrian Odyssey, and as a main […]

The post New Arrivals: Top Fishing Sunglasses You Can Try this 2020 appeared first on Ocean Blue Fishing Adventures.

Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial dysfunction, premature zymogen activation, and necrosis, ultimately leading to pancreatitis. Although stimulation of the mechanically activated, calcium-permeable ion channel Piezo1 in the pancreatic acinar cell is the initial step in pressure-induced pancreatitis, activation of Piezo1 produces only transient elevation in intracellular calcium that is insufficient to cause pancreatitis. Therefore, how pressure produces a prolonged calcium elevation necessary to induce pancreatitis is unknown. We demonstrate that Piezo1 activation in pancreatic acinar cells caused a prolonged elevation in intracellular calcium levels, mitochondrial depolarization, intracellular trypsin activation, and cell death. Notably, these effects were dependent on the degree and duration of force applied to the cell. Low or transient force was insufficient to activate these pathological changes, whereas higher and prolonged application of force triggered sustained elevation in intracellular calcium, leading to enzyme activation and cell death. All of these pathological events were rescued in acinar cells treated with a Piezo1 antagonist and in acinar cells from mice with genetic deletion of Piezo1. We discovered that Piezo1 stimulation triggered transient receptor potential vanilloid subfamily 4 (TRPV4) channel opening, which was responsible for the sustained elevation in intracellular calcium that caused intracellular organelle dysfunction. Moreover, TRPV4 gene–KO mice were protected from Piezo1 agonist– and pressure-induced pancreatitis. These studies unveil a calcium signaling pathway in which a Piezo1-induced TRPV4 channel opening causes pancreatitis.

Infection with the Gram-negative bacterium Helicobacter pylori remains the most important modifiable risk factor for the development of gastric cancer, a leading cause of cancer-related deaths worldwide. How the interactions between H. pylori and its host shape the gastric environment during chronic infection warrants further investigation. In this issue of the JCI, Palrasu et al. used human cell lines and mouse models to provide mechanistic insight into H. pylori’s ability to delay apoptosis in gastric epithelial cells by actively driving the degradation of a proapoptotic factor, SIVA1. Their findings suggest that promoting the survival of gastric epithelial cells has implications not only for H. pylori pathogenesis but for host tumorigenesis.

Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we report that vascular permeability–enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of neutrophil rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the bloodstream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed them to exhibit an activated phenotype and be capable of trafficking to the lungs where their presence was aligned with regions of vascular injury. Collectively, we demonstrate that increased microvascular leakage reverses the localization of directional cues across venular walls, thus causing neutrophils engaged in diapedesis to reenter the systemic circulation. This cascade of events offers a mechanism to explain how local tissue inflammation and vascular permeability can induce downstream pathological effects in remote organs, most notably in the lungs.

Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid turnover, and quaking (Qki) is a major regulator of myelin lipid homeostasis. Oligodendrocyte-specific Qki depletion, without affecting oligodendrocyte survival, resulted in rapid demyelination, within 1 week, and gradually neurological deficits in adult mice. Myelin lipids, especially the monounsaturated fatty acids and very-long-chain fatty acids, were dramatically reduced by Qki depletion, whereas the major myelin proteins remained intact, and the demyelinating phenotypes of Qki-depleted mice were alleviated by a high-fat diet. Mechanistically, Qki serves as a coactivator of the PPARβ-RXRα complex, which controls the transcription of lipid-metabolism genes, particularly those involved in fatty acid desaturation and elongation. Treatment of Qki-depleted mice with PPARβ/RXR agonists significantly alleviated neurological disability and extended survival durations. Furthermore, a subset of lesions from patients with primary progressive multiple sclerosis were characterized by preferential reductions in myelin lipid contents, activities of various lipid metabolism pathways, and expression level of QKI-5 in human oligodendrocytes. Together, our results demonstrate that continuous lipid synthesis is indispensable for mature myelin maintenance and highlight an underappreciated role of lipid metabolism in demyelinating diseases.

Is your standard charge for a speech $300,000?  According to an article appearing on the website of the Las Vegas Review-Journal, and a May 31, 2013 email, Clinton’s standard contract usually includes: Round-trip transportation on a chartered private jet “e.g., a Gulfstream … Continue reading →

As climate change accelerates, IBM is galvanizing the global science community with a massive infusion of computing resources, weather data, and cloud services to help researchers examine the effects of climate change, and explore strategies to mitigate its effects. IBM pledges to help direct the equivalent of up to $200 million for up to five climate-related projects judged to offer the greatest potential impact, and will then broadly share the experiments' results.

IBM today announced that Clarient Global LLC (“Clarient”), a joint venture established to transform client data and document management in the financial services industry, has selected VMware Cloud Foundation on IBM Cloud to continue to enhance its existing SoftLayer private cloud implementation for its Clarient Entity Hub platform.

IBM today announced a new IBM Cloud Private software platform to help companies unlock billions of dollars in technology investment in core data and applications and extend cloud-native tools across public and private clouds.

IBM today announced its intention to acquire Vivant Digital business (Vivant), a boutique digital and innovation agency based here. This acquisition extends the strategy and design expertise of IBM iX, one of the world’s largest digital agencies and global business design partners, with Vivant talent and expertise to accelerate clients’ digital transformations.

IBM today announced it has completed the acquisition of Vivant Digital business (Vivant), a boutique digital and innovation agency based in Australia, to join IBM iX. Financial details were not disclosed.

IBM anunció hoy la primera plataforma de servicios basada en IBM Watson y construida en IBM Cloud para aumentar la inteligencia humana y ayudar a mejorar las operaciones de los proveedores de servicios a través de tecnologías cognitivas.

Este año IBM cumple 90 años de ser un jugador clave en el progreso de México, impulsando a diferentes generaciones a través de la transformación de industrias y profesiones, e impactando el panorama económico, académico y social del país gracias a la estrecha colaboración con todos los actores de la sociedad.

IBM y organizaciones aliadas lanzaron la iniciativa global 'Call for Code', el esfuerzo más grande y ambicioso para reunir a desarrolladores del sector académico y empresarial, para resolver uno de los problemas más acuciantes de la sociedad de nuestro tiempo: prevenir, responder y recuperarse de desastres naturales.

Durante la cumbre Business Connect 2017 en la Ciudad de México, IBM presentó a la Transformación Digital como una de las áreas de mayor crecimiento para los negocios en 2017 y mostró cómo las soluciones cognitivas (de analítica avanzada, de nube, de engagement), están transformando la forma en la que trabajamos y vivimos.

IBM anunció la expansión de la mayor y más diversa oferta de APIs, tecnologías y herramientas cognitivas para los desarrolladores que están creando servicios, productos y aplicaciones que se integran con IBM Watson.

: IBM anunció que recibió el premio de “Compañía de Nube de 2016” de la firma líder Frost & Sullivan. El premio reconoce el liderazgo de IBM en el mercado entregando un completo y totalmente integrado set de servicios de nube incluyendo IaaS, Paas, y SaaS.

La Universidad Anáhuac México e IBM México celebraron hoy la firma de la Cátedra Corporativa en beneficio de la comunidad universitaria. El acuerdo fue signado por el Dr. Cipriano Sánchez, LC, Rector de la Universidad Anáhuac México y Antonio Martins, Presidente y Gerente General de IBM México.

El Instituto Tecnológico de Ocotlán (ITO) e IBM firmaron el compromiso de acuerdo de colaboración que permitirá al Instituto fortalecer la formación laboral, académica y tecnológica de más de 1,300 estudiantes, por medio de Estancias de Experiencia Profesional, Servicio Social y el acceso gratuito al portafolio de soluciones tecnológicas y de software ofrecidas por IBM.

IBM y VON DER HEIDE, compañía especializada en servicios de consultoría de Recursos Humanos, informan que han firmado una importante alianza para expandir su oferta de servicios de Employee Engagement y HR Analytics en toda América Latina. Por medio de las tecnologías de IBM, esta alianza le permitirá a VON DER HEIDE brindar a sus clientes una oferta de consultoría única en el mercado, para transformar estrategias de talento en resultados de negocio.

IBM y la Asociación de Tenis de los Estados Unidos (USTA por sus siglas en inglés) anunciaron que IBM Watson participará en el campeonato US Open por primera vez por medio de una nueva característica de consejería cognitiva piloteada en las aplicaciones móviles oficiales del torneo, a fin de mejorar la experiencia de los aficionados presentes en el Billie Jean King National Tennis Center.

IBM (NYSE: IBM) today announced its intention to acquire Vivant Digital business (Vivant), a boutique digital and innovation agency based here. This acquisition extends the strategy and design expertise of IBM iX, one of the world’s largest digital agencies and global business design partners, with Vivant talent and expertise to accelerate clients’ digital transformations.