rio Human Rights Priorities: An Agenda for Equality and Social Justice By feedproxy.google.com Published On :: Tue, 19 Nov 2019 00:00:00 +0000 Full Article
rio Negative Emissions and Managing Climate Risks Scenarios By feedproxy.google.com Published On :: Thu, 31 Oct 2019 18:15:01 +0000 Research Event 4 July 2019 - 1:30pm to 5:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE This half-day strategic workshop, organized by Chatham House and E3G, brought together key climate experts, policymakers and influential actors, especially in Europe, for a focused and facilitated discussion on the roles, risks and potentials of negative emissions technologies (NETs). An interactive scenario exercise will be conducted, drawing on a climate simulation tool developed by Climate Interactive, to consider the potential roles and risks of different NETs deployments to meet the Paris Agreement targets and to consider the international co-operation required to manage the pathway to net-zero emissions. Participants will explore the political opportunities, discuss different scenarios and risks and identify areas of interventions and collective action.The meeting is part of a series of events being held at Chatham House as part of London Climate Action Week (LCAW). Department/project Energy, Environment and Resources Programme, Bioenergy, Carbon Capture and Storage (BECCS) Full Article
rio Chile’s Social Unrest: Why It’s Time to Get Serious about a ‘Just’ Transition By feedproxy.google.com Published On :: Mon, 04 Nov 2019 15:40:38 +0000 4 November 2019 Patrick Schröder Senior Research Fellow, Energy, Environment and Resources Programme @patricks_CH Google Scholar President Sebastián Piñera’s decision to cancel the COP25 climate negotiations, which Chile was due to host in early December, shows the importance of ensuring the transition to a sustainable world is just. 2019-11-04-Chile-Protests.jpg Demonstrators march in Santiago, Chile during street protests which erupted over a now suspended hike in metro ticket prices. Photo: Getty Images. One year ago, during the last annual Conference of Parties (COP) held in Katowice, the Polish government launched a Solidarity and Just Transition Declaration, signed by 56 governments including the UK, making the case for why the green transition must be just.Three years earlier in 2015, the landmark Paris Agreement also included provisions for a just transition where it stated that the decarbonization process should be ‘Taking into account the imperatives of a just transition of the workforce and the creation of decent work and quality jobs in accordance with nationally defined development priorities’. In practice, however, the concept of a just transition has not yet been implemented and has not been sufficiently considered by governments or corporations around the world.The social unrest that has erupted in Chile’s capital Santiago over the past month, which has forced the Chilean government to ask to move this year’s COP to Madrid, is a case in point. This discontent clearly shows that climate action cannot be separated from social justice concerns. There has not been a real commitment by governments to ensure a just transition based on social dialogue from the local to the national level. This was seen in France with the gilets jaunes protests in November 2018 – one month after President Emmanuel Macron ended the so-called ‘fortune tax’ and instead introduced taxes on diesel fuel as part of an effort to transition to green energy – and the current situation in Chile has some striking parallels. Sustainability transitions are a complex web of political choices and investment decisions which affect countries and societies in many different ways. Questions of social justice are everywhere, but in most cases, poorly understood by decision-makers. For example, although poverty has been reduced significantly over the last decade, Chile has one of the worst rates of inequality in Latin America and the highest Gini index in the OECD. The decisions taken in 2017 to power Metro de Santiago with solar photovoltaics and wind energy are commendable from a climate perspective, however, it led to students and young people protesting against rises in subway fares in October 2019.They were joined by Chileans who are frustrated with rising living costs and by workers and trade unions struggling with low wages. As reported by the Chilean Human Rights Commission (INDH), so far more than 4,200 people have been arrested and more than 1,300 injured and hospitalized.Climate negotiations beyond technicalitiesThis time there is also another important dimension to the protests: social unrest as a reaction to worsening inequality has the potential to derail multilateral cooperation on climate change and other global issues. Since tackling climate change is a race against the clock, the world faces the challenge of addressing both urgency and equity. The world cannot afford delays and needs to move fast but decision-makers need to take time for deliberation and civic participation to avoid rapid and ill-conceived transitions which eventually meet public resistance.Many technical experts and negotiators, who often unintentionally divorce climate policy and technical discussions about emission reductions from social justice concerns, have been caught by surprise by the cancellation of the negotiations. For this year’s COP, one important focus of the official negotiations are the so-called 'Article 6 Rules' – the accounting mechanisms and modalities for a new form of international interaction on carbon markets and off-setting to ensure carbon markets can support countries in enhancing the ambitions of their stated climate action, known as Nationally Determined Contributions (NDCs). What is becoming much more obvious now is that just transitions are at least equally important for achieving NDCs and other long-term mitigation strategies.In order to meet the 1.5 degree target, stated by the Intergovernmental Panel on Climate Change (IPCC), the world will have to invest an average of around $3 trillion a year over the next three decades in transforming its energy supply systems. But how can we ensure that these investments benefit low-income communities? Will they further increase everyday living costs? The climate finance related discussions focussing on commercially-oriented investments for low-carbon energy systems in most cases only consider the aspect of affordability, but not the other important principles of alternative ‘just’ energy finance, such as good governance, due process, intra-generational equity, spatial equity and financial resilience. Investments to support just transitions need to ensure investments, not only for large energy infrastructure, but also in the jobs, skills and work vital to both adaptation and mitigation.Just transitions for a circular economy The just transition concept is also the entry point to broader discussions about inclusive economic transformations, questioning the dominant paradigm of consumerism and ending the wasteful use of critical resources. The current linear economic model of take-make-throw away – in Chile epitomized by the linear extractive model of the mining sector that has contributed to widening inequality – the linear extractive model is not only destructive on the natural environment but also destructive for social cohesion.In Chile, the commodity boom in copper production – the country accounts for about 30 per cent of the world’s output – and more recently lithium – which is used in batteries for mobile phones, laptops and electric cars – have generated enormous prosperity in Chile. But the wealth has been unequally distributed and has not been used to lay the foundation for raising the overall level of incomes.A socially embedded and inclusive circular economy can, therefore, be a way forward from the current situation the Latin American country finds itself in. The circular economy was intended to feature prominently during the 25th COP and Chile’s policies – from the Ministry of Environment and Chile's Production Development Corporation (CORFO) – have played an important role in supporting the development of a circular economy, launching in 2018, the first public circular economy programme in Latin America. The government’s support for start-up companies and entrepreneurs to develop inclusive circular economy business models is the right approach to addressing the issues of waste, employment, services for low-income communities and local economic development. These are solutions that need to be scaled up having the potential to reduce Chile’s economic reliance on the dominant extractive model.As a global community, it is necessary to address the environmental and social objectives equally as not addressing social objectives will become an obstacle in achieving climate mitigation and solving other environmental issues. The Chilean protests are a wake-up call and present an opportunity for the global climate change community – which includes governments – to ensure just transitions are implemented in practice. Full Article
rio Closing the Global Access Gap in Palliative Care and Pain Relief: A Top Priority in Achieving Universal Health Coverage By feedproxy.google.com Published On :: Wed, 26 Jun 2019 13:50:01 +0000 Invitation Only Research Event 17 July 2019 - 12:30pm to 5:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Dr Tedros Adhanom Ghebreyesus, Director-General, World Health Organization The Lancet Commission on Palliative Care and Pain Relief estimated that in 2015, 61 million people experienced serious health-related suffering (SHS) that could have been ameliorated by palliative care. A large proportion of this burden – more than 80 per cent – fell on low- and middle-income countries (LMICs) despite an essential package of palliative care and pain relief services being cost-effective and affordable. As the director general of the World Health Organization (WHO) argues, there cannot be UHC without palliative care and thus, closing this coverage gap should be a top priority for the global UHC movement.The Centre on Global Health Security at Chatham House, building on the momentum of the Lancet Commission, is hosting a roundtable focused on the global unmet need for palliative care and effective pain relief. The primary purpose of this roundtable is to convene leading experts, palliative care service users and advocates with key figures from the UHC movement and global health to highlight the importance of prioritizing this vital part of the continuum of care in UHC reform processes. The roundtable will serve as a scholarly discourse in translating the recommendations of the Lancet Commission into concrete actions, focusing on the political and economic dimensions. Department/project Global Health Programme, Universal Health Coverage Policy Forum Alexandra Squires McCarthy Programme Coordinator, Global Health Programme +44 (0)207 314 2789 Email Full Article
rio Finite-dimensional approximations to the Poincaré–Steklov operator for general elliptic boundary value problems in domains with cylindrical and periodic exits to infinity By www.ams.org Published On :: Fri, 10 Apr 2020 08:09 EDT S. A. Nazarov Trans. Moscow Math. Soc. 80 (2020), 1-51. Abstract, references and article information Full Article
rio CBD News: Statement by Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the ninth Meeting of Joint Liaison Group of the Rio Conventions, New York City, 14 May 2009. By www.cbd.int Published On :: Thu, 14 May 2009 00:00:00 GMT Full Article
rio CBD News: Statement by Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of Informal Expert Workshop on the Updating of the Strategic Plan of the Convention for the Post-2010 Period, London, 18 January 2010 By www.cbd.int Published On :: Mon, 18 Jan 2010 00:00:00 GMT Full Article
rio CBD News: Statement by Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Inaugural Meeting of the Local Action for Biodiversity (LAB) Advisory Committee, 24 March 2010, Rio De Janeiro, Brazil. By www.cbd.int Published On :: Wed, 24 Mar 2010 00:00:00 GMT Full Article
rio CBD Communiqué: Tenth Meeting of the Joint Liaison Group of the Rio Conventions. By www.cbd.int Published On :: Thu, 30 Sep 2010 00:00:00 GMT Full Article
rio CBD News: Statement by Mr Ahmed Djoghlaf, CBD Executive Secretary, on the occasion of the Launch of the 2011 Rio Conventions Calendar, 8 December 2010, Cancun, Mexico. By www.cbd.int Published On :: Wed, 08 Dec 2010 00:00:00 GMT Full Article
rio CBD Communiqué: Modus operandi agreed by Rio conventions By www.cbd.int Published On :: Tue, 20 Sep 2011 00:00:00 GMT Full Article
rio CBD News: As governments meet in the Republic of Korea to address the challenges of land degradation under the United Nations Convention to Combat Desertification, global actors will meet at the Rio Conventions Pavilion to communicate their coordinated By www.cbd.int Published On :: Thu, 13 Oct 2011 00:00:00 GMT Full Article
rio CBD Communiqué: Rio Conventions Pavilion helps raise awareness By www.cbd.int Published On :: Wed, 26 Oct 2011 00:00:00 GMT Full Article
rio CBD News: As the world celebrates World Environment Day and prepares to gather in Rio for the Rio+20 Conference, the Collaborative Partnership on Forests, a voluntary arrangement consisting of 14 international organizations, institutions and secretariats, By www.cbd.int Published On :: Tue, 05 Jun 2012 00:00:00 GMT Full Article
rio CBD News: Rio de Janeiro, Brazil, 13 June 2012 - At the United Nations Conference on Sustainable Development (Rio+20), the secretariats of the biodiversity, climate change and desertification conventions and the Global Environment Facility are joining fo By www.cbd.int Published On :: Wed, 13 Jun 2012 00:00:00 GMT Full Article
rio CBD News: Statement by Mr. Braulio Ferreira de Souza Dias, CBD Executive Secretary, on the occasion of Special Event Celebrating the Twentieth Anniversary of the 1992 Earth Summit, 15 June 2012, Rio de Janeiro, Brazil By www.cbd.int Published On :: Fri, 15 Jun 2012 00:00:00 GMT Full Article
rio CBD News: Statement by Mr. Braulio Ferreira de Souza Dias, CBD Executive Secretary, on the occasion of the World Summit of Legislators, 16 June 2012, Rio de Janeiro, Brazil By www.cbd.int Published On :: Sat, 16 Jun 2012 00:00:00 GMT Full Article
rio CBD News: Statement by Mr. Braulio Ferreira de Souza Dias, CBD Executive Secretary, on the occasion of the United Nations Conference on Trade and Development, Biotrade Congress, 18 June 2012, Rio de Janeiro, Brazil By www.cbd.int Published On :: Mon, 18 Jun 2012 00:00:00 GMT Full Article
rio CBD Press Release: 20 years after their birth, three sister Rio Conventions reaffirm their collective responsibility for sustainable development By www.cbd.int Published On :: Thu, 21 Jun 2012 00:00:00 GMT Full Article
rio CBD News: Statement by Mr. Braulio Ferreira de Souza Dias, CBD Executive Secretary, on the occasion of the Roundtable at the United Nations Conference on Sustainable Development, 21 June 2012, Rio de Janeiro, Brazil By www.cbd.int Published On :: Thu, 21 Jun 2012 00:00:00 GMT Full Article
rio CBD News: Rio de Janeiro, Brazil, 22 June 2012 - Dr Margaret Chan, Director-General of the World Health Organization (WHO), launched the report, Our Planet, Our Health, Our Future. Human Health and the Rio Conventions: Biological Diversity, Climate Change By www.cbd.int Published On :: Fri, 22 Jun 2012 00:00:00 GMT Full Article
rio CBD News: Rio de Janeiro 22 June 2012. The nations of the world have recognized the crucial role of biodiversity in ensuring sustainable development in the outcome document of the Rio + 20 conference and called for greater efforts to implement the Convent By www.cbd.int Published On :: Fri, 22 Jun 2012 00:00:00 GMT Full Article
rio CBD News: Statement by Mr. Braulio F. de Souza Dias , CBD Executive Secretary, at the opening of the Regional Workshop for South, East and Southeast Asia on the Preparation of the Fifth National Report and Regional Scenario Analysis, Incheon City, Republi By www.cbd.int Published On :: Mon, 20 May 2013 00:00:00 GMT Full Article
rio CBD News: Mensaje de Sr. Braulio Ferreira de Souza Dias, Secretario Ejecutivo del CDB, en la ocasión de la XXIX asamblea ordinaria parlamento latinoamericano, Panamá, 18 -19 Octubre de 2013 By www.cbd.int Published On :: Fri, 18 Oct 2013 00:00:00 GMT Full Article
rio CBD News: Governments attending a United Nations meeting on the safe use of living modified organisms have agreed on various actions to advance the implementation of the Cartagena Protocol on Biosafety to the Convention on Biological Diversity By www.cbd.int Published On :: Fri, 03 Oct 2014 00:00:00 GMT Full Article
rio CBD News: To support the mobilisation and alignment of technical and financial resources for priority capacity-building needs, IPBES is developing a prototype Matchmaking Facility. This Facility aims to promote and facilitate dialogue and cooperation amon By us8.campaign-archive1.com Published On :: Mon, 20 Jul 2015 00:00:00 GMT Full Article
rio CBD News: More than two decades have passed since the nations of the world assembled in Rio de Janeiro and agreed to adopt a sustainable development agenda, promising to chart a development path that is equitable, environmentally just and economically rew By www.cbd.int Published On :: Wed, 05 Aug 2015 00:00:00 GMT Full Article
rio CBD News: The oceans have long captured the hearts and minds of people around the world. The mysteries of its depths, the wonder of its creatures and the power of its waves have fed our curiosity and imagination since ancient times. By www.cbd.int Published On :: Tue, 07 Jun 2016 00:00:00 GMT Full Article
rio CBD News: Immediately prior to the UN Biodiversity Conference, and in parallel with the High-Level Segment, the Secretariat of the Convention on Biological Diversity (CBD) and the Government of Mexico are hosting the 2016 Business and Biodiversity Forum i By www.cbd.int Published On :: Fri, 02 Dec 2016 00:00:00 GMT Full Article
rio CBD News: Statement by Ms. Cristiana Pa?ca Palmer, Executive Secretary of the Convention on Biological Diversity, on the occasion of the African Ministerial Summit on Biodiversity: "Land and ecosystem degradation and restoration: Priorities for incre By www.cbd.int Published On :: Tue, 13 Nov 2018 00:00:00 GMT Full Article
rio CBD News: In 1992, at the landmark Rio Earth Summit, the international community, in its wisdom, created three interrelated conventions to safeguard the future of the planet, all peoples, and indeed all life on earth: the United Nations Framework Conventi By www.cbd.int Published On :: Thu, 22 Aug 2019 00:00:00 GMT Full Article
rio CBD Notification SCBD/IMS/JMF/NP/YX/88707 (2020-021): Decision 14/23, Financial Mechanism: Assessment of Funding Needs for the Implementation of the Convention and its Protocols for the Eighth Replenishment Period (July 2022 to June 2026) of the Trust Fun By www.cbd.int Published On :: Tue, 18 Feb 2020 00:00:00 GMT Full Article
rio Control from an interior hypersurface By www.ams.org Published On :: Wed, 08 Apr 2020 11:21 EDT Jeffrey Galkowski and Matthieu Léautaud Trans. Amer. Math. Soc. 373 (2020), 3177-3233. Abstract, references and article information Full Article
rio Boeimg 247 Trio By www.flickr.com Published On :: Sat, 09 May 2020 10:10:47 -0700 dlberek posted a photo: Full Article
rio A posteriori estimates for the stationary Stokes problem in exterior domains By www.ams.org Published On :: Mon, 04 May 2020 11:43 EDT D. Pauly and S. Repin St. Petersburg Math. J. 31 (2020), 533-555. Abstract, references and article information Full Article
rio Survey on gradient estimates for nonlinear elliptic equations in various function spaces By www.ams.org Published On :: Mon, 04 May 2020 11:43 EDT S.-S. Byun, D. K. Palagachev and L. G. Softova St. Petersburg Math. J. 31 (2020), 401-419. Abstract, references and article information Full Article
rio Non-Periodontal Oral Manifestations of Diabetes: A Framework for Medical Care Providers By spectrum.diabetesjournals.org Published On :: 2011-11-01 Beatrice K. GandaraNov 1, 2011; 24:199-205From Research to Practice Full Article
rio The transcriptional regulator IscR integrates host-derived nitrosative stress and iron starvation in activation of the vvhBA operon in Vibrio vulnificus [Gene Regulation] By www.jbc.org Published On :: 2020-04-17T00:06:05-07:00 For successful infection of their hosts, pathogenic bacteria recognize host-derived signals that induce the expression of virulence factors in a spatiotemporal manner. The fulminating food-borne pathogen Vibrio vulnificus produces a cytolysin/hemolysin protein encoded by the vvhBA operon, which is a virulence factor preferentially expressed upon exposure to murine blood and macrophages. The Fe-S cluster containing transcriptional regulator IscR activates the vvhBA operon in response to nitrosative stress and iron starvation, during which the cellular IscR protein level increases. Here, electrophoretic mobility shift and DNase I protection assays revealed that IscR directly binds downstream of the vvhBA promoter PvvhBA, which is unusual for a positive regulator. We found that in addition to IscR, the transcriptional regulator HlyU activates vvhBA transcription by directly binding upstream of PvvhBA, whereas the histone-like nucleoid-structuring protein (H-NS) represses vvhBA by extensively binding to both downstream and upstream regions of its promoter. Of note, the binding sites of IscR and HlyU overlapped with those of H-NS. We further substantiated that IscR and HlyU outcompete H-NS for binding to the PvvhBA regulatory region, resulting in the release of H-NS repression and vvhBA induction. We conclude that concurrent antirepression by IscR and HlyU at regions both downstream and upstream of PvvhBA provides V. vulnificus with the means of integrating host-derived signal(s) such as nitrosative stress and iron starvation for precise regulation of vvhBA transcription, thereby enabling successful host infection. Full Article
rio Dr. Ellen Flaherty, prestigious Henderson lecturer, sets sight on key priority for us all By www.eurekalert.org Published On :: Fri, 08 May 2020 00:00:00 EDT (American Geriatrics Society) The American Geriatrics Society (AGS) today announced that Ellen Flaherty, PhD, APRN, AGSF, an assistant professor at the Dartmouth Geisel School of Medicine and director of the Dartmouth Centers for Health & Aging, will deliver the society's prestigious Henderson State-of-the-Art Lecture. Dr. Flaherty will deliver her talk, Leveraging the Potential of Interprofessional Teams in Primary Care Practice, at the AGS 2021 Annual Scientific Meeting (#AGS21) in Chicago, Ill. (May 12-15, 2021). Full Article
rio Human Rights Priorities: An Agenda for Equality and Social Justice By feedproxy.google.com Published On :: Wed, 23 Oct 2019 13:50:01 +0000 Members Event 19 November 2019 - 6:00pm to 7:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Michelle Bachelet, United Nations High Commissioner for Human RightsChair: Ruma Mandal, Head, International Law Programme, Chatham House Following just over one year in office, UN High Commissioner for Human Rights, Michelle Bachelet, outlines her ongoing priorities at a tumultuous time for fundamental rights protections worldwide.She discusses the rights implications of climate change, gender inequality including the advancement of sexual and reproductive rights, the protection of vulnerable groups and the need to work closely with states, civil society and business to protect and advance human rights. Department/project International Law Programme Members Events Team Email Full Article
rio Impact of 68Ga-PSMA-11 PET/CT on Staging and Management of Prostate Cancer Patients in Various Clinical Settings: A Prospective Single Center Study By jnm.snmjournals.org Published On :: 2020-01-10T04:59:09-08:00 The impact of prostate specific membrane antigen (PSMA) PET/CT on management of prostate cancer (PCa) patients with biochemical recurrence (BCR) is well-established. However, whether and how PSMA PET/CT affects the management of patients undergoing scans for other clinical indications remains unknown. The goal of this study was to determine the impact of 68Ga-PSMA-11 PET/CT on initial and subsequent management decisions in a cohort of PCa patients referred for various indications ("basket trial") excluding the two main classical indications: BCR and presurgical staging. Methods: This was a prospective study of 197 patients that aimed to determine the impact of 68Ga-PSMA-11 PET/CT on PCa stage and management. Indications for PSMA PET/CT were: initial staging of non-surgical candidates (30 patients) and re-staging after definitive treatment (n = 168). The re-staging cohort comprised: patients re-staged with known advanced metastatic disease (n = 103), after androgen deprivation therapy only (n = 16), after surgery with serum PSA levels <0.2 ng/ml (n = 13), after radiation therapy (RT) not meeting the Phoenix criteria (n = 22) and after other primary local treatments [i.e. high-intensity focused ultrasound (HIFU), focal laser ablation, cryoablation, hyperthermia or irreversible electroporation] (n = 13). Patients with BCR and candidates for curative surgery were excluded. Impact on management was assessed using pre- and post-PET questionnaires completed by referring physicians, electronic chart review and/or patient telephone encounters. Results: PSMA PET/CT changed disease stage in 135/197 (69%) patients (38% up-stage, 30% down-stage and no changes in stage in 32%). Management was affected in 104/182 (57%) patients. Specifically, PSMA PET/CT impacted management of patients who were re-staged after RT without meeting the Phoenix criteria for BCR, after other definitive local treatments and with advanced metastatic disease in 13/18 (72%), 8/12 (67%) and 59/96 (61%), respectively. Conclusion: PSMA PET/CT has a profound impact on stage and management of PCa patients outside of the two main classical indications (BCR and presurgical staging) across all examined clinical scenarios. Full Article
rio NEMESIS: Non-inferiority, Individual Patient Meta-analysis of Selective Internal Radiation Therapy with Yttrium-90 Resin Microspheres versus Sorafenib in Advanced Hepatocellular Carcinoma By jnm.snmjournals.org Published On :: 2020-05-01T11:16:57-07:00 In randomized clinical trials (RCTs), no survival benefit has been observed for selective internal radiotherapy (SIRT) over sorafenib in patients with advanced hepatocellular carcinoma (aHCC). This study aimed to assess by means of a meta-analysis whether overall survival (OS) with SIRT, as monotherapy or followed by sorafenib, is non-inferior to sorafenib, and compare safety profiles for patients with aHCC. Methods: We searched MEDLINE, EMBASE, and the Cochrane Library up to February 2019 to identify RCTs comparing SIRT as monotherapy, or followed by sorafenib, to sorafenib monotherapy among patients with aHCC. The main outcomes were OS and frequency of treatment-related severe adverse events (AEs grade ≥3). The per-protocol population was the primary analysis population. A non-inferiority margin of 1.08 in terms of hazard ratio (HR) was pre-specified for the upper boundary of 95% confidence interval (CI) for OS. Pre-specified subgroup analyses were performed. Results: Three RCTs, involving 1,243 patients, comparing sorafenib with SIRT (SIRveNIB and SARAH) or SIRT followed by sorafenib (SORAMIC), were included. After randomization, 411/635 (64.7%) patients allocated to SIRT and 522/608 (85.8%) allocated to sorafenib completed the studies without major protocol deviations. Median OS with SIRT, whether or not followed by sorafenib, was non-inferior to sorafenib (10.2 and 9.2 months, [HR 0.91, 95% CI 0.78–1.05]). Treatment-related severe adverse events were reported in 149/515 patients (28.9%) who received SIRT and 249/575 (43.3%) who received sorafenib only (p<0.01). Conclusion: SIRT as initial therapy for aHCC is non-inferior to sorafenib in terms of OS, and offers a better safety profile. Full Article
rio Taxpayer records exposed by serious ATO, myGov security flaw By www.smh.com.au Published On :: Wed, 18 Nov 2015 23:42:04 GMT Taxpayer says he was hung up on twice by call centre staff when trying to report the issue. Full Article
rio The Syrian Pound Signals Economic Deterioration By feedproxy.google.com Published On :: Thu, 26 Sep 2019 11:30:45 +0000 26 September 2019 Zaki Mehchy Senior Consulting Fellow, Middle East and North Africa Programme @mehchy LinkedIn The Syrian pound’s volatile exchange rate over the past month is not a short-term monetary crisis. It reflects the destruction of the economic foundations in Syria. 2019-09-26-SyriaBank.jpg The Syrian Central Bank building in 2008. Photo: Getty Images. The Syrian currency depreciated by 11% between mid-August and the first week of September, to reach an unprecedented level of SYP692 to the US dollar. According to the government, the main reasons behind this collapse are the international sanctions imposed on Syria and currency speculation.Accordingly, the government has forced speculators and local foreign exchange companies to sell the US dollar instead of holding it. Moreover, Syrian security agencies have pressured profiteers with close links to the regime to effectively participate in campaigns that support the local currency. Indeed, the Syrian pound appreciated in value in only a few days to reach an average of SYP615 for $1 in the second week of September.This high volatility in currency prices results in monetary uncertainty among traders, and thus, increases the possibility of other depreciations in the near future.Currency speculation could be the reason behind the high fluctuations. However, the fall in the exchange rate has been a continuous and steady trend ever since the beginning of the conflict. The Syrian currency is about 13 times less valuable than before conflict, and fell by 20% between January and September 2019. It is therefore more likely that the devaluation reflects a structural deterioration of the Syrian economy.There are a number of interlinked reasons behind this trend: Economic collapseThe conflict in Syria has led to a drastic decline in economic activity. By 2018, the total accumulated economic loss was estimated at about $428 billion, which equaled 6 times Syria’s GDP in 2010. The country’s GDP lost about 65% of its value compared to its level before the war. The conflict has also caused a reallocation of resources to destructive and war-related activities. This drop in economic productivity weighs on the Syrian pound’s stability. Dramatic export declineThe total value of Syrian exports contracted from $12.2 billion in 2010 to less than $700 million in 2018, whereas imports declined from $19.7 billion to $4.4 billion during the same period. Thus, the coverage ratio of exports to imports dropped from 62% to 16% in this period, indicating that the government has become very dependent on external trade partners. Almost all import payments are made in foreign currencies, which increases the devaluation pressure on the Syrian pound.Iran has provided the Syrian regime with credit lines estimated at about $6 billion to import oil and consumer goods from the Islamic Republic. These credit lines do not include all the Iranian financial support to the regime. Iranian oil exports to Syria are estimated at about 2 million barrels a month (a total of around $16 billion during the eight years of conflict). The increasing external debt to Iran, also due to military support, may contribute in stabilizing the Syrian pound for short period, yet it is bound to sustain the devaluation pressure in the long run. Damaging monetary policiesSince the beginning of the conflict, the Central Bank of Syria has issued a series of decisions that have contributed to the weakening of the Syrian pound. For instance, until 2015, the bank adopted a policy of selling hard currencies to local foreign exchange companies. This policy depleted their foreign currency reserves by about $1.2 billion, without halting the deterioration of the pound. The bank has also increased the money supply; there is three times the amount of currency in the local market as today compared to before the conflict, causing a surge in inflation and currency devaluation.The absence of foreign direct investmentBetween 2005 and 2010, Syria received an annual average of $1.5 billion as foreign direct investment (FDI); this amount has dropped almost to zero during the years of conflict. Russia and Iran have continued to invest in Syria, mainly in the mining sector, but the conditions of these investments have limited the inflows of foreign currency to Syria. FDI inflows were a major source of hard currency; their absence is an additional driver of currency depreciation.International sanctionsMany countries have imposed sanctions on various sectors in Syria, including energy and financial transactions. During the last two years, the US has tightened its sanctions by introducing the Caesar law, which aims to isolate the Syrian regime. These sanctions have increased the cost of the Syrian imports and therefore raised demand for foreign currencies. Remittances, estimated at $4.5 million per day as well as foreign investments and exports were also negatively affected, and this has reduced the supply side of hard currencies inside Syria.Currency speculationThe Syrian regime usually intervenes to manage currency speculation through government agencies and friendly business entities. But such speculations are very difficult to control in Syria given the poor economic conditions, the high level of business uncertainty and the lack of trust in institutions. This has driven the Syrian households, those who did not already lose their savings, to buy gold or hard currencies as safe investments.The Syrian pound’s depreciation and its high fluctuations reflect the fragile political and economic situation in the country. The government’s improvised decisions have failed to stabilize it, causing a rise in the prices of basic goods. This has left more than 90% of Syria’s population under the poverty line. Long-term stability in exchange rates requires an inclusive and sustainable development strategy, one that would need to be based on an accountable and transparent political landscape. That seems a long way off. Full Article
rio Problem Notes for SAS®9 - 65834: PROC METADATA returns various errors when the input contains certain multi-byte characters By feedproxy.google.com Published On :: Thu, 7 May 2020 17:12:13 EST The METADATA procedure might return an error similar to one of the following: ERROR: Missing root element definition. Full Article BASE+Base+SAS
rio Acute Hyperglycemia Increases Brain Pregenual Anterior Cingulate Cortex Glutamate Concentrations in Type 1 Diabetes Mellitus By diabetes.diabetesjournals.org Published On :: 2020-04-24T14:58:49-07:00 The brain mechanisms underlying the association of hyperglycemia with depressive symptoms are unknown. We hypothesized that disrupted glutamate metabolism in pregenual anterior cingulate cortex (ACC) in type 1 diabetes (T1D) without depression affects emotional processing. Using proton magnetic resonance spectroscopy (MRS), we measured glutamate concentrations in ACC and occipital cortex (OCC) in 13 T1D without major depression (HbA1c=7.1±0.7% [54±7mmol/mol]) and 11 healthy non-diabetic controls (HbA1c=5.5±0.2% [37±3mmol/mol]) during fasting euglycemia (EU) followed by a 60-minute +5.5mmol/l hyperglycemic clamp (HG). Intrinsic neuronal activity was assessed using resting-state blood oxygen level dependent functional MRI to measure the fractional amplitude of low frequency fluctuations in slow-band 4 (fALFF4). Emotional processing and depressive symptoms were assessed using emotional tasks (Emotional-Stroop, Self-Referent-Encoding-Task SRET) and clinical ratings (HAM-D, SCL-90-R), respectively. During HG, ACC glutamate increased (1.2mmol/kg, +10%, p=0.014) while ACC fALFF4 was unchanged (-0.007, -2%, p=0.449) in T1D; in contrast, glutamate was unchanged (-0.2mmol/kg, -2%, p=0.578) while fALFF4 decreased (-0.05, -13%, p=0.002) in controls. OCC glutamate and fALFF4 were unchanged in both groups. T1D had longer SRET negative-word response-times (p=0.017) and higher depression-rating scores (HAM-D p=0.020; SCL-90-R-depression p=0.008). Higher glutamate change tended to associate with longer Emotional-Stroop response-times in T1D only. Brain glutamate must be tightly controlled during hyperglycemia due to the risk for neurotoxicity with excessive levels. Results suggest that ACC glutamate control mechanisms are disrupted in T1D, which affects glutamatergic neurotransmission related to emotional or cognitive processing. Increased prefrontal glutamate during acute hyperglycemic episodes could explain our previous findings of associations between chronic hyperglycemia, cortical thinning and depressive symptoms in T1D. Full Article
rio Lactation vs Formula Feeding: Insulin, Glucose and Fatty Acid Metabolism During the Postpartum Period By diabetes.diabetesjournals.org Published On :: 2020-05-08T10:11:46-07:00 Milk production may involve a transient development of insulin resistance in non-mammary tissues to support redistribution of maternal macronutrients to match the requirements of the lactating mammary gland. In the present study, adipose and liver metabolic responses were measured in the fasting state and during a 2-step (10 and 20 mU/m2/min) hyperinsulinemic-euglycemic clamp with stable isotopes, in 6-week postpartum women who were lactating (n=12) or formula-feeding (n=6) their infants and who were closely matched for baseline characteristics (e.g., parity, body composition, intrahepatic lipid). When controlling for the low insulin concentrations of both groups, the lactating women exhibited a fasting rate of endogenous glucose production (EGP) that was 2.6-fold greater, and a lipolysis rate that was 2.3-fold greater than the formula-feeding group. During the clamp, the groups exhibited similar suppression rates of EGP and lipolysis. In the lactating women only, higher prolactin concentrations were associated with greater suppression rates of lipolysis, lower intrahepatic lipid and plasma triacylglycerol concentrations. These data suggest that whole-body alterations in glucose transport may be organ specific and facilitate nutrient partitioning during lactation. Recapitulating a shift toward noninsulin-mediated glucose uptake could be an early postpartum strategy to enhance lactation success in women at risk for delayed onset of milk production. Full Article
rio Human Rights Priorities: An Agenda for Equality and Social Justice By feedproxy.google.com Published On :: Wed, 23 Oct 2019 13:50:01 +0000 Members Event 19 November 2019 - 6:00pm to 7:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Michelle Bachelet, United Nations High Commissioner for Human RightsChair: Ruma Mandal, Head, International Law Programme, Chatham House Following just over one year in office, UN High Commissioner for Human Rights, Michelle Bachelet, outlines her ongoing priorities at a tumultuous time for fundamental rights protections worldwide.She discusses the rights implications of climate change, gender inequality including the advancement of sexual and reproductive rights, the protection of vulnerable groups and the need to work closely with states, civil society and business to protect and advance human rights. Department/project International Law Programme Members Events Team Email Full Article
rio Sustainability After Rio+20: Working Towards Global Governance By feedproxy.google.com Published On :: Wed, 12 Sep 2012 10:59:42 +0000 Director's Breakfast Briefing 5 October 2012 - 8:00am to 9:15am Chatham House, London Event participants James Bacchus, Chair, Global Agenda Council on Governance for Sustainability, World Economic Forum; Chair, Appellate Body, World Trade Organization (1995-2003); Chair, Global Practice, Greenberg Taurig LLP In the aftermath of the recent Rio+20 conference, James Bacchus will discuss the potential for establishing new trade, investment and other international rules and arrangements to promote sustainable growth. In particular, he will explore the interconnections and the international arrangements relating to food, energy, water, climate and other issues affecting global sustainable development.Attendance is strictly by invitation only. To enable as open a debate as possible, this event will be held under the Chatham House Rule.About Director's Breakfast Briefings. Full Article
rio Peter Phillips | Protecting our people is priority in the COVID-19 fight By jamaica-gleaner.com Published On :: Sun, 03 May 2020 00:11:19 -0500 The national priority at this time must be the protection of the Jamaican people against the onset of COVID-19. This has to be done by striking the balance between implementing protective public-health measures and providing a supporting economic... Full Article