That brings the number of states with approved plans to 44, plus the District of Columbia and Puerto Rico. Still awaiting the OK: California, Florida, Nebraska, North Carolina, Oklahoma, and Utah

Victoria Petersen, of the Peninsula Clarion on the Kenai Peninsula, will report on the challenges of rural education, especially in a state as vast as Alaska.

While thousands of students in wildfire-ravaged Northern California resumed classes last week, thousands of others in Alaska stayed home after a 7.0 magnitude earthquake struck Nov. 30.

In remote regions of rural Alaska, both schools and the students themselves have to work harder to put together an education that meets students' needs.

That brings the number of states with approved plans to 44, plus the District of Columbia and Puerto Rico. Still awaiting the OK: California, Florida, Nebraska, North Carolina, Oklahoma, and Utah

An Alaskan high school exchange program works to promote understanding between the state's urban centers and its remote Native Villages and communities.

Rural schools everywhere struggle to maintain adequate buildings, but the quest for a new school has been especially long and fraught for this remote Old Believer village.

A group of high school students from Anchorage spent spring break at a remote Native Village as part of an unusual cultural exchange program in Alaska. See what they learned.

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

Alaskan schooling developed on many fronts. An illustrated timeline adds historical context for the growth of the state's education system, from the territory’s earliest Native inhabitants to today.

Recruiters already are offering bonuses, free housing, and airfare to entice teachers to their remote districts—and the competition is about to get worse.

When it comes to education, the 49th state faces its own challenges, some of which are unique to Alaska and some that it shares with other rural states. This series explores how cultural and geographic barriers, teacher shortages, historical developments, and more have shaped schooling in Alaska.

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

Teachers are still on strike in three Washington school districts, and their fights with the districts are escalating.

Five-star wing Deniya Prawl has committed to Lady Vols basketball, marking a significant recruiting win in Kim Caldwell's first year at Tennessee.

LSU women's basketball coach Kim Mulkey provided updates for Shayeann Day-Wilson and Last-Tear Poa on Tuesday after LSU's win vs Charleston Southern.

Tallahassee, FL - The South Georgia Technical College Lady Jets dropped a hard fought three-point loss, 50 – 47, to the nationally ranked Eastern Florida State College Titans before rallying to a 66 – 60 victory over Tallahassee State College in the Tallahassee Community College Classic this weekend to move to 3 – 1 on the season. “We put ourselves in a position to beat a very talented team ...

Steven F. Grieco
Nov 9, 2022; 42:8439-8449
Symposium and Mini-Symposium

Rafael G. Almeida
Oct 18, 2017; 37:10023-10034
Viewpoints

Robbert Havekes
Dec 12, 2012; 32:18137-18149
BehavioralSystemsCognitive

Yasmin L. Hurd
Oct 16, 2019; 39:8250-8258
Symposium and Mini-Symposium

Lindsay P. Cameron
Nov 8, 2023; 43:7472-7482
Symposium and Mini-Symposium

Reelin, a secreted glycoprotein, plays a crucial role in guiding neocortical neuronal migration, dendritic outgrowth and arborization, and synaptic plasticity in the adult brain. Reelin primarily operates through the canonical lipoprotein receptors apolipoprotein E receptor 2 (Apoer2) and very low-density lipoprotein receptor (Vldlr). Reelin also engages with noncanonical receptors and unidentified coreceptors; however, the effects of which are less understood. Using high-throughput tandem mass tag (TMT) liquid chromatography tandem mass spectrometry (LC-MS/MS)-based proteomics and gene set enrichment analysis (GSEA), we identified both shared and unique intracellular pathways activated by Reelin through its canonical and noncanonical signaling in primary murine neurons of either sex during dendritic growth and arborization. We observed pathway cross talk related to regulation of cytoskeleton, neuron projection development, protein transport, and actin filament-based process. We also found enriched gene sets exclusively by the noncanonical Reelin pathway including protein translation, mRNA metabolic process, and ribonucleoprotein complex biogenesis suggesting Reelin fine-tunes neuronal structure through distinct signaling pathways. A key discovery is the identification of aldolase A, a glycolytic enzyme and actin-binding protein, as a novel effector of Reelin signaling. Reelin induced de novo translation and mobilization of aldolase A from the actin cytoskeleton. We demonstrated that aldolase A is necessary for Reelin-mediated dendrite growth and arborization in primary murine neurons and mouse brain cortical neurons. Interestingly, the function of aldolase A in dendrite development is independent of its known role in glycolysis. Altogether, our findings provide new insights into the Reelin-dependent signaling pathways and effector proteins that are crucial for dendritic development.

Low-intensity transcranial focused ultrasound stimulation (TUS) is a novel technique for noninvasive brain stimulation (NIBS). TUS delivered in a theta (5 Hz) burst pattern (tbTUS) induces plasticity in the human primary motor cortex (M1) for 30–60 min, showing promise for therapeutic development. Metaplasticity refers to activity-dependent changes in neural functions governing synaptic plasticity; depotentiation is the reversal of long-term potentiation (LTP) by a subsequent protocol with no effect alone. Metaplasticity can enhance plasticity induction and clinical efficacy of NIBS protocols. In our study, we compared four NIBS protocol combinations to investigate metaplasticity on tbTUS in humans of either sex. We delivered four interventions: (1) sham continuous theta burst stimulation with 150 pulses (cTBS150) followed by real tbTUS (tbTUS only), (2) real cTBS150 followed by sham tbTUS (cTBS only), (3) real cTBS150 followed by real tbTUS (metaplasticity), and (4) real tbTUS followed by real cTBS150 (depotentiation). We measured motor-evoked potential amplitude, short-interval intracortical inhibition, long-interval intracortical inhibition, intracortical facilitation (ICF), and short-interval intracortical facilitation before and up to 90 min after plasticity intervention. Plasticity effects lasted at least 60 min longer when tbTUS was primed with cTBS150 compared with tbTUS alone. Plasticity was abolished when cTBS150 was delivered after tbTUS. cTBS150 alone had no significant effect. No changes in M1 intracortical circuits were observed. Plasticity induction by tbTUS can be modified in manners consistent with homeostatic metaplasticity and depotentiation. This substantiates evidence that tbTUS induces LTP-like processes and suggests that metaplasticity can be harnessed in the therapeutic development of TUS.

Written by the former chief historian of NASA, the book examines the evolution of our cosmic understanding—from early civilizations to the present day

Addressing the plenary meeting in the closing session of the 159^th Session of the Council, the Director-General expressed his appreciation to delegates for their commitment and hard work to [...]

Ahead of the Food Systems Summit, join the Publications team to find out more about where to find FAO publications, the different formats available, how you can re-use the [...]

In 1925, an Alaskan adventurer and his trusted Siberian husky completed a grueling 600-mile journey across the frozen plains. Their exploits would end up saving the lives of 2,000 people.

Kenneth Morris is the great-great-great-grandson of the heralded abolitionist and helped compile an illustrated biography of his ancestor. (Credit: Drew Gardner)

In 1905, New York City hosted a grand procession for the last living soldier of a war that ended 90 years earlier

When plasma falls to the surface it results in a dazzling display known as coronal rain

Venture into Virunga National Park with Smithsonian writer Paul Raffaele as he examines the threats facing mountain gorillas in the Democratic Republic of the Congo

In the Virunga National Forest, the mountain gorilla population sits in the middle of a war zone in the Democratic Republic of the Congo as forest rangers track and keep a watchful eye on the threatened primates Music: Kevin MacLeod

By the 1930s, the black middle class had arrived, with the purchasing power to match. Sensing an opportunity, developers established Idlewild: a summer resort aimed exclusively at African-Americans.

Smithsonian magazine commissioned Drew Gardner for a project that connects Black Americans today to their lost ancestry. Read about Gardner’s project and process, as well as more details about the subjects of this incredible series here: https://www.smithsonianmag.com/history/descendants-black-civil-war-heroes-wear-heritage-pride-180983397/ Video produced by Sierra Theobald. Special thanks to Drew Gardner Additional credits: Emma MacBeath, WikiTree US Black Heritage project; Ottawa Goodman, research and coordinator; Sam Dole, Penumbra Foundation; Elizabeth Zuck, set design; Calvin Osbourne, props and costume; Angela Huff, hair and make up; Diego Huerta, Lexia Krebs, behind-the-scenes filming; background prints by Fujifilm USA

From decorative urns and plates to chandeliers, the Corning Museum of Glass features glass blown items from today to as far back as ancient Egypt.

The two discussed their ancestors’ legacy more than 150 years after the famous figures both attended the Seneca Falls Convention. (Credit: Drew Gardner)

Read more at http://blogs.smithsonianmag.com/aroundthemall/2011/06/dancing-splash-mob-floods-the-natural-history-museum In an effort to celebrate World Oceans Day, organizers planned a "splash" mob at the National Museum of Natural History's Sant Ocean Hall.

The Solar Dynamics Observatory captured this epic footage of Venus crossing the face of the sun on June 5, 2012

Research in Tanzania shows that impalas follow baboons to sausage trees to share fruits and feel safer from predators. (Video courtesy Brooke Davis)

Read more at http://www.smithsonianmag.com/arts-culture/Hazel-Scotts-Lifetime-of-High-Notes.html In a performance filmed for World War II soldiers, Hazel Scott begins with a section from Liszt's "Hungarian Rhapsody No. 2" and ends with a jazzy tune (Army / Navy Screen Magazine).

In a 11-4 vote, the City Council decided to remove the 65-foot-tall monument from its location in the heart of the city

A melting glacier caused a mountain in Greenland to collapse into a narrow fjord, setting off an oscillating wave that rattled seismic detectors around the world

A new study identified the tiny pollutants in the olfactory bulbs of eight cadavers, suggesting microplastics can travel through the nose to the brain