si

Dual-functional porphyrinic zirconium-based metal–organic framework for the fluorescent sensing of histidine enantiomers and Hg2+

Anal. Methods, 2024, 16,2386-2399
DOI: 10.1039/D3AY02241B, Paper
Shili Qin, Fanshu Meng, Fenglong Jin, Xidi Xu, Ming Zhao, Hongtao Chu, Lidi Gao, Shuren Liu
L-Cys/PCN-222 as a novel and dual-functional fluorescent sensor was developed. It not only showed a higher chiral fluorescent recognition of L-histidine but also performed as a visual sensor for Hg2+ in actual surface water.
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si

Anti-aggregation colorimetric sensing of cysteine using silver nanoparticles in the presence of Pb2+

Anal. Methods, 2024, 16,2378-2385
DOI: 10.1039/D4AY00351A, Paper
Lihui Mao, Yi Zhang, Huan Zhang, Huili Liu, Yong-ping Gao
In this study, an unmodified AgNPs was synthesized to prepare AgNPs-Pb2+ as a probe for colorimetric sensing of cysteine. We developed a AgNPs colorimetric method for the determination of cysteine in urine, utilizing the anti-aggregation principle.
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si

A chemiluminescence immunoassay for type IV collagen as a promising marker for liver fibrosis and cirrhosis

Anal. Methods, 2024, 16,2248-2255
DOI: 10.1039/D3AY02240D, Paper
Xiaoling Fu, Fan Zhang, Fangda Zhen, Lian Duan, Jian Zhou, Jianguo Ma
Herein, a magnetic bead-based chemiluminescence assay is reported to detect type IV collagen (col-IV) in serum samples.
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si

Analysing micro- and nanoplastics with cutting-edge infrared spectroscopy techniques: a critical review

Anal. Methods, 2024, 16,2177-2197
DOI: 10.1039/D3AY01808C, Critical Review
Open Access
Junhao Xie, Aoife Gowen, Wei Xu, Junli Xu
In this review, we discussed and compared the applications of Fourier transform infrared spectroscopy, quantum cascade laser infrared spectroscopy, atomic force microscopy-based infrared spectroscopy, and optical photothermal infrared spectroscopy in MNP research from multiple perspectives.
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si

A new colorimetric aptasensor for paraquat detection based on the designed aptamer with multiple paraquat binding sites in combination with gold nanoparticles

Anal. Methods, 2024, 16,2340-2348
DOI: 10.1039/D4AY00053F, Paper
Pakawat Kongpreecha, Sineenat Siri
Given paraquat's environmental health risks, there is a need for a fast and simple detection method. This study presents a novel colorimetric aptasensor with a tailored aptamer, boosting sensitivity by targeting multiple paraquat binding sites.
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si

An immunochromatographic strip sensor for rapid and sensitive detection of candesartan, olmesartan medoxomil, and irbesartan in herbal beverages

Anal. Methods, 2024, 16,2359-2367
DOI: 10.1039/D4AY00151F, Paper
Dingyu Li, Aihong Wu, Liqiang Liu, Hua Kuang, Chuanlai Xu, Xiaoling Wu
Sartans, as a class of antihypertensive drugs, pose a threat to human health when illegally added to herbal beverages.
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si

A novel electrophoretic assisted hydrophobic microdevice for enhancing blood cell sorting: design and numerical simulation

Anal. Methods, 2024, 16,2368-2377
DOI: 10.1039/D4AY00196F, Paper
Xinkun Chen, Xueye Chen
Microfluidic technology has great advantages in the precise manipulation of micro–nano particles, and the hybrid microfluidic separation technology has attracted much attention due to the advantages of both active and passive separation technology at the same time.
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si

A highly sensitive and selective fluorescent biosensor for breast cancer derived exosomes using click reaction of azide–CD63 aptamer and alkyne-polymer dots

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00146J, Paper
Dumei Ma, Yiting Luo, Xiaoya Zhang, Zehu Xie, Yinghua Yan, Chuan-Fan Ding
A fluorescence method based on Cu-triggered click reaction of azide modified CD63 aptamer and alkyne capped Pdots was developed for breast cancer derived exosome detection.
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si

Analysis of brominide disinfection by-products in aquaculture water using ultra-high-performance liquid chromatography–quadrupole–time-of-flight mass spectrometry

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00396A, Paper
Weimin Yang, Yi Zhang, Jilong Huang, Xing Yang, Ning Jiang
Background: Halogenic disinfectants have been shown to produce toxic and carcinogenic disinfection by-products (DBPs) during water disinfection. Dibromohydantoin (DBDMH) is a commonly used water disinfectant in aquaculture. Aquaculture water has...
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si

Detection of Free DNA Based on Metal-Enhanced Fluorescence Triggered by CRISPR-Cas12a and Colorimetric Analysis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00149D, Paper
Ming-Qiu Zheng, Yuyao Li, Liling Zhang, Cheng-Yu Li, Menghan Liu, Hongwu Tang
The CRISPR-Cas system has been found to be extremely sensitive and there is an urgent demand to extend its potential in bioassay. Herein, we developed a novel nanobiosensor to detect...
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si

A simple and rapid colorimetric detection of Staphylococcus Aureus relied on the distance-dependent optical properties of silver nanoparticles

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02189K, Paper
Ngoc Anh Thu Phan, Hoang Men Nguyen, Cam Duyen Thi Vo, Toi Vo Van, Phuoc Long Truong
The quick and accurate diagnosis of pathogens has appeared as a pressing issue in clinical diagnostics, environmental monitoring, and food safety. The current assays are suffering from limited capacities in...
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si

Simple fluorescence “turn-off” assay for Congo red using commercial 2-aminophthalic acid

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00506F, Paper
Jiaqi Qian, Jie Li, Yihan Jiang, Chaoyong Liu, Jiayao Zhu, Liyu Gu, Yongming Guo
2-Aminophthalic acid with a high quantum yield of 38.49% was utilized for fluorescence “turn-off” sensing of Congo red with a linear range of 0.05–50 μM and a limit of detection of 1.72 μM.
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si

Electroanalysis overview: additive manufactured biosensors using fused filament fabrication

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00278D, Minireview
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Robert D. Crapnell, Craig E. Banks
Additive manufacturing (3D-printing), in particular fused filament fabrication, presents a paradigm shift in the way electrochemical based biosensing platforms are produced, giving rise to a new generation of personalized and on-demand biosensors.
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si

Quantifying platinum binding on protein-functionalized magnetic microparticles using single particle-ICP-TOF-MS

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00268G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Veronica C. Bradley, Benjamin T. Manard, Lyndsey Hendriks, Daniel R. Dunlap, Amber N. Bible, Ada Sedova, Patricia Saint-Vincent, Brian C. Sanders, Hunter B. Andrews
This work describes an analytical procedure, single particle-inductively coupled plasma-time-of-flight-mass spectrometry (SP-ICP-TOF-MS), that was developed to determine the platinum binding efficiency of protein-coated magnetic microparticles.
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si

Proximity hybridization based “turn-on” DNA tweezer for accurate and enzyme-free small extracellular vesicles analysis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00487F, Paper
Jinlin Wu, Xi Mei, Xiaoqin Zhan, Fang Liu, Dongfang Liu
Small extracellular vesicles (sEVs) are a type of extracellular vesicles that carry many types of molecular information. The identification of sEVs is essential for the non-invasive detection and treatment of...
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si

Design and fabrication of La-based perovskites incorporated with functionalized carbon nanofibers for the electrochemical detection of roxarsone in water and food samples

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00264D, Paper
Mariya Antony John Felix, Santhiyagu Sahayaraj Rex Shanlee, Shen-Ming Chen, Sundaresan Ruspika, Ramachandran Balaji, Narendhar Chandrasekar, Periyanayagam Arockia Doss
Fabrication of potent electrocatalyst, La-based perovskites coupled with functionalized carbon nanofibers (LMO/f-CNF) for ultrasensitive electrochemical detection of roxarsone in edible and water samples.
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si

The preparation of a boronate affinity-based controlled oriented imprinting coating on a silica nanoparticle surface for the separation and purification of shikimic acid in herbal medicine

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00219A, Paper
Yumin Yang, Daojin Li, Bingqian Liu
Shikimic acid (SA) is one of the most effective drugs against the A (H1N1) virus and has high medicinal value.
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si

Α simplified lateral flow immunosensor for the assay of carcinoembryonic antigen in low-resource settings

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00381K, Paper
Open Access
Ioanna Tsogka, Electra Mermiga, Varvara Pagkali, Christos Kokkinos, Anastasios Economou
Carcinoembryonic antigen (CEA) is a glycoprotein widely used as a tumor marker. In this work, a colorimetric lateral flow immunosensor is developed for rapid and low-cost quantification of CEA in...
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si

A chemodosimetric chemosensor for the ratiometric detection of nerve agent-mimic DCP in solution and vapor phases

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00451E, Paper
Shilpita Banerjee, Pintu Ghosh, Anirban Karak, Dipanjan Banik, Ajit Kumar Mahapatra
The probe MNFZ undergoes a hydrolysis reaction in the presence of DCP to exhibit a naked eye color change from blue to cyan. It was successfully applied to sense DCP in the vapor phase.
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si

Novel advanced materials and magnetic solid phase extraction as approaches in sample preparation to enhance the analysis of ochratoxin A in peanuts

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00246F, Paper
Bingchen Wang, Yifan Wang, Xiuyuan Zhang, Kuo He
In order to improve the detection efficiency of ochratoxin, a superparamagnetic nano-material was synthesized for solid phase extraction of ochratoxin.
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si

Three-dimensional hotspot structures constructed from nanoporous gold with a V-cavity and gold nanoparticles for surface-enhanced Raman scattering

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00348A, Paper
Yang Xu, Yan Wu, Jianjun Wei, Yuanyu Zhao, Peili Xue
A nanoporous gold V-shaped resonant cavity (NPGVRC) structure constructed with plasmonic resonance coupling effect. The NPGVRC has excellent SERS performance and 3D hotspot properties.
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si

A colorimetric tandem combination of CRISPR/Cas12a with dual functional hybridization chain reaction for ultra-sensitive detection of mycobacterium bovis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02200E, Paper
Qiong Liu, Mei Yang, He Zhang, Wenjie Ma, Xin Fu, Huiqing Li, Sainan Gao
Tuberculosis caused by Mycobacterium bovis poses a global infectious threat to humans and animals. Therefore, there is an urgent need to develop a sensitive, precise, and easy-to-readout strategy. Here, a...
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si

Losing a friend, virtually




si

Missing the obvious




si

​Weather gods: On ‘Mission Mausam’

Attempts at controlling the weather are still in the realm of uncertainty




si

​Unrealistic expectations: On India and Russia-Ukraine peace

India’s efforts at peacemaking between Russia and Ukraine have limited potential




si

Clarity of vision: On eye drops for presbyopia and ‘claims’

A useful drug is undone by fantastic claims about its efficacy




si

Down to the wire: On the run-up to the U.S. presidential election

The U.S. presidential race is poised on a knife’s edge




si

Third front: On the expanding nature of the conflict in West Asia

Israel’s fighting three enemy militias at once highlights the pressing need for a ceasefire




si

Wrong notion: On simultaneous elections

The idea of simultaneous elections is inherently anti-federal




si

Sri Lanka’s verdict: On the Island nation’s ninth Presidential election

The spirit of the mandate of the presidential poll was clear — for change




si

Politicising the laddu: On the Tirupati laddu and its ‘adulteration’

The Tirupati laddu issue should be limited to one of quality control




si

Visit wrap-up: On PM Modi’s U.S. visit, announcements

The Modi U.S. visit announcements will see New Delhi being put to the test




si

​Embattled CM: On Karnataka Chief Minister Siddaramaiah

Anti-graft moves should not be overshadowed by political motive




si

​Mad doctrine: On Russia’s revision of its nuclear doctrine

Any threat of use of nuclear weapons must be viewed seriously 




si

​Steady but slow: On the VIPER mission, lessons for India

India’s space programme needs more resources to realise its full potential




si

​The edge of war: On the West Asia situation

Iran should not give Israel an excuse to widen the war




si

​Healthy sign: On the voting in the 2024 J&K Assembly elections

Turnout numbers in the Assembly elections show distinct patterns in south Kashmir




si

​Inflection point: On the escalation in the multi-party West Asia conflict

West Asia needs the intervention of major world powers for peace 




si

Split decision: On the rivalry between the two NCP factions

The ECI and the office of the Speaker have not played fair in cases of defection




si

Deep roots: On the 2024 Physics Nobel Prize 

Physics Nobel Prize acknowledges the diverse foundations of AI




si

Deeper role: On the U.S. and West Asia conflicts   

The escalating conflict cycle in West Asia could have disastrous consequences




si

Neck and neck: On the U.S. presidential election

Trump and Harris offer U.S. voters vastly different choices 




si

Sun signs: On extreme heat and Tamil Nadu’s policy decision

States should prepare to assist the vulnerable during extreme heat events




si

Towards Europe: On the India visits by the leaders of Germany, Spain

India used visits by leaders of Germany and Spain to balance ties in Europe 




si

Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00660G, Review Article
Shutang Li, Jinfei Yang
As research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.
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si

Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
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si

The role of silicon in drug discovery: a review

RSC Med. Chem., 2024, 15,3286-3344
DOI: 10.1039/D4MD00169A, Review Article
Open Access
Jenny-Lee Panayides, Darren Lyall Riley, Felix Hasenmaile, Willem A. L. van Otterlo
This review aims to highlight the role of silicon in drug discovery.
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si

Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies

RSC Med. Chem., 2024, 15,3507-3528
DOI: 10.1039/D4MD00417E, Research Article
Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan Pan
In continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
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si

The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif

RSC Med. Chem., 2024, 15,3576-3596
DOI: 10.1039/D4MD00438H, Research Article
Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang Chen
Rho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.
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