Estado de São Paulo concentra maioria dos casos e óbitos registrados oficialmente, seguido pelo Rio de Janeiro.

Profissionais de enfermagem relatam falta de equipamentos de proteção, baixas nas equipes e lotação; em ofício, governador Witzel reconhece que esforços contra a covid-19 não foram suficientes e que estuda endurecer confinamento.

Purdue and Indiana have prioritized the Valparaiso product for their 2019 class, but they aren't short on competition.

Purdue, along with Notre Dame, Gonzaga, Louisville and Kentucky are recruiting Dickinson. Duke is also in the mix but has yet to offer Dickinson.

An anonymous reader quotes a report from Ars Technica: GPS is facing a major interference threat from a 5G network approved by the Federal Communications Commission, U.S. military officials told Congress in a hearing on Wednesday. In testimony to the Senate Committee on Armed Services, Department of Defense Chief Information Officer Dana Deasy disputed the FCC's claims that conditions imposed on the Ligado network will protect GPS from interference. When the FCC approved Ligado's plan last month, the agency required a 23MHz guard band to provide a buffer between the Ligado cellular network and GPS. Deasy argued that this guard band won't prevent interference with GPS signals. Results from tests by federal agencies show that "conditions in this FCC order will not prevent impacts to millions of GPS receivers across the United States, with massive complaints expected to come," Deasy said. The FCC unanimously approved Ligado's application, but the decision is facing congressional scrutiny. "I do not think it is a good idea to place at risk the GPS signals that enable our national and economic security for the benefit of one company and its investors," Sen. James Inhofe (R-Okla.) said at the hearing, according to CNBC. "This is about much more than risking our military readiness and capabilities. Interfering with GPS will hurt the entire American economy." A spokesperson for FCC Chairman Ajit Pai called the military's concerns "baseless fear-mongering" in a statement quoted by Multichannel News. "The FCC made a unanimous, bipartisan decision based on sound engineering principles," the spokesperson said. The FCC said "the metric used by the Department of Defense to measure harmful interference does not, in fact, measure harmful interference," and that "testing on which they are relying took place at dramatically higher power levels than the FCC approved." "Ligado said Wednesday in a statement that it has gone to great lengths to prevent interference and will provide 'a 24/7 monitoring capability, a hotline, a stop buzzer or kill switch' and will 'repair or replace at Ligado's cost any government device shown to be susceptible to harmful interference,'" CNBC reported. The FCC also said it imposed a power limit of 9.8dBW on Ligado's downlink operations -- "a greater than 99 percent reduction from what Ligado proposed in its 2015 application," Pai said.

Read more of this story at Slashdot.

Officer Frank Hernandez has been involved in at least three on-duty shootings, including one where the city's Police Commission found fault with his actions.

Indianapolis Mayor Joe Hogsett strained to embody unity Thursday at a time when it would have been easy to perceive friction.

The Canadian Forces Snowbirds will not be performing their flyover of Waterloo Region and other southern Ontario communities on Saturday due to snowy weather.

Formula 1 almost doubles the shutdown period for teams as the coronavirus crisis continues to play havoc with the 2020 championship.

Darth Vader's former apprentice Ahsoka Tano, as played by Rosario Dawson, will compete with Baby Yoda for attention this fall on Disney Plus.

New England has a negative point differential heading into Week 4 for the first time since 2008.

Goff started the season with 941 yards and six touchdowns over his first three games then completed 26 of his 33 passes against the Minnesota Vikings for 465 yards and five touchdowns in Week 4.

Getting a jump on early lines can give bettors added value in their wagering. Here are three teams to focus on for Week 5.

The Patriots put their stamp back on the AFC East after throttling the Miami Dolphins 38-7 on Sunday. The Colts are next.

Anderson has had to face Darius Slay, Xavien Howard, Denzel Ward and Jalen Ramsey in coverage during the first four weeks of the season. Better days should be ahead, starting next week against the Colts.

But they should make the playoffs!

Michel will face a Chicago Bears defense that stops opposing rushers a league-low 13 percent of the time.

Mack carried the ball 19 times for 126 yards and a touchdown and added two catches for 33 yards and a touchdown on Sunday against the Bills.

Golden State has had one of the best offenses for the past five years and has done so while slowly moving away from the pick-and-roll.

Baines, a six-time all-star, led the league in a batting category just once over a 22-year career. If that' the new bar for the Hall, it's time to talk about Freddy Garcia and Placido Polanco, too. (Note: It should never be time to talk about Freddy Garcia and Placido Polanco.)

The Patriots are coming off a devastating 34-33 loss to the Miami Dolphins yet were lucky to maintain their playoff position as the No. 2 seed in the AFC

Almost everyone who played for the Thunder in 2017-18 and is also getting major minutes this season has improved their individual defensive rating.

Low-key no longer: The presidential candidate and his actress girlfriend appeared together at public events over the holiday weekend.

The “Saved by the Bell” star later apologized for stirring controversy in a resurfaced interview with conservative Candace Owens.

When it comes to getting schooled on plastic water bottles, look no further than Aquaman.

Trump has gutted the asylum system that grew in part out of our shame over our heartless refugee policies in the 1930s.

Teacher question: You wrote recently that it was a good idea to teach comprehension skills, but our school district says we shouldn’t, that it’s prior knowledge that matters. Do you know the baseball study? Have you read Natalie Wexler’s research? It is really difficult to trust research when everyone tells us something different. Shanahan's response:  I feel your pain.

Teacher question: You wrote recently that it was a good idea to teach comprehension skills, but our school district says we shouldn’t, that it’s prior knowledge that matters. Do you know the baseball study? Have you read Natalie Wexler’s research? It is really difficult to trust research when everyone tells us something different. Shanahan's response:  I feel your pain.

Kingston, Ontario

The Amateur Traveler talks to Corinne from Have Baby Will Travel who is a life-long Torontonian (that is to say that she lives in Toronto, Ontario). Corinne gives us an introduction to her city and its many parks, its great ethnic food, its iconic skyline punctuated by the CN Tower. Its neighborhoods includes two different Chinatowns, Greektown, the Irish-influenced Cabbagetown,  Distillery District, Kensington Market, Harbourfront and St. Lawrence Market, She particularly suggests you visit during Thanksgiving (Canada's which is in October) or Toronto International Film Festival. Corinne also describes side trips from the city heading out towards Niagra and Ontario's wine country. The city houses both a working farm in Riverdale Farms and a warren of underground shops in the Toronto Underground PATH.

Hear about travel to Rio de Janeiro, Brazil as the Amateur Traveler  talks to Kay from TheKayDays.com who is a University student in Rio.

"Rio has a culture and a aura that is completely different from anywhere I have seen before."

Hear about travel to Ottawa, Ontario as the Amateur Traveler talks to return guest Michael Soncina of Sonchy's Adventures about Canada's capital city. Michael was in Ottawa as a part of a press trip looking a new eco district the city is setting up in its downtown.

Hear about a road trip around Ontario as the Amateur Traveler talks to guidebook author Carolyn Heller, author of the Moon guide to Ontario. 

When jokes are so horrible, so obvious, so corny that they make your eyes roll, it’s a good chance that they’re what many call “dad jokes.” Bordering on lame, and all the more hilarious because of it, these jokes are so bad and yet fathers seem to get such joy from trotting out the perfect…

The post Man Posts Hilarious ‘Bad Dad Jokes’ Daily on Sign in Front Lawn To Spread Cheer to Neighbors appeared first on The Western Journal.

Western powers are in a bind, analysts say, as ISIS is likely to continue pursuing attacks abroad in retaliation to the loss of territory in Iraq and Syria.

The province is investing $1.5 million to support a housing project in Muskoka to help people with no place to call home.

The provincial government has announced it will support child care centres that have been closed since March with their fixed operating costs as the fight against COVID-19 continues.

For successful infection of their hosts, pathogenic bacteria recognize host-derived signals that induce the expression of virulence factors in a spatiotemporal manner. The fulminating food-borne pathogen Vibrio vulnificus produces a cytolysin/hemolysin protein encoded by the vvhBA operon, which is a virulence factor preferentially expressed upon exposure to murine blood and macrophages. The Fe-S cluster containing transcriptional regulator IscR activates the vvhBA operon in response to nitrosative stress and iron starvation, during which the cellular IscR protein level increases. Here, electrophoretic mobility shift and DNase I protection assays revealed that IscR directly binds downstream of the vvhBA promoter PvvhBA, which is unusual for a positive regulator. We found that in addition to IscR, the transcriptional regulator HlyU activates vvhBA transcription by directly binding upstream of PvvhBA, whereas the histone-like nucleoid-structuring protein (H-NS) represses vvhBA by extensively binding to both downstream and upstream regions of its promoter. Of note, the binding sites of IscR and HlyU overlapped with those of H-NS. We further substantiated that IscR and HlyU outcompete H-NS for binding to the PvvhBA regulatory region, resulting in the release of H-NS repression and vvhBA induction. We conclude that concurrent antirepression by IscR and HlyU at regions both downstream and upstream of PvvhBA provides V. vulnificus with the means of integrating host-derived signal(s) such as nitrosative stress and iron starvation for precise regulation of vvhBA transcription, thereby enabling successful host infection.

3 February 2016

Drawing on the findings of a recent workshop exploring a potential conflict between China and Japan over disputed islands, this paper suggests there are significant differences between how the United States and Europe prioritize their interests in the Asia-Pacific.

For successful infection of their hosts, pathogenic bacteria recognize host-derived signals that induce the expression of virulence factors in a spatiotemporal manner. The fulminating food-borne pathogen Vibrio vulnificus produces a cytolysin/hemolysin protein encoded by the vvhBA operon, which is a virulence factor preferentially expressed upon exposure to murine blood and macrophages. The Fe-S cluster containing transcriptional regulator IscR activates the vvhBA operon in response to nitrosative stress and iron starvation, during which the cellular IscR protein level increases. Here, electrophoretic mobility shift and DNase I protection assays revealed that IscR directly binds downstream of the vvhBA promoter PvvhBA, which is unusual for a positive regulator. We found that in addition to IscR, the transcriptional regulator HlyU activates vvhBA transcription by directly binding upstream of PvvhBA, whereas the histone-like nucleoid-structuring protein (H-NS) represses vvhBA by extensively binding to both downstream and upstream regions of its promoter. Of note, the binding sites of IscR and HlyU overlapped with those of H-NS. We further substantiated that IscR and HlyU outcompete H-NS for binding to the PvvhBA regulatory region, resulting in the release of H-NS repression and vvhBA induction. We conclude that concurrent antirepression by IscR and HlyU at regions both downstream and upstream of PvvhBA provides V. vulnificus with the means of integrating host-derived signal(s) such as nitrosative stress and iron starvation for precise regulation of vvhBA transcription, thereby enabling successful host infection.

Invitation Only Research Event

Invitation Only Research Event

Event participants

Duncan Robinson, Charlemagne Columnist; Brussels Bureau Chief, the Economist
Chair: Pepijn Bergsen, Research Fellow, Europe Programme, Chatham House

Invitation Only Research Event

Event participants

Duncan Robinson, Charlemagne Columnist; Brussels Bureau Chief, the Economist
Chair: Pepijn Bergsen, Research Fellow, Europe Programme, Chatham House

Research Event

Event participants

Erlan Idrissov, Minister of Foreign Affairs, Kazakhstan

6 February 2014 , Volume 70, Number 1

Masha Gessen, Words will Break Cement: The Passion of Pussy Riot, Granta, £8.70

Research Event

Event participants

HE Dr Motsoahae Thomas Thabane, Prime Minister of Lesotho
Chair: Ian Lucas MP, Shadow Minister for Africa and the Middle East